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| 1 | Lean techniques for the improvement of patients' flow in emergency department显示文摘BACKGROUND: Emergency departments(EDs) face problems with overcrowding, access block, cost containment, and increasing demand from patients. In order to resolve these problems, there is rising interest to an approach called 'lean' management. This study aims to(1) evaluate the current patient flow in ED,(2) to identify and eliminate the non-valued added process, and(3) to modify the existing process.METHODS: It was a quantitative, pre- and post-lean design study with a series of lean management work implemented to improve the admission and blood result waiting time. These included structured re-design process, priority admission triage(PAT) program, enhanced communication with medical department, and use of new high sensitivity troponin-T(hsTnT) blood test. Triage waiting time, consultation waiting time, blood result time, admission waiting time, total processing time and ED length of stay were compared.RESULTS: Among all the processes carried out in ED, the most time consuming processes were to wait for an admission bed(38.24 minutes; SD 66.35) and blood testing result(mean 52.73 minutes, SD 24.03). The triage waiting time and end waiting time for consultation were significantly decreased. The admission waiting time of emergency medical ward(EMW) was significantly decreased from 54.76 minutes to 24.45 minutes after implementation of PAT program(P<0.05).CONCLUSION: The application of lean management can improve the patient flow in ED. Acquiescence to the principle of lean is crucial to enhance high quality emergency care and patient satisfaction. | HY Chan SM Lo LLY Lee WYL Lo WC Yu YF Wu ST Ho RSD Yeung JTS Chan | 2014 | World Journal of Emergency Medicine2014，5，1： | 6 |
| 2 | Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-Analysis显示文摘 | Ulrike Peters Shuo Jiao Fredrick R. Schumacher Carolyn M. Hutter Aaron K. Aragaki John A. Baron Sonja I. Berndt Stéphane Bézieau Hermann Brenner Katja Butterbach Bette J. Caan Peter T. Campbell Christopher S. Carlson Graham Casey Andrew T. Chan Jenny Chan | 2012 | Gastroenterology2012，，： | 4 |
| 3 | Cilostazol for secondary stroke prevention:systematic review and meta-analysis显示文摘Background Stroke is one of the leading causes of death worldwide.Cilostazol,an antiplatelet and phosphodiesterase 3 inhibitor,has not been clearly established for ischaemic stroke use.We aim to determine the efficacy and safety of cilostazol for secondary stroke prevention.Methods MEDLINE,EMBASE,Cochrane Library,Web of Science and ClinicalTrials.gov were searched from inception to 25 September 2020,for randomised trials comparing the efficacy and safety of cilostazol monotherapy or dual therapy with another antiplatelet regimen or placebo,in patients with ischaemic stroke.Version 2 of the Cochrane risk-of-bias tool for randomised trials(RoB 2)was used to assess study quality.This meta-analysis was reported in line with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)statement.Results Eighteen randomised trials comprising 11429 participants were included in this meta-analysis.Most trials possessed low risk of bias and were of low heterogeneity.Cilostazol significantly reduced the rate of ischaemic stroke recurrence(risk ratio,RR=0.69,95%CI 0.58 to 0.81),any stroke recurrence(RR=0.64,95%CI 0.54 to 0.74)and major adverse cardiovascular events(RR=0.67,95%CI 0.56 to 0.81).Cilostazol did not significantly decrease mortality(RR=0.90,95%CI 0.64 to 1.25)or increase the rate of good functional outcome(Modified Rankin Scale