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| 1 | 接受治疗的老年高血压患者的血压、抗高血压药物应用、衰弱指标与严重摔伤风险的关系显示文摘一些研究表明,降压药物、低收缩压和舒张压与跌倒风险增加相关。许多老年人表现出衰弱的指征,这可能会增加跌倒的风险。该研究纳入脑卒中地区和种族差异原因(the reasons for geographic and racial differences in stroke,REGARDS)研究中年龄≥65岁的受试者5236例,探索收缩压、舒张压、抗高血压药物类别数量以及衰弱指标与严重跌倒损伤风险的关系, | 刘莉 叶鹏 Bromfield SG Ngameni CA Colantonio LD Bowling CB Shimbo D Reynolds K Safford MM Banach M Toth PP Muntner P | 2017 | 中华高血压杂志2017，25，8： | 19 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection显示文摘A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum var.cerasiforme and Solanum lycopersicum var.lycopersicum,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and Mesoamerica.The collection is enriched with S.lycopersicum var.cerasiforme from the Amazonian region that has not been analyzed previously nor used extensively.The collection has been morphologically characterized showing diversity for fruit,flower and vegetative traits.Their genomes were sequenced in the Varitome project and are publicly available(solgenomics.net/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff analysis.GWAS has shown associations for different traits,demonstrating the potential of this collection for this kind of analysis.We have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence architecture.To speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different parents.This F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate gene.All data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC genebanks.All these resources together make this collection a good candidate for genetic studies. | Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap María JoséDíez | 2020 | Horticulture Research2020，7，1： | 2 |
| 7 | Adenoviral tranfer of the viral IL-10 gene periarticularly to mouse paws suppresses development of collagen-induced arthritis in both injected and uninjected paws 显示文摘 | Whalen D Lechman EL Carlos CA aeyetal | 2004 | J Immunol2004，162，6： | 1 |
| 8 | Angiostatin generation by human pancreatic cancer显示文摘 | Seidel A Albo D | 1998 | J Surg Res1998，77，1： | 1 |
| 9 | Tbe stress social support and burnout of critical care nurses显示文摘 | Rooks CA | 1985 | The result of reseach heart & lung1985，14，1： | 1 |
| 10 | CD4 + Foxp3 + regulatory T cells in the control of autoimmunity : in vivo veritas 显示文摘 | Piccirillo CA d'Hennezel E Sgouroudis E | 2008 | Curr Opin Immunol2008，20，6： | 1 |
| 11 | A prospective study of central venous hemodialysis catheter colonization and peripheral bacteremia显示文摘 | Dittmer ID Sharp D McNulty CA | 1999 | Clin Nephrol1999，51，： | 1 |
| 12 | Gastrointestinal stromal tumors with prominent myxoid matrix显示文摘 | Suster S Sorace D Moran CA | 1995 | Am J Surg Pathol1995，19，1： | 1 |
| 13 | Carbon monoxide poisoning:Interpretation of randomized clinical trials and unresolved treatment issues显示文摘 | Hampson NB Mathieu D Piantadosi CA | 2001 | Undersea Hyperbar M2001，28，3： | 1 |
| 14 | Transplantation of a multipotent cell population from human adipose tissue induces dystrophin expression in the immunocompetent mdx mouse显示文摘 | Rodriguez AM Pisani D Dechesne CA | 2005 | J Exp Med2005，201，9： | 1 |
| 15 | The cardiovascular dose-response efects of isoflurane alone and combined with butorphanol in the green iguana( Iguana iguana)显示文摘 | Mosley CA Dyson D Smith DA | 2004 | Vet Anaesth Analg2004，31，1： | 1 |
| 16 | Results of a phase I trial of a recombinant vaccinia virus that expresses carcinoembryonic antigen in patients with advanced colorectal cancer 显示文摘 | Mcaneny D Ryan CA Beazley RM | 1996 | Ann Surg Oncol1996，3，5： | 1 |
| 17 | IL-18 in autoimmunity:review显示文摘 | Boraschi D Dinarello CA | | 0，，04： | 1 |
| 18 | Extracorporeal shock wave therapy for epicondylitis-a double blind ran domised controlled trial显示文摘 | Seep CA Nichols D richards C | 2002 | J Orthopaedic Res2002，20，5： | 1 |
| 19 | An Area Preserving Projection from the Regular Octahedron to the Sphere显示文摘 | RO?CA D PLONKA G | 2012 | Results in Mathematics2012，62，34： | 1 |
| 20 | Lung is- chemia reperfusion injury: a bench-to-bedside review 显示文摘 | Weyker PD Webb CA Kiamanesh D | 2013 | Semin Cardiothorae Vasc Anesth2013，17，1： | 1 |
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