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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | The hyperbolic tangent distribution family 显示文摘 | TIBOR B BELA L CSABA M | 1998 | Powder Technology1998，97，： | 2 |
| 3 | Crucial role of endogenous interleukin-lO production in myocardial ischemia/reperfusion injury' 显示文摘 | Yang Z Zingarelli B Csaba S | 2000 | Circulation2000，101，9： | 1 |
| 4 | Aggression to dummy cuckoos by potential European cuckoo hosts显示文摘 | Eivin R?skaft Arne Moksnes B?rd G. Stokke Vítezslav Bicík Csaba Moskát | | Behaviour0，，： | 1 |
| 5 | The caudal end of the rat spinal cord: transformation to and uhrastructure of the ilium terminale 显示文摘 | Miklos R Erika L Csaba B | 2004 | Brain Research2004，1028，1： | 1 |
| 6 | Preparation of chitosan particles suitable for enzyme immobilization显示文摘 | EMESE B AGNES S N CSABA S | 2008 | Biochem Biophys Methods2008，70，6： | 1 |
| 7 | Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autop- sy in fetuses with trisomy 21显示文摘 | Szigeti Z Csaba A Pete B | 2007 | Journal of Ultrasound in Medicine2007，26，1： | 1 |
| 8 | Optimal (short-term) pump schedule detection for water distribution systems by neutral evolutionary search 显示文摘 | ISTVAN S JOZSEF G B CSABA H | 2012 | Applied Soft Computing2012，12，23： | 1 |
| 9 | Building development monitoring in multitemporal remotely sensed image pairs with stochastic birth-death dynamics显示文摘 | Csaba B Xavier D Josiane Z | 2012 | IEEE Transactions on Pattern Analysis and Machine Intelligence2012，34，1： | 1 |
| 10 | Morphological evaluation and comparison of Hungarian and Turkish melon ( Cucumis melo L.) germplasm显示文摘 | Csaba Szamosi Ilknur Solmaz Nebahat Sari Csaba Bársony | 2009 | Scientia Horticulturae2009，，2： | 1 |
| 11 | Crucial role of endogenous interleukin10 production in myocardial ischemia/reperfusion injury显示文摘 | Yang Z Zingarelli B Csaba S | 2000 | Circulation2000，101，9： | 1 |
| 12 | Crucial role of endogenous interleukin- 10 production in myocardial ischemia/reperfusion injury 显示文摘 | Yang Z Zingarelli B Csaba C | 2000 | Circulation2000，101，： | 1 |
| 13 | Correlation of prenatal sonographic diagnosis and morphologic fingings of fetal autopsy in fetuses with trisomy 21 显示文摘 | Szigeti Z Csaba A Pete B | 2007 | J Ultrasound Med2007，26，1： | 1 |
| 14 | A special fructose bisphosphate functions as a cytoplasmic regulatory metabolite in green leaves显示文摘 | Csaba C Norman F W Bob B B | 1982 | Proc Natd Acad Sci1982，79，： | 1 |
| 15 | Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autopsyin fetuses with trisomy 21显示文摘 | Szigeti Z Csaba A Pete B | | 0，，01： | 1 |
| 16 | Anxitey as an independent cardiovascular risk显示文摘 | Csaba B M | 2006 | Neu- ropsychophamacol Hung2006，8，1： | 1 |
| 17 | Correlation of prenatal sonographic diagnosis and morphologic findings of fetal autopsy in fetuses with trisomy 21显示文摘 | Szigeti Z Csaba A Pete B | 2007 | J Ultrasound Med2007，26，1： | 1 |
| 18 | Correlation of prenatal sonographiediagnosis and morphologic findings of fetal autop- syin fetuses with trisomy 21 显示文摘 | Szlgeti Z Csaba A Pete B | 2007 | JUltrasound Med2007，26，1： | 1 |
| 19 | Change detection in optical aerial images by a multi-layer conditional mixed markov model 显示文摘 | Csaba B Tams S | 2009 | IEEE Trans- actions on Geoscience and Remote Sensing2009，47，10： | 1 |
| 20 | Prenatal sonographic findings in 207 fetuses with trisomy 21显示文摘 | Csaba Papp Zoltán Bán Zsanett Szigeti ákos Csaba Levente Lázár Gy. Richard Nagy Zoltán Papp | 2006 | European Journal of Obstetrics and Gynecology2006，，2： | 1 |
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