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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | An Assessment of Ad- vanced Mobile Services Acceptance: Contributions from TAM and Diffusion Theory Models 显示文摘 | Nicolas C L Castillo F J M Bouwman H | 2008 | Information & Management2008，45，6： | 1 |
| 3 | Bayesian modelingand optimization of functional responses affected by noise factors显示文摘 | Del Castillo E Colosimo B M Alshraideh H | 2012 | Journal of Quality Technology2012，44，2： | 1 |
| 4 | MLVA geno- typing of human Brucella isolates from Peru显示文摘 | Stairs H L Espinosa B Castillo R | 2009 | Trans R Soc Trop Med Hyg2009，103，4： | 1 |
| 5 | Film Formation by Col- loidal Overbased Detergents in Lubricated Contacts显示文摘 | F Chinas - Castillo H A Spikes | 2000 | Tribology Transactions2000，43，3： | 1 |
| 6 | 查看详情显示文摘 | H?pfl H Farfán N Castillo D Santillan R Gutierrez A Daran J C | | 0，，： | 1 |
| 7 | Global health opportuni-ties within pediatric subspecialty fellowship training programs :surveying the virtual landscape显示文摘 | Dixon CA Castillo J Castillo H | 2013 | BMC Med Educ2013，20，13： | 1 |
| 8 | Nephthalene,an insect repellent,is produced by Museodor vitigenus,a novel endophytic fungus显示文摘 | Daisy B H Strobel G B Castillo U | 2002 | Microbiology2002，148，11： | 1 |
| 9 | p53, Bcl - 2, PCNA expression, and apoptotic rates during cervical tumorigenesis显示文摘 | Astudillo H Lopez T Castillo S | 2003 | Ann N Y Acad Sci2003，10，10： | 1 |
| 10 | Kinetic parameters for denaturation of bovine milk lactoferrin 显示文摘 | Sanehez L Peiro J M Castillo H | 1992 | Journal of Food Science1992，57，4： | 1 |
| 11 | Antibodydirect epifluorescent filter technique and immunomagnetic separation for 10-h screening and 24-h confirmation of Escherichia coli O157:H7 in beef显示文摘 | RESTAINO L CASTILLO H J STDWART D | 1996 | J Food Prot1996，59，10： | 1 |
| 12 | Di agnoisis of ascending aortic dissection by transesophageal echo cardiography:utility of M mode in recognizing artifacts显示文摘 | Evangelista A Carcia del Castillo H Gonzalez Alujas T | 1996 | J Am Coll Cardiol1996，27，1： | 1 |
| 13 | Naphthalene, an in- sect repellent, is produced by Muscodor vitigenus, a novel endophytic fungus显示文摘 | DAISY B H STROBLE G A CASTILLO U | 2002 | Microbiology2002，148，11： | 1 |
| 14 | Magnetic resonance imaging of arrhythmogenie fight ventrieular dysplasia: sensitiv- ity, specificity, and observer variability of fat detection versusfunctional analysis of the right ventricle显示文摘 | Tandri H Castillo E Ferrari VA | 2006 | J Am Coil Cardiol2006，48，： | 1 |
| 15 | The diagnostic importance of species specific and cross-reactive components of Taenia solium,Echinococcus granulosus,and Hymenolepis nana显示文摘 | Montenegro T Gilman RH Castillo R Tsang V Brandt J Guevara A Sanabria H Verastegui M Sterling C Miranda E 1994 | 1994 | Rev Inst Med Trop Sao Paulo1994，36，4： | 1 |
| 16 | Laparoscopic repair of renal artery aneurysm:a description of the technique and results in 2 cases显示文摘 | Castillo O A Vitagliano G J Sanchez-Salas R Chamorro H Fava M Díaz M A | 2008 | Surg Laparosc Endosc Percutan Tech2008，18，： | 1 |
| 17 | Preparation and characterization of sulfated titanium-modified pillared montmorillonite显示文摘 | Del Castillo H L Gil A Grange P | 1997 | Catalysis Letters1997，43，： | 1 |
| 18 | Development of an interferometric dilatometer for gauge blocks显示文摘 | Castillo H A Mendoza M | 2001 | Proceedings of SPIE2001，4401，： | 1 |
| 19 | Preparation and characteriza- tion of sulfated titanium -modified pillared montmorillonite 显示文摘 | Del Castillo H L Gil A Grange P | 1997 | Catalysis Letter1997，43，12： | 1 |
| 20 | Magnetic resonance imaging and spectroscopy of pilomyxoid astrocytomas: case reports and comparison with pilocytic astrocytomas显示文摘 | Morales H Kwock L Castillo M | 2007 | J Comput Assist Tomogr2007，31，： | 1 |
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