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| 1 | 雅鲁藏布江蛇绿岩再研究:从地质调查到矿物记录显示文摘蛇绿岩带出现于全球大多数碰撞构造带上,通常是板块缝合带的标志,西藏雅鲁藏布江缝合带蛇绿岩带对于此种概念模型是毫无争议的。根据近年来现代洋壳和蛇绿岩研究成果以及分析技术,在20世纪80年代中法合作项目研究成果基础上,笔者再次对西起日喀则拉孜、东至泽当金鲁,长约500km的雅鲁藏布江缝合带蛇绿岩进行了研究。在野外调查基础上,对雅鲁藏布江蛇绿岩中500多个尖晶石样品的地球化学特征进行了分析研究,以探讨蛇绿岩的成因及其动力学背景,提出雅鲁藏布江蛇绿岩带属于超俯冲作用(suprasubduction)的产物,与近年来其他研究成果的认识一致。 | 王成善 李亚林 刘志飞 李祥辉 唐菊兴 REJEAN Hebert COTE Dubois VARFALVY V HUOT F | 2005 | 地质学报2005，79，3： | 29 |
| 2 | The woodchuck as an animal model for pathogenesis and therapy of chronic hepatitis B virus infection显示文摘This review describes the woodchuck and the woodchuck hepatitis virus (WHV) as an animal model for pathogenesis and therapy of chronic hepatitis B virus (HBV) infection and disease in humans. The establishment of woodchuck breeding colonies, and use of laboratory-reared woodchucks infected with defined WHV inocula, have enhanced our understanding of the virology and immunology of HBV infection and disease pathogenesis, including major sequelae like chronic hepatitis and hepatocellular carcinoma. The role of persistent WHV infection and of viral load on the natural history of infection and disease progression has been firmly established along the way. More recently, the model has shed new light on the role of host immune responses in these natural processes, and on how the immune system of the chronic carrier can be manipulated therapeutically to reduce or delay serious disease sequelae through induction of the recovery phenotype. The woodchuck is an outbred species and is not well defined immunologically due to a limitation of available host markers. However, the recent development of several key host response assays for woodchucks provides experimental opportunities for further mechanistic studies of outcome predictors in neonatal- and adult-acquired infections. Understanding the virological and immunological mechanisms responsible for resolution of self-limited infection, andfor the onset and maintenance of chronic infection, will greatly facilitate the development of successful strategies for the therapeutic eradication of established chronic HBV infection. Likewise, the results of drug efficacy and toxicity studies in the chronic carrier woodchucks are predictive for responses of patients chronically infected with HBV. Therefore, chronic WHV carrier woodchucks provide a well-characterized mammalian model for preclinical evaluation of the safety and efficacy of drug candidates, experimental therapeutic vaccines, and immunomodulators for the treatment and prevention of HBV disease sequelae. | Stephan Menne Paul J Cote | 2007 | World Journal of Gastroenterology2007，13，1： | 22 |
| 3 | Animal personality and the ecological impacts of freshwater non-native species显示文摘 | Tristan JUETTE | 2014 | Current Zoology2014，60，3： | 7 |
| 4 | Extra-skeletal manifestations in mice affected by Clcn7-dependent autosomal dominant osteopetrosis type 2 clinical and therapeutic implications显示文摘Autosomal dominant osteopetrosis type 2 (ADO2) is a high-density brittle bone disease characterized by bone pain,multiple fractures and skeletal-related events,including nerve compression syndrome and hematological failure.We demonstrated that in mice carrying the heterozygous Clcn7^G213R mutation,whose human mutant homolog CLCN7^G215R affects patients,the clinical impacts of ADO2 extend beyond the skeleton,affecting several other organs.The hallmark of the extra-skeletal alterations is a consistent perivascular fibrosis,associated with high numbers of macrophages and lymphoid infiltrates.Fragmented clinical information in a small cohort of patients confirms extra-skeletal alterations consistent with a systemic disease,in line with the observation that the CLCN7 gene is expressed in many organs.ADO2 mice also show anxiety and depression and their brains exhibit not only perivascular fibrosis but also β-amyloid accumulation and astrogliosis,suggesting the involvement of the nervous system in the pathogenesis of the ADO2 extra-skeletal alterations.Extra-skeletal organs share a similar cellular pathology,confirmed also in vitro in bone marrow mononuclear cells and osteoclasts,characterized by an impairment of the exit pathway of the Clcn7 protein product,ClC7,through the Golgi,with consequent reduced ClC7 expression in late endosomes and lysosomes,associated with high vesicular pH and accumulation of autophagosome markers.Finally,an experimental siRNA therapy,previously proven to counteract the bone phenotype,also improves the extra-skeletal alterations.These results could have important clinical implications,supporting the notion that a systematic evaluation of ADO2 patients for extra-skeletal symptoms could help improve their diagnosis,clinical management,and therapeutic options. | Antonio Maurizi Mattia Capulli Annabel Curle Rajvi Patel Argia Ucci Juliana Alves Cotes Harriet Oxford Shireen R. Lamandé John F. Bateman Nadia Rucci Anna Teti | 2019 | Bone Research2019，7，2： | 3 |
