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| 1 | Sentinel node navigation surgery in gastric cancer: Current status显示文摘The theory behind using sentinel node mapping and biopsy in gastric cancer surgery, the so-called sentinel node navigation surgery, is to limit the extent of surgi-cal tissue dissection around the affected organ and subsequently the accompanied morbidity. However, ob-stacles on the clinical correspondence of sentinel node navigation surgery in everyday practice have occasion-ally alleviated researchers' interest on the topic. Only recently with the widespread use of minimally invasive surgical techniques, i.e., laparoscopic gastric cancer resections, surgical community's interest on the topic have been unavoidably reflated. Double tracer methods appear superior compared to single tracer techniques. Ongoing research is now focused on the invention of new lymph node detection methods utilizing sophisti-cated technology such as infrared ray endoscopy, flo-rescence imaging and near-infrared technology. Despite its notable limitations, hematoxylin/eosin is still the mainstay staining for assessing the metastatic status of an identified lymph node. An intra-operatively verified metastatic sentinel lymph node will dictate the need for further conventional lymph node dissection. Thus, laparoscopic resection of the gastric primary tumor combined with the appropriate lymph node dissection as determined by the process of sentinel lymph node status characterization represents an option for early gastric cancer. Patients with T3 or more advanced dis-ease should still be managed conventionally with resec-tion plus standard lymph node dissection. | Dimitrios Symeonidis George Koukoulis Konstantinos Tepetes | 2014 | World Journal of Gastrointestinal Surgery2014，6，6： | 9 |
| 2 | Incidental finding of Zinner syndrome in a Greek military recruit: a case report of a rare clinical entity显示文摘Background: Zinner syndrome represents a rare congenital malformation of the urinary tract. It comprises a constellation of Wolffian duct anomalies and is almost exclusively encountered as a classic triad of seminal vesicle cysts, ejaculatory duct obstruction and renal agenesis. Patients can be either asymptomatic or symptomatic. Recently, minimally invasive surgical techniques have emerged, superseding traditional surgery for select symptomatic cases. Our case highlights the finding of a rare clinical syndrome that was incidentally detected during a routine mass screening of military recruits in the Greek Armed Forces.Case presentation: Herein, we present a case of a 19-year-old male who reported having a solitary right kidney when examined in a military training center of Northern Greece. No additional clinical information was available;thus, referral to a tertiary urology department for further investigation ensued. Imaging studies, namely, computed tomography and magnetic resonance imaging, revealed left renal aplasia, multiple left seminal vesicle cysts, and ejaculatory duct obstruction. Laboratory values and urinalysis were within normal range. Semen analysis was significant for cryptozoospermia. Our patient remained asymptomatic during the entire hospitalization. Long-term follow-up was recommended. Nevertheless, he declined further investigation and sought treatment in a private practice setting.Conclusions: This article aims to present the incidental diagnosis of a rare syndrome in a military setting. Population screening conducted in the armed forces permits the identification of undiagnosed diseases that warrant further investigation. To the best of our knowledge, this was the first report of Zinner syndrome in a military recruit and the second case cited of a Greek patient in the published literature. Regular follow-up is the key to timely intervention in conservatively managed cases. | Evangelos NSymeonidis Chrysovalantis Gkekas Ioannis Tsifountoudis Asterios Symeonidis ChristosGeorgiadis Vasileios Kalyvas Apostolos Malioris Michail Papathanasiou | 2019 | Military Medical Research2019，6，3： | 5 |
| 3 | Current surgical management of pancreatic endocrine tumor liver metastases显示文摘BACKGROUND: The management of metastatic disease in pancreatic endocrine tumors (PETs) demands a multidisciplinary approach and the cooperation of several medical specialties. The role of surgery is critical, even when a radical excision cannot always be achieved. DATA SOURCES: A PubMed search of relevant articles published up to February 2011 was performed to identify current information about PET liver metastases regarding diagnosis and management, with an emphasis on surgery. RESULTS: The early diagnosis of metastases and their accurate localization, most commonly in the liver, is very important. Surgical options include radical excision, and palliative excision to relieve symptoms in case of failure of medical treatment. The goal of the radical excision is to remove the primary tumor bulk and all liver metastases at the same time, but unfortunately it is not feasible in most cases. Palliative excisions include aggressive tumor debulking surgeries in well-differentiated carcinomas, trying to remove at least 90% of the tumor mass, combined with other additional destructive techniques such as hepatic artery embolization or chemoembolization to treat metastases or chemoembolization to relieve symptoms in cases of rapidly growing tumors. The combination of chemoembolization and systemic chemotherapy results in better response and survival rates. Other local destructive techniques include ethanol injection, cryotherapy and radiofrequency ablation. CONCLUSION: It seems that the current management of PETs can achieve important improvements, even in advanced cases. | Theodoros E Pavlidis Kyriakos Psarras Nikolaos G Symeonidis Efstathios T Pavlidis Athanasios K Sakantamis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，3： | 5 |
