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	题名	作者	年代	出处	被引量
1	TSC1-mTOR-PLK轴以阶段特异性方式调节从施旺细胞增殖到髓鞘形成的内稳态开关显示文摘恰如其分的外周髓鞘形成取决于雪旺细胞增殖与分化进程间的平衡。丝氨酸/苏氨酸激酶(mTOR)整合多种环境因素,是细胞生长、代谢、发挥作用的中枢调节者。本文报道了一种mTOR的负性调节剂——结节性硬化复合体(TSC1),通过控制细胞增殖和髓鞘稳态,建立了雪旺细胞谱系进展和髓鞘形成的阶段依赖性程序。小鼠雪旺细胞祖细胞中TSC1的解离导致mTOR信号通路激活,继而导致雪旺细胞过量增殖,分化受阻,髓鞘形成减少。转录组分析显示,TSC1突变体中的mTOR活化使得polo样激酶(PLK)依赖性通路和细胞周期调节剂上调。弱化mTOR或者对PLK进行药理抑制部分挽救了因TSC1缺失导致的外周神经发育过程中的髓鞘形成减少。相较之下,成年小鼠成熟雪旺细胞中TSC1缺失可导致髓鞘的过度增殖和过度生长。本文的发现提示了TSC1-mTOR-PLK信号轴在控制雪旺细胞的发育过程中,从增殖到分化和髓鞘内稳态中起到的阶段特异性功能。	Jiang M Rao R Wang J Wang J1 Xu L Wu LM Chan JR Wang H Lu QR 聂昊(编译)	2018	神经损伤与功能重建2018，13，5：	2
2	Computer-aided detec- tion of clustered microcalcifications in digital breast tomosynthe- sis:a 3D approach显示文摘	Sahiner B Chan HP Hadjiiski LM	2012	Med Phys2012，39，1：	1
3	Therapeutically relevant concentrations of raloxifene dilate pressurized rat resistance arteries via calcium-dependent endothelial nitric oxide synthase activation显示文摘	Chan YC Leung FP Wong WT Tian XY Yung LM Lau CW Tsang SY Yao X Chen ZY Huang Y		0，，：	1
4	Effect of CAD on radiologists'detection of lung nodules on thoracic CT scans: a- nalysis of an observer performance study by nodule size 显示文摘	Sahiner B Chan HP Hadjiiski LM	2009	Acad Radiol2009，16，2：	1
5	The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability 显示文摘	Chan LM Lowes S Hirst BH	2004	European Journal of Pharmaceutical Sciences2004，21，1：	1
6	Novel association of smaller anterior chamber width with angle closure in Singaporeans显示文摘	NONGPIUR ME SAKATA LM FRIEDMAN DS HE M CHAN YH LAVANYA R	2010	Oph- thalmology2010，117，10：	1
7	Validation of Anechocardiographicassessment of cardiac function following moderate size myocardial infarction in the rat 显示文摘	Burrell LM Chan R Phillips PA	2006	Clin Exp Pharmacol Physiol2006，23，：	1
8	Association of narrow angles with ante- rior chamber area and volume measured with anterior seg- ment optical coherence tomography显示文摘	WU RY NONGPIUR ME HE MG SAKATA LM FRIEDMAN DS CHAN YH	2011	Arch Ophthalmol2011，129，5：	1
9	Role of Rubella virus Glycoprotein domains in assembly of virus-like particles显示文摘	Garbutt M Law LM Chan H	1999	Virol1999，73，5：	1
10	Quantitative iris parameters and association with narrow angles显示文摘	Wang B Sakata LM Friedman DS Chan YH He M Lavanya R	2010	Ophtha/mo/ogy2010，117，1：	1
11	Overexpression of the 78 - kDa glucose - regulated protein/immunoglobulin - binding protein (GRF78/BiP) inhibits tissue factor procoagulant activity显示文摘	Watson LM Chan AK Berry LR	2003	J Biol Chem2003，278，17：	1
12	alpha 1 -Proteinase inhibitor in gingival crevicular fluid of humans with adult periodontitis: serpinolytic inhibition by doxycycline 显示文摘	Lee HM Golub LM Chan D	1997	J Periodontal Res1997，32，11：	1
13	The effectiveness of a self-efficacy-enhancing intervention for Chinese patients with colorectal cancer:A randomized controlled trial with 6-month follow up显示文摘	Zhang MF Chan SW You LM	2014	Int J Nursing Studies2014，51，8：	1
14	A mitochondrial DNA variant at position 16189 is associated with type 2 diabetes mellitus in Asians显示文摘	Park KS Chan JC Chuang LM	2008	Diabetologia2008，51，4：	1
15	The effects of cetaximab alone and in combination with radiation and/or chemotherapy in lung cancer 显示文摘	Raben D Helfrich B Chan DC Ciardlello F Zhao LM Franklin W	2005	Clin Cancer Res2005，11，2：	1
16	Antiallergic and anti-inflammatory properties of the ethanolic extract from Gleditsia sinensis显示文摘	Dai Y Chan YP Chu LM But PPH	2002	Biol Pharm Bull2002，25，：	1
17	Molecular detection of a novel human influenza (H1N1) of pandemic potential by conventional and real-time quantitative RT-PCR assays显示文摘	Poon Leo LM Chan KH Smith GJ Leung CSW Guan Y Yuen KY Peiris JSM	2009	Clin Chem2009，55，8：	1
18	Computer-aided detection of clustered microcalcifications in digital breasttomosynthesis;a 3D approach显示文摘	Sahiner B Chan HP Hadjiiski LM	2012	Med Phys2012，39，1：	1
19	The ABCs of drug transport in intestine and liver: efflux proteins limiting drug absorption and bioavailability 显示文摘	Chan LM Lowes S Hirst BH	2004	Eur J Pharm Sci2004，21，1：	1
20	Effect of CAD on radiologists' detection of lung nodules on thoracic CT scans : a- nalysis of an observer performance study by nodule size 显示文摘	Sahiner B Chan HP Hadjiiski LM	2009	Acad Radiol2009，16，：	1

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