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| 1 | Metabolic syndrome and risk of subsequent colorectal cancer显示文摘The metabolic syndrome and visceral obesity have anincreasing prevalence and incidence in the generalpopulation. The actual prevalence of the metabolicsyndrome is 24% in US population and between24.6% and 30.9% in Europe. As demonstrated by many clinical trials (NAHANES , INTERHART) the metabolic syndrome is associated with an increased risk of both diabetes and cardiovascular disease. In addition to cardiovascular disease, individual components of the metabolic syndrome have been linked to the development of cancer, particularly to colorectal cancer. Colorectal cancer is an important public health problem; in the year 2000 there was an estimated total of 944 717 incident cases of colorectal cancer diagnosed world-wide. This association is sustained by many epidemiological studies. Recent reports suggest that individuals with metabolic syndrome have a higher risk of colon or rectal cancer. Moreover, the clusters of metabolic syndrome components increase the risk of associated cancer. The physiopathological mechanism that links metabolic syndrome and colorectal cancer is mostly related to abdominal obesity and insulin resistance. Population and experimental studies demonstrated that hyperinsulinemia, elevated C-peptide, elevated body mass index, high levels of insulin growth factor-1, low levels of insulin growth factor binding protein-3, high leptin levels and low adiponectin levels are all involved in carcinogenesis. Understanding the pathological mechanism that links metabolic syndrome and its components to carcinogenesis has a major clinical signifi cance and may have profound health benefi ts on a number of diseases including cancer, which represents a major cause of mortality and morbidity in our societies. | Raluca Pais Horatiu Silaghi Alina Cristina Silaghi Mihai Lucian Rusu Dan Lucian Dumitrascu | 2009 | World Journal of Gastroenterology2009，15，41： | 16 |
| 2 | Diagnostic challenges in non-cirrhotic portal hypertension-porto sinusoidal vascular disease显示文摘Non-cirrhotic portal hypertension consists of a group of diseases characterized by signs and complications of portal hypertension,which differ from cirrhosis through histological alterations,hemodynamic characterization and,clinical outcome.Because of the similarities in clinical presentation and imaging signs,frequently these patients,and particularly those with porto-sinusoidal vascular disease(PSVD),are misdiagnosed as having liver cirrhosis and thus raising difficulties in their diagnosis.The most challenging differentiation to be considered is between PSVD and cirrhosis and,although not pathognomonic,liver biopsy is still the standard of diagnosis.Although they still require extended validation before being broadly used,new non-invasive methods for the diagnosis of porto-sinusoidal vascular disease,like transient elastography,contrast-enhanced ultrasound or metabolomic profiling,have shown promising results.Another issue is the differentiation between PSVD and chronic extrahepatic portal vein obstruction,especially now when it is known that 40%of patients suffering from PSVD develop portal vein thrombosis.In this particular case,once the portal vein thrombosis occurred,the diagnosis of PSVD is impossible according to the current guidelines.Moreover,so far,the differentiation between PSVD and sinusoidal obstruction syndrome has not been clear so far in particular circumstances.In this review we highlighted the diagnostic challenges regarding the PSVD,as well as the current techniques used in the evaluation of these patients. | Oana Nicoara-Farcau Ioana Rusu Horia Stefanescu Marcel Tanțau Radu Ion Badea Bogdan Procopet | 2020 | World Journal of Gastroenterology2020，26，22： | 4 |