| 4 | Use of isolated Roux loop for pancreaticojejunostomy reconstruction after pancreaticoduodenectomy显示文摘AIM: To evaluate the efficacy of the isolated Roux loop technique in decreasing the frequency of pancreaticojejunal anastomosis failure. METHODS: We retrospectively reviewed 88 consecutive patients who underwent pancreaticoduodenectomy (standard or pylorus-preserving). Single jejunal loop was used in 42 patients (SL group) while isolated Roux loop was used in 46 patients (RL group). Demographic characteristics (age, gender) and perioperative results (major/minor complications, mortality, hospital stay) were compared between the two groups. RESULTS: Mortality was almost equal in both groups and overall mortality was 2.27%. Leak rate from the pancreaticojejunal anastomosis and hospital stay were lower in the RL group without significant difference. Morbidity was 39.1% in the RL group, insignificantly higherthan the SL group. Operative time was almost 30 min longer in the RL group. CONCLUSION: The isolated Roux loop, although an equally safe alternative, does not present advantages over the traditional use of a single jejunal loop. Randomized controlled studies are required to further clarify its efficacy. | Konstantinos Ballas Nikolaos Symeonidis Savvas Rafailidis Theodoros Pavlidis Georgios Marakis Nikolaos Mavroudis Athanasios Sakantamis | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 5 | colorectal 癌症阶段特征上的 antiplatelet 治疗的影响显示文摘 AIM:To evaluate whether antiplatelet medication leads to an earlier stage colorectal cancer(CRC) diagnosis.METHODS:From January 2002 until March 2010,patients that presented to our institution with the initial diagnosis of CRC and were submitted to an open curative CRC resection or a palliative procedure were retrospectively reviewed.Exclusion criteria were the use of antithrombotic medication,i.e.,coumarins,and appendiceal malignancies.Data acquired from medical files included age,gender,past medical history,antithrombotic treatment received prior to endoscopic diagnosis,preoperative imaging staging,location of the tumor,surgical and final histopathological report.Patients that did not receive any antithrombotic medication prior to the endoscopic diagnosis comprised the control group of the study,while patients that were on antiplatelet medication comprised the antiplatelet group.Primary end point was a comparison of CRC stage in the two groups of the study.CRC presenting symptoms and the incidence of each cancer stage in the two groups were also evaluated.RESULTS:A total of 387 patients with the diagnosis of CRC were submitted to our department for further surgical treatment.Ninety-eight patients(25.32%),with a median age of 71 years(range 52-91 years),were included in the antiplatelet group,while 289(74.67%) patients,with a median age of 67 years(range 4190 years),were not in any thrombosis prophylaxis medication(control group).Thirty-one patients were treated with some kind of palliative procedure,either endoscopic,such as endoscopic stent placement,or surgical,such as de-compressive colostomy or deviation.Coronary disease(77.55%-76 patients),stroke recurrence prevention(14.28%-14 patients) and peripheral arterial disease(8.16%-8 patients) were the indications for the administration of antiplatelet treatment(aspirin,clopidogrel,ticlopidine or dipyridamole) in the antiplatelet group.All patients on aspirin treatment received a dosage of 100 mg/d,while the minimum prophylactic dosages were also used for the rest of the antiplatelet drugs.Investigation of an iron deficiency anemia(147 patients),per rectum blood loss(84 patients),bowel obstruction and/or perforation(81 patients),bowel habits alterations(32 patients),nonspecific symptoms,such as weight loss,intermittent abdominal pain and fatigue,(22 patients) or population screening(21 patients) were the indications for the endoscopic investigation in both groups.Bleeding,either chronic presenting as anemia or acute was significantly higher(P = 0.002) for the antiplatelet arm of the study(71 patients-72.4% of the antiplatelet group vs 160 patients-55.3% of the control group).The mean tumor,node and metastasis stage was 2.57 ± 0.96 for the control group,2.27 ± 0.93 for the antiplatelet group(P = 0.007) and 2.19 ± 0.92 for the subgroup of patients taking aspirin(P = 0.003).The incidence of advanced disease(stage Ⅳ) was lower for the antiplatelet group of the study(P = 0.033).CONCLUSION:The adverse effect of bleeding that is justifiably attached to this drug category seems to have a favorable impact on the staging characteristics of CRC. | Dimitrios Symeonidis Georgios Koukoulis Grigorios Christodoulidis Ioannis Mamaloudis Ioannis Chatzinikolaou Konstantinos Tepetes | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，9： | 3 |
