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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | The prognostic impact of the time interval to recurrence for the mortality in recurrent colorectal cancer显示文摘 | Kaiser AM Kang JC Chan LS | 2006 | Colorectal Dis2006，8，8： | 1 |
| 3 | Cardiac arrest resuscitation evaluation in LosAngeles: CARELA显示文摘 | Eckstein M Stratton SJ Chan LS | 2005 | Ann Emerg Med2005，45，5： | 1 |
| 4 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 5 | Functional electrical stimula- tion improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke:a random- ized placebo-controlled trial显示文摘 | Yan T Hui Chan CWY Li Ls | 2005 | Stroke2005，36，1： | 1 |
| 6 | Influence of flail chest on outcome among patients with severe thoracic cage trauma显示文摘 | Velmahos GC Vassiliu P Chan LS | | 0，，04： | 1 |
| 7 | Molecular cloning of a cDNA encoding the porcine type XVII collagen noncollagenous 16 A domain and localization of the domain to the upper part of porcine skin basementmembrane zone显示文摘 | Xu L Olivry T Chan LS | | 0，，03： | 1 |
| 8 | Effectiveness and side effects of anti-CD20 therapy for autoantibody-mediated blistering skin diseases: A com- prehensive survey of 71 consecutive patients from the Initial use to 2007显示文摘 | Peterson JD Chan LS | 2009 | Ther Clin Risk Manag2009，5，1： | 1 |
| 9 | Direct toxicity effects of sulfo-conjugated trogUtazone on human hepatocytes 显示文摘 | Saha S New LS Ho HK Chui WK Chan EC | 2010 | Toxicol Lett2010，195，23： | 1 |
| 10 | Role of microRNA-214 in ginsenoside-Rg1-induced angiogenesis显示文摘 | Chan LS Yue PY Mak NK | 2009 | Eur J Pharm Sci2009，38，4： | 1 |
| 11 | Pervention of venous thromboembolism after injury: an evidence based report: part Ⅱ : analysis of risk factors and evaluation of the role of vena caval filters显示文摘 | Velmahos GC Kern J Chan LS | 2000 | J Trauma2000，49，1： | 1 |
| 12 | Va- fiance analysis applied to a stroke pathway:how this can improve efficiency of healthcare delivery 显示文摘 | Widjaja LS Chan BP Chen H | 2002 | Ann Acad Med Singapore2002，31，4： | 1 |
| 13 | Inflammatory cytokine gene expression in the urinary sediment of patients with lupus nephritis显示文摘 | CHAN RW TAM LS LI EK | 2003 | Arthritis Rheum2003，48，5： | 1 |
| 14 | A comprehensive management guide for atopic dermatitis显示文摘 | Peterson JD Chan LS | 2006 | Dermatol Nurs2006，18，6： | 1 |
| 15 | Diagnosis,natural history,and late effects of otitis media with effusion显示文摘 | Shekelle P Takata G Chan LS | 2002 | Evid Rep Technol Assess (Summ)2002，，55： | 1 |
| 16 | Neurotoxicity following the ingestion of a Chinese medicinal plant,Alocasia macrorrhiza显示文摘 | Chan TY Chan LY Tam LS | | 0，，09： | 1 |
| 17 | Prevention ofvenous thromboem-bolism after injury : an evidence - based report ( part II) : analysis of risk factors and evaluation of the role of venacaval filters显示文摘 | Velmahos GC Kern J Chan LS | 2000 | J Trau- ma2000，1，： | 1 |
| 18 | Soluble fibrinogen-like protein2/fibroleukin exhibits immunosuppressive properties:suppressing T cell proliferation and inhibiting maturation of bone marrow-derived dendritic cells显示文摘 | Chan CW Kay LS Khadaroo RG | 2003 | J Immuno12003，170，8： | 1 |
| 19 | Inflammatory cytokine gene expression in the urinary sediment of patients with lupus nephritis显示文摘 | Chan RW Tam LS Li EK | 2003 | Arthritis Rheum2003，48，5： | 1 |
| 20 | A multicenter phase II trial of single-agent cetuximab in advanced esophageal and gastric adenocarcinoma显示文摘 | Chan JA Blaszkowsky LS Enzinger PC | | 0，，06： | 1 |
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