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| 1 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 2 | HIGH SPEED MILLING OF GRAPHITE ELECTRODE WITH ENDMILL OF SMALL DIAMETER显示文摘石墨在用机器制造的电的排出成为占优势的电极材料(EDM ) 当前。直角的切实验被执行学习石墨薄片形成过程的特征。高速度 milling 实验被进行学习工具穿并且切的力量。结果证明切割的深度在石墨薄片形成上有大影响。在高速度 milling 的石墨的移动过程是切和磨擦过程的相互的结果。石墨是容易的由于它的高粗糙海角的性质引起严重磨耗(量) 到涂的 carbideendmills。工具的模式穿的专业是胁腹穿,耙子穿, micro-chipping 和破裂。切的力量能被更高切速度的采纳减少,中等每牙齿喂,切割的更小的光线、轴的深度,并且在切上面。 | WANG Chengyong ZHOU Li FU Hao HU Zhouling | 2007 | Chinese Journal of Mechanical Engineering2007，20，4： | 13 |
| 3 | Chemical Mechanism of Flower Color Microvariation in Paeonia with Yellow Flowers显示文摘Paeonia species are important ornamental plants,including three types:tree peony,herbaceous peony,and Itoh hybrid peony.Paeonia with yellow color is desired and becoming popular.However,the chemical mechanism of the formation of yellow flowers in Paeonia is still unclear.In this study,14 representative samples were selected:four samples of three species of Paeonia,four herbaceous peony cultivars,three lutea hybrid tree peony cultivars,and three Itoh hybrid peony cultivars.The petal extracts of the samples were determined by HPLC-DAD and HPLCQ-TOF-MS/MS.In total,29 flavonoids were isolated and identified,including 28 flavonol glycosides and one chalcone derivative.There were significant differences in the composition and content of flavonoids in petals of different cultivars(species).The total content of flavonoids was between 19.430 and 143.043 mg·g^−1 DW.Flavonol glycosides were detected in all samples.Chalconaringenin 2′-O-glucoside was detected from one herbaceous peony cultivar‘Golden Wheel’lutea hybrid tree peony cultivars,and Itoh peony cultivars.The content of chalconaringenin 2′-O-glucoside in the samples was more than 43% of total flavonoids.The pigment type and content of lutea hybrid tree peonies and Itoh hybrid peonies are similar.Total flavonoids,especially quercetin 3-O-galloylglucoside and chalconaringenin 2′-O-glucoside contribute greatly to the formation of yellow flowers of Paeonia.The results of this study provide a comprehensive understanding of the chemical mechanism for yellow flower coloration of Paeonia,and lay the foundation for yellow flower breeding of Paeonia. | Yong Yang Bing Li Chengyong Feng Qian Wu Qianyu Wang Shanshan Li Xiaonan Yu Liangsheng Wang | 2020 | Horticultural Plant Journal2020，6，3： | 10 |
| 4 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 5 | Dynamics and Small Signal Stability Analysis of PMSG-based Wind Farm with an MMC-HVDC System显示文摘The permanent magnet synchronous generator (PMSG)-based wind farm with a modular multilevel converter (MMC) based HVDC system exhibits various oscillations and can experience dynamic instability due to the interactions between different controllers of the wind farm and MMC stations, which have not been properly examined in the existing literatures. This paper presents a dynamic modeling approach for small signal stability analysis of PMSG-based wind farms with a MMC- HVDC system. The small signal model of the study system is validated by the comprehensive electromagnetic transient (EMT) simulations in PSCAD/EMTDC. Then the eigenvalue approach and participation factors analysis are utilized to comprehensively evaluate the impact of different controllers, system’s parameters and the circulating current suppressing controller (CCSC) on the small signal stability of the entire system. From eigenvalue analysis, it is revealed that as the output active power of the wind farm increases within the rated range, the overall system will exhibit a sub-synchronous oscillation (SSO) instability mode, an extremely