score of 0–1;RR=1.07,95%CI 0.95 to 1.19).Cilostazol demonstrated favourable safety profile,significantly reducing the risk of intracranial haemorrhage(RR=0.46,95%CI 0.31 to 0.68)and major haemorrhagic events(RR=0.49,95%CI 0.34 to 0.70).Conclusions Cilostazol demonstrated superior efficacy and safety profiles compared with traditional antiplatelet regimens such as aspirin and clopidogrel for secondary stroke prevention but does not appear to affect functional outcomes.Future randomised trials can be conducted outside East Asia,or compare cilostazol with a wider range of antiplatelet agents. | Choon Han Tan Andrew GR Wu Ching-Hui Sia Aloysius ST Leow Bernard PL Chan Vijay Kumar Sharma Leonard LL Yeo Benjamin YQ Tan | 2021 | Stroke & Vascular Neurology2021，6，3： | 2 |
| 4 | Minimum graft volume for successful adult-to-adult living donor liver transplantation for fulminant hepatic failure显示文摘 | Lo CM Fan ST Chan JK | 1996 | Transplantation1996，62，5： | 1 |
| 5 | Transurethral surgery and the adductor spasm显示文摘 | Ong EL Chan ST | 2000 | Ann Acad Med Singapore2000，29，2： | 1 |
| 6 | Nitric oxide induces cyclooxyenase expression and inhibits cell growth in colon cancer cell lines 显示文摘 | Lin Q Chan ST Mahendran LIR | 2003 | Carcinogenesis2003，24，4： | 1 |
| 7 | Conjugated poly- hydroxybenzene derivatives block tumor necrosis factor-al- pha-mediated nuclear factor-kappaB activation and cy- clooxygenase-2 gene transcription by targeting IkappaB ki- nase activity 显示文摘 | Chen CC Chiu KT Chan ST | 2001 | Mol Pharmacol2001，60，6： | 1 |
| 8 | Epidemiology of malaria in Attapeu Province, Lao PDR in relation to entomological parameters显示文摘 | Vythilingan I Sidavong B Chan ST | 2005 | Trans R Soc Trop Med Hyg2005，99，11： | 1 |
| 9 | Factorial structure of a short version of the Center for Epidemiologic Studies Depression Scale显示文摘 | Cheng ST Chan A Fung HH | 2006 | Int J Geriatr Psychiatry2006，21，4： | 1 |
| 10 | The Center for Epidemiologic Studies Depression Scale in older Chinese:thresholds for long and short forms显示文摘 | Cheng ST Chan A | 2005 | hat J Geriatr Psychiatry2005，20，5： | 1 |
| 11 | Lamivudine treatment for fulminant hepatic failure due to acute exacerbation of chronic hepatitis B infection显示文摘 | Tsang SW Chan HL Leung NW Chau TN Lai ST Chan FK Sung JJ | 2001 | Aliment Pharmacol Ther2001，15，11： | 1 |
| 12 | A randomized,controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma显示文摘 | Lo CM Liu CL Chan SC Lam CM Poon RT Ng IO Fan ST Wong J | | 0，，06： | 1 |
| 13 | Transurethral surgery and the adduc- tor spasm显示文摘 | Ong EL Chan ST | 2000 | Ann Aead Med Singapore2000，29，2： | 1 |
| 14 | Peripheral T and putative natural killer cell lymphomas commonly coexpress CD95 and CD95 ligand显示文摘 | NGC S LO ST CHAN JK | 1999 | Hum Pathol1999，30，1： | 1 |
| 15 | Phage cocktails and the future of phage therapy 显示文摘 | Chan BK Abedon ST Loc-Carrilo C | 2013 | Future Microbiol2013，8，6： | 1 |
| 16 | A brief version of the Geriatric Depression Scale for the Chinese显示文摘 | Cheng ST Chan A | 2004 | Psychol Assess2004，16，2： | 1 |
| 17 | Phage cocktails and the future of phage therapy显示文摘 | Chan BK Abedon ST Carrillo CL | 2013 | Future Microbial2013，8，： | 1 |
| 18 | Liver transplantation in infants 显示文摘 | Saing H Fan ST Chan KL | 1999 | J Pediatr Surg1999，34，11： | 1 |
| 19 | Transurethral surgery and the adductor spasm显示文摘 | Chan ST | 2000 | Ann Acad Med Singapore2000，29，： | 1 |
| 20 | Nitricoxide indece cyclooxygenase expression and inhibits cell growth in colon cancer cell lines 显示文摘 | Lin Q Chan ST Mahendran LIR | 2003 | Carcinogenesis2003，24，4： | 1 |
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