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| 1 | Discovery and validation of prognostic markers in gastric cancer by genome-wide expression profiling显示文摘AIM: To develop a prognostic gene set that can predict patient overall survival status based on the whole genome expression analysis. METHODS: Using Illumina HumanWG-6 BeadChip followed by semi-supervised analysis, we analyzed the expression of 47 296 transcripts in two batches of gastric cancer patients who underwent surgical resection. Thirty-nine samples in the first batch were used as the training set to discover candidate markers correlated to overall survival, and thirty-three samples in the second batch were used for validation. RESULTS: A panel of ten genes were identified as prognostic marker in the first batch samples and classified patients into a lowand a high-risk group with significantly different survival times (P = 0.000047). This prognostic marker was then verified in an independent validation sample batch (P = 0.0009). By comparing with the traditional Tumor-node-metastasis (TNM) staging system, this ten-gene prognostic marker showed consistent prognosis results. It was the only independent prognostic value by multivariate Cox regression analysis (P = 0.007). Interestingly, six of these ten genes are ribosomal proteins, suggesting a possible association between the deregulation of ribosome related gene expression and the poor prognosis. CONCLUSION: A ten-gene marker correlated with overall prognosis, including 6 ribosomal proteins, was identified and verified, which may complement the predictive value of TNM staging system. | Yue-Zheng Zhang Lian-Hai Zhang Yang Gao Chao-Hua Li Shu-Qinjia Ni Liu Feng Cheng De-Yun Niu William CS Cho Jia-Fu Ji Chang-Qing Zeng | 2011 | World Journal of Gastroenterology2011，17，13： | 5 |
| 2 | Prevalence of myopia among Hong Kong Chinese schoolchildren: changes over two decades 显示文摘 | Lam CS Lam CH Cheng SC | 2012 | Ophthalmic Physiol Opt2012，32，1： | 1 |
| 3 | Stress analysis of thedisc adjacent to interbody fusion in lumbar spine显示文摘 | Chen CS Cheng CK Liu CL | 2001 | MedEng Phys2001，23，7： | 1 |
| 4 | Adiposity,cardio metabolic risk,and vitamin D status:the Framingham Heart Study显示文摘 | Cheng S Massaro JM Fox CS | 2010 | Diabetes2010，59，1： | 1 |
| 5 | Breast cancer risk associated with genotype polymorphism of the catechol estrogen metabolizing genes : a multigenic study on cancer susceptibility 显示文摘 | Cheng TC Chen ST Huang CS | 2005 | Int J Cancer2005，113，3： | 1 |
| 6 | Clinical value ofCYFRA21-1 ,NSE, CA15-3, CAI 9-9 and CA125 assay in the elderly Patients with pleural effusions显示文摘 | Li CS Cheng BC Ge W | 2007 | Int J Clin Praet2007，61，3： | 1 |
| 7 | Differential regulation of cadherins by dexamethasone in human osteoblastic cells 显示文摘 | Lecanda F Cheng SL Shin CS | 2000 | J Cell Biochem2000，77，3： | 1 |
| 8 | Optimal beam design on in- tensity modulated radiation therapy with simultaneous integrated boost in nasopharyngeal cancer显示文摘 | Cheng MC Hu YW Liu CS | 2014 | Med Dosim2014，39，3： | 1 |
| 9 | The management of a severely resorbed edentulous maxilla using a bone graft and a CAD/CAM-guided immediately loaded definitive implant prosthesis:A clinical report显示文摘 | Cheng AC Khin NT Luen CS | 2008 | The Journal of Prosthetic Dentistry2008，99，2： | 1 |
| 10 | Clinical value of CYFRA21-1,NSE,CA15-3,CA19-9 and CA125 assay in the elderly patients with pleural effusions显示文摘 | Li CS Cheng BC | 2007 | Int J Clin Pract2007，61，3： | 1 |
| 11 | Failure analysis of broken pedicle screws on spinal instrumentation显示文摘 | Chen CS Chen WJ Cheng CK | 2005 | Med Eng Phys2005，27，6： | 1 |
| 12 | Effects of verapamil and procainamide on acute atrial electrical remodeling induced by shortterm rapid atrial pacing in humans 显示文摘 | Chu CS Lee KT Cheng KH | 2007 | Kaohsiung J Med Sci2007，23，12： | 1 |
| 13 | Adipocytokines and proinflammatory mediators from abdominal and epicardial adipose tissue in patients with coronary artery disease显示文摘 | Cheng KH Chu CS Lee KT | 2008 | Int J Obes2008，32，2： | 1 |
| 14 | A biomechanical comparison of posterolateral fusion and posterior fusion in the lumbar spine显示文摘 | Chert CS Cheng CK Liu CL | 2002 | J Spinal Disord Tech2002，15，1： | 1 |
| 15 | Comparison of emissions of a direct injection diesel engine operating on biodiesel with emulsified and fumigated methanol显示文摘 | Cheng Chuanhui Cheung CS Chan TL | 2008 | Fuel2008，87，1011： | 1 |
| 16 | Differential regulation ofcadherins by dexamethasone in human osteoblastic cells显示文摘 | Lecanda F Cheng SL Shin CS | 2000 | J Cell Biochem2000，77，3： | 1 |
| 17 | Leisure activities alle-viate depressive symptoms in nursing home residents withvery mild or mild dementia显示文摘 | Cheng ST Chow PK Edwin CS et aZ | 2012 | Am J Geriat Psych2012，20，10： | 1 |
| 18 | Quantitative assessment of retina l thickness in diabetic patients with and without clinically significant macular edema using optical coherence tomography显示文摘 | Yang CS Cheng CY Lee FL Hsu WM Liu JH | 2001 | Acta Ophthalmol Scand2001，79，3： | 1 |
| 19 | GuiUain-Barro syndrome in southern Taiwan: clinical features, prognostic factors and therapeutic outcomes 显示文摘 | Cheng BC Chang WN Chang CS | 2003 | European Journal of Neurology2003，10，： | 1 |
| 20 | The use ofbioimpedance in the detection/screening of tongue cancer 显示文摘 | Sun TP Ching CS Cheng CS | 2010 | Cancer Epidemiol2010，34，2： | 1 |
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