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| 1 | 尿激酶治疗急性心肌梗塞多中心临床试验1406例总结显示文摘为观察尿激酶天普洛欣(UKTP)经静脉溶栓治疗急性心肌梗塞(AMI)的临床有效性及安全性。收集协作组148家医院1994年11月至1996年4月经静脉UKTP溶栓治疗AMI患者1406例,观察临床疗效、副作用及病死率等。其中124例行90分钟冠状动脉造影评价梗塞血管开通情况。结果:梗塞血管临床再灌注率为73.5%,90分钟冠状动脉造影血管开通率为72.6%,5周总病死率为7.8%(109/1406),轻度出血10.2%(143/1406),中重度出血0.43%(6/1406),脑出血0.50%(7/1406)。老年(>65岁)甚至高龄(>75岁)患者溶栓及距发病超过6小时者,其用药仍然安全有效,UKTP合适的用药剂量可能为150万U左右。结果提示UKTP治疗AMI安全有效。 | The collaborative study group for national multicenter clinical trial of urokinase thrombolytic therapy (Correspondence: Hu Dayi, Xu Zhimin. Beijing Red Cross Chao Yao Hospital, Beijing 100020) | 1997 | 中华心血管病杂志1997，25，3： | 139 |
| 2 | 不稳定性心绞痛、急性非Q波心肌梗死不同抗栓疗法的对比研究显示文摘目的 观察不同抗栓方案对急性冠状动脉综合征心脏事件、出血风险和预后的影响。方法 本研究为前瞻性、多中心、随机、开放试验 ,入选患者随机分为静脉滴注普通肝素组和皮下注射低分子量肝素组。入选对象为不稳定性心绞痛或非Q波心肌梗死 ,入选前 4 8小时以内至少有一次心绞痛发作 ,ST段无抬高。肝素 10 0IU/kg静注 ,续 10 0 0IU/h ,维持活化的部分凝血活酶时间 (APTT)或活化的全血凝固时间 (ACT)于正常的 1 5~ 2 0倍 ,连续 7日。低分子量肝素 0 4~ 0 6ml,每日两次皮下注射 ,连续 7日。主要观察终点 :随访治疗 3 0日内发生急性心肌梗死、心脏性或非心脏性死亡和药物治疗无法控制心绞痛 ,需行急性血运重建术。住院至少 7日 ,随访至治疗后 3 0日。结果 本研究共入选符合条件的患者 4 0 2例 ,两组在性别、年龄、心血管危险因素和心绞痛发作方面差异无显著性。治疗后 7日 ,两组用药期间平均胸痛发作次数差异无显著性 ,但肝素组有更多的患者需口服硝酸甘油缓解胸痛 ;病死率在低分子量肝素组较普通肝素组低 ,两组比较P值为 0 0 62 ,复合终点事件 (死亡、心肌梗死和紧急血管重建 )在低分子量肝素组明显下降。低分子量肝素组出血事件明显少于肝素组。治疗开始后 3 0日 ,低分子量肝素组死亡和复合终点事? | Clinical Collaborative Study Group of Low Molecular Weight Heparin (Correspondent: HU Dayi, XU Juntang. Beijing Red Cross Chaoyang Hospital, Beijing University of Medical Sciences, Beijing 100020, China) | 2000 | 中华心血管病杂志2000，28，1： | 172 |
| 3 | STRATIGRAPHIC CONTROLS ON RESERVOIR ATTRIBUTES IN CONTINENTAL STRATA显示文摘在相同沉积相和沉积环境中,沉积记录中作为地层位置函数的不同尺度的地层学与沉积学性质的变化是有序的并可以预测,诸多沉积学和地层学性质,从孔隙度、渗透率到地质体的规模和非均质性对于储集性能和产能都是重要的,地层导致的上术性质的变化与由于原始沉积环境的差异产生的变化同等重要。运用地层观战对沉积物某咱或多种性质变化进行分析,表明这些变化具有规律性并有向一些界限呈单向变化的趋势。与此对照,运用对照时间和地层位置并不敏感的“相”对这些性质进行分绵会发现数值具明显的非相关离散特征,因此,仅根据沉积环境或相组成对储集性能进行评价会造成预测的准确性和精确性变差。由此,文中提出了能够提高储层表征准确性和精确性的一种新的分析思路,即运用地层观战评价相的储多性质,上述原理可用陆相地层中的一些实例加以说明。以河道砂储层为例。 | Cross,TA | 2000 | 地学前缘2000，7，4： | 144 |
| 4 | 2016年国际抗癫痫联盟癫痫发作分类的更新及介绍显示文摘国际抗癫痫联盟(ILAE)提出了癫痫发作类型的操作性修订方案。此修订的目的包括认识到一些发作类型既可以是局灶起源亦可以为全面起源,允许临床在不能观察到发作起源的情况下进行发作分类,纳入某些尚不了解的发作类型,以及采用更加易懂的命名。由于现有知识不足以形成一个科学的分类方案,2016年的分类方案是在1981年和2010年分类的基础上进行的操作性(实用性)修订。新分类的变化包括:(1)'部分性'改为'局灶性';(2)起源未知的癫痫发作也可以归类;(3)知觉状态用作局灶性发作的区分因素;(4)删除'认知障碍性'、'简单部分性'、'复杂部分性'、'精神性'、'继发全面性'等术语;(5)认识到局灶性强直、阵挛、失张力、肌阵挛和癫痫性痉挛发作,这些发作也有双侧性类型;(6)增加了新的全面性发作类型:伴眼睑肌阵挛的失神发作,肌阵挛失神发作,肌阵挛-失张力发作,阵挛-强直-阵挛发作,癫痫性痉挛;癫痫性痉挛可以是局灶性、全面性或起源不明性;(7)双侧强直阵挛发作取代了继发全面性发作。新的分类方案并未进行根本性的改变,但可以使癫痫发作类型的命名有较大的灵活性和透明度。 | Robert S Fisher J Helen Cross 陈佳 王玉平 吴逊 | 2017 | 癫痫杂志2017，3，1： | 25 |
| 5 | Regulation of the G1 phase of the mammalian cell cycle显示文摘In any multi-cellular organism, the balance between cell division and cell death maintains a constant cell number. Both cell division cycle and cell death are highly regulated events. Whether the cell will proceed through the cycle or not, depends upon whether the conditions required at the checkpoints during the cycle are fulfilled. In higher eucaryotic cells, such as mammalian cells, signals that arrest the cycle usually act at a G1 checkpoint. Cells that pass this restriction point are committed to complete the cycle. Regulation of the GI phase of the cell cycle is extremely complex and involves many different families of proteins such as retinoblastoma family cyclin dependent kinases, cyclins, and cyclic kinase inhibitors. | DONJERKOVIC DUBRRAVKA DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD) | 2000 | Cell Research2000，10，1： | 18 |