| 6 | Effect of early propranolol administration on portal hypertensive gastropathy in cirrhotic rats显示文摘AIM:To investigate any protective effect of early propranolol administration in the development of portal hypertensive gastropathy in cirrhotic rats. METHODS:For the development of liver cirrhosis and portal hypertensive gastropathy,60 rats underwent ligation of the left adrenal vein and complete devascularization of the left renal vein,followed by phenobarbital and carbon tetrachloride(CCl4) administration.After two weeks of CCl4 administration, the rats were randomly separated into two groups.In group A,propranolol was continuously administered intragastrically throughout the study,whereas in group B normal saline(placebo)was administered instead. Hemodynamic studies and vascular morphometric analysis of gastric sections were performed after complete induction of cirrhosis. RESULTS:Vascular morphometric studies showed higher numbers of vessels in all mucosal layers in the control group.Statistical analysis revealed a significantly higher total vascular surface in the control group compared to the propranolol group,but with no statistically significant difference between the mean vascular surfaces between the groups.Our study clearly shows that the increased mucosal blood flow is manifested by a marked increase of vessel count. CONCLUSION:Early propranolol's administration in portal hypertensive cirrhotic rats seems to prevent intense gastric vascular congestion that characterizes portal hypertensive gastropathy. | Savas Rafailidis Charalampos Demertzidis Konstantinos Ballas Michail Alatsakis Nikolaos Symeonidis Theodoros Pavlidis Kyriakos Psarras Valentini Tzioufa-Asimakopoulou Athanassios Sakadamis | 2009 | World Journal of Gastroenterology2009，15，34： | 3 |
| 7 | Comparing Cournot and Bertrand equilibria in a differentiated duopoly with product R&D显示文摘 | George Symeonidis | 2003 | International Journal of Industrial Organization2003，，1： | 2 |
| 8 | Mean platelet volume in patients with type 2 diabetes mellitus显示文摘 | N. Papanas G. Symeonidis E. Maltezos G. Mavridis E. Karavageli Th. Vosnakidis G. Lakasas | 2004 | Platelets2004，，8： | 2 |
| 9 | Laparoendoscopic Rendezvous Versus Preoperative ERCP and Laparoscopic Cholecystectomy for the Management of Cholecysto-Choledocholithiasis: Interim Analysis of a Controlled Randomized Trial显示文摘 | George Tzovaras Ioannis Baloyiannis Eleni Zachari Dimitris Symeonidis Dimitris Zacharoulis Andreas Kapsoritakis George Paroutoglou Spyros Potamianos | 2012 | Annals of Surgery2012，，3： | 2 |
| 10 | Capsule contraction syndrome in eight cases of hydrophobic one - piece intraocular lens im- plantation 显示文摘 | Tsinopoulos I Symeonidis C Frangou E | 2008 | Clin Exp Optom2008，91，5： | 1 |
| 11 | Ankle-brachial index:a surrogate marker of microvaseular complications in type 2 diabetic mellitus显示文摘 | Papanas N Symeonidis G Mavridis G | 2007 | International Angiology2007，26，3： | 1 |
| 12 | Impairment of erythrocyte vis- coelasticity is correlated with levels of glycosylated haemoglobin in diabetic patients 显示文摘 | Symeonidis A Athanassiou G Psiroyarmis A | 2001 | Clin Lab Haematol2001，23，2： | 1 |
| 13 | Correlation of matrix metalloproteinase levels with the grade of proliferative vitreoretinopathy in the subretinal fluid and vitreous during rhegmatogenous retinal detachment显示文摘 | Symeonidis C Papakonstantinou E Souliou E | | 0，，： | 1 |
| 14 | Bilateral manifestation of sever anterior capsule contraction syndrome after implantation of a preloaded intraecular lens显示文摘 | Tsinopoulos IT Tsaousis KT Symeonidis C | 2009 | Clin Exp Optom2009，92，6： | 1 |
| 15 | Relative iron 'overload' in offspring of patients with type 2 diabetes mellitus : a new component in the conundrum of insulin resistance syndrome? 显示文摘 | Psyrogiannis A Kyriazopoulou V Symeonidis A | 2003 | Hormones (Athens)2003，2，3： | 1 |
| 16 | A uni- fied framework for providing recommendations in social tagging systems based on ternary semantic analysis 显示文摘 | Symeonidis P Nanopoulos A Manolopoulos Y | 2010 | Transactions on Knowledge and Data Engineering2010，22，： | 1 |
| 17 | Downstream merger and welfare in a bilateral oligopoly 显示文摘 | Symeonidis G | 2010 | International Journal of Industrial Organization1 /2010，28，3： | 1 |
| 18 | Ternary se- mantic analysis of social tags for personalized music rec- ommendation 显示文摘 | Symeonidis P Ruxanda M Nanopoulos A | 2008 | Knowledge Representation Tags Metadata2008，2008，2： | 1 |
| 19 | Matrix metallopro- teinase ( MMP - 2, - 9 ) and tissue inhibitor ( TIMP - 1, - 2) activi- ty in tear samples of pediatric type 1 diabetic patients 显示文摘 | Symeonidis C Papakonstantinou E Galli A | 2013 | Graefes Arch Clin Exp Ophthalmol2013，251，3： | 1 |
| 20 | Treatment with Atorvastatin to the National Cholesterol Educational Program Goal Versus ’Usual’ Care in Secondary Coronary Heart Disease Prevention显示文摘 | Vasilios G. Athyros Athanasios A. Papageorgiou Bodosakis R. Mercouris Valasia V. Athyrou Athanasios N. Symeonidis Elias O. Basayannis Dimokritos S. Demitriadis Athanasios G. Kontopoulos | 2002 | Current Medical Research and Opinion?2002，，4： | 1 |
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