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| 1 | Topical delivery of nerve growth factor for treatment of ocular and brain disorders显示文摘Neurotrophins are a family of proteins that support neuronal proliferation, survival, and differentiation in the central and peripheral nervous systems, and are regulators of neuronal plasticity. Nerve growth factor is one of the best-described neurotrophins and has advanced to clinical trials for treatment of ocular and brain diseases due to its trophic and regenerative properties. Prior trials over the past few decades have produced conflicting results, which have principally been ascribed to adverse effects of systemic nerve growth factor administration, together with poor penetrance of the blood-brain barrier that impairs drug delivery. Contrastingly, recent studies have revealed that topical ocular and intranasal nerve growth factor administration are safe and effective, suggesting that topical nerve growth factor delivery is a potential alternative to both systemic and invasive intracerebral delivery. The therapeutic effects of local nerve growth factor delivery have been extensively investigated for different ophthalmic diseases, including neurotrophic keratitis, glaucoma, retinitis pigmentosa, and dry eye disease. Further, promising pharmacologic effects were reported in an optic glioma model, which indicated that topically administered nerve growth factor diffused far beyond where it was topically applied. These findings support the therapeutic potential of delivering topical nerve growth factor preparations intranasally for acquired and degenerative brain disorders. Preliminary clinical findings in both traumatic and non-traumatic acquired brain injuries are encouraging, especially in pediatric patients, and clinical trials are ongoing. The present review will focus on the therapeutic effects of both ocular and intranasal nerve growth factor delivery for diseases of the brain and eye. | Gemma Eftimiadi Marzia Soligo Luigi Manni Daniela Di Giuda Maria Lucia Calcagni Antonio Chiaretti | 2021 | Neural Regeneration Research2021，16，9： | 11 |
| 2 | Adsorption of Mn^(2+) from aqueous solution using Fe and Mn oxide-coated sand显示文摘The adsorption of Mn2+ onto immobilized Mn-oxide and Fe-oxide adsorbent such as manganese oxide-coated sand 1 (MOCS1), manganese oxide-coated sand2 (MOCS2), iron oxide-coated sand2 (IOCS2), and manganese and iron oxide-coated sand (MIOCS)was investigated. The effects of pH (5.5 to 8.0) and temperature (25 to45°C) on the equilibrium capacitywere examined. Equilibrium studies showed that there is a good fitwith both Freundlich and Langmuir isotherm,which indicates surface heterogeneity and monolayer adsorption of the adsorbents. Kineticdata showed high correlationwith the pseudo second-order model,which signifies a chemisorption-controlled mechanism. The activation energies, activation parameters (ΔG*,ΔH*,ΔS*), and thermodynamic parameters (ΔG0 , ΔH0 , ΔS0 ) confirmed that adsorptionwith MIOCSwas endothermic and more spontaneous at higher temperaturewhile an opposite trendwas observed for the other adsorbents. Thermodynamic studies showed that adsorption involved formation of activated complex,where MOCS1 and MIOCS follow a physical-chemical mechanism,while MOCS2 and IOCS2 follows purely chemical mechanism. | Chi-Chuan Kan Mannie C Aganon Cybelle Morales Futalan Maria Lourdes P Dalida | 2013 | Journal of Environmental Sciences2013，25，7： | 11 |
| 3 | Molecular mechanisms and clinical management of cancer bone metastasis显示文摘As one of the most common metastatic sites of malignancies,bone has a unique microenvironment that allows metastatic tumor cells to grow and flourish.The fenestrated capillaries in the bone,bone matrix,and bone cells,including osteoblasts and osteoclasts,together maintain the homeostasis of the bone microenvironment.In contrast,tumor-derived factors act on bone components,leading to subsequent bone resorption or excessive bone formation.The various pathways involved also provide multiple targets for therapeutic strategies against bone metastases.In this review,we summarize the current understanding of the mechanism of bone metastases.Based on the general process of bone metastases,we specifically highlight the complex crosstalk between tumor cells and the bone microenvironment and the current management of cancer bone metastases. | Manni Wang Fan Xia Yuquan Wei Xiawei Wei | 2020 | Bone Research2020，8，3： | 7 |
