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| 1 | Post-translational processing of the interalpha-trypsin inhibitor in the human hepatoma HepG2 cell line显示文摘 | Héron A Bourguignon J Callé A | 1994 | Biochem J1994，302，2： | 1 |
| 2 | Posttranslationalprocessing of the inter-alpha-trypsininhibitor in the humanhepatoma HepG2 cellline显示文摘 | Héron A Bourguignon J Callé A | | 0，，2： | 1 |
| 3 | A review on polycyclic aromatic hydrocarbon (PAH) emissions from energy generation 显示文摘 | Mastral A M Callén M S | 2000 | Environmental Science and Technology2000，34，15： | 1 |
| 4 | “猪Ⅱ型圆环病毒”专栏三:与PCV2有关的血清学试验重要性显示文摘鉴于由PCV2引起感染的高流行性,以及它可出现在健康和患病的猪中,针对这种病原体的血清学试验作为疾病的诊断性试验已受到质疑。众所周知,圆环病毒的诊断必须以Sorden标准为依据。 | 陶莉 Antonio Callén | 2013 | 国外畜牧学(猪与禽)2013，，5： | 0 |
| 5 | Assessment of PAH emissions as a function of coal combustion variables显示文摘 | Ana María Mastral Marisol Callén Ramón Murillo | 1996 | Fuel1996，，： | 1 |
| 6 | SrCo1-xSbxO3-δperovskite oxides as cathode materials in solid oxide fuel cells显示文摘 | Aguadero A Pérez-Coll D De la Calle C | 2009 | J Power Sources2009，192，： | 1 |
| 7 | Comparison of receptor models for source apportionment of the PM10in Zaragoza(Spain)显示文摘 | Callén M S de la Cruz M T López J M | 2009 | Chemosphere2009，76，： | 1 |
| 8 | A study of trace metals and polycyclic aromatic hydrocarbons in the roadsideenvironment显示文摘 | Harrison R M Tilling R Callén Romero M S | 2003 | Atmospheric Environment2003，37，： | 1 |
| 9 | BaP (PAH) air quality modelling exercise over Zaragoza (Spain) using an adapted version of WRF-CMAQ model显示文摘 | San José R Pérez J L Callén M S | 2013 | Environmental Pollution2013，183，： | 1 |
| 10 | A common founder mutation in FANCA underlies the world's highest prevalence of Fanconi anemia in Gypsy families from Spain显示文摘 | Callén E Casado JA Tischkowitz MD | 2005 | Blood2005，105，5： | 1 |
| 11 | Assessment of tire devolatiliza-tion kinetics显示文摘 | Aylón E Callén M S López J M | 2005 | Journal of Analytical and Applied Pyrolysis2005，74，12： | 1 |
| 12 | Evolutions of efficiency and pressure drop of filter media during clogging and cleaning cycles显示文摘 | S Callé P Contal D Thomas D Bémer D Leclerc | 2002 | Powder Technology2002，，2： | 1 |
| 13 | Adorption ofphenanthrene on activated carbons: breakthrough curve modeling 显示文摘 | Murillo R Garc?a T Aylón E Callén M S | 2004 | Carbon2004，42，： | 1 |
| 14 | Comparison of receptor models for source apportionment of the PM10 in Zaragoza (Spain)显示文摘 | M.S. Callén M.T. de la Cruz J.M. López M.V. Navarro A.M. Mastral | 2009 | Chemosphere2009，，8： | 1 |
| 15 | Catalytic upgrading of biomass derived pyrolysis vapors over metal-loaded ZSM-5 zeolites: Effect of different metal cations on the bio-oil final properties显示文摘 | A. Veses B. Puértolas M.S. Callén T. García | 2015 | Microporous and Mesoporous Materials2015，，： | 1 |
| 16 | Prevalence of Hepatitis C Virus Infection in Alcoholic Patients: Cohort Study and Systematic Review显示文摘 | Ignacio Novo-Veleiro Cristina de la Calle Susana Domínguez-Quibén Isabel Pastor Miguel Marcos Francisco-Javier Laso | 2013 | Alcohol and Alcoholism2013，，5： | 1 |
| 17 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 18 | Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort显示文摘BACKGROUND Colorectal cancer(CRC) is the second most common cause of cancer death worldwide. It is broadly described that cyclooxygenase-2(COX-2) is mainly overexpressed in CRC but less is known regarding post-translational modifications of this enzyme that may regulate its activity, intracellular localization and stability. Since metabolic and proteomic profile analysis is essential for cancer prognosis and diagnosis, our hypothesis is that the analysis of correlations between these specific parameters and COX-2 state in tumors of a high number of CRC patients could be useful for the understanding of the basis of this cancer in humans.AIM To analyze COX-2 regulation in colorectal cancer and to perform a detailed analysis of their metabolic and proteomic profile.METHODS Biopsies from both healthy and pathological colorectal tissues were taken under informed consent from patients during standard colonoscopy procedure in the University Hospital of Bellvitge(Barcelona, Spain) and Germans Trias i Pujol University Hospital(Campus Can Ruti)(Barcelona, Spain). Western blot analysis was used to determine COX-2 levels. Deglycosylation assays were performed in both cells and tumor samples incubating each sample with peptide N-glycosidase F(PNGase F). Prostaglandin E2(PGE2) levels were determined using a specific ELISA. 1 H high resolution magic angle spinning(HRMAS) analysis was performed using a Bruker AVIII 500 MHz spectrometer and proteomic analysis was performed in a nano-liquid chromatography-tandem mass spectrometer(nano LC-MS/MS) using a QExactive HF orbitrap MS.RESULTS Our data show that COX-2 has a differential expression profile in tumor tissue of CRC patients vs the adjacent non-tumor area, which correspond to a glycosylated and less active state of the protein. This fact was associated to a lesser PGE2 production in tumors. These results were corroborated in vitro performing deglycosylation assays in HT29 cell line where COX-2 protein profile was modified after PNGase F incubation, showing higher PGE2 levels. Moreover,HRMAS analysis indicated that tumor tissue has altered metabolic features vs non-tumor counterparts, presenting increased levels of certain metabolites such as taurine and phosphocholine and lower levels of lactate. In proteomic experiments, we detected an enlarged number of proteins in tumors that are mainly implicated in basic biological functions like mitochondrial activity,DNA/RNA processing, vesicular trafficking, metabolism, cytoskeleton and splicing.CONCLUSION In our colorectal cancer cohort, tumor tissue presents a differential COX-2 expression pattern with lower enzymatic activity that can be related to an altered metabolic and proteomic profile. | Patricia Prieto Rafael I Jaén Daniel Calle María Gómez-Serrano Estefanía Nú?ez María Fernández-Velasco Paloma Martín-Sanz Sergio Alonso Jesús Vázquez Sebastián Cerdán Miguel ángel Peinado Lisardo Boscá | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 19 | A multinational study of sleep disorders during female mid-life显示文摘 | Juan E. Blümel Antonio Cano Edward Mezones-Holguín Germán Barón Ascanio Bencosme Zully Benítez Luz M. Bravo Andrés Calle Daniel Flores María T. Espinoza Gustavo Gómez José A. Hernández-Bueno Fiorella Laribezcoa Mabel Martino Selva Lima Alvaro Monterrosa D | 2012 | Maturitas2012，，4： | 1 |
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