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| 1 | Paternal physical exercise modulates global DNA methylation status in the hippocampus of male rat offspring显示文摘It is widely known that maternal physical exercise is able to induce beneficial improvements in offspring cognition; however, the effects of paternal exercise have not been explored in detail. The present study was designed to evaluate the impact of paternal physical exercise on memory and learning, neuroplasticity and DNA methylation levels in the hippocampus of male offspring. Adult male Wistar rats were divided into two groups: sedentary or exercised fathers. The paternal preconception exercise protocol consisted of treadmill running, 20 minutes daily, 5 consecutive days per week for 22 days, while the mothers were not trained. After mating, paternal sperm was collected for global DNA methylation analysis. At postnatal day 53, the offspring were euthanized, and the hippocampus was dissected to measure cell survival by 5-bromo-2′-deoxiuridine and to determine the expression of synaptophysin, reelin, brain-derived neurotrophic factor and global DNA methylation levels. To measure spatial memory and learning changes in offspring, the Morris water maze paradigm was used. There was an improvement in spatial learning, as well as a significant decrease in hippocampal global DNA methylation levels in the offspring from exercised fathers compared with those from sedentary ones; however, no changes were observed in neuroplasticity biomarkers brain-derived neurotrophic factor, reelin and 5-bromo-2′-deoxiuridine. Finally, the global DNA methylation of paternal sperm was not significantly changed by physical exercise. These results suggest a link between paternal preconception physical activity and cognitive benefit, which may be associated with hippocampal epigenetic programming in male offspring. However, the biological mechanisms of this modulation remain unclear. | Christiano Spindler Ethiane Segabinazi Andre Luis Ferreira de Meireles Francele Valente Piazza Filipe Mega Gabriela dos Santos Salvalaggio Matilde Achaval Viviane Rostirola Elsner Simone Marcuzzo | 2019 | Neural Regeneration Research2019，14，3： | 3 |
| 2 | Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat显示文摘 | Lavinsky D Arterni N S Achaval M | 2006 | Graefes Arch Clin Exp Ophthalmol2006，244，2： | 1 |
| 3 | Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat 显示文摘 | Lavinsky D Arterni NS Achaval M | 2006 | Graefe''s Arch Clin Exp Ophthalmol2006，244，2： | 1 |
| 4 | Chronic bilateral common carotid artery occlusion:a model for ocular ischemic syndrome in the rat显示文摘 | Lavinsky D Arterni NS Achaval M | | 0，，2： | 1 |
| 5 | Patients'expectations about total knee arthroplasty outcomes显示文摘 | De Achaval S Kallen MA Amiek B | 2015 | Health Expect2015，2，13： | 1 |
| 6 | Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat显示文摘 | Daniel Lavinsky Nice Sarmento Arterni Matilde Achaval Carlos Alexandre Netto | 2006 | Graefe’s Archive for Clinical and Experimental Ophthalmology2006，，2： | 1 |
| 7 | Neonatal cerebral hypoxia-ischemia causes lateralized memory impairments in the adult rat显示文摘 | Arteni NS Salgueiro J Torres I Achaval M Netto C | 2003 | Brain Res2003，973，2： | 1 |
| 8 | Early handling, but not ma- ternal separation, decreases emotional responses in two paradigms of fear without changes in mesolimbic dopamine 显示文摘 | Madruga C Xavier LL Achaval M | 2006 | Behav Brain Res2006，166，2： | 1 |
| 9 | GMP protects quinolinic acid induced loss of NADPH-diaphorase positive cells in the rat striatum显示文摘 | Malcon C Achaval M Komlos F | 1997 | Neurosci Lett1997，225，： | 1 |
| 10 | Molecular path ways of pain:Fos/Jun-mediated activation of a noncanonical AP-1site in the prodynorphin gene显示文摘 | Naranjo J R Mellstrom B Achaval M | 1991 | Neuron1991，6，4： | 1 |
| 11 | Early enriched housing results in partial recovery of memory deficits in female, but not in male, rats after neonatal hypoxia–ischemia显示文摘 | Lenir Orlandi Pereira Atahualpa Cauê Paim Strapasson Patrícia Machado Nabinger Matilde Achaval Carlos Alexandre Netto | 2008 | Brain Research2008，，： | 1 |
| 12 | Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat显示文摘 | Lavinsky D Artemi NS Achaval M | 2006 | Graefe''s Arch Clin Exp Ophthalmol2006，244，2： | 1 |
| 13 | Decision-making in Parkinson's disease patients with and without pathological gambling显示文摘 | Rossi M Gerschcovich ER de Achaval D | 2010 | Eur J Neurol2010，17，1： | 1 |
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