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| 1 | Increasing trend of prevalence of infertility in Beijing显示文摘 | Zhang Hongxia Wang Shuyu Zhang Songwen Wang Tao Deng Xiaohong | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 2 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 7 |
| 3 | POLYMORPH CONTROL OF ANTIMONY WHITE(Sb_2O_3) PREPARED BY HYDROMETALLURGY METHOD显示文摘POLYMORPHCONTROLOFANTIMONYWHITE(Sb2O3)PREPAREDBYHYDROMETALLURGYMETHOD①ZhangDuomo,XiaoSongwen,ChoTongraeLiuZhihong,GeRongde,C... | Zhang Duomo, Xiao Songwen, Cho Tongrae * Liu Zhihong, Ge Rongde, Chen Huiguang, Guo Xueyi Department of Nonferrous Metallurgy, Central South University of Technology, Changsha 410083 * College of Engineering, Chung Nam National University, South Ko | 1997 | 中国有色金属学会会刊:英文版1997，7，4： | 4 |
| 4 | miR-20b-5p attenuates hypoxia-induced apoptosis in cardiomyocytes via the HIF-1α/NF-κB pathway显示文摘Chronic hypoxia is a common inducer of end-stage cardiovascular disease.In cells under hypoxia,the hypoxia-inducible factor-1(HIF-1)plays a vital role in regulating downstream target genes.However,the mechanism of hypoxia in card io myocytes is still unclear.In this study,we aimed to identify novel downstream epigenetic targets of HIF-1α in cardiomyocytes under hypoxia.H9c2 cells were exposed to hypoxia condition,and quantitative real-time PCR analysis was performed to evaluate the expression of miR-20b-5p.The results indicated that the expression of miR-20b-5p was down-regulated in H9c2 cells under low oxygen condition.Meanwhile,HIF-1α overexpression further down-regulated the miR-20b-5p expression in H9c2 cells transfected with HIF-1α plasmids.In addition,Annexin-V-FITC/PI flow cytometry analysis suggested that overexpression of miR-20b-5p attenuated cell apoptosis under hypoxia condition in H9c2 cells.Western blot analysis showed that the hypoxia apparently increased Bax and cleaved-caspase-3,but decreased Bcl-2 expression in H9c2 cells,indicating that hypoxia-induced NF-κB signaling pathway activation is mediated by miR-20b-5p.Hypoxia-induced H9c2 cell apoptosis was reduced after HIF-1α knockdown as shown by the flow cytometry analysis.In conclusion,we identified that miR-20b-5p plays an important role in mediating cardiomyocytes apoptosis under hypoxia,which is mediated by the HIF-1/NF-κB signaling pathway. | Zhongquan Zhou Songwen Chen Zhiming Tian Shibing Deng Xuying Yi Shaning Yang Xuexin Yang Lijun Jin Wanqing Shi | 2020 | Acta Biochimica et Biophysica Sinica2020，52，9： | 2 |
| 5 | Behavior andproducts of mechano-chemical dechlorination of polyvinylchloride and poly(vinylidene chloride)显示文摘 | Xiao Xiao Zigao Zeng Songwen Xiao | 2008 | Journal ofHazardous Materials2008，151，： | 1 |
| 6 | 显示文摘 | XiaoDaihong(肖代红) SongWen(宋文) ChenKanghua(陈康华)eta1 | | 特利铸造及有色合金0，，： | 1 |
| 7 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 8 | Novel Software Automated Testing System Based on J2EE显示文摘 | Songwen Pei Baifeng Wu Kun Zhu Qiang Yu | 2007 | Tsinghua Science & Technology2007，，： | 1 |
| 9 | Novel Software Automated Testing System Based on J2EE显示文摘 | PEI Songwen WU Baifeng | 2007 | TSING HUA SCIENCE AND TECHNOLOGY2007，，： | 1 |
| 10 | Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study显示文摘 | Caicun Zhou Yi-Long Wu Gongyan Chen Jifeng Feng Xiao-Qing Liu Changli Wang Shucai Zhang Jie Wang Songwen Zhou Shengxiang Ren Shun Lu Li Zhang Chengping Hu Chunhong Hu Yi Luo Lei Chen Ming Ye Jianan Huang Xiuyi Zhi Yiping Zhang Qingyu Xiu Jun Ma Li Zhang C | 2011 | Lancet Oncology2011，，8： | 1 |
| 11 | SIRT1 deacetylates and positively regulates the nuclear receptor LXR显示文摘 | Xiaoling li Songwen Zhang Leonard Guarente | 2007 | Molecular Cell2007，28，1： | 1 |
