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| 1 | shRNA targeting HDGF suppressed cell growth and invasion of squamous cell lung cancer显示文摘导出 Hepatoma 的生长因素(HDGF ) ,有 mitogenic 的原子蛋白质和 angiogenic 活动,被报导了主要涉及 tumorigenesis 和非小的房间肺癌症的前进。在这研究, HDGF 表示被 specific-shRNA 与在肺指向 HDGF 的 lentivirus 表示向量击倒有鳞的房间癌 520 房间。shRNA 击倒的 HDGF 在 vitro 并且在由 MTT,板克隆和移植肿瘤模型试金显示了的 vivo 显著地压制了房间增长。另外, HDGF 的组合式的表达式也禁止了出现在 transwell 和 Boyden 实验的房间移植和侵略。因为参予有鳞的房间肺癌症的致病的 oncogene,和 HDGF 可以是为非小的房间肺癌症的一个关键治疗学的目标,我们断定 HDGF 行动。 | Jie Meng Wei Xie Liming Cao Chengping Hu Zhiyuan Zhen | 2010 | Acta Biochimica et Biophysica Sinica2010，42，1： | 19 |
| 2 | Physics-informed deep learning for incompressible laminar flows显示文摘Physics-informed deep learning has drawn tremendous interest in recent years to solve computational physics problems,whose basic concept is to embed physical laws to constrain/inform neural networks,with the need of less data for training a reliable model.This can be achieved by incorporating the residual of physics equations into the loss function.Through minimizing the loss function,the network could approximate the solution.In this paper,we propose a mixed-variable scheme of physics-informed neural network(PINN)for fluid dynamics and apply it to simulate steady and transient laminar flows at low Reynolds numbers.A parametric study indicates that the mixed-variable scheme can improve the PINN trainability and the solution accuracy.The predicted velocity and pressure fields by the proposed PINN approach are also compared with the reference numerical solutions.Simulation results demonstrate great potential of the proposed PINN for fluid flow simulation with a high accuracy. | Chengping Rao Hao Sun Yang Liu | 2020 | Theoretical & Applied Mechanics Letters2020，10，3： | 11 |
| 3 | Microstructure and Properties of Low Temperature Composite Chromized Layer on H13 Tool Steel显示文摘Low temperature composite chromizing is a process composed of a plain ion-carbonitriding or ion-nitriding at 550~580℃, followed by a low-temperature chromizing in a salt-bath of 590℃. The microstructure and properties of the low temperature composite chromized layer on H13 tool steel were investigated using metallography,X-ray diffraction, microanalysis, hardness and wear tests. It was found that this low temperature process was thermodynamically and kinetically possible, and the composite chromized layer on H13 steel, with a thickness of 3~6μm,consisted of three sub-layers (bands), viz. the outer Cr-rich one, the intermediate (black) one, and the inner, original white layer. After chromizing, the former diffusion layer was thickened. The results of X-ray diffraction showed that the composite chromized layer contained such nitrides and carbides of chromium as CrN, Cr2N, (Cr, Fe)23C6, and (Cr, Fe)7C3, as well as plain α-(Fe, Cr). A high surface microhardness of 1450~1550 HV0.025, which is much higher than that obtained by the conventional ion carbonitriding and ion nitriding, was obtained. In addition, an excellent wear resistance was gained on the composite chromized layer. | Cuilan WU, Chengping LUO and Ganfeng ZOU College of Mechanical Engineering, South China University of Technology, Guangzhou 510641, China | 2005 | Journal of Materials Science & Technology2005，21，2： | 9 |
| 4 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 5 | Low-intensity aerobic exercise training attenuates airway inflammation and remodeling in a rat model of steroid-resistant asthma显示文摘 | Qin Qingwu Chen Xi Feng Juntao Qin Ling Hu Chengping | 2014 | Chinese Medical Journal2014，，17： | 4 |
