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| 1 | Neuroprotective and anti-inflammatory effects of a therapy combining agonists of nicotinic α7 and σ1 receptors in a rat model of Parkinson’s disease显示文摘To date there is no treatment able to stop or slow down the loss of dopaminergic neurons that characterizes Parkinson’s disease.It was recently observed in a rodent model of Alzheimer’s disease that the interaction between the α7 subtype of nicotinic acetylcholine receptor(α7-nAChR)and sigma-1 receptor(σ1-R)could exert neuroprotective effects through the modulation of neuroinflammation which is one of the key components of the pathophysiology of Parkinson’s disease.In this context,the aim of the present study was to assess the effects of the concomitant administration of N-(3R)-1-azabicyclo[2.2.2]oct-3-yl-furo[2,3-c]pyridine-5-carboxamide(PHA)543613 as an α7-nAChR agonist and 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate(PRE)-084 as aσ1-R agonist in a well-characterized 6-hydroxydopamine rat model of Parkinson’s disease.The animals received either vehicle separately or the dual therapy PHA/PRE once a day until day 14 postlesion.Although no effect was noticed in the amphetamine-induced rotation test,our data has shown that the PHA/PRE treatment induced partial protection of the dopaminergic neurons(15-20%),assessed by the dopamine transporter density in the striatum and immunoreactive tyrosine hydroxylase in the substantia nigra.Furthermore,this dual therapy reduced the degree of glial activation consecutive to the 6-hydroxydopamine lesion,i.e,the 18 kDa translocation protein density and glial fibrillary acidic protein staining in the striatum,and the CD11b and glial fibrillary acidic protein staining in the substantia nigra.Hence,this study reports for the first time that concomitant activation of α7-nAChR andσ1-R can provide a partial recovery of the nigro-striatal dopaminergic neurons through the modulation of microglial activation.The study was approved by the Regional Ethics Committee(CEEA Val de Loire n°19)validated this protocol(Authorization N°00434.02)on May 15,2014. | Steven Vetel Laura Foucault-Fruchard Claire Tronel Frédéric Buron Jackie Vergote Sylvie Bodard Sylvain Routier Sophie Sérrière Sylvie Chalon | 2021 | Neural Regeneration Research2021，16，6： | 3 |
| 2 | Glularnine pretreatment reduces IL-8 production in human intestinal epithelial cells by limiting I KBct ubiquitination 显示文摘 | Buron AH Leblond J Jaequot A | 2006 | J Nutr2006，136，6： | 1 |
| 3 | Elaboration and characterization of polyaniline films electrodeposited on tin oxides显示文摘 | Buron C C Lakard B Monnin A F | | 0，，19： | 1 |
| 4 | A comparison of hysteroscopic mechanical tissue removal with bipolar electrical resection for the management of endometrial polyps in an ambulatory care setting. Preliminary results显示文摘 | Pampalona J. Rovira Bastos M. Degollada Moreno G. Mancebo Andrea Buron Pust Gemma Escribano Montesdeoca Angel Guerra Garcia Pru?onosa JC. Mateu Collado R. Carreras Torras P. Bresco | 2014 | The Journal of Minimally Invasive Gynecology2014，，： | 1 |
| 5 | Characterization of a polydnavims (PDV) and virus-like filamentous particle (VLFP) in the braconid wasp Cotesia congregata (Hymenoptera: Braconidae)显示文摘 | BURON I D E BECKAGE N E | 1992 | Journal of Invertebrate Pathology1992，59，： | 1 |
| 6 | Total amino acid requirements of weaned piglets 8 to 25 kg live weight given diets based on wheat and soya - bean meal fortified with free amino acids 显示文摘 | GATEL F BURON G FEKETE J | 1992 | Anim Prod1992，54，： | 1 |
| 7 | GPU Shape Grammars显示文摘 | Jean‐Eudes Marvie Cyprien Buron Pascal Gautron Patrice Hirtzlin Ga?l Sourimant | 2012 | Computer Graphics Forum (pt)2012，，7： | 1 |
| 8 | Use of human cancer cell lines mitochondria to explore the mechanisms of BH3 peptides and ABT-737-induced mitochondrial membrane permeabilization显示文摘 | Buron N Porceddu M Brabant M | | 0，，03： | 1 |
| 9 | Braehy Therapy Versus Prostateetomy in Localized Prostate Cancer: Results of a French Multicenter Prospective Medico-Economic Study 显示文摘 | Buron C Levu B Cosset JM | 2007 | Int J Radiat Oncol Biol Phys2007，67，3： | 1 |
| 10 | Prediction of liver injury induced by chemicals in human with a multiparametric assay on isolated mouse liver mitochondria显示文摘 | Porceddu M Buron N Roussel C | 2012 | Toxicol Sci2012，129，2： | 1 |
| 11 | Optical characterization of concentrated dispersions:applica-tions to laboratory analyses and on-line process monitoring and control 显示文摘 | BURON H MENGUAL O MEUNIER G | 2004 | Polymer International2004，53，： | 1 |
| 12 | Total amino acid requirements of weaned piglets 8 to 25 kg live weight given diets based on wheat and soybean meal fortified with free amino acids显示文摘 | Gatel F Buron G Fekete J | 1992 | Anim Prod1992，54，： | 1 |
| 13 | Optical characterization of concentrated dispersions: applications to laboratory analyses and on-line process monitoring and control 显示文摘 | Buron H Mengual O Meunier G | 2004 | Polymer International2004，53，9： | 1 |
| 14 | Af- finity precipitation of lactate dehydrogen- ase with a triazine dye derivative: selec- tive precipitation of rabbit muscle lactate dehydrogenase with a procion blue H - B analog 显示文摘 | Pearson J C Buron S J Lower C R | 1986 | Analytical Biochemistry1986，158，： | 1 |
| 15 | Human mesenehymal stem cells and immunosuppressive drug interactions in allogeneic responses: an in vitro study using human cells显示文摘 | Buron F Perrin H Malcus C | 2009 | Transplant Proe2009，41，8： | 1 |
| 16 | Estimation of road transportation emissions in Spain from 1988 to 1999 using COPERT Ⅲ program 显示文摘 | BURON J M LOPEZ JM APARICIO F | 2004 | Atmos Environ2004，38，5： | 1 |
| 17 | Tracheal rupture after endotraeheal intubationg a literature systematic review显示文摘 | Minambres E Buron J Ballesteros MA | 2009 | Eur I Cardiothorac Surg2009，35，6： | 1 |
| 18 | Label preference schemes in GMPLS controlled networks显示文摘 | ANDRIOLLI N BURON J RUEPP S | 2006 | IEEE Comm Lett2006，10，12： | 1 |
| 19 | Esti mating glomerular filtration rate in kidney transplant recipients: performance over time of four ereatinine-based formulas 显示文摘 | Buron F Hadj-Aissa A Dubourg L | 2011 | Transplantation2011，92，9： | 1 |
| 20 | Restoration in all-optical GMPLS networks with limited wavelength conversion显示文摘 | RUEPP S ANDRIOLLI N BURON J | 2008 | Computer Networks and ISDN Systems-CN2008，52，10： | 1 |
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