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| 1 | Histone deacetylases,microRNA and leptin crosstalk in pancreatic cancer显示文摘Because pancreatic cancer(PC) historically has had poor prognosis and five year survival rates,it has been intensely investigated.Analysis of PC incidence and biology has shown a link between different risk factors such as smoking,alcoholism,and obesity and disease progression.Important factors affecting PC include the epigenomic changes driven by DNA methylation and histone acetylation,and actions of microRNA inducing oncogenic or tumor suppressor effects.Studies have identified markers whose dysregulation seem to play important roles in PC progression.PC markers involve classical histone deacetylases(HDAC),PC stem cell(PCSC),and leptin.In this review,we discuss the role of several PC biomarkers,and the potential crosstalk between HDAC,microRNA,and leptin in PC progression.Dysregulated expression of these molecules can increase proliferation,survival,PCSC,resistance to chemotherapy and tumor angiogenesis.The potential relationships between these molecules are further analyzed using data from The Cancer Genome Atlas and crosstalk pathways generated by the Pathway Studio Platform(Ariadne Genomics,Inc.).Oncogenic miRNA21 and tumor suppressor miRNA200 have been previously linked to leptin signaling.Preliminary analysis of PC biopsies and signaling crosstalk suggests that the main adipokine leptin could affect the expression of microRNA and HDAC in PC.Data analysis suggests that HDAC-microRNA-leptin signaling crosstalk may be a new target for PC therapy. | Cynthia I Tchio Mantho Adriana Harbuzariu Ruben R Gonzalez-Perez | 2017 | World Journal of Clinical Oncology2017，8，3： | 2 |
| 2 | A comparison among animal model of acute lung injury显示文摘 | Cynthia R Catherine C Carolyn Q | 1998 | Crit Care Med1998，26，： | 2 |
| 3 | (2008) It's time for a change in practice:reducing antibiotic use can alter antibiotic resistance 显示文摘 | Cindy R Friedman Cynthia C Whitney | 2008 | The Journal of Infectious Diseases2008，197，8： | 1 |
| 4 | Epidemiologyand eti- ology of childhood pneumonia 显示文摘 | Igor R Cynthia BP Zrinka B | 2008 | Bulletin of the World Health Organization2008，86，5： | 1 |
| 5 | Development and validation of algorithms for heart failure patient care: a Delphi study显示文摘 | Cynthia PG Asri R Kevin LJ | 2015 | Singapore Med J2015，56，4： | 1 |
| 6 | Update on cell therapy for stroke显示文摘Ischaemic stroke remains a leading cause of death and disability.Current stroke treatment options aim to minimise the damage from a pending stroke during the acute stroke period using intravenous thrombolytics and endovascular thrombectomy;however,there are no currently approved treatment options for reversing neurological damage once a stroke is completed.Preclinical studies suggest that cell therapy may be safe and effective in improving functional outcomes.Several recent clinical trials have reported safety and some improvement in outcomes following cell therapy administration in ischaemic stroke,which are reviewed.Cell therapy may provide a promising new treatment for stroke reducing stroke-related disability.Further investigation is needed to determine specific effects of cell therapy and to optimise cell delivery methods,cell dosing,type of cells used,timing of delivery,infarct size and location of infarct that are likely to benefit from cell therapy. | Cynthia L Kenmuir Lawrence R Wechsler | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 7 | Behavioral Interventions to Address Sleep Disturbances in Children with Autism Spectrum Disorders:A Review 显示文摘 | Kylan S T Cynthia R J | 2013 | Topics in Early Childhood Special Education2013，33，3： | 1 |
| 8 | Flow field in straight and t apered screw extruders using magnetic resonance imaging显示文摘 | Cynthia K A Kauten R J Mccarthy K L | 1995 | Jourhal of Food Engineering1995，25，1： | 1 |
| 9 | Roles of transition nuclear proteins in spermatogenesis 显示文摘 | MARVIN L MEISTRICH BHAGYALAXMI M CYNTHIA R SHIRLEY | 2003 | Chromosoma2003，111，： | 1 |
| 10 | Determination of trans fat in edible oils : current official methods and overview of re- cent developments 显示文摘 | Cynthia T Magdi M M Jeanne I R | 2013 | Analytical and bioanalytical chemis- try2013，405，17： | 1 |
| 11 | Clinicians' Attitudes to Clinical Practice Guidelines: a systematic review显示文摘 | Emma W K Jean R S | 2002 | MJA2002，177，9： | 1 |
| 12 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 13 | Building the New World Order BRIC by BRIC显示文摘 | Cynthia R | | 0，，： | 1 |
| 14 | Soils and global climate change: changes andopportunities显示文摘 | Cynthia R Daniel H | 2000 | Soil Science2000，165，： | 1 |
| 15 | Nighttime blood pressure dipping: the role of the sympathetic nervous system显示文摘 | Andrew Sherwood Patrick R Steffen James A Blumenthal Cynthia Kuhn Alan L Hinderliter | 2002 | American Journal of Hypertension2002，，2： | 1 |
| 16 | Microbicidal action of lactoferrin and lactoferricin and their synergistic effect with metronidazole in Entamoeba histolytica显示文摘 | Nidia L S Magda R L Cynthia O P | 2006 | Biochem Cell2006，84，： | 1 |
| 17 | Translational investigation ketamine reduces the cell death following inflammatory pain in newborn rat brain 显示文摘 | Anand-Kanwaljeet JS Garg S Rovnaghi Cynthia R | 2007 | Pediatric Res2007，62，3： | 1 |
| 18 | Epidemiology and etiolo- gy of childhood pneumonia显示文摘 | Igor R Cynthia BP Zrinka B | 2008 | Bulletin of the World Heath Organization2008，86，5： | 1 |
| 19 | Electronic reverse auction configuration and its impact on buyer price and supplier perceptions of opportunism: A laboratory experiment显示文摘 | Craig R Cartera and Cynthia Kay Stevens | 2007 | Journal of Operations Management2007，25，5： | 1 |
| 20 | The Effects of Intensive Glycemic Control on Neuropathy in the VA Cooperative Study on Type II Diabetes Mellitus (VA CSDM)显示文摘 | Nasrin Azad Nicholas V Emanuele Carlos Abraira William G Henderson John Colwell Seymore R Levin Frank Q Nuttall John P Comstock Clark T Sawin Cynthia Silbert Frank A Rubino | 2000 | Journal of Diabetes and Its Complications2000，，5： | 1 |
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