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| 1 | Percutaneous microwave ablation vs radiofrequency ablation in the treatment of hepatocellular carcinoma显示文摘Hepatocellular cancer ranks fifth among cancers and is related to chronic viral hepatitis, alcohol abuse,steatohepatitis and liver autoimmunity. Surgical resection and orthotopic liver transplantation have curative potential, but fewer than 20% of patients are suitable candidates. Interventional treatments are offered to the vast majority of patients. Radiofrequency(RFA) and microwave ablation(MWA) are among the therapeutic modalities, with similar indications which include the presence of up to three lesions, smaller than 3 cm in size, and the absence of extrahepatic disease. The therapeutic effect of both methods relies on thermal injury, but MWA uses an electromagnetic field as opposed to electrical current used in RFA. Unlike MWA, the effect of RFA is partially limited by the heat-sink effect and increased impedance of the ablated tissue. Compared with RFA, MWA attains a more predictable ablation zone, permits simultaneous treatment of multiple lesions, and achieves larger coagulation volumes in a shorter procedural time. Major complications of both methods are comparable and infrequent(approximately 2%-3%), and they include haemorrhage, infection/abscess, visceral organ injury, liver failure, and pneumothorax. RFA may incur the additional complication of skin burns. Nevertheless, there is no compelling evidence for differences in clinical outcomes, including local recurrence rates and survival. | Loukia S Poulou Evanthia Botsa Ioanna Thanou Panayiotis D Ziakas Loukas Thanos | 2015 | World Journal of Hepatology2015，7，8： | 37 |
| 2 | Portopulmonary hypertension and serum endothelin levels in hospitalized patients with cirrhosis显示文摘BACKGROUND:Cirrhosis is associated with several extrahepatic manifestations including portopulmonary hypertension (PPHT).Recent data suggest that endothelins (ETs) are related to the pathophysiology of PPHT.The study aimed to measure serum ET levels in hospitalized cirrhotic patients and to determine their association with PPHT and patient outcome.METHODS:Fifty-seven cirrhotic patients [43 males;median age 58 (28-87) years] underwent Doppler echocardiography.Patients with systolic pulmonary arterial pressure ≥40 mmHg and pulmonary acceleration time <100 ms were deemed to have PPHT.ET-1,2,and 3 serum levels were measured with an ELISA assay.All-cause mortality was recorded over a median period of 24 months.RESULTS:Nine out of 57 patients (15.8%) had PPHT.Among various clinical variables,only autoimmune hepatitis was associated with PPHT (OR=11.5;95% CI,1.58-83.4;P=0.01).ET-1 levels [9.1 (1.6-20.7) vs 2.5 (1.4-9.2) pg/mL,P=0.02] and the ET-1/ET-3 ratio [4.73 (0.9-22.4) vs 1.6 (0.3-10.7),P=0.02] were significantly higher in patients with PPHT than in those without.ET-2 and ET-3 levels did not differ between the two groups.There was no difference in survival between the two groups,although ET-1 levels were associated with an adverse outcome in Cox regression analysis (HR=1.11;95% CI,1.02-1.22;P=0.02 per unit increase in ET-1).CONCLUSION:Our data suggest that ET-1 and the ET-1/ET-3 ratio are elevated in patients with PPHT and that ET-1 is associated with a poor outcome irrespective of PPHT. | Aristotelis Tsiakalos Gregorios Hatzis Ioannis Moyssakis Aggelos Karatzaferis Panayiotis D Ziakas George E Tzelepis | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，4： | 7 |
| 3 | Melatonin attenuates high fat diet-induced fatty liver disease in rats显示文摘AIM:To investigate melatonin's preventive action in oxidative stress in a rat model with high fat diet-induced non-alcoholic fatty liver disease(NAFLD).METHODS:NAFLD was induced by high fat diet(HFD)in adult,male,Wistar rats,weighing 180-230 g.After acclimatization for one week,they were randomly assigned to 6 experimental groups that comprised animals on regular diet plus 5 or 10 mg/kg melatonin,for 4 or 8 wk;animals on HFD,with or without 5 or 10 mg/kg melatonin,for 4 or 8 wk;and animals on HFD for 8 or 12 wk,with melatonin 10 mg/kg for the last 4 wk.Liver damage was assessed biochemically by the serum levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and histologically.Lipid peroxidation and oxidative stress were assessed by malondialdehyde and glutathione levels in liver tissue.Lipidemic indices and portal vein pressure were also measured.RESULTS:Compared to rats not receiving melatonin,rats on 5 or 10 mg/kg of melatonin had lower mean liver weight(-5.0 g and-4.9 g)(P < 0.001)and lower liver weight to body weight ratio(-1.0%)(P < 0.001),for the two doses,respectively.All rats fed HFD without melatonin developed severe,grade Ⅲ,steatosis.Rats on HFD with concurrent use of melatonin showed significantly less steatosis,with grade Ⅲ steatosis observed in 1 of 29(3.4%)rats on 10 mg/kg melatonin and in 3 of 