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46篇 您的检索式:作者名="CRIGHTON J S"
    题名 作者 年代 出处 被引量
1p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson 2011Cell Research2011,21,4:3
2DRAM, a p53 - induced modulator of autophagy, is critical for apoptosis显示文摘Crighton D Wilkinson S 0 ey J 2006Cell2006,126,1:1
3DRAM, a p53- induced modulator of autophagy, is critical for apoptosis 显示文摘Crighton D Wilkinson S O' Prey J 2006Cell2006,126,1:1
4DRAM,a p53-induced modulator of autophagy,is critical for apoptosis显示文摘Crighton D Wilkinson S O'Prey J 0,,01:1
5A p53- induced modulator of autophagy, is critical for apoptosis 显示文摘D Crighton S Wilkinson J O&apos 2006Ce112006,126,:1
6DRAM, a p53- induced modulator of autophagy,is critical for apoptosis 显示文摘Crighton D Wilkinson S O'Prey J 2006Cell2006,126,1:1
7Structure and compatibility of poly (vinyl alcohol) silk fibroin blend films显示文摘TSUKADA M FREDDI G CRIGHTON J S 0,,:1
8DRAM,a p53-induced modulator of autophagy,is critical for apoptosis显示文摘 Wilkinson S O'Prey J 2006Cell2006,126,1:1
9DRAM, a p53- induced modulator of autophagy, is critical for apoptosis 显示文摘Crighton D Wilkinson S O' Prey J 2006Cell2006,126,1:1
10Structure and compatibility of poly(vinyl alcohol)-Silk fibroin(PVA/SA)blend films显示文摘TSUKADA M FREDDI G CRIGHTON J S 1994Journal of Polymer Science Part B:Polymer Physics1994,32,2:1
11Locating transition states显示文摘Bell S Crighton J S 1984J ChemPhys1984,80,6:1
12DRAM, a p53- induced modulator of autophagy, is critical for apoptosis 显示文摘Crighton D Wilkinson S O' Prey J 2006Cell2006,126,1:1
13DRAM, a p53-induced modulator of autophagy, is critical for apoptosis显示文摘Crighton D Wilkinson S O'Prey J 2007Cell2007,126,1:1
14Structure and Compatibility of Poly ( Vinyl a Lcohol) -Silk Fibroin (PVA/ SF) Blend Films 显示文摘TSUKADA M FREDDI G CRIGHTON J S 1994Polym Sci Part B: Polym Phys1994,32,:1
15DRAM,a p53-induced modulator of autophagy,is critical for apoptosis显示文摘Crighton D Wilkinson S O' Prey J 2006Cell2006,126,1:1
16DRAM,a p53-induced modulator of autophagy,is critical for apoptosis显示文摘CRIGHTON D WILKINSON S O'PREY J 2006Cell2006,126,1:1
17DRAM, a p53-induced modulator of autophagy, is critical for apoptosis显示文摘Crighton D Wilkinson S O' Prey J 2006Cell2006,126,1:1
18DRAM,a p53-induced modulator of autophagy,is critical for apoptosis显示文摘CRIGHTON D WILKINSON S O'PREY J 2006Cell2006,126,1:1
19DRAM, a p53-induced modulator of autophagy, is critical for apoptosis显示文摘Crighton D Wilkinson S O'Prey J 2006Cell2006,126,:1
20DRAM, a p53- induced modulator of autophagy, is critical for apoptosis 显示文摘Crighton D Wilkinson S O'Prey J 2006Cell2006,126,1:1
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