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| 1 | MicroRNAs in the prognosis and therapy of colorectal cancer: From bench to bedside显示文摘MicroRNAs(miRNAs) are small, single-stranded, noncoding RNAs that can post-transcriptionally regulate the expression of various oncogenes and tumor suppressor genes. Dysregulated expression of many miRNAs have been shown to mediate the signaling pathways critical in the multistep carcinogenesis of colorectal cancer(CRC). MiR NAs are stable and protected from RNase-mediated degradation, thereby enabling its detection in biological fluids and archival tissues for biomarker studies. This review focuses on the role and application of miRNAs in the prognosis and therapy of CRC. While stage Ⅱ CRC is potentially curable by surgical resection, a significant percentage of stage Ⅱ CRC patients do develop recurrence. MiRNA biomarkers may be used to stratify such high-risk population for adjuvant chemotherapy to provide better prognoses. Growing evidence also suggests that miRNAs are involved in the metastatic process of CRC. Certain of these miRNAs may thus be used as prognostic biomarkers to identify patients more likely to have micro-metastasis, who could be monitored more closely after surgery and/or given more aggressive adjuvant chemotherapy. Intrinsic and acquired resistance to chemotherapy severely hinders successful chemotherapy in CRC treatment. Predictive miRNA biomarkers for response to chemotherapy may identify patients who will benefit the most from a particular regimen and also spare the patients from unnecessary side effects. Selection of patients to receive the new targeted therapy is becoming possible with the use of predictive miRNA biomarkers. Lastly, forced expression of tumor suppressor miRNA or silencing of oncogenic miRNA in tumors by gene therapy can also be adopted to treat CRC alone or in combination with other chemotherapeutic drugs. | Kenneth KW To Christy WS Tong Mingxia Wu William CS Cho | 2018 | World Journal of Gastroenterology2018，24，27： | 29 |
| 2 | 蛋白质组学与转化医学:用以癌症诊断、预后和疗效预测的分子生物标记物显示文摘“生物医学研究的最新技术进展使鉴定多种分子生物标记物变得更加容易,有助于促进癌症筛查和检测……通过允许医生为患者制定个体化治疗来提高癌症治疗的有效性和安全性。” | William CS CHO 南娟(翻译) 曹志成(校对) | 2011 | 中国肺癌杂志2011，14，8： | 9 |
| 3 | 癌症相关遗传变异的新进展及其在诊断研发中的意义显示文摘"了解更多癌症相关的遗传变异可能有助于癌症的预防和早期诊断,以及为癌症个体化诊断和治疗方案开辟新途径。" | 南娟(翻译) 曹志成(校对) William CS CHO | 2011 | 中国肺癌杂志2011，14，1： | 5 |
| 4 | Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling显示文摘AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a lowand a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. | Yue-Zheng Zhang Lian-Hai Zhang Yang Gao Chao-Hua Li Shu-Qinjia Ni Liu Feng Cheng De-Yun Niu William CS Cho Jia-Fu Ji Chang-Qing Zeng | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 5 | miRNAs在肺癌中的作用显示文摘"这些miRNAs在血清中的高表达是非小细胞肺癌的血液生物标记物……"
肺癌居全球癌症死亡原因的首位,但迄今尚无有效针对这一致命疾患的诊断和预测性生物标记物。新证据表明,miRNAs具有以细胞周期依赖性方式调节转录及翻译的潜能,这为我们在分子水平深入理解癌症开拓了新视野。 | William CS CHO 南娟(翻译) 丁燕(翻译) 曹志成(校对) | 2009 | 中国肺癌杂志2009，12，12： | 4 |