| 12 | Novel Software Automated Testing System Based on J2EE显示文摘 | PEI Songwen WU Baifeng ZHU Kun | 2007 | Tsinghua Science and Technology2007，12，1： | 1 |
| 13 | Behavior and products of mechano-chemical dechlorination of polyvinyl chloride and poly (vinylidene chloride) 显示文摘 | Xiao Xiao Zigao Zeng Songwen Xiao | 2008 | Journal of Hazardous Materials2008，151，： | 1 |
| 14 | Association between polymorphisms of DNA repair genes and survival of advanced NSCLC patients treated with platinum-based chemotherapy显示文摘 | Shengxiang Ren Songwen Zhou Fengyin Wu Ling Zhang Xuefei Li Jie Zhang Jianfang Xu Meijun Lv Jie Zhang Caicun Zhou | 2011 | Lung Cancer2011，，1： | 1 |
| 15 | 非小细胞肺癌患者脑转移的治疗(英文)显示文摘Brain metastasis is a major cause of poor prognosis and high mortality for non-small cell lung cancer patients. The prognosis of non-small-cell lung cancer(NSCLC) patients with brain metastasis is generally poor and more effective treatment is required to improve their prognosis. Whole-brain radiotherapy, surgery, stereotactic radiosurgery, chemotherapy and targeted therapy are the main treatment for brain metastasis. This review focuses on the five therapeutic strategy and in particular, on targeted therapy. | Bing Li Yuchen Bao Bin Chen Songwen Zhou | 2014 | The Chinese-German Journal of Clinical Oncology2014，13，10： | 1 |
| 16 | Over-expression of #-1,4-galactosyltransferase Ⅰ, Ⅱ, and Ⅴ in human astrocytoma显示文摘 | Xiaoyu Zhu Songwen Zhang | 2001 | Journal of Cancer Research and Clinical Oncology2001，127，： | 1 |
| 17 | LCA ease study for lead and zinc preoduction by an imperial smelting proeess in China-a brief presentation显示文摘 | Guo Xueyi Xiao Songwen Li Qihou | 2002 | International Journal on Life Cyele Assessment2002，7，5： | 1 |
| 18 | A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models显示文摘Glioblastoma is carcinogenesis of glial cells in central nervous system and has the highest incidence among primary brain tumors.Brain metastasis,such as breast cancer and lung cancer,also leads to high mortality.The available medicines are limited due to blood-brain barrier.Abnormal activation of phosphatidylinositol 3-kinases(PI3 K)signaling pathway is prevalent in glioblastoma and metastatic tumors.Here,we characterized a 2-amino-4-methylquinazoline derivative XH30 as a potent PI3 K inhibitor with excellent anti-tumor activity against human glioblastoma.XH30 significantly repressed the proliferation of various brain cancer cells and decreased the phosphorylation of key proteins of PI3 K signaling pathway,induced cell cycle arrest in G1 phase as well.Additionally,XH30 inhibited the migration of glioma cells and blocked the activation of PI3 K pathway by interleukin-17 A(IL-17 A),which increased the migration of U87 MG.Oral administration of XH30 significantly suppressed the tumor growth in both subcutaneous and orthotopic tumor models.XH30 also repressed tumor growth in brain metastasis models of lung cancers.Moreover,XH30 reduced IL-17 A and its receptor IL-17 RA in vivo.These results indicate that XH30 might be a potential therapeutic drug candidate for glioblastoma migration and brain metastasis. | Ming Ji Dongjie Wang Songwen Lin Chunyang Wang Ling Li Zhihui Zhang Jing Jin Deyu Wu Yi Dong Heng Xu Duo Lu Xiaoguang Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 1 |
| 19 | Behavior and products of mechano-chemical dechlorination of polyvinyt chloride and poly (vinylidene chloride) 显示文摘 | Xiao Xiao Zigao Zeng Songwen Xiao | 2008 | Journal of Hazardous Materials2008，151，： | 1 |
| 20 | Constructiontechniquesofdirectseedingjujube[J]显示文摘 | CHENGengshan(陈更山) SONGWen(宋文) LUJia-nying(鲁建英) | | 新疆农业科技0，，： | 1 |
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