| 4 | Nomograms based on HPV load for predicting survival in cervical squamous cell carcinoma: An observational study with a longterm follow-up显示文摘Objective: To investigate the prognostic value of pretreatment human papillomavirus(HPV) viral load for cervical cancer, and to develop nomograms based on HPV load and other clinicopathological factors for long-term survival.Methods: We conducted a prospective study on cervical squamous cell carcinoma(SCC) patients diagnosed between January 2003 and December 2008. Cervical samples were tested for HPV viral load by the Hybrid Capture II(HCII) assay before treatment and 6 months after treatment. Clinical characteristics and follow-up information were also collected. A multivariable Cox proportional hazards model was used to adjust covariates in both the radical hysterectomy(RH) treatment group and concurrent chemoradiotherapy(CCRT) treatment group to identify relevant covariates, and then nomograms were constructed and used for internal validation.Results: A total of 520 SCC patients enrolled in this study with a median follow-up of 127 months, 360 patients received RH, whereas 160 patients received CCRT. The median HPV viral load in RH and CCRT groups was356.10 and 294.29, respectively. Tumor size was positively correlated with high pretreatment HPV load in both groups. In CCRT group, the advanced International Federation of Gynecology and Obstetrics(FIGO) stage and enlarged retroperitoneal lymph node status determined by computed tomography(LNSCT) were correlated with low HPV load group. Initial HPV viral load, FIGO stage and lymph node metastasis were prognostic factors for RH group, whereas HPV viral load, squamous cell carcinoma antigen(SCC-Ag) level and LNSCT were identified as prognostic factors for CCRT group. Nomograms incorporating these predictors for 10-year progression-free survival(PFS) were constructed [concordance index(C-index): 0.756, 0.749].Conclusions: A low pretreatment HPV viral load is an independent prognostic factor for poor prognosis of cervical SCC and is related to other clinicopathological factors. The survival nomogram based on HPV viral load could predict the long-term prognosis. | Jing Zuo Ying Huang Jusheng An Xi Yang Ning Li Manni Huang Lingying Wu | 2019 | Chinese Journal of Cancer Research2019，31，2： | 4 |
| 5 | Use of rotational atherectomy for reducing significant dissection in treating de novo femoropopliteal steno-occlusive disease after balloon angioplasty显示文摘动脉的解剖的 BackgroundDevelopment 被认为是为在 femoropopliteal 疾病的跳伞 stenting 的一个重要关键因素。我们试图与旋转 atherectomy 并且没有 it.MethodsFrom 2011年1月处于在处理组之间的解剖率和结果评估差别到2016年10月,我们在 de-novo 的汽球 angioplasty ( BA )以后比较了 angiography , femoropopliteal ,速闭塞的损害他们是否被旋转 atherectomy 在 BA 以前对待。59 损害(8 吸藏;3 包含的腿弯部的片断;损害长度:86.3 | Tae-Hoon Kim Manny Katsetos Khagendra Dahal Michael Azrin Juyong Lee | 2018 | Journal of Geriatric Cardiology2018，15，4： | 3 |
| 6 | Entrepreneurs’ Access to Private Equity in China: The Role of Social Capital显示文摘 | Bat Batjargal Mannie (Manhong) Liu | 2004 | Organization Science2004，，2： | 2 |
| 7 | Role of tumor gene mutations in treatment response to immune checkpoint blockades显示文摘Early studies shed light on the immune suppression of immune checkpoint molecules in the cancer microenvironment,with later studies applying immune checkpoint blockade(ICB)in treatment of various malignancies.Despite the encouraging efficacy of ICBs in a substantial subset of cancer patients,the treatment response varies.Gene mutations of both tumor cells and immune cells in the tumor microenvironment have recently been identified as potential predictors of the ICB response.Recent developments in gene expression profiling of tumors have allowed identification of a panel of mutated genes that may affect tumor cell response to ICB treatment.In this review,we discuss the association of the ICB response with gene expression and mutation profiles in tumor cells,which it is hoped will help to optimize the clinical application of ICBs in cancer patients. | Manni Wang Liu Yu Xiawei Wei Yuquan Wei | 2019 | Precision Clinical Medicine2019，2，2： | 2 |