weak damping mode, and a low frequency oscillation instability mode. From participation factors analysis, it is observed that the SSO mode and weak damping mode are primarily related to the internal dynamics of the MMC, which can be suppressed or improved by CCSC. It is determined that the low frequency oscillation mode is primarily caused by the interactions between the phase locked loop (PLL) control of the wind farm and the voltage and frequency (V-F) control of the MMC station. The analysis also depicts that the larger proportional gain value of the V-F control of the MMC station and smaller PLL bandwidth of the wind farm can enhance the small signal stability of the entire system. | Yifan Wang Chengyong Zhao Chunyi Guo Atiq Ur Rehman | 2020 | CSEE Journal of Power and Energy Systems2020，6，1： | 7 |
| 6 | Extracts from Huangqi(Radix Astragali Mongoliciplus) and Ezhu(Rhizoma Curcumae Phaeocaulis) inhibit Lewis lung carcinoma cell growth in a xenograft mouse model by impairing mitogen-activated protein kinase signaling, vascular endothelial growth factor prod显示文摘OBJECTIVE: To study the anti-tumor effects of the extracts from Huangqi(Radix Astragali Mongolici)and Ezhu(Rhizoma Curcumae Phaeocaulis) on the growth of Lewis lung carcinoma(LLC) in a xenograft mouse model and to investigate the possible underlying mechanism.METHODS: LLC tumor-bearing C57 BL/6 mice were treated with normal saline, cisplatin(2 mg/kg intraperitoneally every other day), or Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis)(1∶1, 2∶1, or 3∶1 ratio;5, 8, or 11 g/kg crude drug intragastrically every day) for 15 d.Body weights and tumor volumes were measured every other day. Tumors were excised on day 15 and analyzed. Tumor microvessel density(MVD)was assessed by immunohistochemical staining of CD34;and expression of vascular endothelial cell growth factor(VEGF), the mitogen-activated protein kinases p38 mitogen-activated protein kinase(MAPK), extracellular signal-regulated kinases 1 and 2(ERK1/2), and Jun N-terminal kinase(JNK)and their phosphorylated forms were assessed by Western blotting.RESULTS: Treatment with cisplatin caused a significant loss of body weight compared with controls,whereas Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) extract combinations had no effect. Extracts from Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) significantly decreased tumor weight and tumor MVD compared with controls,and at the 3∶1 treatment group had similar efficacy to cisplatin in reducing MVD. Tumors from Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) treatments also showed decreased p38 MAPK, p-p38 MAPK, ERK1/2, p-ERK1/2,JNK, and p-JNK expression compared with the control group(all P < 0.01). VEGF protein expression was significantly reduced in the 2∶1 and 3∶1 treatment groups compared with the control group(P < 0.01).CONCLUSION: Extracts from Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) hindered LLC growth in the xenograft mouse model, possibly via inhibition of the MAPK signaling pathway, VEGF production, and tumor angiogenesis. | Xu Chengyong Wang Yuguo Feng Jian Xu Ran Dou Yongqi | 2019 | Journal of Traditional Chinese Medicine2019，39，4： | 7 |
