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| 1 | Therapeutic temperature modulation is associated with pulmonary complications in patients with severe traumatic brain injury显示文摘AIM: To examine complications associated with the use of therapeutic temperature modulation(mild hypothermia and normothermia) in patients with severe traumatic brain injury(TBI). METHODS: One hundred and fourteen charts were reviewed. Inclusion criteria were: severe TBI with Glasgow Coma Scale(GCS) < 9, intensive care unit(ICU) stay > 24 h and non-penetrating TBI. Patients were divided into two cohorts: the treatment group received therapeutic temperature modulation(TTM) with continuous surface cooling and indwelling bladder temperature probes. The control group received standard treatment with intermittent acetaminophen for fever. Information regarding complications during the time in the ICU was collected as follows: Pneumonia was identified using a combination of clinical and laboratory data. Pulmonary embolism, pneumothorax and deep venous thrombosis were identified based onimaging results. Cardiac arrhythmias and renal failure were extracted from the clinical documentation. acute respiratory distress syndrome and acute lung injury were determined based on chest imaging and arterial blood gas results. A logistic regression was conducted to predict hospital mortality and a multiple regression was used to assess number and type of clinical complications. RESULTS: One hundred and fourteen patients were included in the analysis(mean age = 41.4, SD = 19.1, 93 males), admitted to the Jackson Memorial Hospital Neuroscience ICU and Ryder Trauma Center(mean GCS = 4.67, range 3-9), were identified and included in the analysis. Method of injury included motor vehicle accident(n = 29), motor cycle crash(n = 220), blunt head trauma(n = 212), fall(n = 229), pedestrian hit by car(n = 216), and gunshot wound to the head(n = 27). Ethnicity was primarily Caucasian(n = 260), as well as Hispanic(n = 227) and African American(n = 223); four patients had unknown ethnicity. Patients received either TTM(43) or standard therapy(71). Within the TTM group eight patients were treated with normothermia after TBI and 35 patients were treated with hypothermia. A logistic regression predicting in hospital mortality with age, GCS, and TM demonstrated that GCS(Beta = 0.572, P < 0.01) and age(Beta =-0.029) but not temperature modulation(Beta = 0.797, ns) were significant predictors of in-hospital mortality [χ2(3) = 22.27, P < 0.01] A multiple regression predicting number of complications demonstrated that receiving TTM was the main contributor and was associated with a higher number of pulmonary complications(t =-3.425, P = 0.001). CONCLUSION: Exposure to TTM is associated with an increase in pulmonary complications. These findings support more attention to these complications in studies of TTM in TBI patients. | Kristine H O’Phelan Amedeo Merenda Katherine G Denny Kassandra E Zaila Cynthia Gonzalez | 2015 | World Journal of Critical Care Medicine2015，4，4： | 18 |
| 2 | Endoscopic retrograde cholangiography for pediatric choledocholithiasis: Assessing the need for endoscopic intervention显示文摘AIM:To assess pediatric patients for choledocholithiasis.We applied current adult guidelines to identify predictivefactors in children.METHODS:A single-center retrospective analysis was performed at a tertiary children's hospital.We evaluated 44 consecutive pediatric patients who underwent endoscopic retrograde cholangiography(ERCP) for suspected choledocholithiasis.Patients were stratified into those with common bile duct stones(CBDS) at ERCP vs those that did not using the American Society of Gastrointestinal Endoscopy(ASGE) guidelines(Very Strong and Strong criteria) for suspected CBDS.RESULTS:CBDS were identified in 84% at the time of ERCP.Abdominal ultrasound identified CBDS in 36% of patients.Conjugated bilirubin ≥ 0.5 mg/d L was an independent risk factor for CBDS(P = 0.003).The Very Strong(59.5%) and Strong(48.6%) ASGE criteria identified the majority of patients(P = 0.0001).A modified score using conjugated bilirubin had a higher sensitivity(81.2% vs 59.5%) and more likely to identify a stone than the standard criteria,odds ratio of 25.7 compared to 8.8.Alanine aminotransferase and gamma-glutamyl transferase values identified significant differences in a subset of patients with odds ratio of 4.1 and 3.25,respectively.CONCLUSION:Current adult guidelines identified the majority of pediatric patients with CBDS,but specific pediatric guidelines may improve detection,thus decreasing risks and unnecessary procedures. | Douglas S Fishman Bruno P Chumpitazi Isaac Raijman Cynthia Man-Wai Tsai E O’Brian Smith Mark V Mazziotti Mark A Gilger | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，11： | 6 |
