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| 1 | 香港华人妇女产后抑郁危险因素的前瞻性研究显示文摘目的:产后抑郁是一种常见的精神障碍,对产妇、新生儿和其它家庭成员导致广泛的伤害。产后抑郁的病因学研究大多是基于西方样本,对其中的社会文化原因也缺乏实证研究。本研究从人口学、心理社会及种族文化因素等方面探讨中国妇女产后抑郁症状学的决定因素。方法:在大学附属综合医院产前门诊连续收集登记的中国孕妇959例,从她们第一次产前检查开始评估(基线),以后分别在孕期的最后3个月、产后即刻和产后3个月时评估。调查涉及的危险因素分6个方面:人口学和社会经济背景,躯体疾病及精神疾病病史, 产前抑郁情绪,围生期应激源,人际关系,和种族文化环境。采用等级回归进行分析。因变量是产后3个月时的抑郁评分。结果:决定产后抑郁症状学的因素有:目前的生活事件,缺乏社会支持,婚姻不满意,既往有故意自伤史,以及产前存在抑郁情绪。婆媳关系不好和没有陪月在产后阶段也与抑郁评分高有关联。结论:西方研究所确立的产后抑郁危险因素大体适用于中国妇女。产褥期的社会文化特点同样对产妇情绪有影响。 | Dominic TS Lee Alexander SK Yip Sandra SM Chan Fiona FY Lee Tony YS Leung Tony KH Chung | 2005 | 中国心理卫生杂志2005，19，9： | 50 |
| 2 | Pancreatic enzyme replacement therapy for pancreatic exocrine insufficiency in the 21^(st) century显示文摘Restitution of normal fat absorption in exocrine pancreatic insufficiency remains an elusive goal. Although many patients achieve satisfactory clinical results with enzyme therapy, few experience normalization of fat absorption, and many, if not most, will require individualized therapy. Increasing the quantity of lipase administered rarely eliminates steatorrhea but increases the cost of therapy. Enteric coated enzyme microbead formulations tend to separate from nutrients in the stomach precluding coordinated emptying of enzymes and nutrients. Unprotected enzymes mix well and empty with nutrients but are inactivated at pH 4 or below. We describe approaches for improving the results of enzyme therapy including changing to, or adding, a different product, adding non-enteric coated enzymes,(e.g., giving unprotected enzymes at the start of the mealand acid-protected formulations later), use of antisecretory drugs and/or antacids, and changing the timing of enzyme administration. Because considerable lipid is emptied in the first postprandial hour, it is prudent to start therapy with enteric coated microbead prior to the meal so that some enzymes are available during that first hour. Patients with hyperacidity may benefit from adjuvant antisecretory therapy to reduce the duodenal acid load and possibly also sodium bicarbonate to prevent duodenal acidity. Comparative studies of clinical effectiveness of different formulations as well as the characteristics of dispersion, emptying, and dissolution of enteric-coated microspheres of different diameter and density are needed; many such studies have been completed but not yet made public. We discuss the history of pancreatic enzyme therapy and describe current use of modern preparations, approaches to overcoming unsatisfactory clinical responses, as well as studies needed to be able to provide reliably effective therapy. | Tony Trang Johanna Chan David Y Graham | 2014 | World Journal of Gastroenterology2014，20，33： | 17 |
| 3 | Spectrum of NSD1 gene mutations in southern Chinese patients with Sotos syndrome显示文摘Background Sotos syndrome is an overgrowth syndrome with characteristic facial gestalt and mental retardation of variable severity. Haploinsufficiency of the NSD1 gene has been implicated as the major cause of Sotos syndrome, with a predominance of microdeletions reported in Japanese patients. This study was conducted to investigate into the spectrum of NSD1 gene mutations in southern Chinese patients with Sotos syndrome. Methods Thirty-six Chinese patients with Sotos syndrome and two patients with Weaver syndrome were subject to molecular testing. Results NSD1 gene mutations were detected in 26 (72%) Sotos patients. Microdeletion was found in only 3 patients, while the other 23 had point mutations (6 frameshift, 8 nonsense, 2 spice site, and 7 missense). Of these, 19 mutations were never reported. NSD1 gene mutations were not found in the two patients with Weaver syndrome. Conclusions