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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Non-invasive versus invasive mechanical ventilation for respiratory failure in severe acute respiratory syndrome显示文摘Background Severe acute respiratory syndrome is frequently complicated by respiratory failure requiringventilatory support.We aimed to compare the efficacy of non-invasive ventilation against invasive mechanicalventilation treating respiratory failure in this disease.Methods Retrospective analysis was conducted on all respiratory failure patients identified from the HongKong Hospital Authority Severe Acute Respiratory Syndrome Database.Intubation rate, mortality and secondaryoutcome of a hospital utilizing non-invasive ventilation under standard infection control conditions ( NIVHospital) were compared against13 hospitals using solely invasive ventilation (IMVHospitals).Multiple logisticregression analyses with adjustments for confounding variables were performed to test for association betweenoutcomes and hospital groups.Results Both hospital groups had comparable demographics and clinical profiles, but NIV Hospital (42patients) had higher lactate dehydrogenase ratio and worse radiographic score on admission and ribavirin-corticosteroid commencement.Compared to IMV Hospitals (451 patients), NIV Hospital had lower adjustedodds ratios for intubation (0.36, 95% CI 0.164 -0.791,P=0.011) and death (0.235, 95% CI 0.077 -0.716,P=0.011), and improved earlier after pulsed steroid rescue.There were no instances of transmission ofsevere acute respiratory syndrome among health care workers due to the use of non-invasive ventilation.Conclusion Compared to invasive mechanical ventilation, non-invasive ventilation as initial ventilatory supportfor acute respiratory failure in the presence of severe acute respiratory syndrome appeared to be associated withreduced intubation need and mortality. | Loretta YC Yam Alfred YF Chan Thomas MT Cheung Eva LH Tsui Jane CK Chan Vivian CW Wong | 2005 | Chinese Medical Journal2005，，17： | 3 |
| 3 | Nanotoxicity: the growing need for in vivo study显示文摘 | Hans C Fischer Warren CW Chan | 2007 | Current Opinion in Biotechnology2007，，6： | 2 |
| 4 | A study to assess the existence of the symptom cluster of breathlessness,fatigue and anxiety in patients with advanced lung cancer显示文摘 | Chan CW Richardson A Richardson J | 2005 | Eur J Oncol Nurs2005，9，4： | 1 |
| 5 | A novel missense mu- tation (P191L) in the glucose-6-phosphate translocase gene identified in a Chinese family with glycogen storage disease 1b显示文摘 | Lam CW Chan KY Tong SF | 2000 | Hum Mutat2000，16，： | 1 |
| 6 | Autologous fat transfer-a review of the literature with a focus on breast cancer surgery显示文摘 | Chan CW McCulley SJ Macmillan RD | 2008 | J Plast Reconstr Aesth Surg2008，61，12： | 1 |
| 7 | Alpha-2 agonists in acute pain management显示文摘 | Chan AK Cheung CW Chong YK | 2010 | Expert Opin Pharmacother2010，11，17： | 1 |
| 8 | Solution structure of the dimerization domain of ribosomal protein P2 provides insights for the structural organization of eukaryotic stalk显示文摘 | Lee KM Yu CW Chan DS | 2010 | Nucleic Acids Res2010，38，15： | 1 |
| 9 | Evaluating a complex intervention: a process evaluation of a psycho-education program for lung cancer patients receiving palliative radiotherapy 显示文摘 | Chan CW Richardson A Richardson J | 2012 | Contemp Nurse2012，40，2： | 1 |
| 10 | Alpha-2 agonists in acute pain management显示文摘 | Chan AK Cheung CW Chong YK | 2010 | Expert Opin Pharmacother2010，11，17： | 1 |
| 11 | Effects of a single session of whole body vibrationon ankle plantarflexion spasticity and gait performance inpatients with chronic stroke: a randomized controlled trial显示文摘 | Chan KS Liu CW Chen TW | 2012 | Clinical Rehabil- itation2012，26，13： | 1 |
| 12 | The Arabidopsis CDPK-SnRK superfamily of protein kinases显示文摘 | Hrabak EM Chan CW Gribskov M | 2003 | Plant Physiol2003，132，： | 1 |
| 13 | Ursodeoxycholic acid and histological progression in primary biliary cirrhosis显示文摘 | Chan CW Papatheodoridis GV Goulis J | 2003 | J Hepatol2003，39，6： | 1 |
| 14 | A study to assess the ex- istence of the symptom cluster of breathlessness,fatigue and anx- iety in patients with advanced lung cancer显示文摘 | Chan CW Richardson A Riehardson J | 2005 | Eur J Onclo Nurs2005，9，4： | 1 |
| 15 | Diagnostic clues tomegalobastic anae- mia without macrocytosis 显示文摘 | Chan CW Eiu SY Kho CS | 2007 | Int J Lab-Hematol2007，29，3： | 1 |
| 16 | Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘 | Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y | | 0，，： | 1 |
| 17 | Nail infestation by Liposcelis bostrychophila Badonnel 显示文摘 | Lin YC Chan ML Ko CW | 2004 | Clin Exp Dermatol2004，29，6： | 1 |
| 18 | Isolated left ventricular noncompaction:an unusual indication for heart transplantion显示文摘 | Fan KY Chan CW Cheng LC | 2009 | Hong Kong Med J2009，15，5： | 1 |
| 19 | Two-port laparoscopic chole-cystectomy :initial results of a modified technique显示文摘 | Poon CM Chan KW Ko CW | 2002 | J Laparoen-dosc Adv Surg Tech A2002，12，4： | 1 |
| 20 | Effects of aging and tai ehi on a finger - pointing task with a choice paradigm显示文摘 | Tsang WW Kwok JC Hui -Chan CW | 2013 | Evid Based Complement Alternat Med2013，，： | 1 |
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