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| 1 | Targeting inflammation in pancreatic cancer: Clinical translation显示文摘Preclinical modelling studies are beginning to aid development of therapies targeted against key regulators of pancreatic cancer progression. Pancreatic cancer is an aggressive, stromally-rich tumor, from which few people survive. Within the tumor microenvironment cellular and extracellular components exist, shielding tumor cells from immune cell clearance, and chemotherapy, enhancing progression of the disease. The cellular component of this microenvironment consists mainly of stellate cells and inflammatory cells. New findings suggest that manipulation of the cellular component of the tumor microenvironment is possible to promote immune cell killing of tumor cells. Here we explore possible immunogenic therapeutic strategies. Additionally extracellular stromal elements play a key role in protecting tumor cells from chemotherapies targeted at the pancreas. We describe the experimental findings and the pitfalls associated with translation of stromally targeted therapies to clinical trial. Finally, we discuss the key inflammatory signal transducers activated subsequent to driver mutations in oncogenic Kras in pancreatic cancer. We present the preclinical findings that have led to successful early trials of STAT3 inhibitors in pancreatic adenocarcinoma. | Colin William Steele Nina Angharad Kaur Gill Nigel Balfour Jamieson Christopher Ross Carter | 2016 | World Journal of Gastrointestinal Oncology2016，8，4： | 2 |
| 2 | The Economics of Poverty Traps and Persistent Poverty: an Asset-based Approach显示文摘 | Michael R Carter Christopher B Barrett | 2006 | The Journal of Development Studies2006，42，2： | 1 |
| 3 | Retinoid X receptor α downregulation is required for tail and caudal spinal cord regeneration in the adult newt显示文摘Some adult vertebrate species,such as newts,axolotls and zebrafish,have the ability to regenerate their central nervous system(CNS).However,the factors that establish a permissive CNS environment for correct morphological and functional regeneration in these species are not well understood.Recent evidence supports a role for retinoid signaling in the intrinsic ability of neurons,in these regeneration-competent species,to regrow after CNS injury.Previously,we demonstrated that a specific retinoic acid receptor(RAR)subtype,RARβ,mediates the effects of endogenous retinoic acid(RA)on neuronal growth and guidance in the adult newt CNS after injury.Here,we now examine the expression of the retinoid X receptor RXRα(a potential heterodimeric transcriptional regulator with RARβ),in newt tail and spinal cord regeneration.We show that at 21 days post-amputation(dpa),RXRαis expressed at temporally distinct periods and in non-overlapping spatial domains compared to RARβ.Whereas RARβprotein levels increase,RXRαproteins level decrease by 21 dpa.A selective agonist for RXR,SR11237,prevents both this downregulation of RXRαand upregulation of RARβand inhibits tail and caudal spinal cord regeneration.Moreover,treatment with a selective antagonist for RARβ,LE135,inhibits regeneration with the same morphological consequences as treatment with SR11237.Interestingly,LE135 treatment also inhibits the normal downregulation of RXRαin tail and spinal cord tissues at 21 dpa.These results reveal a previously unidentified,indirect regulatory feedback loop between these two receptor subtypes in regulating the regeneration of tail and spinal cord tissues in this regeneration-competent newt. | Sarah E.Walker Rachel Nottrodt Lucas Maddalena Christopher Carter Gaynor E.Spencer Robert L.Carlone | 2018 | Neural Regeneration Research2018，13，6： | 1 |
