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| 1 | 缺血性脑卒中和出血性脑卒中患者发病前后血压的变化显示文摘《中国高血压防治指南2010》指出,急性脑卒中的血压处理缺乏足够的临床试验证据,参考建议如下:急性脑卒中溶栓前血压应控制在<185/110mm Hg(1mm Hg=0.133kPa)。对急性缺血性脑卒中发病24h内血压升高的患者应谨慎处理,收缩压≥180mm Hg或舒张压≥100mm Hg或伴有严重心功能不全、主动脉夹层、高血压脑病者,一般不予降压。降压的合理目标是24h内血压降低约15%。有高血压病史且正在服用降压药物者,如神经功能平稳,可于脑卒中发病后24h开始使用降压药物。因此,了解脑卒中患者发病前后的血压情况对临床治疗有重要的意义。Fischer等研究者探讨缺血性脑卒中和出血性脑卒中患者发病前后血压的变化情况。结果表明,缺血性脑卒中患者发病后首次测量的收缩压低于出血性脑卒中。与发病前比较,缺血性脑卒中发病后收缩压略升高(约10.6mm Hg),24h内轻度降低(约13.6mm Hg);而出血性脑卒中发病后,收缩压明显升高(约40.7mm Hg),24h内明显下降(约41.1mm Hg)。出血性脑卒中发病前几天及几周的平均收缩压逐渐增加,而缺血性脑卒中无明显变化。出血性脑卒中患者发病3h内的最高收缩压比发病前高50.0 mm Hg,而缺血性脑卒中则低5.2mm Hg。综上所述,与发病前比较,出血性脑卒中发病后收缩压升高,而缺血性脑卒中无明显变化。 | Fischer U Cooney MT Bull LM Silver LE Chalmers J Anderson CS Mehta Z Rothwell PM 林东杰 叶鹏 | 2014 | 中华高血压杂志2014，22，4： | 13 |
| 2 | 血清netrin-1增加与缺血性脑卒中预后改善相关显示文摘先前的实验研究表明,血清netrin-1与缺血性脑卒中进展相关。进一步了解缺血性脑卒中患者中netrin-1的变化可能为缺血性脑卒中的预后评估提供新的思路。该研究旨在探讨血清netrin-1与缺血性脑卒中预后的关系。研究人员测定3346例中国急性缺血性脑卒中抗高血压试验(China antihypertensive trial in acute ischemic stroke,CATIS)中缺血性脑卒中患者基线血清netrin-1水平,所有患者均在脑卒中发病后3个月进行随访。主要观察指标是脑卒中发病后3个月内死亡和严重残疾(改良Rankin 量表评分≥3)。 | 刘莉 叶鹏 Guo D Zhu Z Zhong C Peng H Wang A Xu T Peng Y Xu T Chen CS Li Q Ju Z Geng D Chen J Zhang Y He J | 2019 | 中华高血压杂志2019，27，5： | 6 |
| 3 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 4 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 5 | Rapamycin antagonizes cyclosporin A-and tacrolimus (FK506)- mediated augmentation of linker for activation of T cell expression in T cells显示文摘 | CHO CS CHANG Z ELKAHWAJI J | 2003 | Int Immunol2003，15，11： | 1 |
| 6 | Rapamycin antagonizes cyclosporin A-and tacrolimus (FK506) mediated augmentation of linker for activation of T cell expression in T cells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 7 | Rapamycin antagonizes cyclos-porin A-and tacrolimus(FK506)-mediated augmentation of linkerfor activation of T cell expression in T cells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 8 | 5-HT spinalantinociception involves mu opioid receptors: cross-tolerance and antagonist studies显示文摘 | Guo Z Freeman J | 1997 | Br J Anaesth1997，78，5： | 1 |
| 9 | Molecular targets for the cancer preventive activity of tea po]ypbeno]s 显示文摘 | Yang CS Lambert J D Hou Z et aT | 2006 | MoT Carcino2006，45，： | 1 |
| 10 | Rapamycin antagonizes cyclosporine A-and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cell显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 11 | Absorption spectroscopy of colored dissolved organic carbon in Georgia (USA) rivers:the impact of molecular size distribution显示文摘 | Yacobi Y Z Alberts J J Takács M | 2003 | Journal of Limnology2003，62，： | 1 |
| 12 | Rapamycin antagonizes cyclos- porine A - and tacrolimus(FKS06) - mediated augmentation of linker for activation of T cell expression in T cells 显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，： | 1 |
| 13 | Rapamycin antagonizes cyclosporine A-and tacrolimus (FK506)-mediated augmentation of linker for activation of T cell expression in T cells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 14 | National systems of entre- preneurship measurement issues and policy implications 显示文摘 | CS Z J AUTIO E SZERB L | 2014 | Research Policy2014，43，3： | 1 |
| 15 | Hydrous ruthenium oxide nanoparticles anchore d to graphene and carbon nanotube hybrid foam for supercapacitors 显示文摘 | Wang W Guo S Lee I Ahmed K Zhong J Favors Z Zaera F O zkan M Ozkan CS | 2014 | Scientific Reports2014，，12： | 1 |
| 16 | Rapamycin antagonizes cyclosporine A - and tacrolimus(FK506) - mediated augmentation of linker for activation of T cell expression in T cell显示文摘 | Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 17 | Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) inhibits experimental autoimmune encephalomyelitis in dark agouti(DA) rats显示文摘 | Zhu CS H u XQ Xiong Z J | 2008 | Life Sciences2008，83，1112： | 1 |
| 18 | Rapamycin antagonizes cyclosporin A-and tacrolimus(FK506)-mediated augmentation of linker for activation of T cell expression in Tcells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 19 | Rapamyein antagonizes ey- closporin A- and tacrolimus ( FKS06 ) -mediated augmentation of linker for activation ofT cell expression in T cells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immu- nol2003，15，11： | 1 |
| 20 | Targeting FASN inBreast Cancer and the Discovery of PromisingInhibitors from Natural Products Derived fromTraditional Chinese Medicine显示文摘 | Cheng CS Wang Z Chen J | 2014 | Evid BasedComplement Alternat Med2014，2014，： | 1 |
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