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| 1 | ROS play a critical role in the differentiation of alternatively activated macrophages and the occurrence of tumor-associated macrophages显示文摘到巨噬细胞的不同类型的区别决定他们的不同功能。联系肿瘤的巨噬细胞(TAM ) 由于他们的 proangiogenic 和类似于那些的免疫者镇压的功能支持 tumorigenesis 或者激活(M2 ) 巨噬细胞。我们报导那反应的氧种类(ROS ) 生产为巨噬细胞区别和 superoxide 的那抑制是批评的(O 2−) 生产明确地堵住 M2 巨噬细胞的区别。我们发现当单核白血球被触发区分时, O 2− 为 biphasic 英皇家空军之阶级最低之兵激活被产生并且被需要,它为巨噬细胞区别是批评的。我们证明由 butylated hydroxyanisole (BHA ) 和另外的 ROS 禁止者的那 ROS 消除堵住巨噬细胞区别。然而,当房间被极化到时,巨噬细胞区别上的 ROS 消除的禁止的效果被克服古典主义地激活(M1 ) ,然而并非 M2,巨噬细胞。更重要地, ROS 禁止者 BHA 的连续管理高效地堵住了 TAM 的出现并且显著地在老鼠癌症模型压制了 tumorigenesis。由堵住 ROS 指向 TAM 能是为癌症治疗的一个潜在地有效的方法。 | Yan Zhang Swati Choksi Kun Chen Yelena Pobezinskaya Ilona Linnoila Zheng-Gang Liu | 2013 | Cell Research2013，23，7： | 12 |
| 2 | Necroptosis of tumor cells leads to tumor necrosis and promotes tumor metastasis显示文摘 | Delong Jiao Zhenyu Cai Swati Choksi Dan Ma Moran Choe Hyung-Joon Kwon Jin Young Balk Brian G. Rowan Chengyu Liu Zheng-gang Liu | 2018 | Cell Research2018，28，8： | 9 |
| 3 | Activation of cell-surface proteases promotes necroptosis, inflammation and cell migration显示文摘Necroptosis 是词法上类似于坏死的规划、 caspase 独立的房间死亡。导致 TNF 的 necroptosis 被交往受体的蛋白质调停 kinases, RIP1 和 RIP3,和混合的系 kinase 像域(MLKL ) 。在是由 RIP3 的 phosphorylated 以后, MLKL 是到血浆膜的 translocated 并且调停 necroptosis。然而, necroptosis 的实行和它在发炎和另外的细胞的回答的角色留下大部分逃犯。在这研究,我们报导房间表面朊酶的那调停 MLKL 的激活 disintegrin 和 metalloprotease (ADAM ) 家庭支持 necroptosis,发炎和房间移植。当 MLKL 是 phosphorylated 和 translocated 到房间血浆膜时,亚当斯明确地在 necroptosis 的早阶段被激活。亚当斯的激活导致包括粘附分子,受体,生长因素和 cytokines 多样的房间表面蛋白质流的 ectodomain。重要地,流房间表面蛋白质破坏房间粘附并且加速 necroptosis,当劈开的蛋白质的可溶的碎片触发煽动性的回答时。我们也证明从 necroptotic 房间流 E-cadherin ectodomain 支持房间移植。因此,我们的学习提供导致 necroptosis 的发炎和新卓见的新奇机制进房间死亡的这种唯一的形式的生理、病理学的功能。 | Zhenyu Cai Anling Zhang Swati Choksi Weihua Li Tao Li Xue-Min Zhang Zheng-Gang Liu | 2016 | Cell Research2016，26，8： | 5 |
| 4 | Management of pregnancy in Crigler Najjar syndrome type 2显示文摘Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase(UDPGT).Presented here is a case of a female in the first trimester of pregnancy,who was diagnosed to have type 2 Crigler Najjar syndrome.We also discuss the management of this rare disease especially in pregnancy.Unconjugated bilirubin can cross the placental barrier causing neuro-logical damage in the newborn.Patient was carefully monitored during pregnancy and treatment with pheno-barbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/d L.Crigler Najjar syndrome being rare needs to be diagnosed early in pregnancy to avoid adverse fetal outcomes.Phenobarbitone being an inducer of enzyme UDPGT is used as the first line of treatment and is not teratogenic in the low doses used.Treatment protocol followed was on the basis of previous reported cases and successful perinatal outcome was achieved. | Alisha Nitin Chaubal Ruchir Patel Dhaval Choksi Kaivan Shah Meghraj Ingle Prabha Sawant | 2016 | World Journal of Hepatology2016，8，11： | 4 |
| 5 | Outcomes of submucosal(T1b) esophageal adenocarcinomas removed by endoscopic mucosal resection显示文摘AIM To investigate the outcomes and recurrences of p T1 b esophageal adenocarcinoma(EAC) following endoscopic mucosal resection(EMR) and associated treatments.METHODS Patients undergoing EMR with pathologically confirmed T1 b EAC at two academic referral centers were retrospectively identified.Patients were divided into 4 groups based on treatment following EMR:Endoscopic therapy alone(group A),endoscopic therapy with either chemotherapy,radiation or both(group B),surgicalresection(group C) or no further treatment/lost to follow-up(<12 mo)(group D).Pathology specimens were reviewed by a central pathologist.Follow-up data was obtained from the academic centers,primary care physicians and/or referring physicians.Univariate analysis was performed to identify factors predicting recurrence of EAC.RESULTS Fifty-three patients with T1 b EAC underwent EMR,of which 32(60%) had adequate follow-up ≥ 12 mo(median 34 mo,range 12-103).There were 16 patients in group A,9 in group B,7 in group C and 21 in group D.Median follow-up in groups A to C was 34 mo(range 12-103).Recurrent EAC developed overall in 9 