| 7 | The R2R3-MYB transcription factor GhMYB1a regulates flavonol and anthocyanin accumulation in Gerbera hybrida显示文摘Anthocyanins and flavonols have vital roles in flower coloration,plant development,and defense.Because anthocyanins and flavonols share the same subcellular localization and common biosynthetic substrates,these pathways may compete for substrates.However,the mechanism regulating this potential competition remains unclear.Here,we identified GhMYB1a,an R2R3-MYB transcription factor involved in the regulation of anthocyanin and flavonol accumulation in gerbera(Gerbera hybrida).GhMYB1a shares high sequence similarity with that of other characterized regulators of flavonol biosynthesis.In addition,GhMYB1a is also phylogenetically grouped with these proteins.The overexpression of GhMYB1a in gerbera and tobacco(Nicotiana tabacum)resulted in decreased anthocyanin accumulation and increased accumulation of flavonols by upregulating the structural genes involved in flavonol biosynthesis.We further found that GhMYB1a functions as a homodimer instead of interacting with basic helix-loop-helix cofactors.These results suggest that GhMYB1a is involved in regulating the anthocyanin and flavonol metabolic pathways through precise regulation of gene expression.The functional characterization of GhMYB1a provides insight into the biosynthesis and regulation of flavonols and anthocyanins. | Chunmei Zhong Yi Tang Bin Pang Xukun Li Yuping Yang Jing Deng Chengyong Feng Lingfei Li Guiping Ren Yaqin Wang Jianzong Peng Shulan Sun Shan Liang Xiaojing Wang | 2020 | Horticulture Research2020，7，1： | 7 |
| 8 | Radial Grip Rigidity of the Matching of Lengthened Shrink-fit Holder and Cutter in High-speed Milling显示文摘Though the lengthened shrink-fit holder (LSFH) is widely applied in high speed milling of the parts characterized by deep cavities at present,its design and selection mainly depends on the experience and lacks a correct theoretical guidance.In this paper,attention is focus on the radial grip rigidity of the matching of LSFH and cutter in high speed milling.Based on the experiment modal analysis (EMA) technique,an accurate finite element model of the matching of LSFH and cutter is established firstly.Subsequently,the influence of different interference,grip length and spindle speed on the grip rigidity of LSFH are analyzed.The analysis results show that there is a reasonable interference and grip length between the LSFH and cutter so that to have a steepless grip and have a good radial grip rigidity and at the same time to avoid the strength of LSFH to exceed it’s yield limit which will reduce the precision and service life of LSFH,besides when spindle speed reach a extension the weakening influence of the centrifugal force on the radial grip rigidity of the matching of LSFH and cutter should been taken into account.Finally,the finite element analysis results are verified based on the construction of measurement method of the grip rigidity and the results fit very well.The studies provide a theoretical basis for the design,selection and the serialization and standardization of the matching of LSFH and cutter. | ZHOU Houming WANG Chengyong DENG Jianxin PENG Ruitao | 2012 | Chinese Journal of Mechanical Engineering2012，25，1： | 5 |
| 9 | Safety profile of two-dimensional Pd nanosheets for photothermal therapy and photoacoustic imaging显示文摘二维(2D ) nanosheets 在 biomedicines 的领域里与大潜力作为 nanomaterial 的一个重要的类出现了,特别地在癌症 theranostics。然而,由于综合的有效方法的缺乏有控制尺寸的一致 2D nanomaterials, 2D nanomaterials 的尺寸依赖者简历行为的系统的评估很少被报导。就我们的知识而言,我们是第一报导对他们的简历行为的 2D nanomaterials 的尺寸的影响的系统的评估。有从 5 ~ 80 nm 的直径的 2D Pd nanosheets 被综合并且在房间和动物模型测试了估计他们基因表示介绍的尺寸依赖者 bioapplication, biodistribution,消除,毒性,和 genomic。我们的结果证明尺寸显著地影响 Pd nanosheets 的生物行为,包括他们的 photothermal 和 photoacoustic 效果, pharmacokinetics,和毒性。比作大尺寸的 Pd nanosheets,更展出的小尺寸的 Pd nanosheets 在 ultralow 之上预付 photoacoustic 成像和 photothermal 效果激光照耀。而且,在 vivo,结果显示 5-nm Pd nanosheets 与更长的血半衰期逃离网状内皮组织的系统并且能被肾的排泄清除,当时有更大的尺寸的 Pd nanosheets 主要在肝和怒气积累。30-nm Pd nanosheets 展出了最高的肿瘤累积。尽管 Pd nanosheets 没在细胞的水平引起任何可估计的毒性,我们在怒气在肝和发炎观察了细微类脂化合物累积。Genomic 基因表达式分析证明 80-nm Pd nanosheets 与更细胞的部件交往了并且在肝影响了更生物的进程,作为与 5-nm Pd nanosheets 相比。我们相信这个工作将作为 nanomedicines 提供珍贵信息和卓见进 2D Pd nanosheets 的临床的申请。 | Mei Chen Shuzhen Chen Chengyong He Shiguang Mo Xiaoyong Wang Gang Liu Nanfeng Zheng | 2017 | Nano Research2017，10，4： | 5 |