27(11.1%)rats on 5 mg/kg melatonin.Melatonin was ineffective in reversing established steatosis.Melatonin also had no effect on any of the common lipidemic serum markers,the levels of which did not differ significantly among the rats on HFD,irrespective of the use or not of melatonin.Liver cell necrosis was significantly less in rats on HFD receiving melatonin than in those not on melatonin,with the AST levels declining by a mean of 170 U/L(P = 0.01)and 224 U/L(P = 0.001),and the ALT levels declining by a mean of 62.9 U/L(P = 0.01)and 93.4 U/L(P < 0.001),for the 5 and 10 mg/kg melatonin dose,respectively.Melatonin mitigated liver damage due to peroxidation and oxidative stress in liver tissue as indicated by a significant decline in MDA production by 12.7(P < 0.001)and 12.2(P < 0.001)μmol/L/mg protein/mg tissue,and a significant increase in glutathione by 20.1(P = 0.004)and 29.2(P < 0.001)μmol/L/mg protein/mg tissue,for the 5 and 10 mg/kg melatonin dose,respectively.CONCLUSION:Melatonin can attenuate oxidative stress,lessen liver damage,and improve liver histology in rats with high fat diet-induced NAFLD,when given concurrently with the diet. | Gregorios Hatzis Panayiotis Ziakas Nikolaos Kavantzas Aggeliki Triantafyllou Panagiotis Sigalas Ioanna Andreadou Konstantinos Ioannidis Stamatios Chatzis Konstantinos Filis Alexandros Papalampros Fragiska Sigala | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 4 | Molecular basis of statin- associated myopathy 显示文摘 | Vaklavas C Chatzizisis YS Ziakas A | 2009 | Athemsolerosis2009，202，1： | 1 |
| 5 | Left Ventricular Outflow Tract Obstruction as a Risk Factor for Sudden Cardiac Death in Hypertrophic Cardiomyopathy显示文摘 | Georgios K. Efthimiadis Despina G. Parcharidou Georgios Giannakoulas Efstathios D. Pagourelias Panagiotis Charalampidis Gregorios Savvopoulos Antonios Ziakas Haralambos Karvounis Ioannis H. Styliadis Georgios E. Parcharidis | 2009 | The American Journal of Cardiology2009，，5： | 1 |
| 6 | Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss:a systematic review and meta-analysis显示文摘 | Ziakas PD Pavlou M Voulgarelis M | 2010 | Obstet Gynecol2010，115，6： | 1 |
| 7 | Transradial Outpatient Percutaneous Coronary Intervention is Safe,Feasible and Preferred by Most Patients:The North American Experience显示文摘 | Ziakas A Chugh SK Klinke P | 2002 | Indian Heart Journal2002，54，5： | 1 |
| 8 | Molecular basis of statin-associated myopathy显示文摘 | Vaklavas C Chatzizisis YS Ziakas A | | 0，，01： | 1 |
| 9 | Prognosis andoutcome of non-Hodgkin lymphoma in primary Sjogren syndrome显示文摘 | Voulgarelis M Ziakas PD Papageorgiou A | 2012 | Medicine (Baltimore)2012，91，1： | 1 |
| 10 | The utility of the standard 12-Lead elctrocardiogram in the pridiction of proximal right coronary artery occlusion in acute inferior myocardial infarction显示文摘 | Styliadis L Ziakas A Karvounis H | 2008 | Am J Emerg Meal2008，35，1： | 1 |
| 11 | Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment 显示文摘 | Giannouli S Voulgarelis M Ziakas PD | 2006 | Ann Rheum Dis2006，65，2： | 1 |
| 12 | Anaemia in systemic lupus erythematosus: from pathophysiology to clinical assessment 显示文摘 | Giaunouli S Voulgarelis M Ziakas PD | 2006 | Annals of the rhemnatic diseases2006，65，2： | 1 |
| 13 | Comparison of the radial and the femoral approaches in percutaneous coronary intervention for acute myocardial infarction显示文摘 | Ziakas A Klinke P Mildenberger R | 2003 | Am J Cardiol2003，91，5： | 1 |
| 14 | Effect of prophy-lactic lamivudine for chemotherapy-associated hepatitis B reactivation in lymphoma:a meta-analysis of published clinical trials and a decision tree addressing prolonged prophylaxis and maintenance显示文摘 | Ziakas PD Karsaliakos P Mylonakis E | 2009 | Haematologica2009，94，7： | 1 |
| 15 | Suspects in the tale of lupus-associated thrombocytopenia显示文摘 | Ziakas PD Routsias JG Giannouli S | 2006 | Clin Exp Im- muno12006，145，1： | 1 |
| 16 | Risk factors for invasive fungal disease after allogeneic hematopoietic stem cell transplantation: a single center experience显示文摘 | Omer AK Ziakas PD Anagnostou T | 2013 | Boil Blood Marrow Transplant2013，19，8： | 1 |
| 17 | FDG PET scan strategies and longterm outcomes after first-line therapy in Hodgkin' s disease显示文摘 | Poulou LS Karianakis G Ziakas PD | 2008 | Eur J Radiol2008，，： | 1 |
| 18 | Effect of prophylactic lamivudine for chemotherapy-associated hepatitis B reactivation in lymphoma:a meta-analysis of published clinical trials and a decision tree addressing prolonged prophylaxis and maintenance显示文摘 | Ziakas PD Karsaliakos P Mylonakis E | 2009 | Haematologica2009，94，7： | 1 |
| 19 | A multi-dimensional investigation of a regional event portfolio:Advancing theory and praxis显示文摘 | V | 2013 | Event Management2013，，17： | 1 |
| 20 | Molecu- lar basis of statin - associated myopathy 显示文摘 | Vaklavas C Chatzizisis Y S Ziakas A | 2009 | Athero- sclerosis2009，202，1： | 1 |
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