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| 1 | Role of microRNAs in alcohol-induced liver disorders and non-alcoholic fatty liver disease显示文摘MicroRNAs(miRNAs) are small non-coding RNAs that regulate multiple physiological and pathological functions through the modulation of gene expression at the post-transcriptional level. Accumulating evidence has established a role for miRNAs in the development and pathogenesis of liver disease. Specifically, a large number of studies have assessed the role of miRNAsin alcoholic liver disease(ALD) and non-alcoholic fatty liver disease(NAFLD), two diseases that share common underlying mechanisms and pathological characteristics. The purpose of the current review is to summarize and update the body of literature investigating the role of miRNAs in liver disease. In addition, the potential use of miRNAs as biomarkers and/or therapeutic targets is discussed. Among all miRNAs analyzed, miR-34 a, miR-122 and miR-155 are most involved in the pathogenesis of NAFLD. Of note, these three miRNAs have also been implicated in ALD, reinforcing a common disease mechanism between these two entities and the pleiotropic effects of specific miRNAs. Currently, no single miRNA or panel of miRNAs has been identified for the detection of, or staging of ALD or NAFLD. While promising results have been shown in murine models, no therapeutic based-miRNA agents have been developed for use in humans with liver disease. | Jorge-Luis Torres Ignacio Novo-Veleiro Laura Manzanedo Lucía Alvela-Suárez Ronald Macías Francisco-Javier Laso Miguel Marcos | 2018 | World Journal of Gastroenterology2018，24，36： | 19 |
| 2 | Laser produced electromagnetic pulses: generation, detection and mitigation显示文摘This paper provides an up-to-date review of the problems related to the generation,detection and mitigation of strong electromagnetic pulses created in the interaction of high-power,high-energy laser pulses with different types of solid targets.It includes new experimental data obtained independently at several international laboratories.The mechanisms of electromagnetic field generation are analyzed and considered as a function of the intensity and the spectral range of emissions they produce.The major emphasis is put on the GHz frequency domain,which is the most damaging for electronics and may have important applications.The physics of electromagnetic emissions in other spectral domains,in particular THz and MHz,is also discussed.The theoretical models and numerical simulations are compared with the results of experimental measurements,with special attention to the methodology of measurements and complementary diagnostics.Understanding the underlying physical processes is the basis for developing techniques to mitigate the electromagnetic threat and to harness electromagnetic emissions,which may have promising applications. | Fabrizio Consoli Vladimir TTikhonchuk Matthieu Bardon Philip Bradford David CCarroll Jakub Cikhardt Mattia Cipriani Robert JClarke Thomas ECowan Colin NDanson Riccardo De Angelis Massimo De Marco Jean-Luc Dubois Bertr Etchessahar Alejro Laso Garcia David IHillier Ales Honsa Weiman Jiang Viliam Kmetik Josef Krása Yutong Li FredériéLubrano Paul McKenna Josefine Metzkes-Ng Alexre Poyé Irene Prencipe Piotr Ra¸czka Rol ASmith Roman Vrana Nigel CWoolsey Egle Zemaityte Yihang Zhang Zhe Zhang Bernhard Zielbauer David Neely | 2020 | High Power Laser Science and Engineering2020，8，2： | 3 |
| 3 | Alcoholic liver disease and hepatitis C virus infection显示文摘Alcohol consumption and hepatitis C virus(HCV) infection have a synergic hepatotoxic effect, and the coexistence of these factors increases the risk of advanced liver disease. The main mechanisms of this effect are increased viral replication and altered immune response, although genetic predisposition may also play an important role. Traditionally, HCV prevalence has been considered to be higher(up to 50%) in alcoholic patients than in the general po pulation. However, the presence of advanc e d alcoholic liver disease(ALD) or intravenous drug use(IDU) may have confounded the results of previous studies, and the real prevalence of HCV infection in alcoholic patients without ALD or prior IDU has been shown to be lower. Due to the toxic