| 8 | DNA-PK inhibition by M3814 enhances chemosensitivity in non-small cell lung cancer显示文摘A significant proportion of non-small cell lung cancer(NSCLC) patients experience accumulating chemotherapy-related adverse events,motivating the design of chemosensitizating strategies.The main cytotoxic damage induced by chemotherapeutic agents is DNA double-strand breaks(DSB).It is thus conceivable that DNA-dependent protein kinase(DNA-PK) inhibitors which attenuate DNA repair would enhance the anti-tumor effect of chemotherapy.The present study aims to systematically evaluate the efficacy and safety of a novel DNA-PK inhibitor M3814 in synergy with chemotherapies on NSCLC.We identified increased expression of DNA-PK in human NSCLC tissues which was associated with poor prognosis.M3814 potentiated the anti-tumor effect of paclitaxel and etoposide in A549,H460 and H1703 NSCLC cell lines.In the four combinations based on two NSCLC xenograft models and two chemotherapy,we also observed tumor regression at tolerated doses in vivo.Moreover,we identified a P53-dependent accelerated senescence response by M3814 following treatment with paclitaxel/etoposide.The present study provides a theoretical basis for the use of M3814 in combination with paclitaxel and etoposide in clinical practice,with hope to aid the optimization of NSCLC treatment. | Manni Wang Siyuan Chen Yuquan Wei Xiawei Wei | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 2 |
| 9 | Elevated cortical glutamate in young people at increased familial risk of depression 显示文摘 | Taylor M J Mannie Z N Norhury R | 2011 | Int J Neuropsychopharmacol2011，14，： | 1 |
| 10 | Medical management of persistent or recurrent differentiated thyroid carcinoma 显示文摘 | Jun JY Manni A | 2008 | Otolaryngol Clin North Am2008，41，6： | 1 |
| 11 | Histopathological evaluation of retinal damage during intraocular hypertension in rabbit:involvement of ganglion cells and nerve fiber layer显示文摘 | Manni G Lambiase A Centofanti M | 1996 | Graefes Arch Clin Exp Ophthalmol1996，，： | 1 |
| 12 | Glycomic Analysis of Tear and Saliva in Ocular Rosacea Patients: The Search for a Biomarker显示文摘 | Ana Carolina Vieira Hyun Joo An Sureyya Ozcan Jae-Han Kim Carlito B. Lebrilla Mark J. Mannis | 2012 | The Ocular Surface2012，，3： | 1 |
| 13 | Time outdoors,visual activity,and myopia progression in juvenile-onset myopes显示文摘 | Jones-Jordan LA Sinnott LT Cotter SA Kleinstein RN Manny RE Mutti DO | 2012 | Invest Ophthalmol Vis Sci2012，53，11： | 1 |
| 14 | How I treat CNS lymphomas显示文摘 | Rubenstein JL Gupta NK Mannis GN | 2013 | Blood2013，122，： | 1 |
| 15 | Purification and identification of novel antioxidant peptides from enzymatic hydrolysates of sardinelle (Sardinella aurita ) by-products proteins 显示文摘 | Bougatef A Nedjar-Arroume N Manni L | 2010 | Food Chemistry2010，118，3： | 1 |
| 16 | Increased levels of neurotrophins in the cerebrospinal fluid of children with Epstein–Barr virus meningoencephalitis显示文摘 | Antonio Chiaretti Domenico Capozzi Paolo Mariotti Piero Valentini Luigi Manni Danilo Buonsenso Claudia Fantacci Pietro Ferrara | 2014 | International Journal of Infectious Diseases2014，，： | 1 |
| 17 | Progressive impairment of regional myocardial perfusion after initial restoration of postischemic blood flow显示文摘 | Ambrosio G Weiseman HF Mannis JA | 1989 | Circulation1989，80，： | 1 |
| 18 | Intraocular lens power calculation after laser in situ keratomileusis for myopia and hyperopia:a standard approach显示文摘 | Feiz V Mannis MJ Garcia-Ferrer F | 2001 | Cornea2001，20，8： | 1 |
| 19 | Histopathological evaluation of retinal damage during intraocular hypertension in rabbit: involvement of ganglion cells and nerve fiber layer 显示文摘 | Manni G Lambiase A Centofanti M | 1996 | Graefes Arch Clin Exp Ophthalmol1996，234，： | 1 |
| 20 | The pathophysiology of amblyopia: electrophysiological studies 显示文摘 | Levi DM Manny RE | 1983 | Ann NY Acad Sci1983，388，： | 1 |
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