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| 1 | 替诺福韦可降低慢性HBV感染者发生肝细胞癌的风险显示文摘【据《Gastroenterology》2020 年1 月报道】题:在中国,替诺福韦与恩替卡韦相比,可降低慢性HBV 感染者发生肝细胞癌的风险(作者Yip TC 等)在慢性HBV 感染者中,用替诺福韦治疗与恩替卡韦治疗罹患肝细胞癌(HCC)风险的研究结果相互矛盾。 | 冯丽娜 金清龙 YIP TC WONG VW CHAN HL | 2020 | 临床肝胆病杂志2020，36，2： | 17 |
| 2 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 3 | Scrub typhus vaccine candidate Kp r56 induces humoral and cellular immune responses in cynomolgus monkeys显示文摘 | Chattopadhyay S Jiang J Chan TC | 2005 | Infect Immun2005，73，8： | 1 |
| 4 | Reexamination of custody restraint position snd positional asphyxia显示文摘 | Chan TC Vilke GM Neuman T | 1998 | The American Journal of Medicine and Pathology1998，19，3： | 1 |
| 5 | PPAR delta is an APC-regulated target of nonsteroidal anti-inflammatory drugs显示文摘 | He TC Chan TA Vogelstein B | 1999 | Cell1999，99，3： | 1 |
| 6 | Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes显示文摘 | Poon TC Yip TT Chan AT | 2003 | Clin Chem2003，49，： | 1 |
| 7 | Laparo-scopic pyeloplasty:the first 100 cases显示文摘 | Jarrett TW Chan DY Charambura TC | | 0，，03： | 1 |
| 8 | High-throughput quantitative profiling of serum N-glycome by MALDI-TOF mass spectrometry and N-glycomic fingerprint of liver fibrosis显示文摘 | KAM RK POON TC CHAN HL | 2007 | Clin Chem2007，53，7： | 1 |
| 9 | Electrocardiographic manifestations: pulmonary embolism 显示文摘 | Chan TC Vilke GM Brady WJ | 2001 | J Emerg Med2001，21，： | 1 |
| 10 | Paclitaxel enhances in vitra radiation sensitivity of squamous carcinoma cell lines of the head neck 显示文摘 | Chan DC Chou TC | 1996 | Cancer Res1996，56，22： | 1 |
| 11 | Restraint posi-tion and positional asphyxia显示文摘 | Chan TC Vilke GM Neuman T | 1997 | Ann Emerg Med1997，30，5： | 1 |
| 12 | Seasonal influenza activity in Hong Kong and its association with meteorological variations 显示文摘 | Chan PK Mok HY Lee TC | 2009 | J Med Virol2009，81，10： | 1 |
| 13 | The reduction of tuberculosis risks by smoking cessation显示文摘 | Wen CP Cban TC Chan HT | | 0，，： | 1 |
| 14 | Development of a quantitative real time polymerase chain reaction assay specific for Orientia tsutsugamushi 显示文摘 | Jiang J O Chan TC Temenak J | 2004 | Am J TropMed Hyg2004，70，： | 1 |
| 15 | Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes显示文摘 | Poon TC Yip TT Chan AT | 2003 | Clin Chem2003，49，5： | 1 |
| 16 | Laparoscopic pyeloplasty: the first 100 cases显示文摘 | Jarrett TW Chan DY Charambura TC | 2002 | J Urol2002，167，3： | 1 |
| 17 | The influence of air pollution in cities inflammation,oxidative stress,solidification,the young and autonomic dysfunction显示文摘 | Chuang KJ Chan CC Su TC | 2007 | Am J Respir Crit Care Med2007，176，4： | 1 |
| 18 | Reexamination of custody restraint position and positional asphyxia显示文摘 | Chan TC Vilke GM Neuman T | 1998 | Am J Forensic Med Pathol1998，19，3： | 1 |
| 19 | Comprehensive proteomic profiling identifies serum proteomic signatures for detection of hepatocellular carcinoma and its subtypes 显示文摘 | Poon TC Yip TY Chan AT | 2003 | Clin Chem2003，49，5： | 1 |
| 20 | The effect of urban air pollution on inflammation, oxidative stress, coagulation, and autonomic dysfunction in young adults显示文摘 | Chuang KJ Chan CC Su TC | 2007 | Am J Respir Crit Care Med2007，176，： | 1 |
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