| 6 | Prevalence and clinical significance of pathogenic germline BRCA1/2 mutations in Chinese non-small cell lung cancer patients显示文摘Objective: Germline alterations in the breast cancer susceptibility genes type 1 and 2, BRCA1 and BRCA2, predispose individuals to hereditary cancers, including breast, ovarian, prostate, pancreatic, and stomach cancers.Accumulating evidence suggests inherited genetic susceptibility to lung cancer.The present study aimed to survey the prevalence of pathogenic germline BRCA mutations(gBRCAm) and explore the potential association between gBRCAm and disease onset in Chinese advanced non-small cell lung cancer(NSCLC) patients.Methods: A total of 6,220 NSCLC patients were screened using capture-based ultra-deep targeted sequencing to identify patients harboring germline BRCA1/2 mutations.Results: Out of the 6,220 patients screened, 1.03%(64/6,220) of the patients harbored the pathogenic gB RCAm, with BRCA2 mutations being the most predominant mutations(49/64, 76.5%).Patients who developed NSCLC before 50 years of age were more likely to carry gBRCAm(P = 0.036).Among the patients harboring classic lung cancer driver mutations, those with concurrent gBRCAm were significantly younger than those harboring the wild-type gBRCA(P = 0.029).By contrast, the age of patients with or without concurrent gBRCAm was comparable to those of patients without the driver mutations(P = 0.972).In addition, we identified EGFR-mutant patients with concurrent gBRCAm who showed comparable progression-free survival but significantly longer overall survival(P = 0.002) compared to EGFR-mutant patients with wild-type germline BRCA.Conclusions: Overall, our study is the largest survey of the prevalence of pathogenic gBRCAm in advanced Chinese NSCLC patients.Results suggested a lack of association between germline BRCA status and treatment outcome of EGFR-TKI.In addition,results showed a positive correlation between pathogenic gB RCAm and an early onset of NSCLC. | Xingsheng Hu Dongyong Yang Yalun Li Li Li Yan Wang Peng Chen Song Xu Xingxiang Pu Wei Zhu Pengbo Deng Junyi Ye Hanhan Zhang Analyn Lizaso Hao Liu Xinru Mao Hai Huang Qian Chu Chengping Hu | 2019 | Cancer Biology & Medicine2019，16，3： | 4 |
| 7 | A Novel Duplex Low-temperature Chromizing Process at 500℃显示文摘在 500 °C 的一个优化低温度的渗铬过程经由由先锋血浆 nitriding 组成的一个双渗铬过程与 0.45 wt %碳在平凡的中等碳的钢上被认识到,并且跟随的盐洗澡 thermoreactive 免职和散开( TRD )有薄散开层的渗铬 process.CrN 层在下面被形成。双渗铬过程被光显微镜学(OM ) 学习,扫描电子显微镜学(SEM ) ,精力散 X 光检查光谱学(版本) , X 光检查衍射(XRD ) ,和传播电子显微镜学(TEM ) 。在 500 °C 的渗铬速度被增加更多的 Cr-Fe 粉末进盐洗澡成功地提高,这被发现,并且 CrN 层在厚度与一般水准 8.1 亩 m 以优先的氮化物混合物 layer.A CrN 层的成本形成了,在微坚硬的 1382 HV_( 0.01 )被双渗铬更为 24 h.Further 在 500 °C 在底层上形成, CrN 层由 nanocrystalline CrN 谷物组成了。 | Huiliang CAO Cuilan WU Jiangwen LIU Chengping LUO Ganfeng ZOU | 2007 | Journal of Materials Science & Technology2007，23，6： | 3 |
| 8 | Contrasting physical properties of the trilayer nickelates Nd4Ni3O10 and Nd4Ni3O8显示文摘We report the crystal structures and physical properties of trilayer nickelates Nd4Ni3O10and Nd4Ni3O8.Measurements of magnetization and electrical resistivity display contrasting behaviors in the two compounds.Nd4Ni3O10shows a paramagnetic metallic behavior with a metal-to-metal phase transition(T^*)at about 162 K,as revealed by both magnetic susceptibility and resistivity.Further magnetoresistance and Hall coefficient results show a negative magnetoresistance at low temperatures and the carrier type of Nd4Ni3O10is dominated by hole-type charge carriers.The significant enhancement of Hall coefficient and resistivity below T*suggests that effective charge carrier density decreases when cooling through the transition temperature.In contrast,Nd4Ni3O8 shows an insulating behavior.In addition,this compound shows a