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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Splicing factors PTBP1 and PTBP2 promote proliferation and migration of glioma cell lines 显示文摘 | Cheung HC Hal T Zhu W | 2009 | Bra/n2009，132，8： | 1 |
| 3 | Cyclic fatigue and torsional resistance of two new nickel-titanium instruments used in reciprocation motion:Reciproc versus Wave One显示文摘 | Kim HC Kwak SW Cheung GS | 2012 | J Endod2012，38，4： | 1 |
| 4 | Cyclic fatigue and tor- sional resistance of two new nickel-titanium instruments used in reciprocation motion : reciproc versus waveOne 显示文摘 | Kim HC Kwak SW Cheung SP | 2012 | J Endod2012，38，4： | 1 |
| 5 | Local recurrence after subtotal esophagectomy for squammous cell carcinoma显示文摘 | Tam PC Siu KFS Cheung HC | 1987 | Ann Surg1987，205，2： | 1 |
| 6 | Dynamic responses of infinite continuous beams subjected to a moving forcean exact method 显示文摘 | Cai CW Cheung YK Chart HC | 1988 | Journal of Sound and Vibration1988，123，： | 1 |
| 7 | Influence of regional pollution out flow on the concentrations of fine particulate matter and visibility in the coastal area of southern China显示文摘 | CHEUNG HC WANG BAUMANNK e tal | 2005 | Atmospheric Environment2005，39，34： | 1 |
| 8 | Comparison of RapidAre and static gantry intensity-modulated radiotherapy for nasopharyngeal carcinoma显示文摘 | Cheung WK Lee KH Cheng HC | 2010 | J Hong Kong Col Radiol2010，13，： | 1 |
| 9 | Cyclic fatigue and torsional resistance of two new nickel-titanium instruments used in reciprocation motion:Reciproc versus WaveOne显示文摘 | Kim HC Kwak SW Cheung GS | | 0，，04： | 1 |
| 10 | Is pyloroplasty necessary in esophageal replacement by stomach? A prospective randomized controlled trial 显示文摘 | Cheung HC Siu KF Wong J | 1987 | Sttrgery1987，102，1： | 1 |
| 11 | Heterogeneous hardening plasticity model for concrete显示文摘 | CHAN HC CHEUNG YK HUANG YP | | 0，，： | 1 |
| 12 | Local recurrences after subtotal esophagectomy for squamous cell carcinoma 显示文摘 | Tam PC Cheung HC Ma L | 1987 | Ann Surg1987，205，： | 1 |
| 13 | Shrinkage of the esophagus after resection for carcinoma 显示文摘 | Siu KF Cheung HC Wang J | 1986 | Ann Surg1986，203，2： | 1 |
| 14 | Comparison of forces generated during root canal shaping and residual stresses of three nickel-titanium rotary files by using a three-dimensional finite-element analysis显示文摘 | Kim HC Cheung GS Lee CJ | 2008 | J Endod2008，34，6： | 1 |
| 15 | Improved lung function and symptom control with formoterol on demand in asthma 显示文摘 | Cheung D Van Klink HC Aalbers R | 2006 | Eur Respir J2006，27，3： | 1 |
| 16 | Cyclic fatigue and torsional resistance of two new nickel-titanium instruments used in reciprocation motion:Reciproc versus WaveOne显示文摘 | Kim HC Kwak SW Cheung GS | 2012 | J Endod2012，38，4： | 1 |
| 17 | Comparison of forces genera- ted during root canal shaping and residual stresses of three nickel- titanium rotary files by using a three-dimensional finite-element analysis 显示文摘 | Kim HC Cheung GS Lee C J | 2008 | J Endod2008，34，6： | 1 |
| 18 | Comparison of forces gener- ated during root canal shaping and residual stresses of three nickel-titanium rotary files by using a three-dimensional fi- nite-element analysis 显示文摘 | Kim HC Cheung GS Lee C J | 2008 | J Endod2008，34，6： | 1 |
| 19 | Coronary artery fistulas: long term results of surgical correction 显示文摘 | Cheung DC Au WK Cheung HC | 2001 | Ann Thorac Surg2001，71，： | 1 |
| 20 | RapidArc和静态调强在鼻咽癌放疗中的比较研究显示文摘 | Cheung WK Lee KH Cheng HC | 2010 | 香港放射医学杂志2010，，： | 1 |
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