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| 1 | Toward targeting inflammasomes: insights into their regulation and activation显示文摘Inflammasomes are multi-component signaling complexes critical to the initiation of pyroptotic cell death in response to invading pathogens and cellular damage.A number of innate immune receptors have been reported to serve as inflammasome sensors.Activation of these sensors leads to the proteolytic activation of caspase-1,a proinflammatory caspase responsible for the cleavage of proinflammatory cytokines interleukin-1β and interleukin-18 and the effector of pyroptotic cell death,gasdermin D.Though crucial to the innate immune response to infection,dysregulation of inflammasome activation can lead to the development of inflammatory diseases,neurodegeneration,and cancer.Therefore,clinical interest in the modulation of inflammasome activation is swiftly growing.As such,it is imperative to develop a mechanistic understanding of the regulation of these complexes.In this review,we divide the regulation of inflammasome activation into three parts.We discuss the transcriptional regulation of inflammasome components and related proteins,the post-translational mechanisms of inflammasome activation,and advances in the understanding of the structural basis of inflammasome activation. | Shelbi Christgen David E.Place Thirumala-Devi Kanneganti | 2020 | Cell Research2020，30，4： | 17 |
| 2 | Limited value of KAI1/CD82 protein expression as a prognosticmarker in human gastric cancer显示文摘 | Maximilian Knoener Till Krech Florian Puls Ulrich Lehmann Hans Kreipe Matthias Christgen | 2012 | Disease Markers2012，，6： | 1 |
| 3 | Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cellline显示文摘 | Christgen M Bal maier M Bruchhardt H | | 0，，1： | 1 |
| 4 | Reliable micro RNA profiling in routinely processed formalin-fixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology显示文摘 | Hasemeier B Christgen M Kreipe H | 2008 | BMC Biotechnol2008，8，： | 1 |
| 5 | Stable expression of temperature-sensitive P53: a suitable model to study wild-type P53 function in pancreatic carcinoma cells 显示文摘 | Nuevemann D Christgen M Ungefroren H | 2006 | Oncol Rep2006，16，3： | 1 |
| 6 | IPH-926 lobular breast cancer cells are triple-negative but their micro array profile uncovers a luminal subtype显示文摘 | Christgen M Geffers R Kreipe H et a1 | 2013 | Cancer Sci2013，104，12： | 1 |
| 7 | Epigenetic inactivation of micro RNA gene hsa-miR-9-1 in human breast cancer显示文摘 | LEHMANN U HASEMEIER B CHRISTGEN M | 2008 | J Pathol2008，214，： | 1 |
| 8 | Determination of proliferation in breast cancer by immunohistochemical detection of Ki-67显示文摘 | Christgen M Winkens W Kreipe H | 2014 | Pathologe2014，35，1： | 1 |
| 9 | Detection of putative cancer stem cells of the side population phenotype in human tumor cell cultures显示文摘 | Christgen M Ballmaier M Lehmann U | | 0，，： | 1 |
| 10 | Identification of a distinct side population of can cer cells in the Cal -- 5 1 human breast carcinoma cell line显示文摘 | Christgen M Ballmaier M Bruchhardt H | 2007 | Mol Cell Biochem2007，306，12： | 1 |
| 11 | Down-regulationof the fetal stem cell factor SOX 17 by H33342: a mechanismresponsible for differential gene expression in breast cancerside population cells显示文摘 | Christgen M Geffers R Ballmaier M | 2010 | J Biol Chem2010，285，9： | 1 |
| 12 | ABCB1/MDR1 contributes to the anticancer drug-resistant phenotype of IPH-926 human lobular breast cancer cells显示文摘 | Till Krech Elisa Scheuerer Robert Geffers Hans Kreipe Ulrich Lehmann Matthias Christgen | 2011 | Cancer Letters2011，，2： | 1 |
| 13 | Frequent and distinct aberrations of DNA methylation patterns in fibrolamellar carcinoma of the liver显示文摘 | Trankenschuh W Puls F Christgen M | | 0，，10： | 1 |
| 14 | Epigenetic inactivation of microRNA gene hsa-mir-9-1 in human breast cancer显示文摘 | Lehmann U Hasemeier B Christgen M | 2008 | J Pathol2008，214，1： | 1 |
| 15 | MicroRNA profiles of healthy basal and luminal mammary epithelial cells are distinct and reflected in different breast cancer subtypes 显示文摘 | Bockmeyer CL Christgen M Muller M | 2011 | Breast Cancer Res Treat2011，130，3： | 1 |
| 16 | Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line显示文摘 | Christgen M Ballmaier M Bruchhardt H | 2007 | Mol Cell Biochem2007，306，12： | 1 |
| 17 | Reliable microRNA profiling in routinely processed formalinfixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology显示文摘 | Hasemeier B Christgen M Kreipe H | 2008 | BMC Biotechnol2008，8，11： | 1 |
| 18 | Identifica-tion of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line显示文摘 | Christgen M Ballmarier M Bruchhardt H | 2007 | Mol Cell Bioe-hem2007，306，1： | 1 |
| 19 | Identification of a distinct side population of cancer cells in the Cal-51 human breast carcinoma cell line显示文摘 | Christgen M Ballmaier M Bruchhardt H | | 0，，1： | 1 |
| 20 | Identification of a distinct side population of cancer cells in the Cal-51human breast carcinoma cell line显示文摘 | Christgen M Ballmaier M Bruchhardt H | 2007 | Mol Cell Biochem2007，306，： | 1 |
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