| 6 | Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta显示文摘胎盘为成功的怀孕和胎儿和怀孕女人的健康是关键的。然而,人的 trophoblast 系怎么被调整,包括胎盘的房间的分类,子类型糟糕被理解。这里,我们在排序的胎盘的房间上执行了定序的单个房间的 RNA (RNA-seq ) 从第一三个月并且秒三个月人胎盘。已知的 cytotrophoblast 房间(CTB ) 的房间的新子类型, extravillous trophoblast 房间(EVT ) , Hofbauer 房间,和间充质的 stromal 房间被识别, cell-type-specific 基因签名被定义。机能上地,这研究揭示了人的胎盘的许多以前未知的功能。尤其是, 102 多肽荷尔蒙基因被发现被胎盘的房间的各种各样的子类型表示,它在调整母亲的生理学的胎儿的生长和改编到怀孕建议建筑群和这些荷尔蒙的重要角色。这些结果在单个房间的分辨率记录人的胎盘的 trophoblast 区别并且因此在怀孕的早阶段期间推进我们人的胎座式的理解。 | Yawei Liu Xiaoying Fan Rui Wang Xiaoyin Lu Yan-Li Dang Huiying Wang Hai-Yan Lin Cheng Zhu Hao Ge James C. Cross Hongmei Wang | 2018 | Cell Research2018，28，8： | 15 |
| 7 | 90分钟冠状动脉造影评价急性心肌梗塞血管开通及临床再通指标价值显示文摘通过经静脉溶栓开始后90分钟冠状动脉造影(CAG),观察国产尿激酶(天普洛欣,UKTP)静脉溶栓治疗急性心肌梗塞(AMI)血管开通疗效,并评价临床再灌注标准的判断价值如何。方法:从UKTP多中心治疗AMI1406例中,汇集其中所行冠状动脉造影(CAG)共124例资料。结果提示:(1)124例AMI患者,在溶栓开始后90分钟时的梗塞相关血管的血流达TIMIⅢ级者52例(41.9%)、Ⅱ级38例(30.7%),梗塞相关血管再开通率为72.6%;(2)溶栓距起病时间愈早,具有愈高的开通趋势,但差异无统计学意义;(3)以CAG为金标准,临床标准对血管开通判断敏感性为88%,特异性为69%,准确性为83%。结论:UKTP静脉溶栓治疗AMI血管开通疗效肯定,临床标准判断血管再通的敏感性较高,但特异性欠佳,有待提高。 | The multicentre investigating group of thrombolytic therapy on acute myocardial infarction with Urokinase Techpool Correspondence: Hu Dayi, Xu Zhimin. Chaoyang Red Cross Hospital, Capital University of Medical Sciences, Beijing 100020 | 1997 | 中华心血管病杂志1997，25，4： | 11 |
| 8 | Vein transplantation using human umbilical cord blood stem cells in the treatment of stroke sequela显示文摘BACKGROUND: Transplanted mononuclear cell(MNC)of umbilical blood can survive in central nervous system (CNS)of host through blood brain barrier,differentiate into nerver cells,migrate to damaged site and integrate morphological strucgh and function with nerve cells of host so as to improve deficiencies of sensatory function,motor function and cognitive function and influence on stroke sequela.OBJECTIVE: To observe the vein transplantation of human umbilical cord blood stem cells(HUCBSC) for improving neurological function,limb funtion and activity of daily living of patients with stroke and evaluate the reliability.DESIGN: Self-controlled study.SETTING: Department of Neurosurgery,the Second People's Hospital of Zhengzhou City;Red-crossed Blood Center of Henan Province;Department of Neurosurgery,the Fist Affiliated Hospital of Zhenzhou University.PARTICIPANTS:A total of 10 patients with stoke sequela were selected from Department of Cerebral Surgery,the Second People's Hospital of Zhengzhou City from April to December 2005.There were 9males and 1 female aged from 35to 75years with the mean age of 56 years.All of them were diagnosed with CT and MRI examination and coincidence with diagnostic criteria of stroke established by the Fourth National Academic Meeting for Cerebrovascular Disease.All patients provided informed consent. METHODS:80-140 mL umbilical blood of term birth of newborn was selected hermetically and maintained in sterile plastic bag.And then,the blood was centrifugated at the speed of 1500 r/min for 30 minutes at 22℃ in order to separate MNC,i.e.,HUCBSC.In addition,after final diagnosis during hospitalization,stroke patients were perfused with HUCBSC through superficial vein of back of the hand.Each patient was averagely penfused with 6 portions of HUCBSC(cellular numbers≥1×108/portion)and the interval between each portion was 1-7 days with the mean interval of 4 days.MAIN OUTCOME MEASURES: ①Neurological function of stroke patients was evaluated with neurological function deficiency(NFD)before treatment and at 3 months after treatment.The scale includes consciousness,level fix function.facial paralysis,language,muscle force of upper limbs,muscle force of lower limb and step function.The total scores ranged from 0 to 45; meanwhile,the lower the scores were,the better the neurological function of limbs was. ②Motor function of injured limbs was evaluated with Fugl-Meyer Assessment (FMA),including motor function of upper limbs.motor function of lower limbs,balance ability,sensory function and motion of joint.The total scores ranged from 0 to 226;meanwhile,the higher the scores were,the better the motor function of limbs was.