patients(28%) including 6(38%) in group A(median:21 mo,range:6-73),1(11%) in group B(median:30 mo,range:30-30) and 2(29%) in group C(median 21 mo,range:7-35.Six of 9 recurrences were local;of the 6 recurrences,5 were treated with endoscopy alone.No predictors of recurrence of EAC were identified.CONCLUSION Endoscopic therapy of T1 b EAC may be a reasonable strategy for a subset of patients including those either refusing or medically unfit for esophagectomy. | Darren D Ballard Neel Choksi Jingmei Lin Eun-Young Choi B Joseph Elmunzer Henry Appelman Douglas K Rex Hala Fatima William Kessler John M DeWitt | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，20： | 2 |
| 6 | An algorithm for generating geometric buffers for vector feature layers显示文摘The paper presents an algorithm for constructing geometric buffers for vector feature layers and dissolving those buffers using a sweep-line approach and vector algebra.The algorithm works by first constructing a geometric buffer for a vector feature layer,then dissolving each single geometric buffer for that feature layer,and finally dissolving the overlapping buffers of the entire layer.The algorithm has been implemented successfully in a commercial Geographical Information System software package. | Sumeet BHATIA Viral VIRA Deepak CHOKSI P.VENKATACHALAM | 2013 | Geo-Spatial Information Science2013，16，2： | 2 |
| 7 | Switching on cilia: transcriptional networks regulating ciliogenesis显示文摘 | Choksi SP Lauter G Swoboda P | 2014 | Development2014，141，7： | 1 |
| 8 | Transient neurologic deficit after acetazolamide challenge for computed tomography perfusion imaging显示文摘 | Choksi V Hughes M Selwa L | 2005 | J Comput Assist Tomogr2005，29，2： | 1 |
| 9 | Vascular pathology in dermatomyositis and anatomic relations to myopathology 显示文摘 | Pestronk A Sehmidt RE Choksi R | 2010 | Muscle Nerve2010，42，1： | 1 |
| 10 | Analysis of Switched Capacitor Com mon-Mode Feedback Circutit 显示文摘 | Choksi O Carley R | 2003 | IEEE Transactions on Circuit and Systems II: Analog and Digital singal process ing2003，50，12： | 1 |
| 11 | Ring-enhancing lesion in central pontine mylinolysis显示文摘 | Choksi R Roach ES | 2005 | Arch Neurol2005，62，： | 1 |
| 12 | Analysis of Switched - Capacitor Common - Mode Feedback Circuit 显示文摘 | Ojas Choksi Richard Carley L | 2003 | IEEE Transactions on Circuits and Systems - Ⅱ: Analog and Digital Signal Processing2003，50，12： | 1 |
| 13 | An organic CD4 inhibitor reduces the clinical and pathological symptoms of acute experimental allergic encephalomyelitis显示文摘 | Choksi S Huang Z | 2002 | J Autoimmun2002，18，： | 1 |
| 14 | Randomized, Phase II Trial of Pemetrexed and Carboplatin with or without Enzastaurin versus Docetaxel and Carboplatin as First-Line Treatment of Patients with Stage IIIB/IV Non-small Cell Lung Cancer显示文摘 | Mark A. Socinski Robert N. Raju Thomas Stinchcombe Darren M. Kocs Linda S. Couch David Barrera Steven R. Rousey Janak K. Choksi Robert Jotte Debra A. Patt Phillip O. Periman Howard R. Schlossberg Charles H. Weissman Yunfei Wang Lina Asmar Sharon Pritchard | 2010 | Journal of Thoracic Oncology2010，，： | 1 |
| 15 | Sexual transmission of hepatitis B 显示文摘 | Choksi AP Gill HH Desai HG | 1989 | J Assoc Physicians India1989，37，9： | 1 |
| 16 | Oxidatively damaged proteins of heart mitochondrial electron transport complexes 显示文摘 | CHOKSI K B BOYLSTON W H RABEK J P | 2004 | Biochim Biophys Acta2004，1688，2： | 1 |
| 17 | TNF-induced activation of the Nox1 NADPH oxidase and its role in the induction of necrotic cell death显示文摘 | Kim YS Morgan MJ Choksi S | | 0，，05： | 1 |
| 18 | MicroRNAs modulate the noncanonical transcription factor NF-kappaB pathway by regulating expression of the kinase IKKalpha during macrophage differentiation显示文摘 | Li T Morgan M J Choksi S | 2010 | Nat Immunol2010，11，： | 1 |
| 19 | Cell permeable bcl-2 binding peptide:a chemical approach to apotosis induction in tumor cells显示文摘 | Wang JL Zhang ZJ Choksi | 2000 | Cancer Res2000，60，6： | 1 |
| 20 | Dapagliflozin:a novel sodium-glucose cotransporter type 2 inhibitor for the treatment of type 2diabetes mellitus显示文摘 | Shan NK Deeb WE Choksi R | 2012 | Pharmacotherapy2012，32，1： | 1 |
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