| 6 | 癌症研究进展:第100届AACR年会见闻显示文摘本文将综述2009年美国癌症研究学会(AACR)第100届年会的主要报告,并讨论各项科研成果,以及它们对临床实践和在研临床试验的影响。在这些报告中,靶向治疗的预测性生物标记物的相关报道让适当患者选择合适药物变得可行。通过对体细胞基因拷贝数改变、基因组重排及序列突变进行分析,癌基因组的研究结果在深入揭示多种癌症的发病机制中显示了重要作用。有报告再次证实癌干细胞在治疗性抵抗、促血管生成和转移中起重要作用。有报告从不同角度对各种癌症类型中癌干细胞生物学的认识作了介绍。有报告对小分子RNA(microRNA)改变的最新研究成果进行了概述。除癌细胞研究外,研究人员已开始观察肿瘤细胞与其周围环境的信息交流。有报告介绍了肿瘤微环境与炎症方面的最新成果。有报告陈述了纳米技术和生物标记物发现的最新进展。此外,大会上有些临床试验结果支持应用新的靶向治疗方法,而有些研究者则致力于采用现有药物和方法进行癌症预防。本文将对2009年AACR年会的上述及其它重要报告进行讨论,旨在为读者提供全球最重要癌症研究会议上的癌症研究最新进展。 | William CS Cho 南娟(翻译) 丁燕(翻译) 曹志成(校对) | 2009 | 中国肺癌杂志2009，12，11： | 4 |
| 7 | MiRNA作为肺癌分子诊断工具的前景与挑战显示文摘“在过去的十年里,miRNA已成为调节基因表达的关键分子之一。它几乎涉及肺癌癌变的每一个进程,包括肿瘤进展、血管新生、侵袭和转移。” | William CS CHO 丁燕(翻译) 南娟(翻译) 曹志成(校对) | 2012 | 中国肺癌杂志2012，15，2： | 3 |
| 8 | Cardiac remodeling and atrial fibrillation in transgenic mice overexpressing junctin显示文摘 | Hong CS Cho MC Kwak YG | 2002 | FASEB J2002，16，10： | 1 |
| 9 | The role of extracorporeal shock,wave lithotripsy combined with endoscopicmanagement of impactedcysticduct stones inpatients with high surgical risk显示文摘 | Shim CS Moon JH Cho YD | 2005 | Hepatogastroen-terology2005，52，64： | 1 |
| 10 | Preliminary results of a new covered biliary metal stent for malignant biliary obstruction显示文摘 | Shim CS Lee YH Cho YD | 1998 | Endoscopy1998，30，： | 1 |
| 11 | The role of extracorporeal shock wave lithotripsy combined with endoscopic management of impacted cvsticduct stones in patients with high surgical risk显示文摘 | SHIM CS MOON JH CHO YD | 2005 | Hepatogastroenterology2005，52，64： | 1 |
| 12 | Endoscopic surgery for spontaneous basal ganglia hemorrhage: comparing endoscopic surgery, stereotactic aspiration, and craniotomy in non- comatose patients 显示文摘 | Cho DY Chen CC Chang CS | 2006 | Surg Neurol2006，65，6： | 1 |
| 13 | Rapamycin antagonizes cyclosporin A-and tacrolimus (FK506)- mediated augmentation of linker for activation of T cell expression in T cells显示文摘 | CHO CS CHANG Z ELKAHWAJI J | 2003 | Int Immunol2003，15，11： | 1 |
| 14 | Rapamycin antagonizes cyclosporin A-and tacrolimus (FK506) mediated augmentation of linker for activation of T cell expression in T cells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 15 | Rapamycin antagonizes cyclos-porin A-and tacrolimus(FK506)-mediated augmentation of linkerfor activation of T cell expression in T cells显示文摘 | Cho CS Chang Z Elkahwaji J | 2003 | Int Immunol2003，15，11： | 1 |
| 16 | Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues显示文摘 | Ha TS Jeong SY Cho SW Jeon HK Roh GS Choi WS Park CS | | 0，，： | 1 |
| 17 | Shear wave elastography of thyroid nodules in routine clinical practice: preliminary observations and utility for detecting malignancy 显示文摘 | Bhatia KS Tong CS Cho CC | 2012 | Eur Radiol2012，22，11： | 1 |
| 18 | Efficacy and safety of the use of titanium mesh cages and anterior cervical plates for interbody fusion after anterior cervical corpectomy显示文摘 | Chuang HC Cho DY Chang CS | 2006 | Surg Neurol2006，65，5： | 1 |
| 19 | Maspin expression in early oral tongue cancer and its relation to expression of mutant-type p53 and vascular endothelial growth factor 显示文摘 | Cho JH Kim HS Park CS | 2007 | Oral Oncol2007，43，3： | 1 |
| 20 | Endoscopic surgery for spontaneous basal ganglia hemorrhage: comparing endoscopic surgery, stereotactic aspiration, and craniotomy in noncomatose patients 显示文摘 | Cho DY Chen CC Chang CS | 2006 | Surg Neurol2006，65，6： | 1 |
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