| 4 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 5 | RESULTS OF A PROSPECTIVE PROTOCOL OF COMPUTED TOMOGRAPHIC ANGIOGRAPHY IN PLACE OF CATHETER ANGIOGRAPHY AS THE ONLY DIAGNOSTIC AND PRETREATMENT PLANNING STUDY FOR CEREBRAL ANEURYSMS BY A COMBINED NEUROVASCULAR TEAM显示文摘 | Brian L. Hoh Arnold C. Cheung James D. Rabinov Johnny C. Pryor Bob S. Carter Christopher S. Ogilvy | 2004 | Neurosurgery2004，，6： | 1 |
| 6 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 7 | Market reac-tion to the expiration of IPO lockup provision显示文摘 | Brau C A Carter E Christophe G | 2004 | ManagerialFinance2004，，2： | 1 |
| 8 | BAY43 - 9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK Pathway and receptor tyrosine kinase involved in tumor progression and angiogenesis 显示文摘 | ScottM Wilhelm christopher Carter | 2004 | Cancer Res2004，64，： | 1 |
| 9 | Sorafenib (BAY 43-9006) inhibits tumor growth and vascularization and induces tumor apoptosis and hypoxia in RCC xenograft models显示文摘 | Yong S. Chang Jalila Adnane Pamela A. Trail Joan Levy Arris Henderson Dahai Xue Elizabeth Bortolon Marina Ichetovkin Charles Chen Angela McNabola Dean Wilkie Christopher A. Carter Ian C. A. Taylor Mark Lynch Scott Wilhelm | 2007 | Cancer Chemotherapy and Pharmacology2007，，5： | 1 |
| 10 | Profiles of illicit drug use during annual key holiday and control periods in Australia: wastewater analysis in an urban, a semi‐rural and a vacation area显示文摘 | Foon Yin Lai Raimondo Bruno Wayne Hall Coral Gartner Christoph Ort Paul Kirkbride Jeremy Prichard Phong K. Thai Steve Carter Jochen F. Mueller | 2012 | Addiction2012，，3： | 1 |
| 11 | Spindle Cell (Sarcomatoid) Carcinoma of the Breast: A Clinicopathologic and Immunohistochemical Analysis of 29 Cases显示文摘 | Mark R. Carter Jason L. Hornick Susan Lester Christopher D.M. Fletcher | 2006 | The American Journal of Surgical Pathology2006，，3： | 1 |
| 12 | One-year Outcome after Decompressive Surgery for Massive Nondominant Hemispheric Infarction显示文摘 | Bob S. Carter Christopher S. Ogilvy Guillermo J. Candia H. Diana Rosas Ferdinando Buonanno | 1997 | Neurosurgery1997，，6： | 1 |
| 13 | The Economics of Poverty Traps and Persistent Poverty: An Asset Based Approach显示文摘 | Carter Michael R Barrett Christopher B | 2006 | Journal of Development Studies2006，42，2： | 1 |
| 14 | 神经元外单胺递质载体和DNA修复基因表达与SarCNU在荷人肿瘤裸鼠的抗肿瘤作用显示文摘目的 探讨抗癌新药肌氨酰胺亚硝脲 (SarCNU)在体内的抗肿瘤作用是否与神经元外单胺递质载体和DNA修复基因表达相关。方法 采用逆转录 聚合酶连锁反应 (RT PCR) ,测定了 9个人肿瘤动物模型的肿瘤神经元外单胺递质载体 (EMT)和DNA修复基因六氧甲基鸟嘌呤DNA甲基转移酶 (O6 methylguanine DNAmethyltransferase ,MGMT)、核苷酸切除修复基因ERCC1 6的表达 ,并与SarCNU在荷人肿瘤的裸鼠的抗肿瘤作用进行相关性分析。结果 多元回归分析发现 ,EMT、MGMT、ERCC2和ERCC4的不同组合 ,与SarCNU治疗效果间有相关性。而且 ,综合全部 4个因素 (EMT、MGMT、ERCC2和ERCC4) ,其与SarCNU治疗效果的相关性最显著 (r=0 96 1,P =0 0 17)。结论 SarC NU的抗肿瘤作用与肿瘤是否表达EMT和DNA修复基因有关 ,即 :EMT阳性的肿瘤对SarCNU敏感 ;但若同时具有DNA修复基因 ,如MGMT、ERCC2、ERCC4的表达 ,则其敏感性下降。 | 陈忠平 Lawrence CPanasci Christopher A Carter Michael CAlley | 2001 | 中华肿瘤杂志2001，23，2： | 1 |
| 15 | Relationship between hyperglycemia and symptomatic vasospasm after subarachnoid hemorrhage显示文摘 | Neeraj Badjatia Mehmet A. Topcuoglu Ferdinando S. Buonanno Eric E. Smith Raul G. Nogueira Guy A. Rordorf Bob S. Carter Christopher S. Ogilvy Aneesh B. Singhal | 2005 | Critical Care Medicine2005，，7： | 1 |
| 16 | Sorafenib is efficacious and tolerated in combination with cytotoxic or cytostatic agents in preclinical models of human non-small cell lung carcinoma显示文摘 | Christopher A. Carter Charles Chen Cheryl Brink Patrick Vincent Yulia Y. Maxuitenko Karen S. Gilbert William R. Waud Xiaomei Zhang | 2007 | Cancer Chemotherapy and Pharmacology2007，，2： | 1 |
| 17 | 基于前馈人工神经网络的核反应堆反应性估算显示文摘运用前馈人工神经网络(ANN)方法对有效增殖系数keff进行了估算,keff是具有一定装料方式(LP)的核反应堆反应性的重要参数。在核工程领域里,keff通常通过计算机数学模型来计算,例如蒙特卡罗模型和有限元模型,这些模型可能消耗大量的计算机资源。在某些需要进行大量反应堆仿真的情况下(例如,在10^10-10^100的求解空间中寻找一个使丘孵最大的最优LP),需要的计算时间非常长且不切实际。为此,本文通过使用已知的LP和相应的keff训练了一种前馈ANN,以进行快速和准确的keff估算。实验结果表明,所提出的ANN能够提供快速、准确和实用的keff估算。 | Shan Jiang Christopher C Pain Jonathan N Carter Ahmet K Ziver Matthew D Eaton Anthony J H Goddard Simon J Franklin Heather J Phillips 蔡志云(译) | 2009 | 国外核动力2009，30，6： | 0 |
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