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| 1 | Gold nanoprisms as a hybrid in vivo cancer theranostic platform for in situ photoacoustic imaging, angiography, and localized hyperthermia显示文摘高分辨率的 nanosized photoacoustic 对比代理人的发展是令人激动的还挑战性的工艺的进展。此处,抗体(胸联系癌症的抗原 1 (Brcaa1 ) monoclonal 抗体)- 并且肽(RGD )-functionalized 金牌 nanoprisms (AuNprs ) 被用作组合方法论为在使用的 situ photoacoustic 成像, angiography,和局部性的过高热, orthotopic 和下的鼠科的胃的癌当模特儿。结合 RGD 的 PEGylated AuNprs 为结合抗体的 PEGylated AuNprs 被用于指向的肿瘤 angiography,和 Brcaa1 monoclonal 并且为是可得到的在在 orthotopic 的胃的癌的 situ 成像,肿瘤当模特儿。在 situ photoacoustic 成像允许在肿瘤地点的解剖、功能的成像。在 vivo 肿瘤 angiography,成像以一种时间依赖者方式显示出 photoacoustic 信号的改进。而且, photoacoustic 成像证明肿瘤容器清楚地在局部性的过高热以后被损坏。这作为高度敏感的对比和治疗学的代理人是用二根 AuNprs 探针的第一 proof-of-concept 为在 situ 肿瘤察觉和抑制。这些聪明的抗体 / 肽 AuNprs 能被用作一个有效 nanotheranostic 平台为在局部性的过高热处理以后在有高敏感的 vivo 肿瘤察觉,以及为指向治疗,与单个剂量的注射,它导致肿瘤的肿瘤缩放减小和增加老鼠幸存。 | Chenchen Bao Joao Conde Fei Pan Chao Li Chunlei Zhang Furong Tian Shujing Liang Jesus M. de la Fuente Daxiang Cui | 2016 | Nano Research2016，9，4： | 9 |
| 2 | Sedimentary filling and sequence structure dominated by T-R cycles of the Nenjiang Formation in the Songliao Basin显示文摘The Nenjiang Formation in the Songliao Basin is a symmetrical sequence of progradation-retrogradation,and is formed in the transgression cycle and regression cycle(T-R cycles)of the base level of deposition.We analyzed the drilling,well logging,core data,and seismic profiles of basin level,and by using the sequence stratigraphy,identified one secondary sequence boundary,two third-order sequence boundaries,and eight fourth-order sequence boundaries in the Nenjiang Formation.These eleven sequence boundaries can be divided into structural unconformity,depositional unconformity,flooding surface,and forced regression surface.Therefore the Nenjiang Formation can be subdivided into one secondary sequence,three third-order sequences,and ten fourth-order sequences.We have restored the sedimentary filling evolution within the stratigraphic framework of fourth-order sequences in the Nenjiang Formation.The sedimentary period of the first member of the Nenjiang Formation was corresponded to the global transgression period,which is also the development period of transgression cycle(T cycle),when the lake basin had the largest scope and deepest sedimentary water,the SB07(the maximum flooding surface)was formed on the top of strata during this period;covering above the SB07,there developed a set of condensation layer-oil shale,which is distributed in the whole basin and is the important source bed and regional cover.Therefore,a retrogradation sequence was formed in the T cycle of the first member of the Nenjiang Formation,characterized by the retrograding delta at a low angle.The delta has a giant front,a small plain,and many underwater distributary channels.Meanwhile,large gravity flow channels and sublacustrine fans are developed in the front of the delta.During the depositional period of the second member of the Nenjiang Formation,the R cycle began to develop due to the compression of the pacific tectonic domain;the source direction rotated 90°along with the eastern uplifting of the basin,and formed a series of east-west prograded and forced retrogradations.The prograding delta at high angel was developed in the interior of the sequence;the delta had a small front,a giant plain,and fewer underwater distributary channels,with the collapse at the foreslope,forming a series of slump fans.The slump fans can be divided into three types:discrete type,superimposed type,and fluid type.We built a whole'triad model'of the slump fan.Pointed out that the sequence of forced retrogradation formed by R cycle is a good structural mark of basin optimization,and rejected the viewpoint of'transgression'in the Nenjiang Formation of the Songliao Basin. | ZHANG ChenChen ZHANG Shun WEI Wei WU ChaoDong LIANG JiangPing NIU Wen DU JinXia FU XiuLi CUI KunNing WANG Chao WANG Hui | 2014 | Science China Earth Sciences2014，57，2： | 5 |