③Activities of daily living(ADL)was evaluated with Barthel Index(BI),including having meals,taking a bath,dressing oneself,putting on clothes,walking in balance and stair activity.The total scores ranged from 0 to 100;meanwhile,the higher the scores were,the stronger the ADL was.RESULTS:A total of 10 patients were involved in the final analysis.After treatment,NFD of stroke patients was (10.9±5.09)points,which was lower than that before treatment[(25.4±6.09)points,t=8.213,P<0.01].In addition,after treatment,FMA and BI of stroke patients were(80.9±25.00)points and(81.1±15.93)points,re spectively,which were higher than those before treatment[(31.9+21.85)points,(36.2+19.41)points,t=13.024,13.670,P<0.01]. Immuno-suppressive drugs were not used during the whole therapeutic procedure;moreover,immunological rejection and allergic reaction were not observed during the same period.CONCLUSION:Transplanting HUCBSC through superficial vein of back of the hand is regarded as a simple and safe method for the treatment of stroke sequela. | Yong Man1, Jianbin Li2, Bo Yang3, Ji Ma1 1Department of Cerebral Surgery, the Second People’s Hospital of Zhengzhou, Zhengzhou 450000, Henan Province, China 2Red Cross Blood Center of Henan Province, Zhengzhou 450000, Henan Province, China 3Department of Neurosurgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, Henan Province, China | 2006 | Neural Regeneration Research2006，1，7： | 7 |
| 9 | 失独者抑郁的心理弹性多因素作用模型显示文摘目的:中国失独家庭已多达百万个,65.6%的失独者存在严重而持久的抑郁情绪,需要及时干预。本研究旨在探索心理弹性与其影响因素的交互作用,比较心理弹性及其影响因素对于失独者抑郁的效应。方法:采用Connor-Davidson心理弹性量表、Zung抑郁自评量表、简易应对方式问卷、艾森克简式量表中国版、社会支持评定量表、一般自我效能感量表对长沙市9个行政区域212名失独者进行入户调查。基于Kumpfer心理弹性框架和心理应激多因素作用过程的理论模式构建假设模型并进行验证。结果:心理弹性的影响因素有:积极应对(总效应值为0.480)、支持利用(总效应值为0.359)、精神质(总效应值为-0.326)、消极应对(总效应值为0.279)、内外倾(总效应值为0.219)、客观支持(总效应值为0.077)。心理弹性对抑郁的影响以直接效应为主(总效应值为-0.344,占67.1%),也通过自我效能感发挥间接效应(总效应值为-0.169),心理弹性的总效应值占所有变量总效应的20.1%。结论:心理弹性受到人格、积极应对、社会支持等应激中介变量的直接和间接作用;心理弹性对抑郁主要产生直接负性效应,是定位于自我效能感之前的重要应激中介变量。个体-环境互动作用过程对心理弹性的影响较大,人格和支持利用通过影响消极应对、积极应对进而间接影响心理弹性。提高心理弹性应当关注个体-环境作用过程,即利用支持、积极应对、适当的消极应对,进而影响个体对自我的积极评价,这将是开发心理弹性干预方案以改善失独者抑郁的重要内容。 | 王安妮 张雯 郭玉芳 Wendy Cross Virginia Plummer Louisa Lam 张静平 | 2021 | 中南大学学报(医学版)2021，46，1： | 7 |
| 10 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 11 | Activation-induced cell death in B lymphocytes显示文摘Upon encountering the antigen (Ag), the immune system can either develop a specific immune response or enter a specific state of unresponsiveness, tolerance. The response of B cells to their specific Ag can be activation and proliferation, leading to the immune response, or anergy and activation-induced cell death (AICD), leading to tolerance. AICD in B lymphocytes is a highly regulated event initiated by crosslinking of the B cell receptor (BCR). BCR engagement initiates several signaling events such as activation of PLCr, Ras, and PI3K, which generally speaking, lead to survival. However, in the absence of survival signals (CD40 or IL-4R engagement), BCR crosslinking can also promote apoptotic signal transduction pathways such as activation of effector caspases, expression of pro-apoptotic genes, and inhibition of pro-survival genes. The complex interplay between survival and death signals determines the B cell fate and, consequently, the immune response. | DONJERKOVIC DUBRAVKA, DAVID W SCOTT (Department of Immunology, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD, 20855. USA) | 2000 | Cell Research2000，10，3： | 6 |
