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| 1 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 2 | Flight dynamics characteristics of canard rotor/wing aircraft in helicopter flight mode显示文摘The aerodynamic layout of the Canard Rotor/Wing(CRW) aircraft in helicopter flight mode differs significantly from that of conventional helicopters. In order to study the flight dynamics characteristics of CRW aircraft in helicopter mode, first, the aerodynamic model of the main rotor system is established based on the blade element theory and wind tunnel test results. The aerodynamic forces and moments of the canard wing, horizontal tail, vertical tail and fuselage are obtained via theoretical analysis and empirical formula. The flight dynamics model of the CRW aircraft in helicopter mode is developed and validated by flight test data. Next, a method of model trimming using an optimization algorithm is proposed. The flight dynamics characteristics of the CRW are investigated by the method of linearized small perturbations via Simulink. The trim results are consistent with the conventional helicopter characteristics, and the results show that with increasing forward flight speed, the canard wing and horizontal tail can provide considerable lift,which reflects the unique characteristics of the CRW aircraft. Finally, mode analysis is implemented for the linearized CRW in helicopter mode. The results demonstrate that the stability of majority modes increases with increasing flight speed. However, one mode that diverges monotonously,and the reason is that the CRW helicopter mode has a large vertical tail compared to the conventional helicopter. The results of the dynamic analysis provide optimization guidance and reference for the overall design of the CRW aircraft in helicopter mode, and the model developed can be used for control system design. | Honggang GAO Ao HE Zhenghong GAO Yang NA Yangping DENG | 2019 | Chinese Journal of Aeronautics2019，32，7： | 3 |
| 3 | Recent advances in dopaminergic strategies for the treatment of Parkinson’s disease显示文摘Parkinson’s disease(PD)is the second most common progressive neurodegenerative disease worldwide.However,there is no available therapy reversing the neurodegenerative process of PD.Based on the loss of dopamine or dopaminergic dysfunction in PD patients,most of the current therapies focus on symptomatic relief to improve patient quality of life.As dopamine replacement treatment remains the most effective symptomatic pharmacotherapy for PD,herein we provide an overview of the current pharmacotherapies,summarize the clinical development status of novel dopaminergic agents,and highlight the challenge and opportunity of emerging preclinical dopaminergic approaches aimed at managing the features and progression of PD. | Qi Mao Wang-zhi Qin Ao Zhang Na Ye | 2020 | Acta Pharmacologica Sinica2020，41，4： | 2 |
| 4 | Serum lipo-protein(a) concentration as a cardiovascular risk factor in Ku-waiti type 2 diabetic patients 显示文摘 | Abdella NA Mojiminiyi OA Akanji AO | 2001 | J Diabetes Complications2001，15，5： | 1 |
| 5 | Ankle fractures involing the Gbula proximal to the distal tibiofibular syndesmosis 显示文摘 | Ebraheim NA Mekhail AO Gargasz SS | 1997 | Foot Anklelnt1997，18，： | 1 |
| 6 | Associations of plasma homocysteine concentration in subjects with type 2 diabetes mellitus显示文摘 | Abdella NA Mojiminiyi OA Akanji AO | 2002 | Acta Diabetol2002，39，： | 1 |
| 7 | Multi-walled carbon nanotube interactions with human epidermal keratinocytes显示文摘 | Monteiro-Riviere NA Nemanich R J Inman AO | 2005 | Toxicol Lett2005，155，： | 1 |
| 8 | Parallel accelaration of evolutionary rates in synbiont genes underlying host-nutrition显示文摘 | Wernegreen J J Richardson AO Moran NA | 2001 | Mol Phylogen Evol2001，19，： | 1 |
| 9 | Ultrastructural characterization of sulfur mustard-induced vesication in isolated perfused porcine skin显示文摘 | Monteiro-Riviere NA Inman AO | 1997 | Microsc Res Tech1997，37，3： | 1 |
| 10 | Distribution of health care expenditures for HIV-infeeted patients 显示文摘 | Chen RY Aecortt NA Westfall AO | 2006 | Clin Infect Dis2006，42，7： | 1 |
| 11 | Albumin-basednanoparticles as potential controlled release drug delivery systems显示文摘 | ELZOGHBY AO SAMY WM ELGINDY NA | 2012 | J Control Release2012，157，2： | 1 |
| 12 | Associations of plasma homocysteine concentration in subjects with type 2 diabetes meUitus 显示文摘 | Abdella NA Mojiminiyi OA Akanhi AO | 2001 | Acta Diabetol2001，39，4： | 1 |
| 13 | Ankle fractures involving the fibula proximal to the distal tibiofibular syndesmosis显示文摘 | Ebraheim NA Mekhail AO Gargasz SS | 1997 | FootAnkle Int1997，20，： | 1 |
| 14 | Ankle fractures involving the fibular proximal to the distal tibiofibular syndesmosis 显示文摘 | Ebraheim NA Mekhail AO Gargasz SS | 1997 | Foot Ankle Int1997，18，8： | 1 |
| 15 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 16 | Open reduction and internal fixation with bone grafting of clavicular nonunion 显示文摘 | Ebraheim NA Mekhail AO Ortbo MS et aI | 1997 | J Trauma1997，42，4： | 1 |
| 17 | Global burden of invasive nontyphoidal Salmonella disease,2010显示文摘 | Ao TT Feasey NA Gordon MA | 2015 | Emerg Infect Dis2015，21，6： | 1 |
| 18 | ,Multiwalled Carbon Nanotube Interaetions with Human EPidermal Keratinoeytes显示文摘 | Monteiro-Riviere NA Nemaniehb RJ Inman AO etal | 2005 | Toxicology Letters2005，155，3： | 1 |
| 19 | Albumin-based nanoparti- cles as potertial controlled release drug delivery systems 显示文摘 | Elzoghby AO Samy WM Elgindy NA | 2012 | J Control Release2012，157，2： | 1 |
| 20 | Incidence and clinical impact of coronary stent fracture 'after sirolimus-eluting stent implantation 显示文摘 | Ao KI J Na KaZaWa G Tanabe K | 2007 | Catheter Cardiovasc Interv2007，69，6： | 1 |
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