| 10 | Effect of optimal combination of Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) on proliferation and apoptosis of A549 lung cancer cells显示文摘OBJECTIVE: To investigate the effect of optimal combination(E) of Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) on proliferation and apoptosis of A549 lung cancer cells and the possible mechanism underpinning the action.METHODS: A uniform design method was used to optimize the E of Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) in A549 lung cancer cells. MTS assay was applied to analyze the effect of the component formula ofHuangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Curcumae Phaeocaulis) on A549 cells viability in various uniform design groups. A549 cells with exponential growth in routine culture were exposed to Co Cl_2(200 μmol/L) to mimic hypoxic conditions. Group 0 was treated with RPMI-1640, the group Co Cl_2 was treated with Co Cl_2(200 μmol/L),the group DDP + Co Cl_2 was treated with 4 mg/L Cisplatin injection(DDP) + Co Cl_2(200 μmol/L), and the drug group was treated with various dose of E(0.5 E, 1 E, 2 E) + Co Cl_2(200 μmol/L). All groups were cultured for 24 h. Cell apoptosis was measured by Annexin V-FITC/propidium iodide double staining and flow cytometry. Western blot assay and quantitative real-time polymerase chain reaction(q RT-PCR) were employed to detect the protein and m RNA expression of B-celllymphoma-2(Bcl-2),Bcl-2-associated X protein(Bax) and cysteinyl aspartate specific proteinase-3(caspase-3).RESULTS: The E obtained by the uniform design was comprise of 200 mg/L Astragalus polysaccharide(X1) and 32 mg/L Curcumin(X3). Group DDP+Co Cl_2, group 1 E + Co Cl_2 and group 2 E + Co Cl_2 promoted the apoptosis of A549 cells(P < 0.05). Group1 E + Co Cl_2 and group 2 E + Co Cl_2 had no statistically significant differences compared with the group DDP + Co Cl_2(P > 0.05). Compared with group 0, various doses of E + Co Cl_2 could up-regulate the expression of Bax and caspase-3 and down-regulate the expression of Bcl-2 at protein and m RNA levels(P < 0.05).CONCLUSION: Astragalus polysaccharide and Curcumin was the optimal combination of Huangqi(Radix Astragali Mongolici) and Ezhu(Rhizoma Cur-cumae Phaeocaulis). E promoted the apoptosis of A549 cells. Combination of Astragalus polysaccharide and Curcumin increased the expression of Bax and caspase-3, and decreased the expression of Bcl-2 to initiate apoptosis in A549 cells under chemical-induced hypoxia. | Xu Chengyong Wang Yuguo Feng Jian Qin Li Xu Ran Dou Yongqi | 2018 | Journal of Traditional Chinese Medicine2018，38，3： | 4 |
| 11 | Drilling Force and Temperature of Bone under Dry and Physiological Drilling Conditions显示文摘Many researches on drilling force and temperature have been done with the aim to reduce the labour intensiveness of surgery, avoid unnecessary damage and improve drilling quality. However, there has not been a systematic study of mid- and high-speed drilling under dry and physiological conditions(injection of saline). Furthermore, there is no consensus on optimal drilling parameters. To study these parameters under dry and physiological drilling conditions, pig humerus bones are drilled with medical twist drills operated using a wide range of drilling speeds and feed rates. Drilling force and temperature are measured using a YDZ-II01 W dynamometer and a NEC TVS-500 EX thermal infrared imager, respectively, to evaluate internal bone damage. To evaluate drilling quality, bone debris and