| 12 | Analytical Methods for Environmental Risk Assessment of Acid Sulfate Soils: A Review显示文摘Assessment of acid sulfate soil risk is an important step for acid sulfate soil management and its reliability depends very much on the suitability and accuracy of various analytical methods for estimating sulfide-derived potential acidity, actual acidity and acid-neutralizing capacity in acid sulfate soils. This paper critically reviews various analytical methods that are currently used for determination of the above parameters, as well as their implications for environmental risk assessment of acid sulfate soi1s. | C. LIN School of Environmental Science and Management, Southern Cross University, Lismore, NSW (Australia) | 2001 | Pedosphere2001，11，4： | 5 |
| 13 | Characteristics of Some Heavy Metals in Acid Sulfate Topsoils, Eastern Australia显示文摘Forty-five acid sulfate topsoil samples (depth < 0.5 m) from 15 soil cores at 11 locations along the New South Wales coast, Australia, were selected to investigate the chemical behavior of Zn, Mn, Cr, Co and Pb in these soils. The amount of HCI-extractable Mn was much smaller than the mean value of the total Mn documented for other soils. This may be attributed to enhanced mobilization of Mn from the soils under the extremely acidic and seasonally flooded conditions encountered in the investigated soils. The pH-dependency of soluble Zn and Mn was strongly affected by the availability of acid reactive Zn and Mn compounds. There were fairly good relationships between soluble Zn and acid reactive Zn compounds, and between soluble Mn and acid reactive Mn compounds. Soluble Zn and soluble Mn concentrations were important controls on exchangeable Zn and Mn concentrations, respectively. In contrast to the suggestion by other authors that adsorption of Co was closely associated with Mn oxides present in soils, the exchangeable Co in the investigated acid sulfate soils was not clearly related to the abundance of Mn minerals. In addition to the fact that there are few Mn minerals present in the soils, this might also be because the availability of canon exchange sites on the crystal surfaces of Mn oxides was reduced under extremely acidic conditions. | C. LIN, D. MCCONCHIE, R. T. BUSH, L. A. SULLIVAN and M. ROSICKY (School of Resource Science and Management, Southern Cross University, Lismore, NSW (Australia)) | 2001 | Pedosphere2001，11，1： | 4 |
| 14 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 15 | Characteristics of Phosphorus in Some Eastern Australian Acid Sulfate Soils显示文摘Forty-five acid sulfate topsoil samples (depth < 0.5 m) from 15 soil cores were collected from 11 locations along the New South Wales coast, Australia. There was an overall trend for the concentration of the HC1extractable P to increase along with increasing amounts of organic C and the HCl-extractable trivalent metals in the topsoils of some less-disturbed acid sulfate soils (pH <4.5). This suggests that inorganic P in these soils probably accumulated via biological cycling and was retained by complexation with trivalent metals or their oxides and hydroxides. While there was no clear correlation between pH and the water-extractable P, the concentration of the water-extractable P tended to increase with increasing amounts of the