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| 1 | Biliary complications after liver transplantation:current perspectives and future strategies显示文摘Importance:Liver transplantation(LT)is a life-saving therapy for patients with end-stage liver disease and with acute liver failure,and it is associated with excellent outcomes and survival rates at 1 and 5 years.The incidence of biliary complications(BCs)after LT is reported to range from 5%to 20%,most of them occurring in the first three months,although they can occur also several years after transplantation.Objective:The aim of this review is to summarize the available evidences on pathophysiology,risk factors,diagnosis and therapeutic management of BCs after LT.Evidence Review:a literature review was performed of papers on this topic focusing on risk factors,classifications,diagnosis and treatment Findings:Principal risk factors include surgical techniques and donor’s characteristics for biliary leakage and anastomotic biliary strictures and vascular alterations for non-anastomotic biliary strictures.MRCP is the gold standard both for intra-and extrahepatic BCs,while invasive cholangiography should be restricted for therapeutic uses or when MRCP is equivocal.About treatment,endoscopic techniques are the first line of treatment with success rates of 70-100%.The combined success rate of ERCP and PTBD overcome 90%of cases.Biliary leaks often resolve spontaneously,or with the positioning of a stent in ERCP for major bile leaks Conclusions and Relevance:BCs influence morbidity and mortality after LT,therefore further evidences are needed to identify novel possible risk factors,to understand if an immunological status that could lead to their development exists and to compare the effectiveness of innovative surgical and machine perfusion techniques. | Bianca Magro Matteo Tacelli Alessandra Mazzola Filomena Conti Ciro Celsa | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 12 |
| 2 | Association of thromboxane A1 synthase ( TBXAS1 ) gene polymorphism with acute urticaria induced by nonsteroidal anti-inflammatory drugs显示文摘 | Carmen Vidal Liliana Porras-Hurtado Raquel Cruz Joaquín Quiralte Victoria Cardona Carlos Colás Luisa F. Castillo Carmen Marcos Teresa Soto Raquel Lopez-Abad Dolores Hernández Maria Teresa Audicana Margarita Armisén Virginia Rodríguez Celsa Perez-Carral Es | 2013 | The Journal of Allergy and Clinical Immunology2013，，： | 1 |
| 3 | Immune activation and CD8^+T cell differentiation towards senescence in HIV- 1 Infection 显示文摘 | Laura P Celsa A Spina | 2004 | PLoS Biology2004，2，2： | 1 |
| 4 | Activation of Shiga-like toxins by mouse and human intestinal mucus correlates with virulence of enterohemorrhagic Escherichia coli O91 :H21 isolates in orally infected, streptomycin-treated mice显示文摘 | Melton Celsa AR Darnell SC O' Brien AD | 1996 | Infect Immun1996，64，： | 1 |
| 5 | Agrobacterium-mediated transformation of the endophytic fungus Acremonium implicatum associated with Brachiaria grasses显示文摘 | Javier A Segenet K Celsa G | | 0，，03： | 1 |
| 6 | The presence of the pAA plasmid in the German O104:I-I4 Shiga toxin Type 2a (Stx2a) -producing enteroaggregative Escherichia coli strain promotes the translocation of Stx2a across an epithelial cell monolayer显示文摘 | BOISEN N HANSEN A M MELTON - CELSA A R | 2014 | J Infect Dis2014，210，12： | 1 |
| 7 | Mouse model of hemolytic - uremic syndrome caused by endotoxin - free Shiga toxin 2 (Stx2) and protection from lethal outcome by anti - Stx2 antibody显示文摘 | SAUTER K A MELTON - CELSA A R LARKIN K | 2008 | Infect Immun2008，76，10： | 1 |
| 8 | Activation of Shiga toxin type 2d (Stx2d) by elastase involves cleavage of the C-terminal two aminoacids of the A2 peptide in the context of the appropriate B pentamer显示文摘 | Melton Celsa A R Kokai Kun J F O'Brien A D | 2002 | Molecular Microbiology2002，43，1： | 1 |
| 9 | Immunotherapy for the treatment of hepatocellular carcinoma: finally in clinical practice显示文摘Clinical guidelines for the prevention,diagnosis and management of human disease are evidence-based tools that rely on quality of clinical research,including data from randomized controlled clinical trials(RCTs)and real-world evidence.The Society for Immunotherapy of Cancer(SITC)recently published a clinical practice guideline on immunotherapy for the treatment of hepatocellular carcinoma(HCC)(1). | Ciro Celsa Lucia Cerrito Leonardo Stella Roberta Ciccia Giuseppe Cabibbo Francesca Romana Ponziani | 2023 | Hepatobiliary Surgery and Nutrition2023，12，2： | 0 |
| 10 | Hepatology|老年肝硬化患者经颈静脉肝内门体分流术后死亡率的预测模型显示文摘经颈静脉肝内门体分流术(TIPS)可提高伴顽固性腹水和门静脉高压性出血的肝硬化患者的生存率。然而,对老年患者(≥70岁)进行TIPS的适应证存在争议,并且缺乏针对这种特殊情况的特定预测模型。为开发和验证用于准确预测老年人死亡率的多变量模型,来自意大利佛罗伦萨大学的Vizzutti等在4个转诊中心前瞻性纳入411例患者,均接受了治疗顽固性腹水或静脉曲张出血的二级预防TIPS手术(衍生队列);另纳入415例具有TIPS适应证的患者组成外部队列(验证队列)。 | 李丽 华瑞 VIZZUTTI F CELSA C CALVARUSO V | 2022 | 临床肝胆病杂志2022，38，9： | 0 |
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