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| 1 | 埃索美拉唑能有效控制内镜阴性胃食管反流症状——6个月“按需治疗”对照试验显示文摘 | Talley NJ Lauritsen K Tunturi-Hihnala H Lind T Moum B Bang C Schulz T Omland TM Delle M Junghard O 钟捷 | 2003 | 中华消化杂志2003，23，1： | 6 |
| 2 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 3 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Internal fixation of pelvic ring fracture显示文摘 | Matta TM Saucedo T | 1989 | Clin Orthop1989，242，1： | 1 |
| 7 | Exacerbation of radiocontrast nephrotoxicity by endothelin receptor antagonism显示文摘 | Wang A Holcslaw T Bashore TM | 2000 | Kidney Int2000，57，4： | 1 |
| 8 | The Super-oxide synt hases of rose cells-comparison of Assays 显示文摘 | MURPHY TM vU H NGUYEN T | 1998 | Plant Physiol1998，17，： | 1 |
| 9 | The use of laparoseopic surgery in pregnancy: evaluation of safety and efficacy显示文摘 | Corneille MG Gallup TM Bening T | 2010 | AmJ Surg2010，200，3： | 1 |
| 10 | Secondary metabolites and nutrient concentra- tions in silver bitch seedling under five levels of daily UV-B exposure and two relative nutrient addition rates 显示文摘 | DE LA ROSA TM JULKUNEN-TIIT- TO R LEHTO T | 2001 | New Phytologist2001，150，1： | 1 |
| 11 | Heart rate and performance during combat missions in a flight simulator 显示文摘 | Lahtinen TM Koskelo JP Laitinen T | 2007 | Aviat Space Environ Med2007，78，4： | 1 |
| 12 | Adenocarcinoma in shu of the uterine cervix:management and outcome显示文摘 | Widrieh T Kennedy AW Myers TM | 1996 | Gynecol Oncol1996，61，3： | 1 |
| 13 | Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1Subtype B Gag Proteins显示文摘 | Boutwell C L Carlson J M Lin T H Seese A Power K A Peng J Tang Y Brumme Z L Heckerman D Schneidewind A Allen TM | 2013 | J Virol2013，87，7： | 1 |
| 14 | Low-dose CT of the paranasal sinuses with eye lens protection:effect on image quality and radiation dose显示文摘 | Hagtvedt T Aalokkken TM Notthellen J | 2002 | Eur Radiol2002，12，： | 1 |
| 15 | Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study 显示文摘 | Eagan TM Ueland T Wagner PD | 2010 | EurRespirJ2010，35，3： | 1 |
| 16 | KIT-D816 mutations in AML1/ETO-positive AML are associated with impaired event-free and overall survival 显示文摘 | Schnittger S Kohl TM Haferlach T | 2006 | Blood2006，107，5： | 1 |
| 17 | Re- covery of function after brain damage: severe and chronic disruption by diazepam 显示文摘 | Schallert T Hernandez TD Barth TM | 1986 | Brain Res1986，379，1： | 1 |
| 18 | Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study显示文摘 | Bielecki TM Gazdzik TS Arendt J Szczepanski T Krol W Wielkoszynski T | 2007 | J Bone Joint Surg Br2007，89，3： | 1 |
| 19 | A complex containing N-CoR, roSin3 and bistone deacetylase mediates tran- scriptional repression显示文摘 | HEINZEL T RM LAVINSKY TM MULLEN | 1997 | Nature1997，387，： | 1 |
| 20 | Immune responses to the ycobacterium tuberculosis-specific antigen ESAT-6 signal subclinical infection among contacts tuberculosis patients显示文摘 | Doherty TM Demissie A Olobo J Wolday D Britton S Eguale T Ravn P.Andersen P | | 0，，： | 1 |
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