Most cases of Sotos syndrome are caused by NSD1 gene defects, but the spectrum of mutations is different from that of Japanese patients. Genotype-phenotype correlation showed that patients with microdeletions might be more prone to congenital heart disease but less likely to have somatic overgrowth. The two patients with Weaver syndrome were not found to have NSD1 gene mutations, but the number was too small for any conclusion to be drawn. | Tony M.F. Tong Edgar W.L. Hau Ivan F.M. Lo Daniel H.C. Chan Stephen T.S. Lam | 2005 | Chinese Medical Journal2005，，18： | 10 |
| 4 | 我国基层医学实验室标准化建设建议显示文摘基层医学实验室正面临着如何发展的问题。本文根据我国基层医学实验室发展的现况分析了存在的问题和制约基层检验能力发展的因素,结合国外标准化医学实验室认证体系的发展,剖析了基层医学实验室按照国外标准化模式发展面临的瓶颈,提出了我国基层医学实验室标准化建设的发展方向。 | 刘湘莲 夏英华 何志辉 吴桦轩 Tony chan 李富华 张容瑜 谢文福 何群 | 2017 | 华南预防医学2017，43，6： | 6 |
| 5 | Nontexture Inpainting by Curvature-Driven Diffusions显示文摘 | Tony F. Chan Jianhong Shen | 2001 | Journal of Visual Communication and Image Representation2001，，4： | 4 |
| 6 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 7 | Management of Hepatocellular Carcinoma: Beyond Sorafenib显示文摘 | Stephen Chan Tony Mok Brigette Ma | 2012 | Current Oncology Reports2012，，3： | 2 |
| 8 | A study of circulating interleukin 10 in prognostication of unresectable hepatocellular carcinoma显示文摘 | Stephen L. Chan Frankie K. F. Mo Cesar S. C. Wong Charles M. L. Chan Linda K. S. Leung Edwin P. Hui Brigette B. Ma Anthony T. C. Chan Tony S. K. Mok Winnie Yeo | 2011 | Cancer2011，，16： | 2 |
| 9 | Epigenetic and genetic alternation of PTEN in cervical neoplasm显示文摘 | Tak-Hong Cheung Keith Wing-Kit Lo So-Fan Yim Loucia Kit-Ying Chan Mei-Sze Heung Chun-Sing Chan Albert Yu-Kiu Cheung Tony Kwok-Hung Chung Yick-Fu Wong | 2004 | Gynecologic Oncology2004，，3： | 2 |
| 10 | Mathematical models for local non-texture inpainting显示文摘 | Chan Tony Shen Jianhong | 2001 | SIAM J Appl Math2001，62，3： | 1 |
| 11 | Community nursing services for postdischarge chronically ill patients显示文摘 | Susan KY Chow Frances KY Wong Tony MF Chan Loretta YF Chung Katherine KP Chang Rance PL Lee | 2008 | Journal of Clinical Nursing2008，，7： | 1 |
| 12 | Level set based shape prior segmentation 显示文摘 | Chan Tony Zhu Wei | 2005 | IEEE Computer Society Conference on Computer Vision and Pattern Recognition(S1063-6919)2005，2，： | 1 |
| 13 | Active contours with out edges 显示文摘 | Chan Tony F Vese Luminita A | 2001 | IEEE Transactions on Image Processing2001，10，2： | 1 |
| 14 | Dynamic cluster formation using level set methods显示文摘 | Yip Andy M Ding Chris Chan Tony F | 2006 | IEEE Trans on Pattern Analysis and Machine Intelligence2006，28，6： | 1 |
| 15 | Active Contours Without Edges显示文摘 | TONY F CHAN LUMINITA A VESE | 2001 | IEEE Transactions on Image Processing Vol 10 No 22001，2001，： | 1 |
| 16 | Total variation blind deconvolution显示文摘 | Tony F Chan Chiu-Kwong Wong | 1998 | IEEE Trans on Image Procession1998，7，3： | 1 |
| 17 | A Multiphase Level Set Framework for Image Segmentation Using the Mumford and Shah Model显示文摘 | Luminita A. Vese Tony F. Chan | 2002 | International Journal of Computer Vision2002，，3： | 1 |
| 18 | Early Cholecystectomy Safely Decreases Hospital Stay in Patients With Mild Gallstone Pancreatitis: A Randomized Prospective Study显示文摘 | Armen Aboulian Tony Chan Arezou Yaghoubian Amy H. Kaji Brant Putnam Angela Neville Bruce E. Stabile Christian de Virgilio | 2010 | Annals of Surgery2010，，4： | 1 |
| 19 | A Multiphase Level Set Framework for Image Segmentation Using the Mumford and Shah Model显示文摘 | Luminita A. Vese Tony F. Chan | | 0，2002，： | 1 |
| 20 | Total Variation Wavelet Thresholding显示文摘 | Tony F. Chan Hao-Min Zhou | 2007 | Journal of Scientific Computing2007，，2： | 1 |
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