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| 1 | Starting glargine in insulin-nave type 2 diabetic patients based on body mass index is safe显示文摘AIM:To evaluate the safety of four insulin titration algorithms in a homogeneous population of insulin-na ve type 2 diabetic patients.METHODS:We conducted a 24-wk,open,single-center study with 92 insulin-na ve type 2 diabetes patients who failed treatment with one or two oral drugs.The patients were randomized to one of the four following algorithms:LANMET(n=26)and LANMET PLUS(n=22)algorithms,whose patients received a fixed initial insulin dose of 10 U,and DeGold(n=23)and DeGold PLUS(n=21)algorithms,whose patients’initial insulin dose was based on their body mass index(BMI).In addition,patients in the PLUS groups had their insulin titrated twice a week from 2 to 8 U.In the other two groups,the titration was also performed also twice a week,but in a fixed increments of 2 U.The target fasting glucose levels for both groups was 100 mg/dL.RESULTS:There was no significant difference in efficacy parameters.There was no significant difference when comparing moderate hypoglycemia events in algorithms starting with a 10 U fixed dose and algorithms based on BMI.However,there was a significant increase in moderate hypoglycemia events among the PLUS treated patients when the LANMET and DeGold algorithms were compared with the 2 fast-titration PLUS algorithms.We observed 12 hypoglycemia events in the first group,which corresponded to 0.94 events/patient per year,and we observed 42 events in the second group,which corresponded to 2.81 events/patient per year(P<0.037).No further significant differences were observed when other comparisons between the algorithms were carried out.CONCLUSION:Starting insulin glargine based on BMI is safe,but fast titration algorithms increase the risk of moderate hypoglycemia. | Denise R Franco Juliana Baptista Fatima RM Abreu Risoneide B Batista Freddy G Eliaschewitz | 2014 | World Journal of Diabetes2014，5，1： | 2 |
| 2 | Structure and physical properties of silk fibroin polyacrylamide blend films显示文摘 | Freddi G Taukads M Beretta S | 1997 | J Appl Polym Sci1997，71，： | 1 |
| 3 | Physical-properties and phase-separation structure of antheraea-pernyl Bombyx mori silk fibroin blend films显示文摘 | Tsukada M Freddi G Kasai N | 1994 | J Polym Sci B Polym Phys1994，32，： | 1 |
| 4 | Promoter methyla- tion-mediated inactivation of PCDH10 in acute lympho- blastic leukemia contributes to chemotherapy resistance 显示文摘 | Narayan G Freddy AJ Xie D | 2011 | Genes Chromosomes Cancer2011，50，12： | 1 |
| 5 | Dcgumming of silk fabric with several proteases显示文摘 | FREDDI G MOSSOTTI R INNOCENTI R | 2003 | Journal of Biotechnology2003，106，1： | 1 |
| 6 | Physical Properties of 2-Hydroxyethylmethacrylate-Grafted Silk Fibers显示文摘 | TSUKADA M FREDDI G | 1993 | Jof Appl Polym Sci1993，49，： | 1 |
| 7 | 显示文摘 | Tsukada M Freddi G Kasai N | 1994 | Journal of Polymer Science: Part B: Polymer Physics1994，32，： | 1 |
| 8 | Transforming growth factor betal: implications in adrenocortical tumorigenesis 显示文摘 | Arnaldi G Freddi S Mancini T | 2000 | Endocr Res2000，26，4： | 1 |
| 9 | De Novo Engineering ofReticular Connective Tissue In Vivo by Silk Fibroin Nonwoven Ma-terials 显示文摘 | Dal Pra I Freddi G Chiarini A | 2005 | Biomaterials2005，26，14： | 1 |
| 10 | A novel sot - gel multilayer approach for cotton fabric finishing by tetraethoxysilaneprecursor显示文摘 | Couconic Donelli I Freddi G | 2013 | Surface and Coatings Technology2013，，235： | 1 |
| 11 | 显示文摘 | Vasconcelos A Freddi G Cavaco-Paulo A | 2008 | Biomacromolecules2008，9，4： | 1 |
| 12 | Structure and compatibility of poly(vinyl alcohol)/silk fibroin (PVA/SF) blend films显示文摘 | RSUKAD M FREDDI G CRIGHTION J | 1994 | J Polym Sci Part B:Polym Phys1994，32，： | 1 |
| 13 | 显示文摘 | Freddi G Pessina G Tsukada M | 1999 | Int J Bio Macro1999，24，： | 1 |
| 14 | De novo engineering of reticular connective tissue in vivo by silk fibroin nonwoven materials显示文摘 | Dal Pra I Freddi G Minie J | 2005 | Biomaterials2005，26，14： | 1 |
| 15 | Defect detection in unpolished Si wafers by shearography显示文摘 | Udupa G Ngoi B Freddy H | 2004 | Meas Sci Technol2004，15，： | 1 |
| 16 | Preparation and application of porous silk fibroin materials显示文摘 | Tsukada M Freddi G Minoura N | 1994 | Jorurnal Applied Polymer Science1994，54，4： | 1 |
| 17 | Structure and compatibility of poly (vinyl alcohol) silk fibroin blend films显示文摘 | TSUKADA M FREDDI G CRIGHTON J S | | 0，，： | 1 |
| 18 | Solvay will make epichlorohydrin from glycerol 显示文摘 | FREDDY G | 2006 | Industrial Bioprocessing2006，28，3： | 1 |
| 19 | Preparation of water-repellent silks by a reaction with octadecenylsuccinic anhydride显示文摘 | Arai T Freddi G Innocenti R | 2003 | Journal of Applied Polymer Science2003，89，2： | 1 |
| 20 | Sweooing and dissolution of silk fibroin (Bombyx mori) in N-methyl morpholineN-exide显示文摘 | Freddi G Pessina G Tsukada M | 1999 | Int J Bio Macro1999，24，23： | 1 |
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