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| 1 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 2 | Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastmparesis显示文摘 | Ordog T Takayama I Cheung WK | | 0，，10： | 1 |
| 3 | Remodeling of networks of interstitial cells of Cajal in a murine model of diabetic gastroparesis显示文摘 | Ordog T Takayama I Cheung WK | 2000 | Diabetes2000，49，10： | 1 |
| 4 | Biomechanical analysis of unilateral fixation with interbody cages显示文摘 | Chen HH Cheung HH Wang WK | 2005 | Spine2005，1530，4： | 1 |
| 5 | Biomechanical analysis of Unilateral fixation with interbody cages显示文摘 | Chen HH Cheung HH Wang WK | 2005 | Spine2005，30，4： | 1 |
| 6 | Remodeling of networks of interstitial cell of Cajal in a routine model of diabetic gastroparesis 显示文摘 | Ordog T Takayama I Cheung WK | 2000 | Diabetes2000，49，10： | 1 |
| 7 | A comparison of dexmedetomidine and midazolam for sedation in third molar surgery显示文摘 | CHEUNG CW YING CL CHIU WK et d | 2007 | Anaesthesia2007，62，11： | 1 |
| 8 | Biomechanicalanalysis of unilateral fixation with interbody cages显示文摘 | Chen HH Cheung HH Wang WK | 2005 | Spine(Phila Pa 1976)2005，30，4： | 1 |
| 9 | Interleukin-25 induced chemokines and interleukin-6 release from eosinophils is mediated by p38显示文摘 | Wong CK Cheung PF lp WK | 2000 | Genomics2000，66，2： | 1 |
| 10 | Effects of all-trans-retinoic acid on human SH-SYSY neuroblastoma as in vitro model in neurotoxicity research显示文摘 | Cheung YT Lau WK Yu MS | 2009 | Neurotoxicology2009，30，1： | 1 |
| 11 | Improved anterior hepatic transection for isolated hepatocellular carcinoma in the eaudate显示文摘 | Cheung TT Yuen WK Poon RT | 2014 | Hepatobiliary Pancreat Dis Int2014，13，2： | 1 |
| 12 | Remodeling of networks of interstitial cells of cajal in a murine model of diabetic gastroparesis 显示文摘 | Ordog T Takayama I Cheung WK | 2000 | Diabetes2000，49，10： | 1 |
| 13 | Therapeutic role of lymph node resection in endometrioid eorpus cancer: a study of 12,333 patients 显示文摘 | Chan JK Cheung MK Htzh WK | 2006 | Cancer2006，107，8： | 1 |
| 14 | Therapeutic role of lymph node resection in endometrioid corpus cancer:a study of 12333 patients显示文摘 | Chan JK Cheung MK Huh WK | 2006 | Cancer2006，107，8： | 1 |
| 15 | Modulating effects of mannose-binding lectin genotype on arterial stiffness in children after Kawasaki disease显示文摘 | Cheung YF Ho MH Ip WK | 2004 | Pediatr Res2004，56，4： | 1 |
| 16 | The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin显示文摘 | Xenocostas A Cheung WK Farrell F | 2005 | Eur J Clin Pharmacol2005，61，3： | 1 |
| 17 | Coronary artery fis-tulas:longterm results of surgical correction显示文摘 | Cheung DL Au WK Cheung HH | | 0，，： | 1 |
| 18 | Nosocomialoutbreak of parvovirus B19 infection in a renal transplantunit显示文摘 | Lui SL Luk WK Cheung CY | 2001 | Transplantation2001，71，1： | 1 |
| 19 | Therapeutic role of lymph node resection in endometrioid corpus cancer: a study of 12,333 patients显示文摘 | Chan JK Cheung MK Huh WK | 2006 | Cancer2006，107，： | 1 |
| 20 | Three-dimensional accuracy of implant placement in a computer-assissted navigation system 显示文摘 | Chiu WK Luk WK Cheung LK | 2006 | Int J Oral Maxillofac Implants2006，21，3： | 1 |
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