| 3 | Catalytic oxidation of CO on mesoporous codoped ceria catalysts:Insights into correlation of physicochemical property and catalytic activity显示文摘Codoping approach is an appealing strategy to further improve the catalytic activity of Ce-based catalysts.In the present study,Mn and/or Cu doped ceria solid solutions MnxCuyCe1-x-yO2,CuxCe1-xO2,MnxCe1-xO2 and pure CeO2 were prepared by CTAB-assisted hydrothermal method for CO oxidation.XRD,SEM,EDS,BET,Raman,H2-TPR,XPS and in situ DRIFTS techniques were carried out to study the physicochemical properties and to correlate them to the activity.The doped samples maintain the cubic fluorite structure of CeO2 with high crystallinity and small crystallite size,forming Ce-based solid solutions.The obtained catalysts have large mesoporous structure with average pore size of 10-14 nm.The doped transition metal enhances the oxygen vacancies and improves reducibility of the solids.The synergistic interaction of Mn and Cu codoping induces mo re oxygen vacancies,pro moting the increase of surface adsorbed oxygen and the transfer of bulk oxygen of catalyst,thereby enhancing the catalytic activity for CO oxidation.Besides,the decomposition rate of the carbonate species which is derived from in situ DRIFTS for each catalyst can provide a measure to evaluate its catalytic activity of CO oxidation. | Hongjian Zhu Yingying Chen Yibo Gao Wenxu Liu Zhongpeng Wang Chenchen Cui Wei Liu Liguo Wang | 2019 | Journal of Rare Earths2019，37，9： | 5 |
| 4 | One Step Quick Detection of Cancer Cell Surface Marker by Integrated NiFe-based Magnetic Biosensing Cell Cultural Chip显示文摘RGD peptides has been used to detect cell surface integrin and direct clinical effective therapeutic drug selection. Herein we report that a quick one step detection of cell surface marker that was realized by a specially designed NiF e-based magnetic biosensing cell chip combined with functionalized magnetic nanoparticles. Magnetic nanoparticles with 20-30 nm in diameter were prepared by coprecipitation and modified with RGD-4C, and the resultant RGD-functionalized magnetic nanoparticles were used for targeting cancer cells cultured on the NiF e-based magnetic biosensing chip and distinguish the amount of cell surface receptor-integrin.Cell lines such as Calu3, Hela, A549, CaF br, HEK293 and HUVEC exhibiting different integrin expression were chosen as test samples. Calu3, Hela, HEK293 and HUVEC cells were successfully identified. This approach has advantages in the qualitative screening test. Compared with traditional method, it is fast, sensitive, low cost,easy-operative, and needs very little human intervention. The novel method has great potential in applications such as fast clinical cell surface marker detection, and diagnosis of early cancer, and can be easily extended to other biomedical applications based on molecular recognition. | Chenchen Bao Lei Chen Tao Wang Chong Lei Furong Tian Daxiang Cui Yong Zhou | 2013 | Nano-Micro Letters2013，5，3： | 5 |
| 5 | Runxl protects against the pathological progression of osteoarthritis显示文摘Runt-related transcription factor-1(Runxl)is required for chondrocyte-to-osteoblast lineage commitment by enhancing both chondrogenesis and osteogenesis during vertebrate development.However,the potential role of Runxl in joint diseases is not well known.In the current study,we aimed to explore the role of Runxl in osteoarthritis induced by anterior cruciate ligament transaction(ACLT)surgery.We showed that chondrocyte-specific Runxl knockout(Runx1f/fCol2a1-Cre)aggravated cartilage destruction by accelerating the loss of proteoglycan and collagen II in early osteoarthritis.Moreover,we observed thinning and ossification of the growth plate,a decrease in chondrocyte proliferative capacity and the loss of bone matrix around the growth plate in late osteoarthritis.We overexpressed Runxl by adeno-associated virus(AAV)in articular cartilage and identified its protective effect by slowing the destruction of osteoarthritis in cartilage in early osteoarthritis and alleviating the pathological progression of growth plate cartilage in late osteoarthritis.ChIP-seq analysis identified new targets that interacted with Runxl in cartilage pathology,and we confirmed the direct interactions of these factors with Runxl by ChIP-qPCR.This study helps us to understand the function of Runxl in osteoarthritis and provides new clues for targeted osteoarthritis therapy. | Chenchen Zhou Yujia Cui Yueyi Yang Daimo Guo Demao Zhang Yi Fan Xiaobing Li Jing Zou Jing Xie | 2021 | Bone Research2021，9，4： | 4 |
