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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 3 | Coexpression of receptor-tyrosine-kinases in gastric adenocarcinoma-a rationale for a molecular targeting strategy?显示文摘AIM: To define the (co-)expression pattern of target receptor-tyrosine-kinases (RTK) in human gastric adenocarcinoma. METHODS: The (co-)expression pattern of VEGFR1-3,PDGFRα/b and EGFR1 was analyzed by RT-PCR in 51 human gastric adenocarcinomas. In addition,IHC staining was applied for confirmation of expression and analysis of RTK localisation. RESULTS: The majority of samples revealed a VEGFR1 (98%),VEGFR2 (80%),VEGFR3 (67%),PDGFRα (82%) and PDGFRβ(82%) expression,whereas only 62% exhibited an EGFR1 expression. 78% of cancers expressed at least four out of six RTKs. While VEGFR1-3 and PDGFRα revealed a predominantly cytoplasmatic staining in tumor cells,accompanied by an additional nuclear staining for VEGFR3 ,EGFR1 was almost exclusively detected on the membrane of tumor cells. PDGFRβ was restricted to stromal pericytes,which also depicted a PDGFRα expression.receptor-tyrosine-kinases coexpression in gastric adenocarcinoma and might therefore encourage an application of multiple-target RTK-inhibitors within a combination therapy. | Daniel Drescher Markus Moehler Ines Gockel Kirsten Frerichs Annett Müller Friedrich Dünschede Thomas Borschitz Stefan Biesterfeld Martin Holtmann Thomas Wehler Andreas Teufel Kerstin Herzer Thomas Fischer Martin R Berger Theodor Junginger Peter R Galle Carl C Schimanski | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 4 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 5 | Probable involvement of thaxtomins A in pathogenicity of Streptomyces scabies on seedlings显示文摘 | LEINER R H FRY B A CARLING D E | 1996 | Phytopathology1996，86，： | 2 |
| 6 | Perihepatic Lymph Node Micrometastases Impact Outcome after Partial Hepatectomy for Colorectal Metastases显示文摘 | Joseph J. Bennett MD Carl R. Schmidt MD David S. Klimstra MD Stephen R. Grobmyer MD Nicole M. Ishill MS Michael D'Angelica MD Ronald P. DeMatteo MD Yuman Fong MD Leslie H. Blumgart MD William R. Jarnagin MD | 2008 | Annals of Surgical Oncology2008，，4： | 2 |
| 7 | Energy-efficient area monitoring by sensor networks显示文摘 | Carle J and Simplot D | 2004 | IEEE Computer Magazine2004，37，2： | 1 |
| 8 | Parameter-optimized digital holographic microscope for high resolution living-cell analysis显示文摘 | Carl D Kemper B Wernicke G | 2004 | Appl Opt2004，43，6： | 1 |
| 9 | Copy number gain and oncogenic activity of YWHAZ/14 3-3 in head and neck squamous cell carcinoma显示文摘 | Mauting Lin Carl D Morrison Susie Jones | 2009 | Int J Cancer2009，125，3： | 1 |
| 10 | Carnosols?ure, der wichtige antioxydativ wirksame Inhaltsstoff des Rosmarin- und Salbeiblattes显示文摘 | Carl Heinz Brieskorn Hans-Jürgen D?mling | 1969 | Zeitschrift für Lebensmittel - Untersuchung und - Forschung1969，，1： | 1 |
| 11 | Correct formulation of theKappa coefficient of agreement显示文摘 | William D H Carl W R | | 0，，04： | 1 |
| 12 | LIGHT, a New Member of the TNF Superfamily, and Lymphotoxin α Are Ligands for Herpesvirus Entry Mediator显示文摘 | Davide N Mauri Reinhard Ebner Rebecca I Montgomery Kristine D Kochel Timothy C Cheung Guo-Liang Yu Steve Ruben Marianne Murphy Roselyn J Eisenberg Gary H Cohen Patricia G Spear Carl F Ware | 1998 | Immunity1998，，： | 1 |
| 13 | Tissue distribution of the AMP-activated protein kinase, and lack of activation by cyclic-AMP- dependent protein kinase, studied using a specific and sensitive peptide assay显示文摘 | DAVIES S P CARLING D HARDIE D G | 1989 | Eur J Biochem1989，186，12： | 1 |
| 14 | The suitability of aluminum as an alternative material for car bodies显示文摘 | Carle D Blount G | 1999 | Materials and Design1999，20，4： | 1 |
| 15 | Advances in modeling the effects of selected parameters on the SLS显示文摘 | John D W Carl R D | 1998 | Rapid Prototyping Journal1998，4，2： | 1 |
| 16 | Evaluation of a school-based intervention for HIV/AIDS prevention among Belizean adolescents显示文摘 | Janni Kinsler Carl D Sneed Donald E Monsky | 2004 | Health Education Research2004，19，6： | 1 |
| 17 | Assessment of plantar pressure in forefoot relief shoes of different designs显示文摘 | Carl H D Pfander D Swoboda B | 2006 | Foot Ankle Int2006，27，2： | 1 |
| 18 | ^13C NMR spectra of sapogenin 显示文摘 | Hann E Carl D | 1975 | Tetrahedron Left1975，42，： | 1 |
| 19 | Functional analysis of mutations in the gamma 2 subunit of AMP-activated protein kinase associated with cardiac hypertrophy and Wolff-Parkinson-White syndrome显示文摘 | CARLING D | 2002 | J Biol Chem2002，77，51： | 1 |
| 20 | Familial Nonmedullary Thyroid Carcinoma显示文摘 | Malchoff Diana M | 2006 | Cancer Contral2006，13，2： | 1 |
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