|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Pollution levels and characteristics of phthalate esters in indoor air in hospitals显示文摘The concentrations of phthalate esters(PAEs) in Chinese hospitals were investigated by simultaneously determining concentrations of gas- and particle-phase PAEs. PAEs were detected in two third-class first-grade hospitals, two second-class first-grade hospitals, and a community health service center. Hospital drugstores had the highest concentration(24.19 μg/m3), which was 1.54 times that of newly decorated houses. The second highest concentration was found in the transfusion rooms, averaging 21.89 μg/m3; this was followed by the concentrations of PAEs in the nurse's workstations, the wards, and the doctor's offices, with mean concentrations of 20.66, 20.0, and 16.92 μg/m3, respectively. The lowest concentrations were found in the hallways(16.30 μg/m3). Of the six different kinds of PAEs found, major pollutants included diethyl phthalates, dibutyl phthalates, butylbenzyl phthalates and di(2-ethylhexyl) phthalates, comprising more than 80% of all PAEs present.Meanwhile, a comparison between different wards showed that PAE concentrations in the maternity wards were 1.63 times higher than in the main wards. Based on known health hazards, our results suggest that the PAEs seriously influence the health of the pregnant women and babies; therefore, it is of great importance to take the phthalate concentrations in hospitals into consideration. In addition, hospital indoor air was more seriously contaminated than the air of newly decorated houses. | Xueqing Wang Min Song Min Guo Chenchen Chi Feifei Mo Xueyou Shen | 2015 | Journal of Environmental Sciences2015，27，11： | 4 |
| 2 | Pollution levels and characteristics of phthalate esters in indoor air of offices显示文摘The pollution status and characteristics of PAEs(phthalate esters) were investigated in indoor air of offices, and PAEs of both gas-phase and particulate-phase were detected in all the samples. The concentration(sum of the gas phase and the particulate phase) was4748.24 ng/m3, ranging between 3070.09 and 6700.14 ng/m3. Diethyl phthalate, dibutyl phthalate, and di(2-ethylhexyl) phthalate were the most abundant compounds, together accounting for 70% of the ∑ 6PAEs. Dividing the particulate-phase PAEs into four size ranges(< 2.5, 2.5–5, 5–10, > 10 μm), the result indicated that PAEs in PM2.5were the most abundant,with the proportion of 72.64%. In addition, the PAE concentration in PM2.5correlated significantly with the total particulate-phase PAEs(R2= 0.85). Thus, the amount of PAEs in PM2.5can be estimated from the total amount of particulate-phase PAEs using this proportion. In a comparison between the offices and a newly decorated study room, it was found that pollution characteristics were similar between these two places. Thus, it is implied that the PAE concentration decreased by 50% 2 yr after decorating. | Min Song Chenchen Chi Min Guo Xueqing Wang Lingxiao Cheng Xueyou Shen | 2015 | Journal of Environmental Sciences2015，27，2： | 3 |
| 3 | A high-energy-density sodium-ion full battery based on tin anode显示文摘Sodium-ion batteries(SIBs) have been considered as promising candidates for large-scale energy storage, owing to the high abundance and low cost of sodium(Na) resources. However, the development of full SIB has been hindered by low energy density because of the sluggish kinetics of large Na^+. Here, we report a full SIB with commercial tin(Sn) anode, cross-linked Na_3V_2(PO_4)_3/carbon nanotubes composites(NVP-CNT) cathode, and ether-based electrolyte. Sn is capable of delivering high reversible capacity via formation of Na15 Sn4 and stable solid-electrolyte interface(SEI) in initial cycles. Meanwhile, the NASICON-type NVP enables ultrafast and stable Na^+intercalation/extraction, and the incorporation of CNT can improve its electrical conductivity. The assembled full SIB delivers high output voltage of ~3.2 V, high energy density of 253.4 W h kg^(-1) at1600 W kg^(-1) based on total mass of both cathode and anode, and remarkable capacity retention of 96.1% after 180 cycles. These merit construction of high-energy full SIBs and will promote the development of SIBs. | Mingming Song Chenchen Wang Dongfeng Du Fujun Li Jun Chen | 2019 | Science China Chemistry2019，62，5： | 3 |
