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| 1 | 与在人的疾病的糖尿病 mellitus 和肥胖有关的肾的 hyperfiltration显示文摘 High intraglomerular pressure is associated with renal hyperf iltration, leading to the initiation and progression of kidney disease in experimental models of diabetes mellitus (DM). In humans, hyperf iltration is observed in patients with type 1 and type 2 DM, and is also seen in patients with pre-diabetic conditions, such as the metabolic syndrome. From a mechanistic perspective, both vascular and tubular factors likely contribute to the pathogenesis of hyperf iltration. Until now, human studies have primarily focused on the use of medications that inhibit the renin angiotensin system to reduce efferent vasoconstriction and thereby improve hyperfiltration. More recent advances in the development of investigational adenosine antagonists and inhibitors of sodium glucose cotransport may help to elucidate tubular factors that contribute to afferent vasodilatation. In this review, we summarize available data from experimental and human studies of type 1 and type 2 DM and obesity to provide an overview of factors that contribute to the hyperf iltration state. We have focused on the renin angiotensin system, cyclooxygenase-2 system, nitric oxide, protein kinase C and endothelin as vascular determinants of hyperfiltration. We also dis-cuss relevant tubular factors, since experimental models have suggested that inhibition of sodium-glucose cotransport may be renoprotective. | Alexa N Sasson David ZI Cherney | 2012 | World Journal of Diabetes2012，3，1： | 11 |
| 2 | Renal Hemodynamic Effect of Sodium-Glucose Cotransporter 2 Inhibition in Patients With Type 1 Diabetes Mellitus显示文摘 | David Z.I. Cherney Bruce A. Perkins Nima Soleymanlou Maria Maione Vesta Lai Alana Lee Nora M. Fagan Hans J. Woerle Odd Erik Johansen Uli C. Broedl Maximilian von Eynatten | 2014 | Circulation2014，，： | 2 |
| 3 | Chemical changes at the surface of RTV silicone rubber coatings on insu- lators during dry-band arcing 显示文摘 | Seog-Hyeon Kim Cherney E A Hackam R | 1994 | IEEE Transactions on Die- lectrics and Electrical Insulation1994，1，1： | 1 |
| 4 | Interferoninducible protein 10 identified as a mediator of tumor necrosis in vivo 显示文摘 | Sgadari C Angiolillo AL Cherney BW | 1996 | Proc Natl Acad Sci USA1996，93，13： | 1 |
| 5 | Aphasia, alexia, and oral reading 显示文摘 | Cherney LR | 2004 | Topic Stroke Rehab2004，11，1： | 1 |
| 6 | Cloning,expression,purification,crystallization and preliminary X-ray studies of epoxide hydrolases A and B from Mycobacterium tuberculosis显示文摘 | Biswal B K Garen G Cherney M M | | 0，，02： | 1 |
| 7 | Flashover performance of artificially contaminated and iced long-rod transmission line insulators显示文摘 | Cherney E A | | 0，，01： | 1 |
| 8 | Effects of filler level in RTV silicone rubber coatings used in HV insulators显示文摘 | Kim S H Cherney E A | 1982 | IEEE Trans on Electrical Insulation1982，27，6： | 1 |
| 9 | Micro floral and compositional changes in alfalfa hay treated with sodium diacetate and stored at different moisture contents显示文摘 | Cherney J H Johnson K D Tuite J | 1986 | Anim Feed Sci Technol1986，17，： | 1 |
| 10 | Fibre and soluble phenolic monomer composition of morphological components of sorghum stover显示文摘 | Debbie J R Cherney J J | 1991 | Journal of the Science of Food and Agriculture1991，54，4： | 1 |
| 11 | Potassium management for brown midrib sorghum x Sudan grass as replacement for corn silage in the northeastern USA显示文摘 | Ketterings Q M Godwin G Cherney J | 2005 | Agronomy&Grop Science2005，191，： | 1 |
| 12 | Fermentation characteristics of corn forage ensiled in mini-silos显示文摘 | Cherney D J R Cherney J H Cox W J | 2004 | Journal of Animal Science2004，87，： | 1 |
| 13 | Suppression mechanism of leakage current on RTV coated porcelain and silicone rubber insulators显示文摘 | Kim S H Cherney E A Hackam R | 1991 | IEEE Transactions on Power Delivery1991，4，6： | 1 |
| 14 | Thermal Conductivity of Filled Silicone Rubber and Its Relationship to Erosion Resistance in the Inclined Plane Test 显示文摘 | MEYER L H JAYARAM S CHERNEY E A | 2004 | IEEE Transactions on Dielectrics and Electrical Insulation2004，11，4： | 1 |
| 15 | The effect of empagliflozin on arterial stiffness and heart rate variability in sub- jects with uncomplicated type 1 diabetes mellltus 显示文摘 | Cherney DZ Perkins BA Soleymanlou N | 2014 | Cardiovasc Diabeto12014，13，： | 1 |
| 16 | A method for detecting the transition from corona from water droplets to dryband arcing on silicone rubber insulators 显示文摘 | LOPES S JAYARAM S H CHERNEY E A | 2002 | IEEE Transactions on Dielectrics and Electrical Insulation2002，9，6： | 1 |
| 17 | Application of com- posite insulators to transmission lines显示文摘 | Cherney E A Karady G Brown R L etal | 1983 | IEEE Transactions on Power Apparatus and Systems1983，102，5： | 1 |
| 18 | Refined X-ray crystallographic structure of the poliovirus 3C gene product 1 1 Edited By D. Rees显示文摘 | Steven C Mosimann Maia M Cherney Samuel Sia Steve Plotch Michael N.G James | 1997 | Journal of Molecular Biology1997，，5： | 1 |
| 19 | Evidence-based systematic review: effects of intensity of treatment and constraint-induced language therapy for individuals with stroke-induced aphasia 显示文摘 | Cherney LR Patterson JP Raymer A | 2008 | Speech Lang Hear Res2008，51，5： | 1 |
| 20 | Insights into theregulation of renal hemodynamic function in diabetic mellitus显示文摘 | Cherney DZ Scholey JW Miller JA | 2008 | Curr Diabetes Rev2008，4，4： | 1 |
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