| 5 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 3 |
| 6 | Integrating green supply chain management into an embryonic eco-industrial development: a case study of the Guitang Group显示文摘 | Qinghua Zhu Raymond P Cote | 2004 | Journal of Cleaner Production2004，，8： | 2 |
| 7 | Role of EUS for preoperative evaluation of cholangiocarcinoma: a large single-center experience显示文摘 | Mehdi Mohamadnejad John M. DeWitt Stuart Sherman Julia K. LeBlanc Henry A. Pitt Michael G. House Kelly J. Jones Evan L. Fogel Lee McHenry James L. Watkins Gregory A. Cote Glen A. Lehman Mohammad A. Al-Haddad | 2011 | Gastrointestinal Endoscopy2011，，1： | 2 |
| 8 | A next-generation marker genotyping platform(AmpSeq)in heterozygous crops:a case study for marker-assisted selection in grapevine显示文摘Marker-assisted selection(MAS)is often employed in crop breeding programs to accelerate and enhance cultivar development,via selection during the juvenile phase and parental selection prior to crossing.Next-generation sequencing and its derivative technologies have been used for genome-wide molecular marker discovery.To bridge the gap between marker development and MAS implementation,this study developed a novel practical strategy with a semi-automated pipeline that incorporates trait-associated single nucleotide polymorphism marker discovery,low-cost genotyping through amplicon sequencing(AmpSeq)and decision making.The results document the development of a MAS package derived from genotyping-by-sequencing using three traits(flower sex,disease resistance and acylated anthocyanins)in grapevine breeding.The vast majority of sequence reads(⩾99%)were from the targeted regions.Across 380 individuals and up to 31 amplicons sequenced in each lane of MiSeq data,most amplicons(83 to 87%)had<10%missing data,and read depth had a median of 220–244×.Several strengths of the AmpSeq platform that make this approach of broad interest in diverse crop species include accuracy,flexibility,speed,high-throughput,low-cost and easily automated analysis. | Shanshan Yang Jonathan Fresnedo-Ramíre Minghui Wang Linda Cote Peter Schweitzer Paola Barba Elizabeth M Takacs Matthew Clark James Luby David C Manns Gavin Sacks Anna Katharine Mansfield Jason Londo Anne Fennell David Gadoury Bruce Reisch Lance Cadle-Davidson Qi Sun | 2016 | Horticulture Research2016，3，1： | 2 |
| 9 | Gas–metal reaction products in the erosion of chromium-plated gun bores显示文摘 | Paul J Cote Christopher Rickard | 2000 | Wear2000，，1： | 2 |
| 10 | Exposure to pulsed high frequency electromagnetic field during waking affects human sleep EEG 显示文摘 | HUBER R GRAF T COTE KA | 2000 | Neuroreport2000，11，： | 1 |
| 11 | New directions in management accounting research 显示文摘 | Atkinson A A Balakrishnan P B Cote J M Grout T M Roberts H Ulan E Wu A | | Journal of Management Accounting Research0，997，： | 1 |
| 12 | Botulinum toxin type A iniections: Adverse events reported to the US Food and Drug Administration in therapeutic and cosmetic cases显示文摘 | Cote TR Mohan AK Polder JA | 2005 | J Am Acad Dermatol2005，53，： | 1 |
| 13 | Air flow obstruction,dyspnea,exercise performance(BODE) index jn chronic obstruction pulmonary diseases显示文摘 | CeUi BR Cote C Marin JM | 2004 | N Engl J Med2004，350，10： | 1 |
| 14 | Non-noble metal-based catalysts for the reduction of oxygen in polymer eleectrolyte fuel cells显示文摘 | LALANDE G FAUBERT G | 1988 | J New Mat Electrochem Systems1988，1，： | 1 |
| 15 | Relaxation of Crystals with the Quasi-Newton Method显示文摘 | Pfrommer B G Cote M Louie S G | 1997 | Journal of Computational Physics1997，131，1： | 1 |
| 16 | Increasing N and P resorption effi- ciency and proficiency in northern deciduous hardwoods with decrea- sing foliar N and P concentrations 显示文摘 | Cote B Fyles J W Djalivand H | 2002 | Annals of forest science2002，59，3： | 1 |
| 17 | Support vector network显示文摘 | Cotes C Vapnic V | 1995 | Machine Learning1995，20，1： | 1 |
| 18 | The annual incidence and course of nect pain in the general population: a population - based cohort study 显示文摘 | Cote P Cassidy JD Carroll LJ | 2004 | Pain2004，112，： | 1 |
| 19 | Analysis of soil wetting and solute transport in subsurface trickle irrigation显示文摘 | Cote Claire M Bristow Keith L Charlesworth pllilip B | 2003 | Irrigation Science2003，22，3： | 1 |
| 20 | Investigation of the speciation of uranium( VI ) in concentrated phosphoric acid and in synergistic extraction systems by time-resolved laser-in- duced fluorescence spectroscopy (TRLFS) 显示文摘 | BELTRAMI D MERCIER-BION F COTE G | 2014 | Journal of Molec- ular Liquids2014，190，： | 1 |
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