| 6 | Klotho in Osx+-mesenchymal progenitors exerts pro-osteogenic and anti-inflammatory effects during mandibular alveolar bone formation and repair显示文摘Maxillofacial bone defects are commonly seen in clinical practice.A clearer understanding of the regulatory network directing maxillofacial bone formation will promote the development of novel therapeutic approaches for bone regeneration.The fibroblast growth factor(FGF)signalling pathway is critical for the development of maxillofacial bone.Klotho,a type I transmembrane protein,is an important components of FGF receptor complexes.Recent studies have reported the presence of Klotho expression in bone.However,the role of Klotho in cranioskeletal development and repair remains unknown.Here,we use a genetic strategy to report that deletion of Klotho in Osx-positive mesenchymal progenitors leads to a significant reduction in osteogenesis under physiological and pathological conditions.Klotho-deficient mensenchymal progenitors also suppress osteoclastogenesis in vitro and in vivo.Under conditions of inflammation and trauma-induced bone loss,we find that Klotho exerts an inhibitory function on inflammation-induced TNFR signaling by attenuating Rankl expression.More importantly,we show for the first time that Klotho is present in human alveolar bone,with a distinct expression pattern under both normal and pathological conditions.In summary,our results identify the mechanism whereby Klotho expressed in Osx+-mensenchymal progenitors controls osteoblast differentiation and osteoclastogenesis during mandibular alveolar bone formation and repair.Klotho-mediated signaling is an important component of alveolar bone remodeling and regeneration.It may also be a target for future therapeutics. | Yi Fan Chen Cui Clifford JRosen Tadatoshi Sato Ruoshi Xu Peiran Li Xi Wei Ruiye Bi Quan Yuan Chenchen Zhou | 2022 | Signal Transduction and Targeted Therapy2022，7，6： | 3 |
| 7 | Design of SERS nanoprobes for Raman imaging:materials, critical factors and architectures显示文摘Raman imaging yields high specificity and sensitivity when compared to other imaging modalities, mainly due to its fingerprint signature. However, intrinsic Raman signals are weak, thus limiting medical applications of Raman imaging. By adsorbing Raman molecules onto specific nanostructures such as noble metals, Raman signals can be significantly enhanced, termed surfaceenhanced Raman scattering(SERS). Recent years have witnessed great interest in the development of SERS nanoprobes for Raman imaging. Rationally designed SERS nanoprobes have greatly enhanced Raman signals by several orders of magnitude, thus showing great potential for biomedical applications.In this review we elaborate on recent progress in design strategies with emphasis on material properties,modifying factors, and structural parameters. | Mingwang Li Yuanyuan Qiu Chenchen Fan Kai Cui Yongming Zhang Zeyu Xiao | 2018 | Acta Pharmaceutica Sinica B2018，8，3： | 3 |
| 8 | Ecology of industrial pollution in China显示文摘Industrial development has brought China both opportunities and challenges since the reform and opening up in 1978.Spatial and temporal analysis showed that rapid industrialization has made eastern China under a more serious pollution stress.The most serious effects of industrial pollution were reflected in aquatic and soil ecosystem degradation,and damage can be observed from species,population,and community to ecosystem level.Public consciousness about contaminated sites rose from 2004 leading to greater efforts in ecological remediation,monitoring,and risk governance.Considerable efforts are still needed in expanding the extent and breadth of monitoring to explore where the greatest ecological risks lie and how to control them.Ecology of industrial pollution has become a popular discipline in China and will be further developed to help achieve the Sustainable Development Goals.Future research for a better ecological risk management should be focused on multi-media transfer and effects of mixed pollutants,mechanisms for clean energy and material flow,and integration of ecological risk with human health risk. | Jingjing Yuan Yonglong Lu Chenchen Wang Xianghui Cao Chunci Chen Haotian Cui Meng Zhang Cong Wang Xiaoqian Li Andrew C.Johnson Andrew J.Sweetman Di Du | 2020 | Ecosystem Health and Sustainability2020，6，1： | 2 |
