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| 1 | The Tartary Buckwheat Genome Provides Insights into Rutin Biosynthesis and Abiotic Stress Tolerance显示文摘 | Zhang, Lijun Li, Xiuxiu Ma, Bin Gao, Qiang Du, Huilong Han, Yuanhuai Li, Yan Cao, Yinghao Qi, Ming Zhu, Yaxin Lu, Hongwei Ma, Mingchuan Liu, Longlong Zhou, Jianping Nan, Chenghu Qin, Yongjun Wang, Jun Cui, Lin Liu, Huimin Liang, Chengzhi Qiao, Zhijun | 2017 | Molecular Plant2017，10，9： | 53 |
| 2 | Reprogramming of ovine adult fibroblasts to pluripotency via drug-inducible expression of defined factors显示文摘在 enucleated 鸡蛋的体的房间的 Reprogramming 做了多丽,绵羊,在 1996 的第一个成功地克隆的哺乳动物。然而,绵羊的机制体的房间 reprogramming 还没被探讨了。而且,绵羊胚胎的茎(ES ) 细胞仍然不是可得到的,它限制精确修改基因的绵羊的产生。在这研究,我们报导体的房间能是的那只绵羊直接 reprogrammed 到导致的 pluripotent 用定义因素(Oct4, Sox2, c-Myc, Klf4, Nanog, Lin28, SV40 大 T 和 hTERT ) 的茎(iPS ) 房间。我们的观察显示从绵羊的体的细胞比从另外的种,在 iPS,细胞被报导了的体的细胞对改编更困难。我们证明绵羊 iPS 房间表示 ES 房间标记,包括碱的磷酸酶, Oct4, Nanog, Sox2, Rex1,阶段特定的胚胎的 antigen-1, TRA-1-60, TRA-1-81 和 E-cadherin。绵羊 iPS 房间展出了正常 karyotypes 并且能在 vitro 并且在 teratomas 区分进所有三细菌层。我们的学习可以帮助在绵羊揭示体的房间 reprogramming 的机制并且提供一个平台为绵羊 ES 房间探索文化条件。而且,绵羊 iPS 房间可以直接被用来产生精确修改基因的绵羊。 | Lei Bao Lixiazi He Jijun Chen Zhao Wu Jing Liao Lmgdun Rao Jiangtao Ren Hui Li Hui Zhu Lei Qian Yijun Gu Huimin Dai Xun Xu Jinqiu Zhou Wen Wang Chun Cui Lei Xiao | 2011 | Cell Research2011，21，4： | 32 |
| 3 | An ACC Oxidase Gene Essential for Cucumber Carpel Development显示文摘在植物的性决心产生便于 outcrossing 并且提高基因差异的单性的花。在黄瓜和甜瓜,乙烯支持心皮开发并且逮捕雄蕊开发。五性决心基因被识别了,包括四个编码在乙烯生合成催化限制率的步骤的 1-aminocyclopropane-1-carboxylate (ACC ) synthase,和抄写因素基因在甜瓜对应于孟德尔的地点 gynoecious 并且是女性的一个否定管理者的 CmWIP1。ACC oxidase (ACO ) 把 ACC 变换成乙烯;然而,它留下逃犯在黄瓜染色体的基因为性决心是它 ACO 并且怎么批评的 CmWIP1 镇压女花的开发。在这研究,我们在 ACO 基因发现了那个变化, CsACO2,在忍受仅仅男的花的黄瓜授与 androecy。变化破坏 CsACO2 的酶的活动,导致从射击尖端的 50% 更少的乙烯排放。CsACO2 在心皮 primordia 被表示,它的表示为性决心在关键阶段在女花与 CsACS11 的重叠了,大概提供为合适的 CsACS2 要求的足够的乙烯表示。CmACO3, CsACO2 的 ortholog,在心皮区域显示出一个类似的表示模式,建议 CsACO2/CmACO3 的保存功能。我们表明了那 CsWIP1, CmWIP1 的 ortholog,能直接绑 CsACO2 的倡导者并且镇压它的表示。一起拿,我们建议由 WIP1 抄写因素和 ACO 组成的一个大概保存的规章的模块在黄瓜和甜瓜控制单性的花开发。 | Huiming Chen Jinjing Sun Shuai Li Qingzhi Cui Huimin Zhang Fengjiao Xin Huaisong Wang Tao Lin Dongli Gao Shenhao Wang Xia Li Donghui Wang Zhonghua Zhang Zhihong Xu Sanwen Huang | 2016 | Molecular Plant2016，9，9： | 16 |
| 4 | Efficacy of capecitabine-based combination therapy and singleagent capecitabine maintenance therapy in patients with metastatic breast cancer显示文摘Objective: The purpose of this study was to observe the efficacy and toxicities of capecitabine-based chemotherapy and capecitabine monotherapy as maintenance therapy in the treatment of metastatic breast cancer(MBC).Patients and methods: A total of 98 MBC patients were treated with capecitabine combined with vinorelbine(NX). Results: The median number of treatment was 6 cycles(1-7 cycles). There were two cases of complete remission(CR), 58 partial remission, 27 stable disease(SD), 11 progression disease. The overall response rate(ORR)(CR + PR) was 61.2%. The clinical benefit rate(CBR) was 75.5%. Fifty of effective patients received with capecitabine monotherapy as maintenance therapy. The ORR(CR + PR) was 4%. The CBR was 48%. The median progression-free survival(PFS) was 12 months. In maintenance therapy or not, the median post metastasis survival rate(MSR) was 63 and 28 months, respectively. In the combination therapy group, the major grade 3/4 toxicities included hand-foot syndrome(3.1%), skin pigmentation(2.0%), diarrhoea and abdominal distension(5.1%), stomatitis(1.0%), and leukopenia(20.4%).Conclusions: Capecitabine-based combination therapy and single-agent capecitabine maintenance therapy were well tolerated and effective to MBC. | Huimin Lv Min Yan Mengwei Zhang Limin Niu Huiai Zeng Shude Cui | 2014 | Chinese Journal of Cancer Research2014，26，6： | 8 |