combined effect of HCV and alcohol, patients with HCV infection should be screened for excessive ethanol intake. Patients starting treatment for HCV infection should be specifically advised to stop or reduce alcohol consumption because of its potential impact on treatment efficacy and adherence and may benefi t from addi tionalsupport during antiviral therapy. This recommendation might be extended to all currently recommended drugs for HCV treatment. Patients with alcohol dependence and HCV infection, can be treated with acamprosate, nalmefene, topiramate, and disulfiram, although baclofen is the only drug specifically tested for this purpose in patients with ALD and/or HCV infection. | Ignacio Novo-Veleiro Lucía Alvela-Suárez Antonio-Javier Chamorro Rogelio González-Sarmiento Francisco-Javier Laso Miguel Marcos | 2016 | World Journal of Gastroenterology2016，22，4： | 2 |
| 4 | Stepped-impedance lowpass filters with spurious pass-band suppression显示文摘 | J Garcia-Garcia J Bonache F Falcone J D Baena F Martin I Gil T Lopetegi M A G Laso A Marcotegui R Marques M Sorolla | 2004 | Electronic Letters2004，40，14： | 1 |
| 5 | Multiple-frequency-tuned photonic bandgap microstrip structures显示文摘 | M A G Laso T Lopetegi M J Erro | 2000 | IEEE Microwave and Guided Wave Letters2000，10，6： | 1 |
| 6 | On- line FT - Raman and dispersive Raman spectra database of artists materials ( e - VISART database ) 显示文摘 | Castro K Pe'rez - Alonso M Rodri'guez - Laso M D | 2005 | Anal Bioanal Chem2005，382，： | 1 |
| 7 | High frequency oscillatory ventilation in the newborn infant显示文摘 | Gutlerrez Laso A Garcia Canto E Izquierdo Macian I | 1997 | An Esp Pediatr1997，46，2： | 1 |
| 8 | Ibuprofeno frente a indometacina para el tratamiento de la persistencia del conducto arterioso del prematuro: revisión sistemática y metaanálisis显示文摘 | A. Gimeno Navarro V. Modesto Alapont F. Morcillo Sopena C. Fernández Gilino I. Izquierdo Macián A. Gutiérrez Laso | 2007 | Anales de Pediatria2007，，4： | 1 |
| 9 | High performance double-sided microstrip PBG filter 显示文摘 | TAKIN LASO M A G DELOSE | 2002 | Microwave and Optical Technology Letters2002，，10： | 1 |
| 10 | Recent advances in the catalytic asymmetric nitroaldol (Henry) reaction 显示文摘 | C Palomo M Oiarbide A Laso | 2007 | Eur J Org Chem2007，，： | 1 |
| 11 | Systematic review with meta‐analysis: the I148M variant of patatin‐like phospholipase domain‐containing 3 gene ( PNPLA3 ) is significantly associated with alcoholic liver cirrhosis显示文摘 | A.‐J. Chamorro J.‐L. Torres J.‐A. Mirón‐Canelo R. González‐Sarmiento F.‐J. Laso M. Marcos | 2014 | Aliment Pharmacol Ther2014，，6： | 1 |
| 12 | Recent Advances in the Catalytic Asymmetric Nitroaldol(Henry) Reaction显示文摘 | Palomo C Oiarbide M Laso A | | 0，，： | 1 |
| 13 | Real-timespectrum analysis in microstrip technology显示文摘 | LASO MAQ LOPETEGI T ERRO M J | 2003 | IEEE TransMicrow Theory Tech2003，51，3： | 1 |
| 14 | Effects of antiepileptic drugs on immune system显示文摘 | Basta-Kaim A Budziszewska B LasońW | | 0，，11： | 1 |
| 15 | Production of inflammstory cytokines by peripheral blood monocytes in chronic alcoholism: Relationship with ethanol intake and liver disease 显示文摘 | Laso FJ Vaquero JM Almeida J Marcos M Orfao A | 2007 | Cytometry B Clin Cytom2007，72，5： | 1 |
| 16 | Calculation of viscoelastic flow using molecular models: the CONNFFESSIT approach显示文摘 | Laso M Ottinger H C | 1993 | Journal of Non-Newtonian Fluid Mechanics1993，47，： | 1 |
| 17 | Production of inflammatory cytokines by peripheral blood monocytes in chronic alcoholism: Relationship with ethanol intake and liver disease 显示文摘 | Laso FJ Vaquero JM Almeida J | 2007 | Cyto metry B Clin Cytom2007，72，5： | 1 |
| 18 | Hemophagocytie lymphohistiocytosis associated with viral infections: diagnostic challenges and therapeutic dilemmas 显示文摘 | Mostaza-Femamdez JL Guerra Laso J Carriedo Ule D | 2014 | Rev Clin Esp2014，214，6： | 1 |
| 19 | Mycoplasma pneumoniae detection with PCR in renal tissue of a patient with acute glomerulonephritis显示文摘 | Laso Mdel C Cadario ME Haymes L | 2006 | Pediatr Nephrol2006，21，10： | 1 |
| 20 | Babinet Principle Applied to the Design of Metasurfaees and Metamaterials 显示文摘 | Falcone F Lopetegi T Laso M A G | 2004 | Phys Rev Lett2004，93，19： | 1 |
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