| 9 | Tetrahedral framework nucleic acids promote scarless healing of cutaneous wounds via the AKT-signaling pathway显示文摘While the skin is considered the first line of defense in the human body,there are some vulnerabilities that render it susceptible to certain threats,which is an issue that is recognized by both patients and doctors.Cutaneous wound healing is a series of complex processes that involve many types of cells,such as fibroblasts and keratinocytes.This study showed that tetrahedral framework nucleic acids(tFNAs),a type of self-assembled nucleic-acid material,have the ability to promote keratinocyte(HaCaT cell line)and fibroblast(HSF cell line)proliferation and migration in vitro.In addition,tFNAs increased the secretion of vascular endothelial growth factor(VEGF)and basic fibroblast growth factor(bFGF)in HSF cells and reduced the production of tumor necrosis factor-alpha(TNF-α)and interleukin-1 beta(IL-1β)in HaCaT cells by activating the AKT-signaling pathway.During in vivo experiments,tFNA treatments accelerated the healing process in skin wounds and decreased the development of scars,compared with the control treatment that did not use tFNAs.This is the first study to demonstrate that nanophase materials with the biological features of nucleic acids accelerate the healing of cutaneous wounds and reduce scarring,which indicates the potential application of tFNAs in skin tissue regeneration. | Junyao Zhu Mei Zhang Yang Gao Xin Qin Tianxu Zhang Weitong Cui Chenchen Mao Dexuan Xiao Yunfeng Lin | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 10 | Changes in cP- KC isoform-specific membrane translocation and protein expression in the brain of hypoxic preconditioned mice 显示文摘 | Niu Chenchen Li Junfa Cui Xiuyu | 2005 | Neurosci Lett2005，384，： | 1 |
| 11 | Diverse transcriptional patterns of homoeologous recombinant transcripts in triploid fish(Cyprinidae)显示文摘Homoeologous recombination(HR),the exchange of homoeologous chromosomes,contributes to subgenome adaptation to diverse environments by producing various phenotypes.However,the potential relevance of HR and innate immunity is rarely described in triploid cyprinid fish species.In our study,two allotriploid genotypes(R_(2)C and RC_(2)),whose innate immunity was stronger than their inbred parents(Carassius auratus red var.and Cyprinus carpio L.),were obtained from backcrossing between male allotetraploids of C.auratus red var.×C.carpio L.and females of their two inbred parents,respectively.The work detected 140 HRs shared between the two triploids at the genomic level.Further,transcriptions of 54 homoeologous recombinant genes(HRGs)in R_(2)C and 65 HRGs in RC_(2) were detected using both Illumina and PacBio data.Finally,by comparing expressed recombinant reads to total expressed reads in each of the genes,a range of 0.1%-10% was observed in most of the 99-193 HRGs,of which six recombinant genes were classified as'response to stimulus'.These results not only provide a novel way to predict HRs in allopolyploids based on cross prediction at both genomic and transcriptional levels,but also insight into the potential relationship between HRs related to innate immunity and adaptation of the triploids and allotetraploids. | Li Ren Xueyin Zhang Jiaming Li Xiaojing Yan Xin Gao Jialin Cui Chenchen Tang Shaojun Liu | 2021 | Science China(Life Sciences)2021，64，9： | 0 |
| 12 | Supramolecular assembly-derived carbon-nitrogen-based functional materials for photo/electrochemical applications: progress and challenges显示文摘Supramolecular chemistry during the synthesis of carbon-nitrogen-based materials has recently experienced a renaissance in the arena of photocatalysis and electrocatalysis.In this review,we start with the discussion of supramolecular assemblies-derived carbon-nitrogen-based materials’regulation from the aspect of morphology,chemical composition,and micro/nanostructural control.Afterwards the recent advances of these materials in energy and environment related applications,including degradation of pollutants,water splitting,oxygen reduction reactions,CO_(2) reduction reactions along with organic synthesis are summarized.The correlations between the structural features and physicochemical properties of the carbonnitrogen-based materials and the specific catalytic activity are discussed in depth.By highlighting the opportunities and challenges of supramolecular assembly strategies,we attempt an outlook on possible future developments for highly efficient carbon-based photo/electrocatalysts. | Fanglei Yao Chenchen Fang Junjie Cui Liming Dai Xiaoyuan Zhang Liang Xue Pan Xiong Yongsheng Fu Wenyao Zhang Jingwen Sun Junwu Zhu | 2023 | National Science Open2023，2，4： | 0 |