| 5 | Effect of cold rolling process on microstructure and mechanical properties of high strength β titanium alloy thin sheets显示文摘The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short time.Compared to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching. | Yan Ma Zhaoxin Du Xiaoming Cui Jun Cheng Guolong Liu Tianhao Gong Huimin Liu Xiaopeng Wang Yuyong Chen | 2018 | Progress in Natural Science:Materials International2018，28，6： | 6 |
| 6 | IL-17A-dependent gut microbiota is essential for regulating diet-induced disorders in mice显示文摘The gut microbiota plays a key role in obesity and related metabolic disorders, and multiple factors including diet, host genotype, and age regulate it. Many studies have examined the contribution of extrinsic factors to the regulation of the gut microbiota, but the importance of the host genetic constitution cannot be ignored. Interleukin 17A(IL-17A), a pro-inflammatory cytokine, is important in the defense against infection and diseases. Here, we investigated the association among IL-17, a high-fat diet(HFD), and the gut microbiota. Mice deficient in IL-17A were resistant to diet-induced obesity and related diseases. Compared with the Ⅱ-17^(-/-)mice, wild-type(WT) mice challenged with HFD showed obvious weight fluctuations, such as those seen in type 2 diabetes, and hematological changes similar to those associated with metabolic syndrome. However, housing WT mice and Ⅱ-17a^(-/-)mice together significantly alleviated these symptoms in the WT mice. A metagenomic analysis of the mouse feces indicated that the microbial community compositions of these two groups differed before HFD feeding. The HFD mediated shifts in the gut microbial compositions, which were associated with the mouse phenotypes.We also identified potentially beneficial and harmful species present during this period, and drew networks of the most abundant species. A functional analysis indicated pathway changes in the WT and Ⅱ-17a^(-/-)mice when fed the HFD. Collectively, these data underscore the importance of the host factor IL-17 A in shaping and regulating the gut microbiota, which conversely, influences the host health. | Yujing Bi Chunxiao Li Lin Liu Jiyuan Zhou Zhengchao Li Huimin Deng Chunyan Wu Yanping Han Yajun Song Yafang Tan Xiaoyi Wang Zongmin Du Yujun Cui Yanfeng Yan Fachao Zhi Guangwei Liu Nan Qin Heping Zhang Ruifu Yang | 2017 | Science Bulletin2017，62，15： | 5 |
| 7 | Antagonism of toll-like receptor 2 attenuates the formation and progression of abdominal aortic aneurysm显示文摘Abdominal aortic aneurysm(AAA) is an inflammatory vascular disorder with high mortality.Accumulating evidence shows that toll-like receptor 2(TLR2) plays a critical role in the regulation of wound-repairing process after tissue injury.We wondered if TLR2 signaling contributed to the pathogenesis of AAA and that targeting TLR2 would attenuate AAA development and progression.In this study,enhanced expression of TLR2 and its ligands were observed in human AAA tissue.Neutralization of TLR2 protected against AAA development and caused established AAA to regress in mouse models of AAA.In addition,TLR2-deficient mice also failed to develop AAA.The prophylactic and therapeutic effects of blocking TLR2 were accompanied by a significant resolution of inflammation and vascular remodeling,as indicated by the decreased expression or activity of MMP-2/9,α-SMA,inflammatory cytokines,and transcription factors NF-κB,AP-1 and STAT1/3 in AAA tissue.Mechanistically,blocking TLR2 decreased the expression and interaction of TLR2 and several endogenousligands,which diminished chronic inflammation and vascular remodeling in the vascular tissue of AAA.Our studies indicate that the interactions between TLR2 and its endogenous ligands contribute to the pathogenesis of AAA and that targeting TLR2 offers great potential toward the development of therapeutic agents against AAA. | Huimin Yan Bing Cui Xiaowei Zhang Xiaoming Fu Jun Yan Xiaoxing Wang Xiaoxi Lv Zhong Chen Zhuowei Hu | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 3 |