| 3 | A Mammalian microRNA Expression Atlas Based on Small RNA Library Sequencing显示文摘 | Pablo Landgraf Mirabela Rusu Robert Sheridan Alain Sewer Nicola Iovino Alexei Aravin Sébastien Pfeffer Amanda Rice Alice O. Kamphorst Markus Landthaler Carolina Lin Nicholas D. Socci Leandro Hermida Valerio Fulci Sabina Chiaretti Robin Foà Julia Schliwka | 2007 | Cell2007，，7： | 4 |
| 4 | A review of the technologies for wave energy extraction显示文摘The main objective of this article is to provide a comprehensive picture of existing wave technologies being used for wave energy extraction.The overview will explain their potential and also the challenges wave technologies face.The article will also briefly discuss the benefits of combined offshore wind-wave projects,also known as hybrids.Key factors and impacts on relevant existing wave technologies will be outlined,including capacity factor and capture width.Finally the levelized cost of energy(LCOE)targets for the most promising technologies will be discussed. | Eugen Rusu Florin Onea | 2018 | Clean Energy2018，2，1： | 3 |
| 5 | Towards 3D Point cloud based object maps for household environments显示文摘 | Radu Bogdan Rusu Zoltan Csaba Marton Nico Blodow Mihai Dolha Michael Beetz | 2008 | Robotics and Autonomous Systems2008，，11： | 2 |
| 6 | Size-controlled hydroxyapatite nanoparticles as self-organized organicinorganic composite materials显示文摘 | Rusu V M Ng C H Wilke M | 2005 | Biomaterials2005，26，： | 1 |
| 7 | Heterojunction with polycrystalline thin films for optoelectronic devices applications显示文摘 | PURICA M BUDIANU E RUSU E | 2000 | Microelectr Eng2000，52，： | 1 |
| 8 | A bovine whey protein extract can enhance innate immunity by priming normal human blood neutrophils显示文摘 | Daniel Rusu Rjean Drouin Yves Pouliot | 2009 | The Journal of Nutrition2009，139，： | 1 |
| 9 | Anatomical considerations on the corona morris显示文摘 | Rusu MC Cergan R Motoc AG | 2010 | Surg Radiol Anat2010，32，1： | 1 |
| 10 | On the structural and optical properties of antimony trisulfide thin films 显示文摘 | Tigau N Rusu D I Gheorghies C | 2002 | Journal of Optoelectronics and Advanced Materials2002，4，4： | 1 |
| 11 | Modeling waves in open coastal ar- eas and harbours with phase-resolving and phase-averaged models显示文摘 | RUSU E SOARES C G | 2013 | Journal of Coastal Research2013，29，1： | 1 |
| 12 | Optical and Structural Investigation of ZnO Thin Films Prepared by Chemical Vapor Deposition (CVD) 显示文摘 | PURICA M BUDIANU E RUSU E | 2002 | Thin Solid Films2002，，： | 1 |
| 13 | From safety verification to safety testing 显示文摘 | Rusu V MARCHAND H TSCHAEN V JE'RON T JEANNET B | 2004 | Lecture Notes in Computer Science LNCS2004，2978，： | 1 |
| 14 | A comparaison between the total PSA,the Gleason score and the bone scintiscan results for different agegroups显示文摘 | Rusu D Rusu V Stefanescu C | 2010 | Rev Med Chir Soc Med Nat Iasi2010，114，2： | 1 |
| 15 | Structural and electrical properties of antimony trisulfide thin films 显示文摘 | Tigau N Rusu G I Ciupina V | 2005 | Journal of Optoelectronics and Advanced Materials2005，7，2： | 1 |
| 16 | The spinal trigeminal nucleus-considerations on the structure of the nucleus caudalis显示文摘 | Rusu MC | 2004 | Folia Morphol(Warsz)2004，63，3： | 1 |
| 17 | A 65-nm Dual-Core Multithreaded Xeon Processor with 16-MB L3 Cache显示文摘 | Rusu S Tam S Muljono H | 2007 | IEEE Journal of Solid-State Circuits2007，42，1： | 1 |
| 18 | A mammalian microRNA expression atlas based on small RNA library sequencing显示文摘 | Landgraf P Rusu M Sheridan R | 2007 | Cell2007，129，7： | 1 |
| 19 | Behavior-Based Neuro-Fuzzy Controller for Mobile Robot Navigation 显示文摘 | Petru Rusu | 2003 | IEEE Transactions on Instrument and Measurement2003，52，3： | 1 |
| 20 | Postcholecystectomy syndromes and magnesium deficiency显示文摘 | Porr PJ Sza' ntay J Rusu M | 2004 | J Am Coil Nutr2004，23，6： | 1 |
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