hole morphology are observed by SEM(scanning electron microscopy). Changes in drilling force and temperature give similar results during drilling such that the value of each parameter peaks just before the drill penetrates through the osteon of the compact bone into the trabeculae of the spongy bone. Drilling temperatures under physiological conditions are much lower than those observed under dry conditions, while a larger drilling force occurs under physiological conditions than dry conditions. Drilling speed and feed rate have a significant influence on drilling force, temperature, bone debris and hole morphology. The investigation of the effect of drilling force and temperature on internal bone damage reveals that a drilling speed of 4500 r/min and a feed rate of 50 mm/min are recommended for bone drilling under physiological conditions. Drilling quality peaks under these optimal parameter conditions. This paper proposes the optimal drilling parameters under mid- and high-speed surgical drilling, considering internal bone damage and drilling quality, which can be looked as a reference for surgeons performing orthopedic operations. | XU Linlin WANG Chengyong JIANG Min HE Huiyu SONG Yuexian CHEN Hanyuan SHEN Jingnan ZHANG Jiayong | 2014 | Chinese Journal of Mechanical Engineering2014，27，6： | 3 |
| 12 | GENERATE TRIANGUUTED SURFACES FROM MASSIVE UNORGANIZED POINTS显示文摘triangulated 从巨大的未组织起来的点出现的为重建的一个成长区域的方法被介绍。节省记忆空间,戒指数据结构被采用造在点和 triangulated 表面之间的连接。数据结构允许所有附近的顶点的有效检索和给定的绿色冰的三角形。为了缩小搜索,邻近的点变化并且避免 trinangle 交叉,一个影响区域为 eachactive 边被定义。在 triangulated 表面的成长区域的过程, minimum-edge-angle-productalgorithm 被提出选择一个适当的点为一个活跃的边形成一个新三角形。结果显示介绍方法有高效率并且需要更少的存储器空格,有可靠拓扑的质量的优化 triangulated 表面能在三角测量以后被获得。 | WU Shixiong WANG Chengyong CHEN Zichen | 2006 | Chinese Journal of Mechanical Engineering2006，19，1： | 3 |
| 13 | Comparison of developmental toxicity of different surface modified CdSe/ZnS QDs in zebrafish embryos显示文摘Quantum dots(QDs)are new types of nanomaterials.Few studies have focused on the effect of different surface modified QDs on embryonic development.Herein,we compared the in vivo toxicity of Cd Se/Zn S QDs with carboxyl(-COOH)and amino(-NH 2)modification using zebrafish embryos.After exposure,the two Cd Se/Zn S QDs decreased the survival rate,hatching rate,and embryo movement of zebrafish.Moreover,we found QDs attached to the embryo membrane before hatching and the eyes,yolk and heart after hatching.The attached amount of carboxyl QDs was more.Consistently,the Cd content in embryos and larvae was higher in carboxyl QD-treatment.We further observed that the two QDs caused zebrafish pericardial edema and cardiac dysfunction.In line with it,both carboxyl and amino QDs upregulated the transcription levels of cardiac development-related genes,and the levels were higher in carboxyl QD-treated groups.Furthermore,the chelator of Cd^2+diethylene triamine pentacetate acid could partially rescued the developmental toxicity caused by the two types of QDs suggesting that both the nature of QDs and the release of Cd^2+contribute to the developmental toxicity.In conclusion,the two Cd Se/ZnS QDs have developmental toxicity and affect the cardiac development,and the carboxyl QDs is more toxic possibly due to the higher affinity and more release to embryos and larvae.Our study provides new knowledge that the surface functional modification of QDs is critical on the development on aquatic species,which is beneficial to develop and applicate QDs more safely and environmentfriendly. | Naying Zheng Jinhui Yan Wang Qian Chao Song Zhenghong Zuo Chengyong He | 2021 | Journal of Environmental Sciences2021，33，2： | 3 |