| 3 | 2008 estimate of worldwide rotavirus-associated mortality in children younger than 5 years before the introduction of universal rotavirus vaccination programmes: a systematic review and meta-analysis显示文摘 | Jacqueline E Tate Anthony H Burton Cynthia Boschi-Pinto A Duncan Steele Jazmin Duque Umesh D Parashar | 2012 | The Lancet Infectious Diseases2012，，2： | 2 |
| 4 | Late-developing infection in instrumented idiopathic scoliosis显示文摘 | Clark RN Harry L | 1999 | Spine1999，24，： | 1 |
| 5 | Late-developing infection in instrumented idiopathic scoliosis 显示文摘 | Cynthia E Clark RN Harry L | 1999 | Spine1999，24，： | 1 |
| 6 | Immunological treatment of liver tumors显示文摘Although multiple options for the treatment of liver tumors have often been described in the past, including liver resection, radiofrequency ablation with or without hepatic pump insertion, laparoscopic liver resection and the use of chemotherapy, the potential of immunotherapy and gene manipulation is still largely unexplored.Immunological therapy by gene manipulation is based on the interaction between virus-based gene delivery systems and dendritic cells. Using viruses as vectors, it is possible to transduce dendritic cells with genes encoding tumor-associated antigens, thus inducing strong humoral and cellular immunity against the antigens themselves.Both chemotherapy and radiation therapy have the disadvantage of destroying healthy cells, thus causing severe side-effects. We need more precisely targeted therapies capable of killing cancer cells while sparing healthy cells. Our goal is to establish a new treatment for solid liver tumors based on the concept of cytoreduction,and propose an innovative algorithm. | Maurizio Chiriva-Internati Fabio Grizzi Cynthia A Jumper Everardo Cobos Paul L Hermonat Eldo E Frezza | 2005 | World Journal of Gastroenterology2005，11，42： | 1 |
| 7 | A Multilevel Examination of Work-Life Practices: Is More Always Better? 显示文摘 | Richard E Kopelman David J Prottas Cynthia A Thompson | 2006 | Journal of Managerial Issues2006，，2： | 1 |
| 8 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 9 | Subduction components and the generation of arc-like melts in the Zambales ophiolite,Philippines:Pb,Sr and Nd isotopic constraints显示文摘 | John E Samuel B M Cynthia A E | | 0，，： | 1 |
| 10 | Mycoplasma pneumoniae Protein P30 Is Required for Cytadherence and Associated with Proper Cell Development显示文摘 | Cynthia E Susan J Melisa J | 1999 | Journal of Bacteriology1999，181，4： | 1 |
| 11 | The tumor microenvironment 显示文摘 | Cynthia E Paul C | 2012 | Surgical Oncol- ogy2012，21，3： | 1 |
| 12 | Late-developing infection instrumented idiopathic scoliosis显示文摘 | Clark RN Harry L | 1999 | Spine1999，24，18： | 1 |
| 13 | The tumor microenvironment显示文摘 | Cynthia E Weber Paul C Kuo | 2012 | Surgical Oncology2012，21，3： | 1 |
| 14 | 2012 ACCF/ AHA/HRS focused update of the 2008 guidelines for device-based therapy of dardiac rhythm abnormalities : A report of the american college of cardiology founda- tion/american heart association task force on practice guidelines显示文摘 | Cynthia M Tracy E John P | 2012 | Circulation2012，126，： | 1 |
| 15 | Exercise-induced alterations in plasma con- centrations of ghrelin, adiponectin, leptin, glucose, insulin, and cortisol in horses显示文摘 | MARY E GORDON KENNETH H MCKEEVER CYNTHIA L BETROS | 2007 | The Veterinary J2007，173，3： | 1 |
| 16 | Late-development infection instrumented idiopathic scoliosis显示文摘 | Cynthia E Clark RN Harry L | 1999 | Spine1999，24，18： | 1 |
| 17 | Current status of phthaloeyanines in photodynamie therapy of cancer 显示文摘 | Cynthia M A Wesley M S Johan E V L | 2001 | J Porphyrins Phthalocyanines2001，5，： | 1 |
| 18 | Modeling the effect of shelterbelts on maize projuctivity under climate change:An application of the EPIC model显示文摘 | William E E Cynthia J Mary M E | 1997 | Agriculture Ecosystems & Environment1997，61，： | 1 |
| 19 | The Dynamics of AdaBoost : Cyclic Behavior and Convergence of Margins 显示文摘 | CYNTHIA R DAUBECHIES I SCHAPIRE R E | 2004 | Journal of Machine Learning Research2004，5，： | 1 |
| 20 | Measuring security price performance using daily NASDAQ returns 显示文摘 | Campbell Cynthia J Wasley Charles E | 1993 | Journal of Financial Economics1993，33，1： | 1 |
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