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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 3 | Similarities and dissimilarities of newborn and adolescent rats in the binding capacity of thymic glucocorticoid receptors显示文摘 | Csaba G Inczefi-Gonda A | 2001 | Mech Ageing Dev2001，122，： | 1 |
| 4 | Amplification of hormone receptors by neonatal oxytocin and vasopressin treatment显示文摘 | Csaba G Rónai A László V | | 0，，01： | 1 |
| 5 | Capsaicin-sensitive local sensory innervation is involved in pacing-induced preconditioning in rat hearts: role of nitric oxide and CGRP?显示文摘 | P. Ferdinandy Tamás Csont Csaba Csonka Marianna T?r?k Mária Dux József Németh László I. Horváth László Dux Zoltán Szilvássy Gábor Jancsó | 1997 | Naunyn - Schmiedeberg’s Archives of Pharmacology1997，，3： | 1 |
| 6 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 7 | Light-dependent induction of proline biosynthesis by abscisic acid and salt stress is inhibited by brassinosteroid in Arabidopsis显示文摘 | Edit ábrahám Gábor Rigó Gy?ngyi Székely Réka Nagy Csaba Koncz László Szabados | 2003 | Plant Molecular Biology2003，，3： | 1 |
| 8 | Optimal (short-term) pump schedule detection for water distribution systems by neutral evolutionary search 显示文摘 | ISTVAN S JOZSEF G B CSABA H | 2012 | Applied Soft Computing2012，12，23： | 1 |
| 9 | Controlled domain wall motion in micron-scale permalloy square rings 显示文摘 | Imre A Csaba G Metlushko V | 2003 | PhysicaE2003，19，： | 1 |
| 10 | Majority logic gate for magnetic quantum-dot cellular automata 显示文摘 | IMRE A CSABA G JI L L | 2006 | Science2006，311，5758： | 1 |
| 11 | Closely Spaced Nanomagnets by Dual E-beam Exposure for Low-energy Nanomagnet Logic 显示文摘 | Shah F A Csaba G Butler K | 2013 | Journal of Applied Physics2013，113，17： | 1 |
| 12 | Majority Logic Gate for Magnetic Quantum-dot Cellular Automata显示文摘 | Imre A Csaba G Ji L L | 2006 | Science2006，311，5758： | 1 |
| 13 | Thyrotropic hormone (TSH) regulation of triiodothyronine (T3) concentration in immune cells显示文摘 | Csaba G Pa′llinger E | 2009 | Inflamm Res2009，58，： | 1 |
| 14 | Switching Behavior of Sharply Pointed Nanomagnets for Logic Applications 显示文摘 | Dey H Csaba G Hu X S | 2013 | IEEE Transactions on Magnetics2013，49，7： | 1 |
| 15 | Transgenerational effect of a single neonatal ben zpyrene treatment on the glucocorticoid receptor of the rat thymus显示文摘 | Csaba G Inczefi GA | 1998 | Hum Exp Toxicol1998，17，： | 1 |
| 16 | Effects of taxol treatment on the microtubular system and mitochondria of Tetra hymena显示文摘 | Kovács P Csaba G Pallinger E Czaker R | | 0，，： | 1 |
| 17 | Insulin is necessary for the hypertrophic effect of cholecystokinin-octapeptide following acute necrotizing experimental pancreatitis显示文摘AIM: In previous experiments we have demonstrated that by administering low doses of cholecystokinin-octapeptide (CCK-8), the process of regeneration following L-arginine (Arg)-induced pancreatitis is accelerated. In rats that were also diabetic (induced by streptozotocin, STZ), pancreatic regeneration was not observed. The aim of this study was to deduce whether the administration of exogenous insulin could in fact restore the hypertrophic effect of CCK-8 in diabetic-pancreatitic rats.METHODS: Male Wistar rats were used for the experiments.Diabetes mellitus was induced by administering 60 mg/kg body mass of STZ intraperitoneally (i.p.), then, on d 8, pancreatitis was induced by 200 mg/100 g body mass Argi.p. twice at an interval of 1 h. The animals were injected subcutaneously twice daily (at 7 a.m. and 7 p.m.) with 1 μglkg of CCK-8 and/or 2 IU mixed insulin (300 g/L shortaction and 700 g/L intermediate-action insulin) for 14 d after pancreatitis induction. Following this the animals were killed and the serum amylase, glucose and insulin levels as well as the plasma glucagon levels, the pancreatic mass/body mass ratio (pm/bm), the pancreatic contents of DNA, protein, amylase, lipase and trypsinogen were measured. Pancreatic tissue samples were examined by light microscopy on paraffin-embedded sections.RESULTS: In the diabetic-pancreatitic rats treatment with insulin and CCK-8 significantly elevated pw/bm and the pancreatic contents of protein, amylase and lipase vs the rats receiving only CCK-8 treatment. CCK-8 administered in combination with insulin also elevated the number of acinar cells with mitotic activities, whereas CCK-8 alone had no effect on laboratory parameters or the mitotic activities in diabetic-pancreatitic rats.CONCLUSION: Despite the hypertrophic effect of CCK-8 being absent following acute pancreatitis in diabetic-rats,the simultaneous administration of exogenous insulin restored this effect. Our results clearly demonstrate that insulin is necessary for the hypertrophic effect of low-doses of CCK-8 following acute pancreatitis. | Péter Hegyi Zoltán RakonczayJr Réka Sári László Czakó Norbert Farkas Csaba Góg József Németh János Lonovics Tamás Takács | 2004 | World Journal of Gastroenterology2004，10，15： | 1 |
| 18 | Introduction of the family Alloherpesviridae: the first molecular detection of herpesviruses of cyprinid fish in Hungary显示文摘 | Doszpoly A Benko M Csaba G | 2011 | Magyar Allatorvosok Lapja2011，133，3： | 1 |
| 19 | Effects of treatment with the plant hormone gibberellin on neonatal rats显示文摘 | Csaba G Darvas S Laszlo V | 1977 | Acta Biol Med Ger1977，36，： | 1 |
| 20 | Transgenerational effect of a single neonatal benzpyrene treatment on the glucocorticoid receptor of the rat thymus 显示文摘 | Csaba G Inczefi-Gonda A | 1998 | Hum Exp Toxicol1998，17，2： | 1 |
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