|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Understanding divergent domestication traits from the whole-genome sequencing of swamp-and river-buffalo populations显示文摘Domesticated buffaloes have been integral to rice-paddy agro-ecosystems formillennia,yet relatively little is known about the buffalo genomics.Here,we sequenced and assembled reference genomes for both swamp and river buffaloes and we re-sequenced 230 individuals(132 swamp buffaloes and 98 river buffaloes)sampled from across Asia and Europe.Beyond the many actionable insights that our study revealed about the domestication,basic physiology and breeding of buffalo,we made the striking discovery that the divergent domestication traits between swamp and river buffaloes can be explained with recent selections of genes on social behavior,digestion metabolism,strengths and milk production. | Xier Luo Yu Zhou Bing Zhang Yi Zhang Xiaobo Wang Tong Feng Zhipeng Li Kuiqing Cui Zhiqiang Wang Chan Luo Hui Li Yanfei Deng Fenghua Lu Jianlin Han Yongwang Miao Huaming Mao Xiaoyan Yi Cheng Ai Shigang Wu Alun Li Zhichao Wu Zijun Zhuo Do Da Giang Bikash Mitra Mohammad Farhad Vahidi Shahid Mansoor Sahar Ahmed Al-Bayatti Eka Meutia Sari Neena Amatya Gorkhali Sigit Prastowo Laiba Shafique Guoyou Ye Qian Qian Baoshan Chen Deshun Shi Jue Ruan Qingyou Liu | 2020 | National Science Review2020，7，3： | 3 |
| 2 | Anti-osteoarthritis effect of a combination treatment with human adipose tissue-derived mesenchymal stem cells and thrombospondin 2 in rabbits显示文摘BACKGROUND Osteoarthritis(OA),a chronic age-related disease characterized by the slowly progressive destruction of articular cartilage,is one of the leading causes of disability.As a new strategy for treatment of OA,mesenchymal stem cells(MSCs)have the potential for articular cartilage regeneration.Meanwhile,thrombospondin 2(TSP2)promotes the chondrogenic differentiation of MSCs.AIM To investigate whether TSP2 induces chondrogenic differentiation of human adipose-derived MSCs(hADMSCs)and potentiates the therapeutic effects of hADMSCs in OA rabbits.METHODS We investigated the chondrogenic potential of TSP2 in hADMSCs by analyzing the expression of chondrogenic markers as well as NOTCH signaling genes in normal and TSP2 small interfering RNA(siRNA)-treated stem cells.Anterior cruciate ligament transection surgery was performed in male New Zealand white rabbits,and 8 wk later,hADMSCs(1.7×10^6 or 1.7×10^7 cells)were injected into the injured knees alone or in combination with intra-articular injection of TSP2(100 ng/knee)at 2-d intervals.OA progression was monitored by gross,radiological,and histological examinations.RESULTS In hADMSC culture,treatment with TSP2 increased the expression of chondrogenic markers(SOX9 and collagen Ⅱ)as well as NOTCH signaling genes(JAGGED1 and NOTCH3),which were inhibited by TSP2 siRNA treatment.In vivo,OA rabbits treated with hADMSCs or TSP2 alone exhibited lower degree of cartilage degeneration,osteophyte formation,and extracellular matrix loss 8 wk after cell transplantation.Notably,such cartilage damage was further alleviated by the combination of hADMSCs and TSP2.In addition,synovial inflammatory cytokines,especially tumor-necrosis factor-α,markedly decreased following the combination treatment.CONCLUSION The results indicate that TSP2 enhances chondrogenic differentiation of hADMSCs via JAGGED1/NOTCH3 signaling,and that combination therapy with hADMSCs and TSP2 exerts synergistic effects in the cartilage regeneration of OA joints. | Kyungha Shin Yeseul Cha Young-Hwan Ban Da Woom Seo Ehn-Kyoung Choi Dongsun Park Sung Keun Kang Jeong Chan Ra Yun-Bae Kim | 2019 | World Journal of Stem Cells2019，11，12： | 2 |