| 4 | Injectable self-healing hydrogel with siRNA delivery property for sustained STING silencing and enhanced therapy of intervertebral disc degeneration显示文摘Inflammatory responses of nucleus pulposus(NP)can induce imbalanced anabolism and catabolism of extracellular matrix,and the cytosolic dsDNA accumulation and STING-NF-κB pathway activation found in NP inflammation are considered as fairly important cause of intervertebral disc(IVD)degeneration.Herein,we constructed a siSTING delivery hydrogel of aldehyde hyaluronic acid(HA-CHO)and poly(amidoamine)PAMAM/siRNA complex to intervene the abnormal STING signal for IVD degeneration treatment,where the formation of dynamic Schiff base bonds in the system(siSTING@HPgel)was able to overcome the shortcomings such as low cellular uptake,short half-life,and rapid degradation of siRNA-based strategy.PAMAM not only formed complexes with siRNA to promote siRNA transfection,but also served as dynamic crosslinker to construct hydrogel,and the injectable and self-healing hydrogel efficiently and steadily silenced STING expression in NP cells.Finally,the siSTING@HPgel significantly eased IVD inflammation and slowed IVD degeneration by prolonging STING knockdown in puncture-induced IVD degeneration rat model,revealing that STING pathway was a therapeutic target for IVD degeneration and such novel hydrogel had great potential for being applied to many other diseases for gene delivery. | Jiaxin Chen Haifeng Zhu Yutao Zhu Chenchen Zhao Shengyu Wang Yixin Zheng Ziang Xie Yang Jin Honghai Song Linjun Yang Jin Zhang Jiayong Dai Zhijun Hu Huaiyu Wang | 2022 | Bioactive Materials2022，7，3： | 2 |
| 5 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice 显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，1： | 1 |
| 6 | Research on cementitious behavior and mechanism of pozzolanic cement with coal gangue显示文摘 | LI Dongxu SONG Xuyan GONG Chenchen | 2006 | Cement and Concrete Research2006，36，： | 1 |
| 7 | The E3 ubiquitin ligase NEDD4-1 protects against acetaminophen-induced liver injury by targeting VDAC1 for degradation显示文摘Acetaminophen(APAP)overdose is a major cause of liver injury.Neural precursor cell expressed developmentally downregulated 4—1(NEDD4-1)is an E3 ubiquitin ligase that has been implicated in the pathogenesis of numerous liver diseases;however,its role in APAP-induced liver injury(AILI)is unclear.Thus,this study aimed to investigate the role of NEDD4-1 in the pathogenesis of AILI.We found that NEDD4-1 was dramatically downregulated in response to APAP treatment in mouse livers and isolated mouse hepatocytes.Hepatocyte-specific NEDD4-1 knockout exacerbated APAP-induced mitochondrial damage and the resultant hepatocyte necrosis and liver injury,while hepatocyte-specific NEDD4-1 overexpression mitigated these pathological events both in vivo and in vitro.Additionally,hepatocyte NEDD4-1 deficiency led to marked accumulation of voltage-dependent anion channel 1(VDAC1)and increased VDAC1 oligomerization.Furthermore,VDAC1 knockdown alleviated AILI and weakened the exacerbation of AILI caused by hepatocyte NEDD4-1 deficiency.Mechanistically,NEDD4-1 was found to interact with the PPTY motif of VDAC1 through its WW domain and regulate K48-linked ubiquitination and degradation of VDAC1.Our present study indicates that NEDD4-1 is a suppressor of AILI and functions by regulating the degradation of VDAC1. | Yiwei Zhu Lin Lei Xinghui Wang Linfang Chen Wei Li Jinxia Li Chenchen Zhao Xiliang Du Yuxiang Song Wenwen Gao Guowen Liu Xinwei Li | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 8 | Construction of nanoreactors on TiO_(2)nanotube arrays as a POCT device for sensitive colorimetric detection显示文摘With increasing attention to personalized healthcare,miniaturized and easily implementable devices are desired for point-of-care testing(POCT).Herein,hydrophilic patterns were designed on freestanding TiO_(2)nanotube arrays(Ti NTs)as nanoreactors for a naked-eye colorimetric assay.With a high aspect ratio,TiN Ts can provide a long observation length combined with a limited volume.Moreover,by combining the photocatalytic property of TiO_(2)and spatiotemporal controllability of light,hydrophilic nanoreactors were fabricated with minimal volume,and thus the indicator and analyte are limited in a confined void by the hydrophobic surroundings,thus allowing a higher sensitivity for sensing.We believe the proposed sensing platform could provide a promising strategy in developing POCT devices for routine health monitoring. | Jingwen Xu Chenchen Liang Zhida Gao Yan-Yan Song | 2023 | Chinese Chemical Letters2023，34，5： | 1 |
| 9 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 10 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice 显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 11 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 12 | Research on cementitious behavior and mechanism of pozzolanic cement with coal gangue显示文摘 | Dongxu Li Xuyan SONG Chenchen Gong | 2006 | Cement and Concrete Research2006，36，： | 1 |
| 13 | Modulating the C-terminus of DEP1 synergistically enhances grain quality and yield in rice显示文摘Grain shape is a key breeding target that influences both grain yield and appearance quality in rice. Breeding for long-slender grains is an effective strategy to improve grain quality (Jain et al., 2004;Wang et al., 2012, 2015a). In the past two decades, several quantitative trait loci (QTLs) responsible for grain size and shape have been identified, including GS3 (Fan et al., 2006), GS5 (Li et al., 2011). | Haixiang Huang Yafeng Ye Wenzhen Song Qi Li Ruixi Han Chenchen Wu Shuoxun Wang Jianping Yu Xueying Liu Xiangdong Fu Qian Liu Kun Wu | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 14 | Research on Cementitious Behavior and Mechanism of Pozzolanic Cement with Coal Gangue显示文摘 | Li Dongxu Song Xuyan Gong Chenchen | 2006 | Cement and Concrete Research2006，36，7： | 1 |