paramagnetic behavior with the similar magnetic moment as that of Nd4Ni3O10derived from the Curie-Weiss fitting.This may suggest that the magnetic moments in both systems are contributed by Nd^3+ ions.By applying pressures up to about 49 GPa,the insulating behavior is still present and becomes even stronger under a high pressure.Our results suggest that the different Ni configurations(Ni^1+/2+ or Ni^2+/3+)and the changes of coordination environment of Ni sites may account for the contrasting behaviors in trilayer nickelates Nd4Ni3O10and Nd4Ni3O8. | Qing Li ChengPing He XiYu Zhu Jin Si XinWei Fan Hai-Hu Wen | 2021 | Science China(Physics,Mechanics & Astronomy)2021，64，2： | 2 |
| 9 | Interface self‐reinforcing ability and antibacterial effect of natural chitosan modified polyvinyl chloride‐based wood flour composites显示文摘 | Kaimeng Xu Kaifu Li Tuhua Zhong Chengping Xie | 2014 | J. Appl. Polym. Sci2014，，3： | 2 |
| 10 | Numerical Simulation of the Solitary Wave Interacting with an Elastic Structure Using MPS-FEM Coupled Method显示文摘Fluid-Structure Interaction(FSI) caused by fluid impacting onto a flexible structure commonly occurs in naval architecture and ocean engineering. Research on the problem of wave-structure interaction is important to ensure the safety of offshore structures. This paper presents the Moving Particle Semi-implicit and Finite Element Coupled Method(MPS-FEM) to simulate FSI problems. The Moving Particle Semi-implicit(MPS) method is used to calculate the fluid domain, while the Finite Element Method(FEM) is used to address the structure domain. The scheme for the coupling of MPS and FEM is introduced first. Then, numerical validation and convergent study are performed to verify the accuracy of the solver for solitary wave generation and FSI problems. The interaction between the solitary wave and an elastic structure is investigated by using the MPS-FEM coupled method. | Chengping Rao Youlin Zhang Decheng Wan | 2017 | Journal of Marine Science and Application2017，16，4： | 2 |
| 11 | Natural infection with torque teno sus virus 1 (TTSuV1) suppresses the immune response to porcine reproductive and respiratory syndrome virus (PRRSV) vaccination显示文摘 | Zhicheng Zhang Yang Wang Hongjie Fan Chengping Lu | 2012 | Archives of Virology2012，，5： | 2 |
| 12 | Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus -infected lungs 显示文摘 | Chengping Hu Katrin Wedde - Beer Alexander Auais | 2002 | Am J Physiol Lung Cell Mol Physiol2002，283，2： | 1 |
| 13 | Effect of molybdenum on diamond deposition and adhesion显示文摘 | Huang Yuansheng Qiu Wanqi Luo Chengping | 2005 | Thin Solid Films2005，472，： | 1 |
| 14 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 15 | 显示文摘 | 程萍(ChengP) 顾明元(GuMY) 金燕苹(JinYP) | | 化学进展0，，： | 1 |
| 16 | An evolution- ary real-time 3D route planner for aircraft显示文摘 | Changuien Z Mingyue D Chengping Z | 2003 | Systems Engineering and Electronics Journal of2003，14，1： | 1 |
| 17 | Clinical characteristics and prognostic significance of 92 cases ofpatients with primary mixed?histology lung cancer显示文摘 | Pengbo Deng Chengping Hu Lihua Zhou Yuanyuan Li Li Huang | 2013 | Molecular and Clinical Oncology2013，，5： | 1 |
| 18 | Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence显示文摘 | Yang Wang Wei Zhang Zongfu Wu Xianglei Zhu Chengping Lu | 2011 | Veterinary Microbiology2011，，1： | 1 |
| 19 | 基于直接子野优化的全乳腺调强放射治疗[J]显示文摘 | AhunbavEE ChenGP ThatcherS eta1 | | 国际放射肿瘤学-生物学-物理学杂志0，，： | 1 |
| 20 | ThenovelBH-3mimeticapogossypoloneinducesBeclin-1-andROS-mediatedautophagyinhumanhepato-cellularcarcinomacells显示文摘 | ChengP NiZ DaiX etal | 2013 | CellDeathDis2013，4，： | 1 |
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