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| 1 | A longitudinal study of SARS-CoV-2-infected patients reveals a high correlation between neutralizing antibodies and COVID-19 severity显示文摘Understanding the immune responses elicited by SARS-CoV-2 infection is critical in terms of protection against reinfection and,thus,for public health policy and vaccine development for COVID-19.In this study,using either live SARS-CoV-2 particles or retroviruses pseudotyped with the SARS-CoV-2 S viral surface protein(Spike),we studied the neutralizing antibody(nAb)response in serum samples from a cohort of 140 SARS-CoV-2 qPCR-confirmed infections,including patients with mild symptoms and also more severe forms,including those that required intensive care.We show that nAb titers correlated strongly with disease severity and with anti-spike IgG levels.Indeed,patients from intensive care units exhibited high nAb titers;conversely,patients with milder disease symptoms had heterogeneous nAb titers,and asymptomatic or exclusive outpatient-care patients had no or low nAbs.We found that nAb activity in SARS-CoV-2-infected patients displayed a relatively rapid decline after recovery compared to individuals infected with other coronaviruses.Moreover,we found an absence of cross-neutralization between endemic coronaviruses and SARS-CoV-2,indicating that previous infection by human coronaviruses may not generate protective nAbs against SARS-CoV-2.Finally,we found that the D614G mutation in the spike protein,which has recently been identified as the current major variant in Europe,does not allow neutralization escape.Altogether,our results contribute to our understanding of the immune correlates of SARS-CoV-2-induced disease,and rapid evaluation of the role of the humoral response in the pathogenesis of SARS-CoV-2 is warranted. | Vincent Legros Solène Denolly Manon Vogrig Bertrand Boson Eglantine Siret Josselin Rigaill Sylvie Pillet Florence Grattard Sylvie Gonzalo Paul Verhoeven Omran Allatif Philippe Berthelot Carole Pélissier Guillaume Thiery Elisabeth Botelho-Nevers Guillaume Millet Jérôme Morel Stéphane Paul Thierry Walzer François-Loïc Cosset Thomas Bourlet Bruno Pozzetto | 2021 | Cellular & Molecular Immunology2021，18，2： | 3 |
| 2 | Characterization of Hepatitis C Virus Particle Subpopulations Reveals Multiple Usage of the Scavenger Receptor BI for Entry Steps显示文摘 | Viet Loan Dao Thi Christelle Granier Mirjam B. Zeisel Maryse Guérin Jimmy Mancip Ophélia Granio Fran?ois Penin Dimitri Lavillette Ralf Bartenschlager Thomas F. Baumert Fran?ois-Lo?c Cosset Marlène Dreux | 2012 | Journal of Biological Chemistry2012，，37： | 2 |
| 3 | The role of IL-1 and IL-1Ra in joint inflammation and cartilage degradation显示文摘 | Cosset M Berenbaum F | 2006 | Vitam Horm2006，74，： | 1 |
| 4 | Politi- cal Connections of Newly Privatized Firms 显示文摘 | BOUBAKR1 N COSSET J C SAFFAR W | 2008 | Jour- nal of Corporate Finance2008，14，5： | 1 |
| 5 | Braehy Therapy Versus Prostateetomy in Localized Prostate Cancer: Results of a French Multicenter Prospective Medico-Economic Study 显示文摘 | Buron C Levu B Cosset JM | 2007 | Int J Radiat Oncol Biol Phys2007，67，3： | 1 |
| 6 | Contribution of redox status to hepatitis C virus E 2 envelope protein function and antigenicity显示文摘 | Emmanuet Fenouilfet Dimitri LaviHete SiIvia Loureiro George Krashias Guillemette Maurin Fran?ois-Lo?c Cosset lan M Jones Eym Barbouche | 2008 | The Journal of biological chemist ry2008，283，26： | 1 |
| 7 | The role of IL-1 and IL-1 Ra in joint inflammation and cartilage degradation 显示文摘 | Jacques C Cosset M Berenbanm F | 2006 | Vitam Horm2006，74，： | 1 |
| 8 | EGFR and EphA2are host factors for hepatitis C virus entry and possible targets for antiviral therapy显示文摘 | Lupberger J Zeisel M B Xiao F Thumann C Fofana I Zona L Davis C Mee C J Turek M Gorke S Royer C Fischer B Zahid M N Lavillette D Fresquet J Cosset F L Rothenberg S M Pietschmann T Patel A H Pessaux P Doffol M Raffelsbe-rger W Poch O McKeating J A Brino L Baumert T F | 2011 | Nat Med2011，17，5： | 1 |
| 9 | Cell and cytokine profiles in nasal secretions from patientswith nasal polyposis:effects of topical steroids and surgical treatment显示文摘 | Bolard F Cosset P Lamblin C | 2001 | Allergy2001，56，4： | 1 |
| 10 | Political connections of newly privatized firms 显示文摘 | Boubakri N J C Cosset W Saffar | 2008 | Journal of Corporate Finance2008，14，5： | 1 |
| 11 | The role of state and foreign owners in corporate risk-taking:Evidence from privatization 显示文摘 | BOUBAKRI N COSSET J C SAFFAR W | 2013 | Journal of Financial Economics2013，，108： | 1 |
| 12 | Political connections of newly privatized firms 显示文摘 | Bouhakri N Cosset J C Saffar W | 2008 | Journal of Corporate Finance2008，14，5： | 1 |
| 13 | The financial and operating performance of newly privatized firms: Evidence from developing countries显示文摘 | Narjess B Cosset J C | 1998 | Journal of Finance1998，53，3： | 1 |
| 14 | Liberalization, corporate governance and the performanee of privatized firms in developing countries显示文摘 | Bonbakri N Cosset J C Guedhami O | 2005 | Journal of Corporate Finance2005，11，5： | 1 |
| 15 | Political connections of newly privatized firms 显示文摘 | Boubakri N Cosset J C Saffar W | 2008 | Journal of corporate fi- nance2008，14，5： | 1 |
| 16 | Brachytherapy versus prostatectomy in localized prostate cancer:results of a French multicenter prospective medico-economic study显示文摘 | Buron C Le Vu B Cosset JM | | 0，，03： | 1 |
| 17 | The Role of State and Foreign Owners in Corporate Risk-taking: Evidence From Privatization显示文摘 | Boubakri N Cosset J C Saffar W | 2013 | Journal of Financial Economics2013，108，3： | 1 |
| 18 | Political connections of newly privatized firms显示文摘 | Boubakri N Cosset J C Saffar W | 2008 | Journal of Corporate Finance2008，14，5： | 1 |
| 19 | The financial and operating performance of newly privatized firms:evidence from developing countries显示文摘 | Boubakri N Cosset J C | 1998 | The Journal of Finance1998，53，3： | 1 |
| 20 | Privatization and Bank Performance in Developing Countries 显示文摘 | Boubakri N Cosset J C | 2005 | Journal of Banking and Finance2005，29，8： | 1 |
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