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| 1 | New eolian red clay sequence on the western Chinese Loess Plateau linked to onset of Asian desertification about 25 Ma ago显示文摘The expansion of inland Asia deserts has considerably influenced the environmental, social and economic activities in Asia. Aridification of inland Asia, especially timing of the initiation of Asian desertification, is a contentious topic in paleoclimatology. Late Cenozoic eolian loess-red clay sequences on the Chinese Loess Plateau, which possess abundant paleoclimatic and paleo-environmental information, can be regarded as an indicator of inland Asia desertification. Here we present a detailed magnetostratigraphic investigation of a new red clay sequence about 654 m in Zhuanglang located at the western Chinese Loess Plateau. Sedimentological, geochemical, mineralogical, and quartz morphological lines of evidence show that the red clay is of eolian origin. Magnetostratigraphic correlations indicate that this core sequence spans from 25.6 to 4.8 Ma, and typical eolian red clay appears as early as 25 Ma. This extends the lower limit of the red clay on the Chinese Loess Plateau from the previously thought early Miocene back into the late Oligocene. This new red clay record further implies that the inland Asia desertification was initiated at least by the late Oligocene. This sequence provides a unique high-resolution geological record for understanding the inland Asia desertification process since the late Oligocene. | QIANG XiaoKe AN ZhiSheng SONG YouGui CHANG Hong SUN YouBin LIU WeiGuo AO Hong DONG JiBao FU ChaoFeng WU Feng LU FengYan CAI YanJun ZHOU WeiJian CAO JunJi XU XinWen AI Li | 2011 | Science China Earth Sciences2011，54，1： | 73 |
| 2 | Exosome-functionalized magnesium-organic framework-based scaffoldswith osteogenic, angiogenic and anti-inflammatory properties foraccelerated bone regeneration显示文摘Exosomes derived from human adipose-derived stem cells (hADSCs-Exos) have shown potential as an effectivetherapeutic tool for repairing bone defects. Although metal-organic framework (MOF) scaffolds are promisingstrategies for bone tissue regeneration, their potential use for exosome loading remains unexplored. In this study,motivated by the potential advantages of hADSCs-Exos and Mg-GA MOF, we designed and synthesized anexosome-functionalized cell-free PLGA/Mg-GA MOF (PLGA/Exo-Mg-GA MOF) scaffold, taking using of thebenefits of hADSCs-Exos, Mg2+, and gallic acid (GA) to construct unique nanostructural interfaces to enhanceosteogenic, angiogenic and anti-inflammatory capabilities simultaneously. Our in vitro work demonstrated thebeneficial effects of PLGA/Exo-Mg-GA MOF composite scaffolds on the osteogenic effects in human bonemarrow-derived mesenchymal stem cells (hBMSCs) and angiogenic effects in human umbilical endothelial cells(HUVECs). Slowly released hADSCs-Exos from composite scaffolds were phagocytosed by co-cultured cells,stabilized the bone graft environment, ensured blood supply, promoted osteogenic differentiation, and acceleratedbone reconstruction. Furthermore, our in vivo experiments with rat calvarial defect model showed thatPLGA/Exo-Mg-GA MOF scaffolds promoted new bone formation and satisfactory osseointegration. Overall, weprovide valuable new insights for designing exosome-coated nanocomposite scaffolds with enhanced osteogenesisproperty. | Yue Kang Chang Xu Ling’ao Meng Xufeng Dong Min Qi Daqing Jiang | 2022 | Bioactive Materials2022，7，12： | 11 |
| 3 | Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins显示文摘Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated endocytosis.After reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs.Peroxisomes are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane contacts.However,whether and how cholesterol is conveyed from peroxisomes to the ER remain unknown.Here,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in lysosomes.Furthermore,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ER.Together,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell. | Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang Zimu Zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song | 2019 | Science China(Life Sciences)2019，62，9： | 8 |