| 14 | Microstructure of Hardened Steel at High Temperature and High Strain Rate显示文摘In high-speed machining,hardened steel materials are subjected to high temperatures and high strain rates.Under these conditions,the composition and microstructure of the material may change,and phenomena,such as thermal softening,emerge.These effects are difficult to detect by only observing the chip morphology.Here,using a microscopic detection method,the dynamic mechanical behavior and microstructure of SDK11 hardened steel(62HRC)is investigated at high temperature and high strain-rate,and the relationship between strain hardening,thermal softening,and strain-rate strengthening is determined.The metallographic phases of specimens treated using a split-Hopkinson pressure bar,and″chips″generated during high-speed machining at high temperature and high strain rate state are compared.The results indicate that the phase composition at low temperature and low strain rate differs from that at high temperature and high strain rate.It is further concluded that shear slip occurs at high temperature and high strain rate,and the shear behavior is more pronounced at higher strain rates. | Ding Feng Tang Dewen Wang Chengyong Zhang Fenglin Zheng Lijuan | 2017 | Transactions of Nanjing University of Aeronautics and Astronautics2017，34，4： | 2 |
| 15 | Haplotype-resolved genome of diploid ginger (Zingiber officinale) and its unique gingerol biosynthetic pathway显示文摘Ginger(Zingiber officinale),the type species of Zingiberaceae,is one of the most widespread medicinal plants and spices.Here,we report a high-quality,chromosome-scale reference genome of ginger‘Zhugen’,a traditionally cultivated ginger in Southwest China used as a fresh vegetable,assembled from PacBio long reads,Illumina short reads,and high-throughput chromosome conformation capture(Hi-C)reads.The ginger genome was phased into two haplotypes,haplotype 1(1.53 Gb with a contig N50 of 4.68 M)and haplotype 0(1.51 Gb with a contig N50 of 5.28 M).Homologous ginger chromosomes maintained excellent gene pair collinearity.In 17,226 pairs of allelic genes,11.9%exhibited differential expression between alleles.Based on the results of ginger genome sequencing,transcriptome analysis,and metabolomic analysis,we proposed a backbone biosynthetic pathway of gingerol analogs,which consists of 12 enzymatic gene families,PAL,C4H,4CL,CST,C3’H,C3OMT,CCOMT,CSE,PKS,AOR,DHN,and DHT.These analyses also identified the likely transcription factor networks that regulate the synthesis of gingerol analogs.Overall,this study serves as an excellent resource for further research on ginger biology and breeding,lays a foundation for a better understanding of ginger evolution,and presents an intact biosynthetic pathway for species-specific gingerol biosynthesis. | Hong-Lei Li Lin Wu Zhaoming Dong Yusong Jiang Sanjie Jiang Haitao Xing Qiang Li Guocheng Liu Shuming Tian Zhangyan Wu Bin Wu Zhexin Li Ping Zhao Yan Zhang Jianmin Tang Jiabao Xu Ke Huang Xia Liu Wenlin Zhang Qinhong Liao Yun Ren Xinzheng Huang Qingzhi Li Chengyong Li Yi Wang Baskaran Xavier-Ravi Honghai Li Yang Liu Tao Wan Qinhu Liu Yong Zou Jianbo Jian Qingyou Xia Yiqing Liu | 2021 | Horticulture Research2021，8，1： | 2 |
