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| 1 | Topical delivery of nerve growth factor for treatment of ocular and brain disorders显示文摘Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity. Nerve growth factor is one of the best-described neurotrophins and has advanced to clinical trials for treatment of ocular and brain diseases due to its trophic and regenerative properties. Prior trials over the past few decades have produced conflicting results, which have principally been ascribed to adverse effects of systemic nerve growth factor administration, together with poor penetrance of the blood-brain barrier that impairs drug delivery. Contrastingly, recent studies have revealed that topical ocular and intranasal nerve growth factor administration are safe and effective, suggesting that topical nerve growth factor delivery is a potential alternative to both systemic and invasive intracerebral delivery. The therapeutic effects of local nerve growth factor delivery have been extensively investigated for different ophthalmic diseases, including neurotrophic keratitis, glaucoma, retinitis pigmentosa, and dry eye disease. Further, promising pharmacologic effects were reported in an optic glioma model, which indicated that topically administered nerve growth factor diffused far beyond where it was topically applied. These findings support the therapeutic potential of delivering topical nerve growth factor preparations intranasally for acquired and degenerative brain disorders. Preliminary clinical findings in both traumatic and non-traumatic acquired brain injuries are encouraging, especially in pediatric patients, and clinical trials are ongoing. The present review will focus on the therapeutic effects of both ocular and intranasal nerve growth factor delivery for diseases of the brain and eye. | Gemma Eftimiadi Marzia Soligo Luigi Manni Daniela Di Giuda Maria Lucia Calcagni Antonio Chiaretti | 2021 | Neural Regeneration Research2021，16，9： | 11 |
| 2 | A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing显示文摘 | Pablo Landgraf Mirabela Rusu Robert Sheridan Alain Sewer Nicola Iovino Alexei Aravin Sébastien Pfeffer Amanda Rice Alice O. Kamphorst Markus Landthaler Carolina Lin Nicholas D. Socci Leandro Hermida Valerio Fulci Sabina Chiaretti Robin Foà Julia Schliwka | 2007 | Cell2007，，7： | 4 |
| 3 | NGF, DCX, and NSE upregulation correlates with severity and outcome of head trauma in children显示文摘 | A Chiaretti G Barone R Riccardi A Antonelli P Pezzotti O Genovese L Tortorolo G Conti | 2009 | Neurology2009，，7： | 3 |
| 4 | Interleukin 1 beta and interleukin 6 relationship with paediatric head trauma severity and outcome显示文摘 | Chiaretti A Crenovese O Aloe L | 2005 | Childs Nerv Syst2005，21，3： | 1 |
| 5 | Propofol/alfentanil and propofol/ketamine procedural sedation in children with acute lymphoblastic leukaemia : safety, efficacy and their corre- lation with pain neuromediator expression 显示文摘 | Chiaretti A Ruggiero A Barone G | 2010 | Eur J Cancer Care (Engl)2010，19，2： | 1 |
| 6 | NGF, DCX and NSE upregulation correlateas with severity and outcome of head trauma inchildren显示文摘 | Chiaretti A Barone G Riceardi R | 2009 | Neurology2009，72，7： | 1 |
| 7 | Increased levels of neurotrophins in the cerebrospinal fluid of children with Epstein–Barr virus meningoencephalitis显示文摘 | Antonio Chiaretti Domenico Capozzi Paolo Mariotti Piero Valentini Luigi Manni Danilo Buonsenso Claudia Fantacci Pietro Ferrara | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 8 | Clinico-biological features of 5202 patients with acute lymphoblastic leukemia enrolled in the Italian AIEOP and GIMEMA protocols and stralified in age cohorts显示文摘 | Chiaretti S Vitale A Cazzaniga G | 2013 | Haematologica2013，98，11： | 1 |
| 9 | Intraventricular nerve growth factor infusion: a possible treatment for neurological deficits following hypoxic-ischemic brain injury in infants 显示文摘 | Chiaretti A Genovese O Riceardi R | 2005 | J Neurosci Res2005，27，7： | 1 |
| 10 | NGF,DCX and NSE up-regulation correlates with severity and outcome of head trauma in children 显示文摘 | Chiaretti A Barone G Riccardi R | 2009 | Neurology2009，72，： | 1 |
| 11 | NGF, DCX and NSE upregu- lation correlates with severity and outcome of head trauma in children 显示文摘 | Chiaretti A Barone G Riccardi R | 2009 | Neurology2009，72，7： | 1 |
| 12 | A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing显示文摘 | Pablo Landgraf Mirabela Rusu Robert Sheridan Alain Sewer Nicola Iovino Alexei Aravin Sébastien Pfeffer Amanda Rice Alice O. Kamphorst Markus Landthaler Carolina Lin Nicholas D. Socci Leandro Hermida Valerio Fulci Sabina Chiaretti Robin Foà Julia Schliwka | 2007 | Cell2007，，7： | 1 |
| 13 | Clinico-biologic features of 5202 acute lymphoblastic leukemia patients enrolled in the Italian AIEOP and GIMEMA Protocols and stratified in age-cohorts显示文摘 | Chiaretti S Vitale A Cazzaniga G | | 0，，11： | 1 |
| 14 | lntraventricular nerve growth factor infusion: a possible treatment for neurological deficits following hypoxic- ischemic brain injury in infants显示文摘 | CHIARETTI A GENOVESE O RICCARDI R | 2005 | Neurol Res2005，27，7： | 1 |
| 15 | Gene expression profile of adult T-cell acute lymphocytic leukemia identifies distinct subsets of patients with different response to therapy and survival显示文摘 | Chiaretti S Li X Gentleman R | 2004 | Blood2004，103，7： | 1 |
| 16 | NGF,DCF,DCX and NSE upregulation correlates with severity and outcome of head trauma in children显示文摘 | Chiaretti A Barone G Riccardi R | 2009 | Neurology2009，72，7： | 1 |
| 17 | Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia 显示文摘 | FULCI V CHIARETTI S GOLDONI M | 2007 | Blood2007，109，11： | 1 |
| 18 | The influence of hemocoagulative disorders in the outcome of children with head injury显示文摘 | Chiaretti A Pezzotti P Mestrovic J | 2001 | Pediatr Neurosurg2001，34，3： | 1 |
| 19 | Nerve growth factor and doubleeortin expression correlates with improved outcome in children with severe traumatic brain injury 显示文摘 | Chiaretti A Antonelli A Genovese O | 2008 | J Trauma2008，65，1： | 1 |
| 20 | Nerve growth fctor and doublecortin expression correlates with improved outcome in childrenwith severe traumatic brain injury 显示文摘 | Chiaretti A Antonellai A Genovese O | 2008 | Trauma2008，65，1： | 1 |
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