| 4 | A novel ground surface subsidence prediction model for sub-critical mining in the geological condition of a thick alluvium layer显示文摘在中国的煤矿的一个实质的数字处于在这些情形下面的厚冲积层层的地质的条件,它不说得通由使用这份报纸论述的常规预言模型预言地面表面沉淀和另外的变丑为处于厚冲积层层的地质的条件的 亚critical 采矿的一个新奇地面表面沉淀预言模型地质的作文和厚冲积层的机械性质被认为是随机的媒介,这是岩石质量上的一致地分布式的负担;然而,在弯曲地区的岩石团的overburden 被看在之上作为控制扎根的表面沉淀的一个难阶层,为岩石的不同沉淀和排水量机制集中并且厚冲积层层分别地被考虑并且在这个模型描述了,它在一个实际预言盒子中显示令人满意的表演。 | Zhanqiang CHANG Jinzhuang WANG Mi CHEN Zurui AO Qi YAO | 2015 | Frontiers of Earth Science2015，9，2： | 5 |
| 5 | Sensitivity analysis of the SWAP(Soil-Water-Atmosphere-Plant)model under different nitrogen applications and root distributions in saline soils显示文摘Sensitivity analysis is important for determining the parameters in the model calibration process.In our study,a variance-based global sensitivity analysis(extended Fourier amplitude sensitivity test,EFAST)was applied to an agro-hydrological model(the SWAP(Soil-Water-Atmosphere-Plant model)model).The sensitivities of 20 parameters belonging to 4 categories(soil hydraulics,solute transport,root water uptake,and environmental stresses)for the simulated accumulated transpiration,dry matter(DM),and yield of sunflowers were analyzed under three nitrogen application rates(N1,N2,and N3),four salinity levels(S1,S2,S3,and S4),and three root distributions(R1,R2,and R3).The results indicated that for predominantly loamy soils,the high-impact parameters for accumulated transpiration,DM,and yield were the soil hydraulic parameters(αand n),critical stress index for compensatory root water uptake(ωc),the salt level at which salt stress starts(Pi),the decline of root water uptake above Pi(SSF),residual water content(θr),saturated water content(θs),and relative uptake of solutes by roots(TSCF).We also found that nitrogen application did not change the order of the parameter impacts on accumulated transpiration,DM,and yield.However,TSCF replacedαas the highest-impact parameter for the accumulated transpiration,DM,and yield at high salinity levels(S2 and S3).Furthermore,αwas also the highest-impact parameter for DM and yield under different root distributions,but the highest-impact parameters for transpiration wereωc,α,andθs under R1,R2,and R3,respectively.Nitrogen application could be neglected when considering the interactive effects of nitrogen application,salinity level,and root distribution on the transpiration,DM,and yield.Additionally,the mean values and uncertainties of the transpiration,DM,and yield were similar in all scenarios,except S3,which showed a sharp decrease in the mean values.We suggest determining the above eight parameters(α,n,ωc,Pi,SSF,θr,θs,and TSCF)and the saturated vertical hydraulic conductivity(Ks)based on rigorous calibrations with direct or indirect local measurements using economical methods(e.g.,a literature review),with limited observations for other parameters when using the SWAP model and other similar agro-hydrological models. | Guoqing LEI Wenzhi ZENG Yonghua JIANG Chang AO Jingwei WU Jiesheng HUANG | 2021 | Pedosphere2021，31，5： | 4 |
| 6 | Ruxolitinib attenuates secondary injury after traumatic spinal cord injury显示文摘Excessive inflammation post-traumatic spinal cord injury(SCI)induces microglial activation,which leads to prolonged neurological dysfunction.However,the mechanism underlying microglial activation-induced neuroinflammation remains poorly understood.Ruxolitinib(RUX),a selective inhibitor of JAK1/2,was recently reported to inhibit inflammatory storms caused by SARS-CoV-2 in the lung.However,its role in disrupting inflammation post-SCI has not been confirmed.In this study,microglia were treated with RUX for 24 hours and then activated with interferon-γfor 6 hours.The results showed that interferon-γ-induced phosphorylation of JAK and STAT in microglia was inhibited,and the mRNA expression levels of pro-inflammatory cytokines tumor necrosis factor-α,interleukin-1β,interleukin-6,and cell proliferation marker Ki67 were reduced.In further in vivo experiments,a mouse model of spinal cord injury was treated intragastrically with RUX for 3 successive days,and the findings suggest that RUX can inhibit microglial proliferation by inhibiting the interferon-γ/JAK/STAT pathway.Moreover,microglia treated with RUX centripetally migrated toward injured foci,remaining limited and compacted within the glial scar,which resulted in axon preservation and less demyelination.Moreover,the protein expression levels of tumor necrosis factor-α,interleukin-1β,and interleukin-6 were reduced.The neuromotor function of SCI mice also recovered.These findings suggest that RUX can inhibit neuroinflammation through inhibiting the interferon-γ/JAK/STAT pathway,thereby reducing secondary injury after SCI and producing neuroprotective effects. | Zhan-Yang Qian Ren-Yi Kong Sheng Zhang Bin-Yu Wang Jie Chang Jiang Cao Chao-Qin Wu Zi-Yan Huang Ao Duan Hai-Jun Li Lei Yang Xiao-Jian Cao | 2022 | Neural Regeneration Research2022，17，9： | 3 |