HCl-extractable P. This disagrees with some established models which suggest that the concentration of solution P in acid soils is independent of total P and decreases with increasing acidity. The high concentration of sulfate present in acid sulfate soils appeared to affect the chemical behavior of P in these soil systems. Comparison was made between a less disturbed wetland acid sulfate soil and a more intensively disturbed sugarcane acid sulfate soil.The results show that reclamation of wetland acid sulfate soils for sugarcane production caused a significant decrease in the HCl-extractable P in the topsoil layer as a result of the reduced bio-cycling of phosphorus following sugarcane farming. Simulation experiment shows that addition of hydrated lime had no effects on the immobilization of retained P in an acid sulfate soil sample within a pH range 3.5~4.6. When the pH was raised to above 4.6, soluble P in the soil extracts had a tendency to increase with increasing pH until the 15th extraction (pH 5.13). This, in combination with the poor pH-soluble P relationship observed from the less-disturbed acid sulfate soils, suggests that soluble P was not clearly pH-dependent in acid sulfate soils with pH < 4.5. | C. LINSchool of Environmental Science and Management, Southern Cross University, Lismore, NSW (Australia) | 2002 | Pedosphere2002，12，3： | 4 |
| 16 | Acid Sulfate Soils in Australia: Characteristics,Problemsand Management显示文摘Acid soils(ASS) are widely distributed in Australia. This has only been recognized recentlywhen intensive research on ASS has been done in this country. This paper reviews aspects concerning a)the distribution and acid potential, b) controls on acidic status, and c) problems and management of ASSin Australia It is believed that the Australian experience may be useful for other countries where potentialproblems from ASS exist but insrfficient attention was paid to them. | C. LIN(School of Resource Science and Management, Southern Cross Universitg, Lismore, N.S. W. 248O (Australia)) | 1999 | Pedosphere1999，9，4： | 3 |
| 17 | Factors influencing mercury accumulation in three species of forage fish from Caddo Lake, Texas, USA显示文摘Most studies that have examined mercury (Hg) contamination of fish have focused on game species feeding near the top of the food web, while studies that examine forage fish that feed near the base of the food web are rare. We conducted a survey of Hg contamination in three species of forage fish, brook silverside (Labidesthes sicculus), threadfin shad (Dorosoma petenense) and gizzard shad (Dorosoma cepedianum), from Caddo Lake, Texas, USA and found species-specific differences in Hg concentrations. We examined total length, age, trophic position (determined using δ15N), and growth rate of forage fish as factors that could have influenced within-and between-species differences in Hg concentration. Total length and age were the best predictors of within-species differences in Hg concentration. Between-species differences in Hg concentrations were most strongly influenced by trophic position. | Matthew M Chumchal Ray W Drenner David R Cross K David Hambright | 2010 | Journal of Environmental Sciences2010，22，8： | 3 |
