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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Clinical significance of granuloma in Crohn's disease显示文摘AIM: Granuloma is considered the hallmark of microscopic diagnosis in Crohn's disease (CD), but granulomas can be detected in only 21-60% of CD patients. The aim of this studywas to evaluate the frequency of granulomas by multiple endoscopic biopsies in patients with CD and to examine whether group of patients with or without granuloma exhibit a different clinical course.METHODS: Fifty-six patients with newly diagnosed Cdwere included in the study. Jejunoscopy, enteroclysis and ileo-colonoscopy were performed in all patients. At least two biopsy specimens from each examined gastrointestinal segment were examined microscopically searching granuloma. The clinical course was followed in all patients, and extraintestinal manifestations as well as details of any immunosuppressive therapy and surgical intervention were noted.RESULTS: Granuloma was found in 44.6% of the cases (25 patients). Patients with granuloma had higher activity parameters at the time of the biopsies. Extraintestinal manifestations were observed and surgical interventions were performed more often in the granuloma group. The need of immunosuppressive therapy was significantly more frequent in the patients with granuloma. Granuloma formation is more often seen in younger patients, and mainly in the severe, active penetrating disease. CONCLUSION: The significantly higher frequency of surgical interventions and immunosuppressive therapy suggests that granuloma formation is associated with a more severe disease course during the first years of CD. | Tamás Molnár László Tiszlavicz Csaba Gyulai Ferenc Nagy János Lonovics | 2005 | World Journal of Gastroenterology2005，11，20： | 5 |
| 3 | The hyperbolic tangent distribution family 显示文摘 | TIBOR B BELA L CSABA M | 1998 | Powder Technology1998，97，： | 2 |
| 4 | Amplification of hormone receptors by neonatal oxytocin and vasopressin treatment显示文摘 | Csaba G Rónai A László V | | 0，，01： | 1 |
| 5 | Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?显示文摘 | P. Ferdinandy Tamás Csont Csaba Csonka Marianna T?r?k Mária Dux József Németh László I. Horváth László Dux Zoltán Szilvássy Gábor Jancsó | 1997 | Naunyn - Schmiedeberg’s Archives of Pharmacology1997，，3： | 1 |
| 6 | The effects of vitamin E on tissue oxidation in nephrotoxic (anti-glomerular basement membrane) nephritis显示文摘 | Em?ke Endreffy Sándor Túri Zoltán Lászik Csaba Bereczki Katalin Kása | 1991 | Pediatric Nephrology1991，，3： | 1 |
| 7 | Production of a defensin-like antifungal protein NFAP from Neosartorya fischeri in Pichia pastoris and its antifungal activity against filamentous fungal isolates from human infections显示文摘 | Máté Virágh Dóra V?r?s Zoltán Kele Laura Kovács ádám Fizil Gergely Lakatos Gergely Maróti Gyula Batta Csaba Vágv?lgyi László Galgóczy | 2014 | Protein Expression and Purification2014，，： | 1 |
| 8 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 9 | Light-dependent induction of proline biosynthesis by abscisic acid and salt stress is inhibited by brassinosteroid in Arabidopsis显示文摘 | Edit ábrahám Gábor Rigó Gy?ngyi Székely Réka Nagy Csaba Koncz László Szabados | 2003 | Plant Molecular Biology2003，，3： | 1 |
| 10 | The caudal end of the rat spinal cord: transformation to and uhrastructure of the ilium terminale 显示文摘 | Miklos R Erika L Csaba B | 2004 | Brain Research2004，1028，1： | 1 |
| 11 | Cholinergic excition of septohippocampal GABA but not choliergic neurons: implications for learning and memory显示文摘 | Min Wu Marya SB Csaba L | 2000 | The Journal of Neuronscince2000，20，10： | 1 |
| 12 | Majority logic gate for magnetic quantum-dot cellular automata 显示文摘 | IMRE A CSABA G JI L L | 2006 | Science2006，311，5758： | 1 |
| 13 | Majority Logic Gate for Magnetic Quantum-dot Cellular Automata显示文摘 | Imre A Csaba G Ji L L | 2006 | Science2006，311，5758： | 1 |
| 14 | Serum interleukin6 and bone metabolism in patients with thyroid funtion disorder显示文摘 | Peter L Janos F Csaba H | 1997 | J Clin Endocrinol Metab1997，82，1： | 1 |
| 15 | Prenatal sonographic findings in 207 fetuses with trisomy 21显示文摘 | Csaba Papp Zoltán Bán Zsanett Szigeti ákos Csaba Levente Lázár Gy. Richard Nagy Zoltán Papp | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 1 |
| 16 | The proteasome inhibitor MG132 protects against acute pancreatitis 显示文摘 | Tama's L Csaba S Tama's T | 2005 | Free Radic Biol Med2005，39，9： | 1 |
| 17 | Cholinergic excition of septohippocampal GABA but not choliergic neurons: implications for learning and memory 显示文摘 | WU M MARYA S CSABA L | 2000 | J Neuronscince2000，20，10： | 1 |
| 18 | Diabetes mellitus at- tenuates the repolarization reserve in mammalian heart显示文摘 | Csaba L Laszlo V Tamas B | 2007 | Cardiovasc Res2007，73，3： | 1 |
| 19 | Gallbladder hypomotility in diabetic polyneuropathy显示文摘 | Tamás T. Várkonyi M.D. Csaba Lengyel M.D. László Madácsy M.D. Borbála Vel?sy M.D. Ph.D. Péter Kempler M.D. Ph.D. D.Sc. Tamás Fazekas M.D. Ph.D. D.Sc. László Pávics M.D. Ph.D. László Csernay M.D. Ph.D. D.Sc. János Lonovics M.D. Ph.D | 2001 | Clinical Autonomic Research2001，，6： | 1 |
| 20 | Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis显示文摘AIM: In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8), the process of regeneration following L-arginine (Arg)-induced pancreatitis is accelerated. In rats that were also diabetic (induced by streptozotocin, STZ), pancreatic regeneration was not observed. The aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats.METHODS: Male Wistar rats were used for the experiments.Diabetes mellitus was induced by administering 60 mg/kg body mass of STZ intraperitoneally (i.p.), then, on d 8, pancreatitis was induced by 200 mg/100 g body mass Argi.p. twice at an interval of 1 h. The animals were injected subcutaneously twice daily (at 7 a.m. and 7 p.m.) with 1 μglkg of CCK-8 and/or 2 IU mixed insulin (300 g/L shortaction and 700 g/L intermediate-action insulin) for 14 d after pancreatitis induction. Following this the animals were killed and the serum amylase, glucose and insulin levels as well as the plasma glucagon levels, the pancreatic mass/body mass ratio (pm/bm), the pancreatic contents of DNA, protein, amylase, lipase and trypsinogen were measured. Pancreatic tissue samples were examined by light microscopy on paraffin-embedded sections.RESULTS: In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein, amylase and lipase vs the rats receiving only CCK-8 treatment. CCK-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities, whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats.CONCLUSION: Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats,the simultaneous administration of exogenous insulin restored this effect. Our results clearly demonstrate that insulin is necessary for the hypertrophic effect of low-doses of CCK-8 following acute pancreatitis. | Péter Hegyi Zoltán RakonczayJr Réka Sári László Czakó Norbert Farkas Csaba Góg József Németh János Lonovics Tamás Takács | 2004 | World Journal of Gastroenterology2004，10，15： | 1 |
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