| 7 | Diagnostic value of fecal occult blood testing for screening colorectal cancer显示文摘DiagnosticvalueoffecaloccultbloodtestingforscreeningcolorectalcancerCHENKun1,JIAODengAo1,ZHENGShu2,ZHOULun2,YUHai2,YUANYaC... | CHEN Kun 1, JIAO Deng Ao 1, ZHENG Shu 2, ZHOU Lun 2, YU Hai 2, YUAN Ya Chang 3, YAO Kai Yan 3, MA Xing Yuan 3 and ZHANG Yang 1 | 1997 | World Journal of Gastroenterology1997，3，3： | 3 |
| 8 | Improvement of microalgae lipid productivity and quality in an ion-exchange-membrane photobioreactor using real municipal wastewater显示文摘To improve the productivity and quality of microalgae-based biodiesel when using municipal wastewater(MW)as nutrients source,an ion-exchange-membrane photobioreactor(IEM-PBR)was used in this study to eliminate the negative effects of pollutants in MW on microalgae Chlorella vulgaris and Scenedesmus obliquus.In the IEM-PBR,the real MW and microalgae cultures were separated in two chambers by the ion-exchange-membranes(IEMs).Nutrients(N,P,etc.)in the MW permeated into microalgae cultures through the IEMs,while pollutants(suspended solids,competitors,etc.)in the MW could hardly permeate into microalgae cultures.As a result,the lipid productivity in the IEM-PBR was improved to 85.7 mg/(L·d)for C.vulgaris and 111.8 mg/(L·d)for S.obliquus,which was slightly higher than that in the traditional photobioreactor(T-PBR)with real MW after centrifugation(82.5 mg/(L·d)for C.vulgaris and 105.8 mg/(L·d)for S.obliquus),but much higher than that in the T-PBR with untreated MW and primary MW(with lipid productivity of 20-30 mg/(L·d)).Besides,the lipid quality obtained in the IEM-PBR had higher proportion of cetane number(ca.60%)and lower linolenic acid content(ca.8%),which showed a superior quality in the IEM-PBR to that in the T-PBR.It demonstrated that the IEM-PBR is an effective approach to improve the productivity and quality of microalgae biodiesel. | Chang Haixing Fu Qian Huang Yun Xia Ao Liao Qiang Zhu Xun | 2017 | International Journal of Agricultural and Biological Engineering2017，10，1： | 2 |
| 9 | Magnetostratlgraphy of the Suerkuli Basin Indicates Pliocene (3,2 Ma) Activity of the Middle Altyn Tagh Fault, Northern Tibetan Plateau 显示文摘 | Chang H Ao H An Z | 2012 | Journal of Asian Earth Scienees2012，44，： | 1 |
| 10 | Vegetation - Climate Relationship and Its Application in the Division o( Vegetation Zone in China显示文摘 | FANG Jing - Yun SONG Yong - Chang LIU Hong - Yah PI- AO Shi- Long | 2002 | Aeta Botanica Sinica2002，44，9： | 1 |
| 11 | Magnetostratigraphic age of the Xiantai Paleolithic site in the Nihewan Basin and implications for early human colonization of Northeast Asia显示文摘 | Chenglong Deng Qi Wei Rixiang Zhu Hongqiang Wang Rui Zhang Hong Ao Liao Chang Yongxin Pan | 2006 | Earth and Planetary Science Letters2006，，1： | 1 |
| 12 | STAT4 is required for interleukin-12-indueed ehromatin remodelling of the CD25 locus 显示文摘 | Sullivan AO Chang CH Yu Q | 2004 | J Biol Chem2004，279，8： | 1 |
| 13 | Amino acid transporters in plants显示文摘 | Lopez AO Chang HC Bush DR | 2000 | Biochim Biophys Acta2000，1465，： | 1 |
| 14 | Alpha Klotho and phosphate homeostasis显示文摘 | Ao Bian Changying Xing Ming Chang Hu | 2014 | J Endocrinol invest2014，37，11： | 1 |
| 15 | Application of fuzzy multi objective function on reducing groundwater demand for aquaculture in land subsidence areas 显示文摘 | Ao Chang Yang Pao Shan Yu | 2006 | Water Resources Management2006，，20： | 1 |
| 16 | An alpha-globin gene initiation codon mutation in a black family with HbH disease显示文摘 | Olivieri NF Chang LS Poon AO | 1987 | Blood1987，70，3： | 1 |