| 18 | Model-based and Fuzzy Logic Approaches to Condition Monitoring of Operational Wind Turbines显示文摘It is common for wind turbines to be installed in remote locations on land or offshore, leading to difficulties in routine inspection and maintenance. Further, wind turbines in these locations are often subject to harsh operating conditions. These challenges mean there is a requirement for a high degree of maintenance. The data generated by monitoring systems can be used to obtain models of wind turbines operating under different conditions, and hence predict output signals based on known inputs. A model-based condition monitoring system can be implemented by comparing output data obtained from operational turbines with those predicted by the models, so as to detect changes that could be due to the presence of faults. This paper discusses several techniques for model-based condition monitoring systems: linear models, artificial neural networks, and state dependent parameter 'pseudo' transfer functions.The models are identified using supervisory control and data acquisition(SCADA) data acquired from an operational wind firm. It is found that the multiple-input single-output state dependent parameter method outperforms both multivariate linear and artificial neural network-based approaches. Subsequently, state dependent parameter models are used to develop adaptive thresholds for critical output signals. In order to provide an early warning of a developing fault, it is necessary to interpret the amount by which the threshold is exceeded, together with the period of time over which this occurs. In this regard, a fuzzy logic-based inference system is proposed and demonstrated to be practically feasible. | Philip Cross Xiandong Ma | 2015 | International Journal of Automation and computing2015，12，1： | 3 |
| 19 | Iron Monosulfide Distribution in Three Coastal Floodplain Acid Sulfate Soils, Eastern Australia显示文摘The distribution of iron monosulfide (quantified as acid volatile sulfur: SAV) was compared with geo- chemical properties that are known to affect its formation and accumulation in three coastal Holocene acid sulfate soils (ASS) at Tuckean Swamp, McLeods Creek and Bungawalbyn Swamp respectively. These properties included PH, reactive iron (FeR), pore-water sulfate (SO:42-) and organic carbon (OC). Iron monosulfide was concentrated at the oxic/anoxic boundary. The Tuckean Swamp and McLeods Creek sites are Holocene sediments, whereas the Bungawalbyn Swamp is a Holocene peat. The concentration of SAV averaged 0.2 g kg-l in a 0.5 m thick soil layer at the Tuckean Swamp, but was an order of magnitude lower in the oxic/anoxic transition layers at McLeods Creek and Bungawalbyn Swamp. The SAV mineral greigite (Fe3S4) was identified in the Tuckean Swamp by X-ray diffraction and scanning electron microscopy with quantitative energy dispersive X-ray analysis (SEM-EDX). Very small concentrations of greigite were also observed in the McLeods Creek, based on crystal morphology and elemental composition. The concentration of SAV was a small fraction of the total reduced sulfur, representing at most 3% of the Pyrite sulfur. However, the presence of this highly reactive sulfide mineral, distributed within pores where oxygen diffusion is most rapid, has important implications to the potential rate of acid production from these sediments. | R. T. BUSH, L. A. SULLIVAN and C. LIN School of Resource Science and Management, Southern Cross University, Lismore, NSW 2480 (Australia) | 2000 | Pedosphere2000，10，3： | 3 |
| 20 | The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate显示文摘 | Patrick S. Ward Jay Patel David R. Wise Omar Abdel-Wahab Bryson D. Bennett Hilary A. Coller Justin R. Cross Valeria R. Fantin Cyrus V. Hedvat Alexander E. Perl Joshua D. Rabinowitz Martin Carroll Shinsan M. Su Kim A. Sharp Ross L. Levine Craig B. Thompson | 2010 | Cancer Cell2010，，3： | 2 |
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