| 13 | A novel ceria hollow nanosphere catalyst for low temperature NOx storage显示文摘In this work,a highly active CeO_(2) catalyst with hollow nanosphere morphology for low temperature NO_(x) storage was prepared by a surfactant-assisted solvothermal reaction.The physicochemical properties of ceria samples were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),transmission electron microscopy(TEM),N_(2) adsorption–desorption,H_(2)-temperature programmed reduction(H_(2)-TPR),X-ray photoelectron spectroscopy(XPS)and in situ diffused reflectance infrared Fourier transform spectroscopy(DRIFTS).The as-prepared CeO_(2) nanosphere possesses excellent NO oxidation capacity,smaller mesopores,better reducibility and more surface Ce^(3+)content.Compared with CeO_(2) with nanorod and nanoparticle morphologies,CeO_(2) nanosphere shows better intrinsic low temperature NO_(x) trapping performance,with a wide operating temperature window(150–300℃),high NO_(x) adsorption capacity(NAC,640–745μmol/g)and high NO_(x) storage capacity(NSC,250–350μmol/g).Two reaction pathways are speculated for NO_(x) adsorption on CeO_(2) nanosphere,including“nitrate route”and“nitrite route”.The thermally unstable surface nitrites formed on the CeO_(2) nanosphere allow ceria to release more NO_(x) during the desorption process.The present work provides a new ceria morphology for NO_(x) traps,which may become a potential excellent NO_(x) storage material. | Wenxu Liu Huiming Cao Zhongpeng Wang Chenchen Cui Liangran Gan Wei Liu Liguo Wang | 2022 | Journal of Rare Earths2022，40，4： | 0 |
| 14 | Palladium-Catalyzed Intramolecular Dehydrogenative Arylboration of Alkenes显示文摘The palladium-catalyzed borylative cyclization via C—H activation has been developed.By this chemistry,the indole-fused dihydro-pyrrole motif,which is a kind of important unit in natural products and bio-active molecules,could be constructed and installed with a boric ester group.Furthermore,the utilities of products have been illustrated by the study of further transformations.Importantly,by using chiral ligand,the enantioselectivity of this borylative cyclization reaction could be controlled.Moreover,the borylative mechanism,which should proceed through a Pd(II)/Pd(IV)catalytic cycle,has been proposed based on the DFT calculations. | Chenchen Zou Hongli Wu Yuqi Ji Penglin Zhang Huanhuan Cui Genping Huang Chun Zhang | 2022 | Chinese Journal of Chemistry2022，40，20： | 0 |
| 15 | Morphological characteristics and atomic evolution behavior of nanojoints in Ag nanowire interconnect network显示文摘Ag nanowires(AgNWs)have shown great application value in the field of flexible electronics due to their excellent optical and electrical properties,and the quality of its joints of AgNWs in the thin film network directly plays a key role in its performance.In order to further improve the joint quality of AgNWs under thermal excitation,the thermal welding process and atomic evolution behavior of AgNWs were investigated through a combination of in situ experimental and molecular dynamics simulations.The influence of processing time,temperature,and stress distribution due to spatial arrangement on nanojoints was systematically explored.What is more,the failure mechanisms and their atomic interface behavior of the nanojoints were also investigated. | Jianlei Cui Xiaoying Ren Xuesong Mei Zhengjie Fan Chenchen Huang Zhijun Wang Xiaofei Sun Wenjun Wang | 2023 | International Journal of Extreme Manufacturing2023，5，2： | 0 |
| 16 | Driving forces for ultrafast laser-induced sp^(2) to sp^(3) structural transformation in graphite显示文摘Understanding the microscopic mechanism of photoinduced sp^(2)-to-sp^(3) structural transformation in graphite is a scientific challenge with great importance.Here,the ultrafast dynamics and characteristics of laser-induced structural transformation in graphite are revealed by non-adiabatic quantum dynamic simulations.Under laser irradiation,graphite undergoes an interlayer compression and sliding stage,followed by a key period of intralayer buckling and interlayer bonding to form an intermediate sp^(2)-sp^(3) hybrid structure,before completing the full transformation to hexagonal diamond.The process is driven by the cooperation of charge carrier multiplication and selective phonon excitations through electron-phonon interactions,in which photoexcited hot electrons scattered into unoccupied high-energy conduction bands play a key role in the introduction of in-plane instability in graphite.This work identifies a photoinduced non-adiabatic transition pathway from graphite to diamond and shows far-reaching implications for designing optically controlled structural phase transition in materials. | Chenchen Song Mengxue Guan Yunzhe Jia Daqiang Chen Jiyu Xu Cui Zhang Sheng Meng | 2023 | npj Computational Materials2023，，1： | 0 |
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