| 8 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 9 | Derivation and characterization of human embryonic stem cell lines from the Chinese population显示文摘人的胚胎的干细胞(hESCs ) 无止境地装自我更新并且在人的身体区分进所有房间类型。因此,他们在再生药,人的发展生物学和药发现是珍贵的。很多根 hESC 线从中国人口被导出,但是他们限制了为研究目的是可得到的。这里,我们报导线从中国起源的人的胚囊导出的二 hESC 的推导和描述。这些 hESCs 快车碱的磷酸酶和 hESC 特定的标记,包括的 Oct4, Nanog, SSEA-3, SSEA-4, TRA-1-60 和 TRA-1-81。他们也有 telomerase 活动和正常 karyotypes 的高水平。这些房间能在 vitro 形成胚胎植物或动物身体并且能被 teratoma 形成在 vivo 区分进所有三细菌层。最新确定的 hESCs 将为研究目的被散布。从中国人口的 hESC 线的可获得性将从不同的种族组在 hESCs 在差别上便于研究。 | Zhao Wu Hui Li Lingjun Rao Lixiaz iHe Lei Bao Jing Liao Chun Cui Zhenyu Zuo Qiao Li Huimin Dai Lei Qian Qing Tian Lei Xiao Xiao junTan | 2011 | Journal of Genetics and Genomics2011，38，1： | 3 |
| 10 | The relationship between managerial ownership and firm performance in high R&D firms显示文摘 | Huimin Cui Y.T.Mak | | 0，，08： | 1 |
| 11 | The relationship between managerial ownership and firm performance in high R&D firms显示文摘 | Cui Huimin Mak Y T | | 0，，： | 1 |
| 12 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 13 | The Relationship Between Managerial Ownership and Firm Performance in High R&D Firms显示文摘 | Huimin Cui Y T Mak | 2002 | Journal of Corporate Finance2002，8，4： | 1 |
| 14 | Effects of Bias Voltage on the Microstructure and Mechanical Properties of (T i, M, Car)N Hard Films with N-Gradient Distributions显示文摘 | Zhang Jun Lv Huimin Cui Guanying | 2011 | Thin Sohd Fihns2011，519，15： | 1 |
| 15 | The relationship between managerial ownership and firm performance in high R&D firms 显示文摘 | Huimin Cui Mak Y T | 2002 | Journal of Corporate Finance2002，，8： | 1 |
| 16 | The relationship between managerial ownership and firm performance in high R:D firms 显示文摘 | CUI Huimin MAK Y T | 2002 | Journal of Corporate Finance2002，，8： | 1 |
| 17 | Improved Thr-eshold Denoising Method Based on Wavelet Transform显示文摘 | Cui Huimin Zhao Ruimei HOU Yanli | 2012 | Physics Procedia2012，，33： | 1 |
| 18 | Improved threshold denoising method based on wavelet transform 显示文摘 | CUI Huimin ZHAO Ruimei HOU Yanli | 2012 | Physics procedia2012，33，： | 1 |
| 19 | Core-shell-structured Co@Co4N nanoparticles encapsulated into MnO-modified porous N-doping carbon nanocubes as bifunctional catalysts for rechargeable Zn–air batteries显示文摘Designing the highly catalytic activity and durable bifunctional catalysts toward oxygen reduction/evolution reaction(ORR/OER) is paramount for metal–air batteries. Metal–organic frameworks(MOFs)-based materials have attracted a great deal of attention as the potential candidate for effectively catalyzing ORR/OER due to their adjustable composition and porous structure. Herein, we first introduce the Mn species into zeolitic-imidazole frameworks(ZIFs) and then further pyrolyze the Mn-containing bimetallic ZIFs to synthesize core-shell-structured Co@Co4N nanoparticles embedded into MnO-modified porous N-doped carbon nanocubes(Co@Co4N/MnO–NC). Co@Co4N/MnO–NC exhibits the outstanding catalytic activity toward ORR and OER which is attributed to its abundant pyridinic/graphitic N and Co4N,the optimized content of MnO species, highly dispersed catalytic sites and porous carbon matrix. As a result, the Co@Co4N/MnO–NC-based Zn–air battery exhibits enhanced performances, including the high discharge capacity(762 mA h gZn-1), large power density(200.5 mW cm-2), stable potential profile over 72 h, low overpotential(<1.0 V) and superior cycling life(2800 cycles). Moreover, the belt-shaped Co@Co4N/MnO–NC cathode-based Zn–air batteries are also designed which exhibit the superb electrochemical properties at different bending/twisting conditions. | Fengmei Wang Huimin Zhao Yiru Ma Yu Yang Bin Li Yuanyuan Cui Ziyang Guo Lei Wang | 2020 | Journal of Energy Chemistry2020，29，11： | 1 |
| 20 | The Relationship Between Managerial Ownership and Firm Performance in High R&D Firms显示文摘 | CUI HUIMIN Y.T.MAK | | 0，，08： | 1 |
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