| 16 | CO_2 sensing properties and mechanism of PrFeO_3 and NdFeO_3 thick film sensor显示文摘The CO_2 sensing of PrFeO_3 and NdFeO_3 sensors were investigated. Experimental results show that the resistances for PrFeO_3 and NdFeO_3 in CO_2 gas are larger than those in air and the responses for PrFeO_3and NdFeO_3 sensors increase with an increase in room-temperature relative humidity. When exposed to1000 ppm CO_2, the response of PrFeO_3 thick film based on nano-powders annealed at 700℃can reach8.44 at 160℃for the background of wet air with 58%of room-temperature relative humidity (RH),which is much larger than the corresponding value (3.03) in wet air with 25%RH. The sensing response S of NdFeO_3 thick-film sensor based on nano-powders annealed at 600℃to 3000 ppm CO_2 at the operating temperature 200℃can reach 2.36 for the background of wet air with 72%RH, which is larger than the corresponding value (1.83) in the air with 25%RH. Compared with other CO_2 sensing materials, the PrFeO_3 sensor has larger response at lower operating temperature for CO_2 gas and may be used as a new CO_2 sensing material. | Yanping Chen Dandan Wang Hongwei Qin Heng Zhang Zhongli Zhang Guangjun Zhou Chengyong Gao Jifan Hu | 2019 | Journal of Rare Earths2019，37，1： | 2 |
| 17 | A systematic review of radiofrequency ablation versus percutaneous ethanol injection for small hepatocellular carcinoma up to 3 cm显示文摘 | Ai Shen Hua Zhang Chengyong Tang Yong Chen Yefei Wang Chao Zhang Zhongjun Wu | 2013 | J Gastroenterol Hepatol2013，，5： | 2 |
| 18 | Efficacy of Liangxue Guyuan decoction(凉血固元汤)on radiation-induced intestinal injury in rats via the toll-like receptor 4/myeloid differentiation primary response 88/nuclear factor-kappa B pathway显示文摘OBJECTIVE:To evaluate the efficacy of Liangxue Guyuan decoction(凉血固元汤,LGD)on radiation-induced intestinal injury in rats,and the possible underlying mechanism of action.METHODS:A total of 255 male Sprague-Dawley rats were used.15 rats were assigned to the control group and the remaining 240 rats were exposed to a^(60)Co source at a dose of 11 Gy.Irradiated rats were randomly divided into model,dexamethasone(DXM),low-dose LGD(LGDl),and high-dose LGD(LGDh)groups and treated for 11 d.The survival rate,weight of body,intestinal pathology and the expression of toll-like receptor 4(TLR4),myeloid differentiation primary response 88(MyD88),and nuclear`factor-kappa B(NF-κB)were recorded.RESULTS:Radiation reduced the survival rate and weight of rats,destroyed the intestinal structure,induced an inflammatory reaction,and increased both protein and mRNA expression of TLR4,MyD88,and NF-κB in ileum.However,LGDh increased the survival rate,inhibited weight loss,alleviated inflammation and improve the expression of TLR4 pathway.CONCLUSIONS:LGD increased the survival rate and inhibit weight loss of irradiated rats,and reduced inflammation and intestinal injury.The underlying mechanism may involve regulation of the TLR4/MyD88/NF-κB pathway. | WANG Yuguo DOU Yongqi FENG Jian XU Chengyong WANG Qian | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 2 |
| 19 | Electrical contacts in monolayer blue phosphorene devices显示文摘半导体的单层(ML ) 蓝色 phosphorene (BlueP ) 与 ML 黑 phosphorene (BP ) 分享类似的稳定性,并且它最近有在 Au 表面上是成年的。潜在的 ML BlueP 设备经常与金属要求直接接触启用搬运人的注射。第一次,用 ab initio,电子结构计算和量搬运模拟我们在与在一只领域效果晶体管(联邦货物税) 跨越一个宽工作函数范围的金属的接触执行 ML BlueP 的界面的性质的系统的研究配置。ML BlueP 由于和五金属的强壮的相互作用经历了 metallization。与 0.42 的一个卡住的因素由于导致金属的差距状态(米格机) 在 ML BlueP 联邦货物税有强壮的费密水平(FLP ) ,卡住。分别地, ML BlueP 与 0.22, 0.22,和 0.80 eV 的电子 Schottky 障碍高度(SBH ) 与 Sc, Ag,和磅电极形成 n 类型 Schottky 接触并且与有 0.61 和 0.79 eV 的洞 SBH 的 Au 和 Pd 电极的 p 类型 Schottky 接触分别地。米格机被在 ML BlueP 和金属电极之间插入 graphene 消除,从强壮的 FLP 由转变伴随了到弱 FLP。我们的学习不仅提供卓见进 ML BlueP 金属接口,而且在 ML BlueP 设备的设计帮助。 | Jingzhen Li Xiaotian Sun Chengyong Xu Xiuying Zhang Yuanyuan Pan Meng Ye Zhigang Song Ruge Quhe Yangyang Wang Han Zhang Ying Guo Jinbo Yang Feng Pan Jing Lu | 2018 | Nano Research2018，11，4： | 2 |
| 20 | Reversible data-hiding scheme for 2-D vector maps based on difference expansion 显示文摘 | WANG XIAOTONG SHAO CHENGYONG XU XIAOGANG | 2007 | IEEE Transactions on Information Forensics and Security2007，2，3： | 1 |
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