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| 1 | Stimuli-responsive fluorescent supramolecular polymer network based on a monofunctionalized leaning tower[6]arene显示文摘A fluorescent supramolecular polymer network with an excellent triple-stimuli responsive property based on metal-ligand coordination and host-guest interactions has been constructed from a terpyridine-monofunctionalized leaning tower[6]arene,a tetraphenylethylene AIEgen,and a bridging coordination ion(Zn^2+).Addition of competitive binding agents,trifluoroacetic acid,and/or pillar[5]arene can break the metal coordination and/or host-guest inclusion complexation,and thermal heating can weaken the non-covalent interactions in the supramolecular polymer gel,all leading to the gel-to-sol transition. | Zengjie Liu Jiarui Wu Chunyu Wang Jie Yang Yan Wang Ying-Wei Yang | 2019 | Chinese Chemical Letters2019，30，12： | 3 |
| 2 | A trilogy antimicrobial strategy for multiple infections of orthopedic implants throughout their life cycle显示文摘Bacteria-associated infection represents one of the major threats for orthopedic implants failure during their life cycles.However,ordinary antimicrobial treatments usually failed to combat multiple waves of infections during arthroplasty and prosthesis revisions etc.As these incidents could easily introduce new microbial pathogens in/onto the implants.Herein,we demonstrate that an antimicrobial trilogy strategy incorporating a sophisticated multilayered coating system leveraging multiple ion exchange mechanisms and fine nanotopography tuning,could effectively eradicate bacterial infection at various stages of implantation.Early stage bacteriostatic effect was realized via nano-topological structure of top mineral coating.Antibacterial effect at intermediate stage was mediated by sustained release of zinc ions from doped CaP coating.Strong antibacterial potency was validated at 4 weeks post implantation via an implanted model in vivo.Finally,the underlying zinc titanate fiber network enabled a long-term contact and release effect of residual zinc,which maintained a strong antibacterial ability against both Staphylococcus aureus and Escherichia coli even after the removal of top layer coating.Moreover,sustained release of Sr2+and Zn2+during CaP coating degradation substantially promoted implant osseointegration even under an infectious environment by showing more peri-implant new bone formation and substantially improved bone-implant bonding strength. | Yikai Wang Wangsiyuan Teng Zengjie Zhang Xingzhi Zhou Yuxiao Ye Peng Lin An Liu Yan Wu Binghao Li Chongda Zhang Xianyan Yang Weixu Li Xiaohua Yu Zhongru Gou Zhaoming Ye | 2021 | Bioactive Materials2021，6，7： | 3 |
| 3 | STUDY ON STRATEGY OF DYNAMIC JOINT ROUTING AND RESOURCE ALLOCATION IN LAYERED OPTICAL TRANSPORT NETWORKS显示文摘A layered network model for optical transport networks is proposed in this paper,which involves Internet Protocol(IP) ,Synchronous Digital Hierarchy(SDH) and Wavelength Division Mul-tiplexing(WDM) layers. The strategy of Dynamic Joint Routing and Resource Allocation(DJRRA) and its algorithm description are also presented for the proposed layered network model. DJRRA op-timizes the bandwidth usage of interface links between different layers and the logic links inside all layers. The simulation results show that DJRRA can reduce the blocking probability and increase network throughput effectively,which is in contrast to the classical separate sequential routing and resource allocation solutions. | Su Yang Xu Zhanqi Zhao Ruiqin Liu Zengji | 2008 | Journal of Electronics(China)2008，25，2： | 2 |
| 4 | Research on a New Topology of Switching Fabric in Large Capacity Routers显示文摘 | Yang Jungang Qiu Zhiliang Liu Zengji | 2003 | Journal of Xidian University2003，30，7： | 1 |
| 5 | Cepstral Analysis of Voice in Children WithVelopharyngeal Insufficiency After CleftPalate Surgery显示文摘 | Zengjie Yang Jincai Fan Jia Tian | 2014 | J Voice2014，28，4： | 1 |
| 6 | A real-world study of immune checkpoint inhibitors in advanced triple-negative breast cancer显示文摘Background:Triple-negative breast cancer(TNBC)is the most aggressive type of breast cancer.Immune checkpoint inhibitors(ICIs)have been widely used to treat various tumors and have changed the landscape of tumor management,but the data from real-world studies of ICIs for TNBC treatment remain limited.The aim of this study was to evaluate the efficacy of ICIs in the treatment of patients with advanced TNBC in a real-world setting and to explore possible correlates.Methods:The clinical data of advanced TNBC patients who received ICI treatment in the Chinese People's Liberation Army(PLA)General Hospital were collected.Treatment responses,outcomes and adverse events(AEs)were assessed.Results:Eighty-one patients were included in the study.The confirmed objective response rate(ORR)was 32.1%,and the disease control rate(DCR)was 64.2%.The median progression-free survival(PFS)was 4.2 months,and the median overall survival(OS)was 11.0 months.PFS and OS were longer in patients who achieved clinical benefit from ICIs and shorter in patients who received later-line ICIs and higher levels of inflammation;specifically,patients with higher TILs had longer PFS.Overall AEs were tolerable.Conclusions:ICIs are effective in the treatment of advanced TNBC,and the adverse reactions are tolerable.A panel of biomarkers including LDH,ALP,and bNLR were identified to predict the efficacies of ICIs in TNBC treatment. | Zheng Zhang Yadi Zhang Chuanling Liu Jiakang Shao Yimeng Chen Yimin Zhu Li Zhang Boyu Qin Ziqing Kong Xixi Wang Yutong Wang Deqin Huang Liqun Liu Yuxin Zhou Ran Tao Zengjie Yang Mei Liu Weihong Zhao | 2023 | Cancer Innovation2023，2，3： | 0 |
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