| 17 | Primary gastric melanoma: A case report with imaging findings and 5-year follow-up显示文摘BACKGROUND Most melanomas identified in the stomach are metastatic;primary gastric melanoma(PGM)is extremely rare,and the relevant studies are relatively scarce.PGM may be incorrectly diagnosed as other gastric malignant tumor types.CASE SUMMARY We describe a rare case of PGM confirmed through long-term clinical observation and pathological diagnosis.A 67-year-old woman presented to our hospital with recurrent chest tightness and chest pain.Digital gastrointestinal radiography revealed a circular shadow in the gastric cardia.Computed tomography(CT)revealed a heterogeneous tumor with uneven enhancement.Enlarged lymph nodes were noted in the lesser curvature of the stomach.On magnetic resonance imaging(MRI),T1-and T2-weighted imaging revealed hyperintensity in and hypointensity in the tumor,respectively,both of which increased substantially after uneven enhancement.Near total gastrectomy was performed,and the tumor was pathologically confirmed to be a gastric melanoma.Because no other possible primary site of malignant melanoma was suspected,a clinical diagnosis of PGM was made.The patient was followed for nearly 5 years,during which she received CT reexamination,but no recurrence or metastasis was observed.CONCLUSION Certain imaging characteristics could be revealed in PGM.Imaging examination can be of great value in preoperative diagnosis,differential diagnosis,and followup of patients with PGM. | Jian Wang Fang Yang Wei-Qun Ao Chang Liu Wen-Ming Zhang Fang-Yi Xu | 2019 | World Journal of Gastroenterology2019，25，44： | 1 |
| 18 | Determination of trace gold and palladium in geological samples by atomic absorption spectrometry with separation and enrichment of chromeayuorls chelate forming resin显示文摘 | Ao Chang li Li Zengwen Zhang Kai | 1996 | Microchemical Journal1996，54，： | 1 |
| 19 | Decarboxylated osteocalcin,a possible drug for type 2 diabetes,triggers glucose uptake in MG63 cells显示文摘BACKGROUND Uncarboxylated osteocalcin(GluOC)has been reported to improve glucose metabolism,prevent type 2 diabetes,and decrease the severity of obesity in mice with type 2 diabetes.GluOC can increase glucose uptake in a variety of cells.Glucose metabolism is the main source of energy for osteoblast proliferation and differentiation.We hypothesized that decarboxylated osteocalcin(dcOC),a kind of GluOC,can increase glucose uptake in MG63 cells(osteoblast-like osteosarcoma cells)and influence their proliferation and differentiation.AIM To investigate the effects of dcOC on glucose uptake in human osteoblast-like osteosarcoma cells and the possible signaling pathways involved.METHODS MG63 cells(human osteoblast-like osteosarcoma cells)were treated with dcOC(0,0.3,3,10,or 30 ng/mL)for 1 and 72 h,and glucose uptake was measured by flow cytometry.The effect of dcOC on cell proliferation was measured with a CCK-8 assay,and alkaline phosphatase(ALP)enzyme activity was measured.PI3K was inhibited with LY294002,and hypoxia-inducible factor 1 alpha(HIF-1α)was silenced with siRNA.Then,GPRC6A(G protein-coupled receptor family C group 6 subtype A),total Akt,phosphorylated Akt,HIF-1α,and glucose transporter 1(GLUT1)levels were measured by Western blot to elucidate the possible pathways by which dcOC modulates glucose uptake.RESULTS The glucose uptake of MG63 cells was significantly increased compared with that of the paired control cells after short-term(1 h)treatment with dcOC at different concentrations(0.3,3,and 10 ng/mL groups,P<0.01;30 ng/mL group,P<0.05).Glucose uptake of MG63 cells was significantly increased compared with that of the paired control cells after long-term(72 h)treatment with dcOC at different concentrations(0.3,3,and 10 ng/mL groups,P<0.01;30 ng/mL group,P<0.05).DcOC triggered Akt phosphorylation in a dose-dependent manner,and the most effective stimulatory concentration of dcOC for short-term(1 h)was 3 ng/mL(P<0.01).LY294002 abolished the dcOC-mediated(1 h)promotion of Akt phosphorylation and glucose uptake without affecting GLUT1 protein expression.Long-term dcOC stimulation triggered Akt phosphorylation and increased the protein levels of HIF-1α,GLUT1,and Runx2 in a dose-dependent manner.Inhibition of HIF-1αwith siRNA abolished the dcOC-mediated glucose uptake and substantially decreased GLUT1 protein expression.DcOC interven-tion promoted cell proliferation in a time-and dose-dependent manner as determined by the CCK-8 assay.Treatment with both 3 ng/mL and 10 ng/mL dcOC affected the ALP activity in MG63 cells after 72 h(P<0.01).CONCLUSION Short-and long-term dcOC treatment can increase glucose uptake and affect proliferation and ALP activity in MG63 cells.This effect may occur through the PI3K/Akt,HIF-1α,and GLUT1 signaling factors. | Shi Jin Xiao-Cen Chang Jing Wen Jing Yang Na Ao Ke-Ying Zhang Lin-Na Suo Jian Du | 2021 | World Journal of Diabetes2021，12，7： | 1 |
| 20 | Development of an intelligent feeding controller for indoor intensive culturing of eel显示文摘 | CHANG C M FANG W AO R C | 2005 | Aquaeultural Engineering2005，32，： | 1 |
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