| 3 | Characterization of Cr - doped TiO2 thin films prepared by cathodic arc plasma deposition显示文摘 | Chan Mu - Hsuan Ho Wei - Yu Wang Da - Yung | 2007 | Surface and Coatings Technology2007，202，47： | 1 |
| 4 | Nuclear and cytoplasmic Bcl-2 expression in endometrial hyperplasia and adenocarcinoma显示文摘 | Chan KW Mole MM Levison DA | 1995 | J Pathol1995，177，： | 1 |
| 5 | Prevalence of dating partner violence and suicidal ideation among male and female university students worldwide显示文摘 | CHAN KL STRAUS MA BROWNRIDGE DA | | 0，，06： | 1 |
| 6 | Walking behaviour and glycemic control in type 2 diabetes : seasonal and gender differences- study design and methods显示文摘 | Dasgupta K Chan C Da Costa D | 2007 | Cardiovasc Diabetol2007，15，6： | 1 |
| 7 | Supramolocular structure and nuclear targeting efficiency determine the enhancement of trans- fection by modified polylysine显示文摘 | Chan CK Senden T Jans DA | 2000 | Gene therapy2000，7，19： | 1 |
| 8 | Endothelin and the nervous system显示文摘 | Greenberg DA Chan J Sanpson HA | 1998 | Neurology1998，46，： | 1 |
| 9 | Living Arrangements of Older Malaysians:Who Coresides with their Adult Children显示文摘 | Da Vanzo Julie and Angelique Chan | 1997 | Demography1997，31，1： | 1 |
| 10 | Application of high pressure processing to improve the functional properties of pale, soft, and exudative (PSE)-like turkey meat显示文摘 | Chan JTY Omana DA Betti M | 2011 | Innovative Food Science and Emerging Technologies2011，12，3： | 1 |
| 11 | Macrophage migration inhibitory factor for the early prediction of infarct size显示文摘 | Chan W White DA Wang XY | 2013 | J Am Heart Assoc2013，2，00： | 1 |
| 12 | Molecular imaging of hypoxia-inducible factor 1 alpha and yon Hippel-Lindau interaction in mice显示文摘 | Choi CY Chan DA Paulmurugan R | 2008 | Mol Imaging2008，7，3： | 1 |
| 13 | Closing the gaps in pediatric laboratory reference intervals: a CALIPER data-base of 40 biochemical markers in a healthy and multiethnic popu- lation of children 显示文摘 | Colantonio DA Kyriakopoulou L Chan MK | 2012 | Clin Chem2012，58，5： | 1 |
| 14 | Targeting GLUTIand the Warburg effect in renal cell carcinoma by chemical syn-thetic lethality 显示文摘 | CHAN DA SUTPHIN PD NGUYEN P | 2011 | Sci Transl Med2011，3，94： | 1 |
| 15 | The effect of sprue design on the marginal accuracy of titanium castings显示文摘 | Chan DCN Blackman R Kaiser DA | 1998 | J Oral Rehabil1998，25，： | 1 |
| 16 | Acute left ventricular remodeling following myocardial infarction: coupling of regional healing with remote extracellular matrix expansion显示文摘 | Chan W Duffy SJ White DA | 2012 | JACC Cardiovasc Imaging2012，5，9： | 1 |
| 17 | Hypoxia, gene expression, and metastasis 显示文摘 | Chan DA Giaccia AJ | 2007 | Cancer Metastasis Rev2007，26，2： | 1 |
| 18 | Nodular Leydig cell hyperplasia in a boy with familial male- limited precocious puberty 显示文摘 | Leschek EW Chan WY Diamond DA | 2001 | J Pediatr2001，138，6： | 1 |
| 19 | 1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitore of enoyl acyl carrier protein reductase (FabI)显示文摘 | HEERDING DA CHAN G DEWOLF WE | 2001 | Bioorg Med Ghem Lett2001，11，16： | 1 |
| 20 | Characterization of the low molecular weight human serum proteome显示文摘 | Chan KC Prieto DA | 2003 | Mol Cell Proteomics2003，2，10： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员