| 15 | Inhibition of autophagy by 3?MA enhances endoplasmic reticulum stress?inducedapoptosis in human nasopharyngeal carcinoma cells显示文摘 | Lele Song Hao Liu Linyan Ma Xudng Zhang Zhiwen Jiang Chenchen Jiang | 2013 | Oncology Letters2013，，4： | 1 |
| 16 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice 显示文摘 | Li Junfa Niu Chenchen Han Song | 2005 | Brain Res2005，1060，： | 1 |
| 17 | Identification of protein kinase C isoforms involved in cerebral hypoxic preconditioning of mice显示文摘 | Li Junfai Niu Chenchen Han Song | 2005 | Brain Res2005，1060，12： | 1 |
| 18 | A novel self‐assembly albumin nanocarrier for reducing doxorubicin‐mediated cardiotoxicity显示文摘 | Ahu Yuan Jinhui Wu Chenchen Song Xiaolei Tang Qian Qiao Lili Zhao Guangming Gong Yiqiao Hu | 2013 | J Pharm Sci2013，，5： | 1 |
| 19 | Design and in-situ construct BiOI/Bi/TiO_(2)photocatalysts with metal-mediated heterostructures employing oxygen vacancies in TiO_(2)nanosheets显示文摘The conventional p-n heterojunction photocatalysts suffer from the incompatibility between the interfacial charge transfer efficiency and the redox ability of charge carriers.To optimize the interfacial charge transfer of the conventional BiOI/TiO_(2) p-n photocatalyst,we synthesized the BiOI/Bi/TiO_(2) ternary photocatalyst with sandwiched metallic bismuth(Bi~0)by the oxygen-vacancy assisted method.The DFT calculation and structural characterizations confirmed the reaction of the electron-rich oxygen vacancies in the 2D-TiO_(2) nanosheets(TiO_(2)-NS)with the adsorbed BiO~+species.This reaction broke the Bi-O bonds to form Bi^(0) nanoparticles in-situ at the interface but still maintained the p-n heterojunction well.The NO-TPD and XRD analyses for samples correlated the Bi~0 formation with the oxygen vacancy concentrations well.The sandwiched Bi~0 functioned as an electronic transfer mediator like that in the Z-scheme heterostructure.Comparing with 0.20 BiOI/TiO_(2)-NP(NP,Nanoparticles),0.20 BiOI/Bi/TiO_(2)-NS-a(NS,Nanosheet)showed a much improved catalytic performance,i.e.,duplicated apparent quantum yield(AQY)and triplicated reaction rate constant(k).Also,the formation mechanism and the reaction mechanism were investigated in detail.This work provides a new strategy for the improving of the conventional p-n photocatalysts and new insights into the nature of the photocatalysis. | Chenchen Zhang Wenbin Chen Dairong Hu Hanjie Xie Yibing Song Binbin Luo Yiwen Fang Wenhua Gao Ziyi Zhong | 2022 | Green Energy & Environment2022，7，4： | 0 |
| 20 | Characteristics of gut microbiota in representative mice strains:Implications for biological research显示文摘Background:Experimental animals are used to study physiological phenomena,pathological mechanisms,and disease prevention.The gut microbiome is known as a potential confounding factor for inconsistent data from preclinical studies.Although many gut microbiome studies have been conducted in recent decades,few have focused on gut microbiota fluctuation among representative mouse strains.Methods:A range of frequently used mouse strains were selected from 34 isolation packages representing disease-related animal(DRA),immunity defect animal(IDA),or gene-editing animal(GEA)from the BALB/c and C57BL/6J backgrounds together with normal mice,and their microbial genomic DNA were isolated from mouse feces to sequence for the exploration of gut microbiota.Results:Mouse background strain,classification,introduced source,introduced year,and reproduction type significantly affected the gut microbiota structure(p<0.001 for all parameters),with background strain contributing the greatest influence(R^(2)=0.237).In normal groups,distinct gut microbiota types existed in different mouse strains.Sixty-four core operational taxonomic units were obtained from normal mice,and 12 belonged to Lactobacillus.Interestingly,the gut microbiota in C57BL/6J was more stable than that in BALB/c mice.Furthermore,the gut microbiota in the IDA,GEA,and DRA groups significantly differed from that in normal groups(p<0.001 for all).Compared with the normal group,there was a significantly higher Chao 1 and Shannon index(p<0.001 for all)in the IDA,GEA,and DRA groups.Markedly changed classes occurred with Firmicutes and Bacteroidetes.The abundances of Helicobacter,Blautia,Enterobacter,Bacillus,Clostridioides,Paenibacillus,and Clostridiales all significantly decreased in the IDA,GEA,and DRA groups,whereas those of Saccharimonas,Rikenella,and Odoribacter all significantly increased. | Jianguo Guo Chenchen Song Yunbo Liu Xuying Wu Wei Dong Hua Zhu Zhiguang Xiang Chuan Qin | 2022 | Animal Models and Experimental Medicine2022，5，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员