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| 1 | Moving toward an understanding of the metastatic process in hepatocellular carcinoma显示文摘INTRODUCTIONClinical factors contributing to the therapeutic challenge of hepatocellular carcinoma (HCC) are manifold :tumors arise often in patients with compromised liver function ,therefore limiting therapeutic options ;symptoms develop only at later stages of tumor progression ,and tumors tend to invade normal stuctures or occur in multiple locations simultaneously. | W.Michael Korn Division of Gastroenterology and Comprehensive Cancer Canter,University of California San Francisco,San Francisco,CA 94143-0128,USA | 2001 | World Journal of Gastroenterology2001，7，6： | 13 |
| 2 | 儿童扩张型心肌病的发病率、病因及预后显示文摘背景:扩张型心肌病(dilated cardiomyopathy,DCM)是儿童心肌病最常见的类型,也是小儿心脏移植最常见的原因。但是,目前尚不清楚儿童DCM的流行病学特点和临床过程。
目的:详细描述儿童DCM的发病率、病因、预后及相关危险因素。
设计及地点:本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。
参试者:共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和/或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。
主要观测指标:每年每10万儿童的发病率、死亡率和心脏移植率。
结果:18岁以下儿童DCM每年的总发病率为0.57/10万,男孩的年发病率高于女孩(分别为0.66/10万和0.47/10万;P〈0.001),黑人的年发病率高于白人(分别为0.98/10万和0.46/10万;P〈0.001),婴儿(〈1岁)的年发病率高于儿童(分别为4.40/10万和0.34/10万;P〈0.001)。绝大部分属特发性,最常见的病因为心肌炎(46%)和神经肌肉性疾病(26%)。1年和5年死亡/移植率分别为31%和46%。死亡/移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因(P均〈0.001)。
结论:儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因,限制了特异性治疗。 | Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper E. John Orav Sarah Clunie Jane Messere Gerald F. Cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven E. Lipshultz 康俊萍(译) 马长生(校) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 3 |
| 3 | Impact of sleep debt on metabolic and endocrine function显示文摘 | Spiegel K Leproult R Van Canter | | 0，，： | 1 |
| 4 | Giardia Lamblia,Hapoid genome size determined by pulsed field gel electrophoresis is less than 12Mb显示文摘 | Fan J B S H Korman C R Canter | 1991 | Nucleic Acids Res1991，19，： | 1 |
| 5 | Documentation of cumulative impacts in environmental impact statements 显示文摘 | Cooper T A Canter L W | 1997 | Environmental Impact Assessment Review1997，7，： | 1 |
| 6 | Herbal medicines for the treatment of rhinosinusitis:a systematic review显示文摘 | Guo R Canter PH Ernst E | | 0，，： | 1 |
| 7 | Pediatric flexible ureteroscopic lithotripsy: the children's hospital of Philadelphia experience显示文摘 | KIM S S KOLON T F CANTER D | 2008 | J Urol2008，180，： | 1 |
| 8 | Distance estimation in cities 显示文摘 | Canter D Tagg S K | 1975 | Environment and Psychology1975，7，1： | 1 |
| 9 | Delayed proximal ureteric stricture formation after complex partial nephreetomy显示文摘 | Reyes JM Canter DJ Sirohi M | 2012 | BJU Int2012，109，4： | 1 |
| 10 | Baseline Renal Function Status Limits Patient Eligibility to Receive Perioperative Chemotherapy for Invasive Bladder Cancer and Is Minimally Affected by Radical Cystectomy显示文摘 | Daniel Canter Rosalia Viterbo Alexander Kutikov Yu-Ning Wong Elizabeth Plimack Fang Zhu Megan Oblaczynski Raffi Berberian David Y.T. Chen Richard E. Greenberg Robert G. Uzzo Stephen A. Boorjian | 2011 | Urology2011，，1： | 1 |
| 11 | Overnight pulse oximetry in snoring and non-snoring children 显示文摘 | Owen GO Canter RJ Robinson A | 1995 | Clin Otolaryngol1995，20，： | 1 |
| 12 | Coagulation monitoring: current techniques and clinical use of viscoelastic point-of-care coagulation devices显示文摘 | Canter MT Hofer CK | 2008 | Anesth Analg2008，106，5： | 1 |
| 13 | A new experiment hypertrophic scar model in guinea pigs显示文摘 | Aksoy HM Vargel I Canter HI | 2002 | Ansth Plast Surg2002，26，： | 1 |
| 14 | The diagnostic di- lemma of follicular variant of papillary thyroid carcinoma 显示文摘 | Kesmodel SB Terhune KP Canter R J | 2003 | Surgery2003，134，6： | 1 |
| 15 | Ecological Compensation of the Impacts of a Road 显示文摘 | CuperusR K J Canters A G Piepers | 1996 | EcologicalEngineering1996，，7： | 1 |
| 16 | Carbon nanotubes for lithium ion batteries 显示文摘 | Landi B J Canter M J Cress C D | 2009 | Energy Environ Sei2009，2，6： | 1 |
| 17 | Low-Energy Positron Diffraction from a Cu (111) Surface 显示文摘 | Rosenberg J J Weiss A H Canter K F | 1980 | Phys Rev Lett1980，44，： | 1 |
| 18 | Dilated cardiomyopathy and heart failure in children显示文摘 | Hsu DT Canter CE | 2010 | Heart Fail Clin2010，6，4： | 1 |
| 19 | Pathological Concordance and Surgical Outcomes of Sporadic Synchronous Unilateral Multifocal Renal Masses Treated with Partial Nephrectomy显示文摘 | Simhan J Canter DJ Sterious SN | | 0，，01： | 1 |
| 20 | Impact of sleep debt on metabolic and endocrine function 显示文摘 | Spiegel K Leproult R Van Canter E | 1999 | Lancet1999，354，9188： | 1 |
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